{"id":8496,"date":"2023-07-18T10:56:23","date_gmt":"2023-07-18T07:56:23","guid":{"rendered":"https:\/\/urbancare.clinic\/a-step-closer-to-an-anti-aging-pill-harvard-researchers-find-age-reversing-chemical-cocktails\/"},"modified":"2023-07-18T10:56:23","modified_gmt":"2023-07-18T07:56:23","slug":"hatua-ya-karibu-na-kidonge-cha-kuzuia-kuzeeka-watafiti-wa-harvard-wapata-visa-vya-kemikali-vya-kubadili-umri","status":"publish","type":"post","link":"https:\/\/urbancare.clinic\/sw\/hatua-ya-karibu-na-kidonge-cha-kuzuia-kuzeeka-watafiti-wa-harvard-wapata-visa-vya-kemikali-vya-kubadili-umri\/","title":{"rendered":"Hatua ya Kukaribia Kidonge cha Kuzuia Kuzeeka? Watafiti wa Harvard Wanapata Cocktail za Kemikali Zinazorudisha Umri"},"content":{"rendered":"
<\/div>\n

Wanasayansi wamekuwa katika mbio za kutafuta kidonge cha "chemchemi ya ujana" ambacho kina uwezo wa kuongeza maisha marefu au kubadili kuzeeka. Bado tupo? Inaonekana kama sisi ni hatua ya karibu na kichochezi kisichoweza kuepukika cha maisha.<\/p>\n

Katika kile ambacho kinaweza kuwa ugunduzi wa kutisha, kundi la watafiti kutoka Harvard wamegundua visa sita vya kemikali ambavyo wanasema vinaweza kubadilisha mchakato wa kuzeeka katika seli za ngozi ya binadamu na panya.<\/p>\n

\u201cTunashukuru kushiriki chapisho letu la hivi punde: Hapo awali tumeonyesha ubadilishaji wa umri unawezekana kwa kutumia tiba ya jeni kuwasha jeni za kiinitete. Sasa tunaonyesha kuwa inawezekana kwa vinywaji vya kemikali, hatua kuelekea ufufuaji wa mwili mzima kwa bei nafuu,\u201d alitweet Dk. David Sinclair, mwanabiolojia wa molekuli katika Shule ya Matibabu ya Harvard na mwandishi mwenza wa utafiti huo.<\/p>\n

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Asante kwa kushiriki chapisho letu la hivi punde: Hapo awali tumeonyesha ubadilishaji wa umri unawezekana kwa kutumia tiba ya jeni kuwasha jeni za kiinitete. Sasa tunaonyesha kuwa inawezekana kwa vinywaji vya kemikali, hatua kuelekea ufufuaji wa mwili mzima kwa bei nafuu 1\/17 https:\/\/t.co\/J9c01lv5FQ<\/a><\/p>\n

- David Sinclair (@davidasinclair) Julai 12, 2023<\/a><\/p><\/blockquote>\n<\/div>\n<\/div>\n<\/figure>\n

"Tunatambua cocktail sita za kemikali, ambazo, chini ya wiki moja na bila kuathiri utambulisho wa seli, hurejesha wasifu wa nakala wa ujana wa jenomu na kubadili umri wa maandishi. Kwa hivyo, kuzaliwa upya kwa mabadiliko ya umri kunaweza kupatikana, sio tu kwa maumbile, lakini pia njia za kemikali, "watafiti waliandika katika utafiti uliochapishwa katika jarida la Aging.<\/p>\n

Utafiti ulitathmini athari za a mchanganyiko wa dawa<\/a> ambayo ina metformin ya homoni ya ukuaji na dawa inayowezesha kimeng'enyo cha protini kinase (AMPK) katika ufufuaji wa misuli iliyozeeka, tishu za ini na viungo vingine.<\/p>\n

"Utafiti juu ya mishipa ya macho, tishu za ubongo, figo na misuli umeonyesha matokeo ya kuahidi, kwa kuboresha maono na kupanua maisha ya panya na, hivi karibuni, mwezi wa Aprili mwaka huu, kuboresha maono ya nyani," Dk. Sinclair. sema<\/a>.<\/p>\n

