{"id":7637,"date":"2022-11-22T13:00:22","date_gmt":"2022-11-22T10:00:22","guid":{"rendered":"https:\/\/urbancare.clinic\/clinicopathological-and-prognostic-values-of-pd-l1-expression-in-oesophageal-squamous-cell-carcinoma-a-meta-analysis-of-31-studies-with-5368-patients\/"},"modified":"2022-11-22T13:00:22","modified_gmt":"2022-11-22T10:00:22","slug":"maadili-ya-kiafya-na-ya-ubashiri-ya-usemi-wa-pd-l1-katika-saratani-ya-umio-ya-squamous-kiini-uchambuzi-wa-meta-wa-masomo-31-na-wagonjwa-5368","status":"publish","type":"post","link":"https:\/\/urbancare.clinic\/sw\/clinicopathological-and-prognostic-values-of-pd-l1-expression-in-oesophageal-squamous-cell-carcinoma-a-meta-analysis-of-31-studies-with-5368-patients\/","title":{"rendered":"Maadili ya kliniki na ya ubashiri ya usemi wa PD-L1 katika saratani ya seli ya squamous ya esophageal: uchambuzi wa meta wa masomo 31 na wagonjwa 5368."},"content":{"rendered":"<div><img decoding=\"async\" src=\"https:\/\/urbancare.clinic\/wp-content\/uploads\/2023\/02\/clinicopathological-and-prognostic-values-of-pd-l1-expression-in-oesophageal-squamous-cell-carcinoma-a-meta-analysis-of-31-studies-with-5368-patients.jpg\" class=\"ff-og-image-inserted\" style=\"display:none\"><\/div>\n<p><span class=\"highwire-journal-article-marker-start\"><\/span><\/p>\n<div class=\"section abstract\" id=\"abstract-1\" readability=\"39\">\n<h2>Muhtasari<\/h2>\n<p id=\"p-1\">Vizuizi kadhaa vya ukaguzi wa kinga vinavyolenga kano 1 ya kifo (PD-L1)\/kifo kilichoratibiwa 1 vimefanikiwa kuboresha ubashiri wa saratani ya umio ya squamous cell carcinoma (ESCC) kwa idhini katika nchi fulani. Hata hivyo, iwapo usemi wa PD-L1 unahusishwa na kiwango cha manufaa bado haijulikani wazi na kiwango cha umoja cha kingamwili na thamani iliyokatwa ya ugunduzi wa PD-L1 pia haipo. Uchambuzi wa sasa wa meta ulilenga kuchunguza uhusiano kati ya usemi wa PD-L1 na vipengele vya kiafya pamoja na ubashiri katika ESCC.<\/p>\n<p id=\"p-2\">Utafutaji wa kimfumo kwenye hifadhidata za PubMed, Embase, Maktaba ya Cochrane na Wavuti wa Sayansi ulifanyika hadi tarehe 30 Machi 2021. Uwiano kati ya usemi wa PD-L1 na vipengele vya kiafya, pamoja na ubashiri katika ESCC, ulikadiriwa kwa modeli ya madoido bila mpangilio.<\/p>\n<p id=\"p-3\">Jumla ya wagonjwa 5368 kutoka kwa masomo 31 ya nyuma waliandikishwa. Ufafanuzi wa kupita kiasi wa PD-L1 ulihusishwa kwa kiasi kikubwa na metastasis ya nodi za lymph (OR 1.342, 95% CI 0.995 hadi 1.809, p=0.050) na metastasis ya mbali (OR 1.516, 95% CI 1.001 hadi 2090, p=090). HR iliyojumuishwa ilionyesha kuwa usemi wa kupindukia wa PD-L1 ulihusiana kwa kiasi kikubwa na maisha duni ya jumla (OS) ya wagonjwa walio na ESCC (HR 1.306, 95% CI 1.108 hadi 1.539, p&lt;0.010) lakini sio kuishi bila magonjwa (DFS) (HR 1.180) (HR 1.180) 95% CI 0.937 hadi 1.487, p=0.160). Heterogeneity ilipungua kwa kiasi kikubwa katika uchanganuzi wa vikundi vidogo. Udhihirisho wa kupita kiasi wa PD-L1 ulihusishwa na DFS duni katika sehemu ya \u22651% (HR 1.642, 95% CI 1.367 hadi 1.973, p&lt;0.010; I<sup>2<\/sup>=0%) na Mfumo mbaya zaidi wa Uendeshaji katika sehemu iliyokatwa ya \u226510% (HR 1.575, 95% CI 1.175 hadi 2.111, p&lt;0.010; I<sup>2<\/sup>=0%).<\/p>\n<p id=\"p-4\">Ufafanuzi wa kupita kiasi wa PD-L1 ulihusishwa na nodi ya limfu na metastasis ya mbali pamoja na maisha duni ya ESCC.<\/p>\n<\/div>\n<ul class=\"kwd-group\">\n<li class=\"kwd\">ugonjwa wa umio<\/li>\n<li class=\"kwd\">epidemiolojia<\/li>\n<li class=\"kwd\">epidemiolojia<\/li>\n<li class=\"kwd\">elimu ya kinga<\/li>\n<\/ul>\n<p><span class=\"highwire-journal-article-marker-end\"><\/span><a href=\"http:\/\/pmj.bmj.com\/cgi\/content\/short\/98\/1166\/948?rss=1\">Chanzo cha matibabu cha kila siku<\/a><\/p>\n<p>","protected":false},"excerpt":{"rendered