Timu hiyo ilidai kuwa ilipata athari za kurudisha umri na michanganyiko yote sita. Madhara ya matibabu ya siku nne kwa kutumia Visa yalilinganishwa na jumla ya mabadiliko yaliyoonekana baada ya mwaka mmoja wa matibabu ya kuzaliwa upya katika utafiti wa kihistoria kutoka 2019.<\/p>\n

"Ugunduzi huu mpya unatoa uwezekano wa kubadili uzee kwa kidonge kimoja, na matumizi kuanzia kuboresha macho hadi kutibu kwa ufanisi magonjwa yanayohusiana na umri," Dk. Sinclair aliongeza.<\/p>\n

Hata hivyo, watafiti wengine hupokea matokeo hayo wakiwa na mashaka kidogo. Matt Kaeberlein, biogerontologist, aliiambia Dunia<\/a> kwamba ni utafiti wa awali tu na watafiti wanapaswa kuthibitisha angalau moja ya mchanganyiko katika mfano wa wanyama kwa ufanisi wake katika vipimo vya afya vinavyohusiana na umri au maisha.<\/p>\n

Dk. Charles Brenner, mtafiti wa kimetaboliki, aliibua wasiwasi kuhusu usalama wa dawa zinazotumiwa katika Visa. "Hizi kwa ujumla si salama peke yake au kwa mchanganyiko," Brenner alisema.<\/p>\n

Imechapishwa na Medicaldaily.com<\/p>\n

Chanzo cha matibabu cha kila siku<\/a><\/p>\n

","protected":false},"excerpt":{"rendered":"

<\/div>\n

Wanasayansi wamekuwa katika mbio za kutafuta kidonge cha "chemchemi ya ujana" ambacho kina uwezo wa kuongeza maisha marefu au kubadili kuzeeka. Bado tupo? Inaonekana kama sisi ni hatua ya karibu na kichochezi kisichoweza kuepukika cha maisha.<\/p>\n

Katika kile ambacho kinaweza kuwa ugunduzi wa kutisha, kundi la watafiti kutoka Harvard wamegundua visa sita vya kemikali ambavyo wanasema vinaweza kubadilisha mchakato wa kuzeeka katika seli za ngozi ya binadamu na panya.<\/p>\n

\u201cTunashukuru kushiriki chapisho letu la hivi punde: Hapo awali tumeonyesha ubadilishaji wa umri unawezekana kwa kutumia tiba ya jeni kuwasha jeni za kiinitete. Sasa tunaonyesha kuwa inawezekana kwa vinywaji vya kemikali, hatua kuelekea ufufuaji wa mwili mzima kwa bei nafuu,\u201d alitweet Dk. David Sinclair, mwanabiolojia wa molekuli katika Shule ya Matibabu ya Harvard na mwandishi mwenza wa utafiti huo.<\/p>\n

\n
\n
\n
\n

Asante kwa kushiriki chapisho letu la hivi punde: Hapo awali tumeonyesha ubadilishaji wa umri unawezekana kwa kutumia tiba ya jeni kuwasha jeni za kiinitete. Sasa tunaonyesha kuwa inawezekana kwa vinywaji vya kemikali, hatua kuelekea ufufuaji wa mwili mzima kwa bei nafuu 1\/17 https:\/\/t.co\/J9c01lv5FQ<\/a><\/p>\n

- David Sinclair (@davidasinclair) Julai 12, 2023<\/a><\/p><\/blockquote>\n<\/div>\n<\/div>\n<\/figure>\n

"Tunatambua cocktail sita za kemikali, ambazo, chini ya wiki moja na bila kuathiri utambulisho wa seli, hurejesha wasifu wa nakala wa ujana wa jenomu na kubadili umri wa maandishi. Kwa hivyo, kuzaliwa upya kwa mabadiliko ya umri kunaweza kupatikana, sio tu kwa maumbile, lakini pia njia za kemikali, "watafiti waliandika katika utafiti uliochapishwa katika jarida la Aging.<\/p>\n

Utafiti ulitathmini athari za a mchanganyiko wa dawa<\/a> ambayo ina metformin ya homoni ya ukuaji na dawa inayowezesha kimeng'enyo cha protini kinase (AMPK) katika ufufuaji wa misuli iliyozeeka, tishu za ini na viungo vingine.<\/p>\n

"Utafiti juu ya mishipa ya macho, tishu za ubongo, figo na misuli umeonyesha matokeo ya kuahidi, kwa kuboresha maono na kupanua maisha ya panya na, hivi karibuni, mwezi wa Aprili mwaka huu, kuboresha maono ya nyani," Dk. Sinclair. sema<\/a>.<\/p>\n

Timu hiyo ilidai kuwa ilipata athari za kurudisha umri na michanganyiko yote sita. Madhara ya matibabu ya siku nne kwa kutumia Visa yalilinganishwa na jumla ya mabadiliko yaliyoonekana baada ya mwaka mmoja wa matibabu ya kuzaliwa upya katika utafiti wa kihistoria kutoka 2019.<\/p>\n

"Ugunduzi huu mpya unatoa uwezekano wa kubadili uzee kwa kidonge kimoja, na matumizi kuanzia kuboresha macho hadi kutibu kwa ufanisi magonjwa yanayohusiana na umri," Dk. Sinclair aliongeza.<\/p>\n

Hata hivyo, watafiti wengine hupokea matokeo hayo wakiwa na mashaka kidogo. Matt Kaeberlein, biogerontologist, aliiambia Dunia<\/a> kwamba ni utafiti wa awali tu na watafiti wanapaswa kuthibitisha angalau moja ya mchanganyiko katika mfano wa wanyama kwa ufanisi wake katika vipimo vya afya vinavyohusiana na umri au maisha.<\/p>\n

Dk. Charles Brenner, mtafiti wa kimetaboliki, aliibua wasiwasi kuhusu usalama wa dawa zinazotumiwa katika Visa. "Hizi kwa ujumla si salama peke yake au kwa mchanganyiko," Brenner alisema.<\/p>\n

Imechapishwa na Medicaldaily.com<\/p>","protected":false},"author":2,"featured_media":8497,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"Default","format":"standard","meta":{"fifu_image_url":"https:\/\/urbancare.clinic\/wp-content\/uploads\/2023\/07\/a-step-closer-to-an-anti-aging-pill-harvard-researchers-find-age-reversing-chemical-cocktails.jpg","fifu_image_alt":"","footnotes":""},"categories":[27],"tags":[],"class_list":["post-8496","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blog"],"yoast_head":"\nA Step Closer To An Anti-Aging Pill? Harvard Researchers Find Age-Reversing Chemical Cocktails - Urban Care Clinic<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/urbancare.clinic\/sw\/hatua-ya-karibu-na-kidonge-cha-kuzuia-kuzeeka-watafiti-wa-harvard-wapata-visa-vya-kemikali-vya-kubadili-umri\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"A Step Closer To An Anti-Aging Pill? Harvard Researchers Find Age-Reversing Chemical Cocktails - Urban Care Clinic\" \/>\n<meta property=\"og:description\" content=\"Scientists have been in a race to find a "fountain of youth" pill that has the potential to increase longevity or reverse aging. Are we there yet? Looks like we are a step closer to the ever-elusive elixir of life.In what could be a groundbreaking discovery, a group of researchers from Harvard has identified six chemical cocktails that they say can reverse the aging process in both human and mouse skin cells."Grateful to share our latest publication: We've previously shown age reversal is possible using gene therapy to turn on embryonic genes. Now we show it's possible with chemical cocktails, a step towards affordable whole-body rejuvenation," tweeted Dr. David Sinclair, a molecular biologist at Harvard Medical School and co-author of the study.Grateful to share our latest publication: We\u2019ve previously shown age reversal is possible using gene therapy to turn on embryonic genes. Now we show it\u2019s possible with chemical cocktails, a step towards affordable whole-body rejuvenation 1\/17 https:\/\/t.co\/J9c01lv5FQ\u2014 David Sinclair (@davidasinclair) July 12, 2023 "We identify six chemical cocktails, which, in less than a week and without compromising cellular identity, restore a youthful genome-wide transcript profile and reverse transcriptomic age. Thus, rejuvenation by age reversal can be achieved, not only by genetic, but also chemical means, " the researchers wrote in the study published in the journal Aging.The study evaluated the impact of a drug concoction that contains the growth hormone metformin and a drug that activates the enzyme-activated protein kinase (AMPK) in the rejuvenation of aged muscles, liver tissue and other organs."Studies on the optic nerve, brain tissue, kidney and muscle have shown promising results, with improved vision and extended lifespan in mice and, recently, in April of this year, improved vision in monkeys," Dr. Sinclair said.The team claimed they found age-reversing effects with all six combinations. The impact of a four-day treatment using the cocktails was comparable to the total change seen after a year of a regenerative treatment in a landmark study from 2019."This new discovery offers the potential to reverse aging with a single pill, with applications ranging from improving eyesight to effectively treating age-related diseases," Dr. Sinclair added.However, some researchers receive the findings with a pinch of skepticism. Matt Kaeberlein, a biogerontologist, told Earth that it is just a preliminary study and the researchers should validate at least one of the concoctions in an animal model for its effectiveness in age-related health metrics or lifespan.Dr. Charles Brenner, a metabolism researcher, raised concerns about the safety of the drugs used in the cocktails. "These are generally not safe alone or in a combination," Brenner said.Published by Medicaldaily.com\" \/>\n<meta property=\"og:url\" content=\"https:\/\/urbancare.clinic\/sw\/hatua-ya-karibu-na-kidonge-cha-kuzuia-kuzeeka-watafiti-wa-harvard-wapata-visa-vya-kemikali-vya-kubadili-umri\/\" \/>\n<meta property=\"og:site_name\" content=\"Urban Care Clinic\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/urbancarezanzibar\" \/>\n<meta property=\"article:published_time\" content=\"2023-07-18T07:56:23+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/urbancare.clinic\/wp-content\/uploads\/2023\/07\/a-step-closer-to-an-anti-aging-pill-harvard-researchers-find-age-reversing-chemical-cocktails.jpg\" \/>\n<meta name=\"author\" content=\"Urban Care Clinic\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:image\" content=\"https:\/\/urbancare.clinic\/wp-content\/uploads\/2023\/07\/a-step-closer-to-an-anti-aging-pill-harvard-researchers-find-age-reversing-chemical-cocktails.jpg\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Urban Care Clinic\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"dakika 2\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/urbancare.clinic\/a-step-closer-to-an-anti-aging-pill-harvard-researchers-find-age-reversing-chemical-cocktails\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/urbancare.clinic\/a-step-closer-to-an-anti-aging-pill-harvard-researchers-find-age-reversing-chemical-cocktails\/\"},\"author\":{\"name\":\"Urban Care Clinic\",\"@id\":\"https:\/\/urbancare.clinic\/#\/schema\/person\/f286c4d84be896d302aceda3ed7e789c\"},\"headline\":\"A Step Closer To An Anti-Aging Pill? 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Watafiti wa Harvard Wanapata Cocktails za Kemikali Inayorudisha Umri - Kliniki ya Huduma ya Mjini","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/urbancare.clinic\/sw\/hatua-ya-karibu-na-kidonge-cha-kuzuia-kuzeeka-watafiti-wa-harvard-wapata-visa-vya-kemikali-vya-kubadili-umri\/","og_locale":"en_US","og_type":"article","og_title":"A Step Closer To An Anti-Aging Pill? Harvard Researchers Find Age-Reversing Chemical Cocktails - Urban Care Clinic","og_description":"Scientists have been in a race to find a \"fountain of youth\" pill that has the potential to increase longevity or reverse aging. Are we there yet? Looks like we are a step closer to the ever-elusive elixir of life.In what could be a groundbreaking discovery, a group of researchers from Harvard has identified six chemical cocktails that they say can reverse the aging process in both human and mouse skin cells.\"Grateful to share our latest publication: We've previously shown age reversal is possible using gene therapy to turn on embryonic genes. Now we show it's possible with chemical cocktails, a step towards affordable whole-body rejuvenation,\" tweeted Dr. David Sinclair, a molecular biologist at Harvard Medical School and co-author of the study.Grateful to share our latest publication: We\u2019ve previously shown age reversal is possible using gene therapy to turn on embryonic genes. Now we show it\u2019s possible with chemical cocktails, a step towards affordable whole-body rejuvenation 1\/17 https:\/\/t.co\/J9c01lv5FQ\u2014 David Sinclair (@davidasinclair) July 12, 2023 \"We identify six chemical cocktails, which, in less than a week and without compromising cellular identity, restore a youthful genome-wide transcript profile and reverse transcriptomic age. Thus, rejuvenation by age reversal can be achieved, not only by genetic, but also chemical means, \" the researchers wrote in the study published in the journal Aging.The study evaluated the impact of a drug concoction that contains the growth hormone metformin and a drug that activates the enzyme-activated protein kinase (AMPK) in the rejuvenation of aged muscles, liver tissue and other organs.\"Studies on the optic nerve, brain tissue, kidney and muscle have shown promising results, with improved vision and extended lifespan in mice and, recently, in April of this year, improved vision in monkeys,\" Dr. Sinclair said.The team claimed they found age-reversing effects with all six combinations. The impact of a four-day treatment using the cocktails was comparable to the total change seen after a year of a regenerative treatment in a landmark study from 2019.\"This new discovery offers the potential to reverse aging with a single pill, with applications ranging from improving eyesight to effectively treating age-related diseases,\" Dr. Sinclair added.However, some researchers receive the findings with a pinch of skepticism. Matt Kaeberlein, a biogerontologist, told Earth that it is just a preliminary study and the researchers should validate at least one of the concoctions in an animal model for its effectiveness in age-related health metrics or lifespan.Dr. Charles Brenner, a metabolism researcher, raised concerns about the safety of the drugs used in the cocktails. \"These are generally not safe alone or in a combination,\" Brenner said.Published by Medicaldaily.com","og_url":"https:\/\/urbancare.clinic\/sw\/hatua-ya-karibu-na-kidonge-cha-kuzuia-kuzeeka-watafiti-wa-harvard-wapata-visa-vya-kemikali-vya-kubadili-umri\/","og_site_name":"Urban Care Clinic","article_publisher":"https:\/\/www.facebook.com\/urbancarezanzibar","article_published_time":"2023-07-18T07:56:23+00:00","og_image":[{"url":"https:\/\/urbancare.clinic\/wp-content\/uploads\/2023\/07\/a-step-closer-to-an-anti-aging-pill-harvard-researchers-find-age-reversing-chemical-cocktails.jpg","type":"","width":"","height":""}],"author":"Urban Care Clinic","twitter_card":"summary_large_image","twitter_image":"https:\/\/urbancare.clinic\/wp-content\/uploads\/2023\/07\/a-step-closer-to-an-anti-aging-pill-harvard-researchers-find-age-reversing-chemical-cocktails.jpg","twitter_misc":{"Written by":"Urban Care Clinic","Est. reading time":"dakika 2"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/urbancare.clinic\/a-step-closer-to-an-anti-aging-pill-harvard-researchers-find-age-reversing-chemical-cocktails\/#article","isPartOf":{"@id":"https:\/\/urbancare.clinic\/a-step-closer-to-an-anti-aging-pill-harvard-researchers-find-age-reversing-chemical-cocktails\/"},"author":{"name":"Urban Care Clinic","@id":"https:\/\/urbancare.clinic\/#\/schema\/person\/f286c4d84be896d302aceda3ed7e789c"},"headline":"A Step Closer To An Anti-Aging Pill? 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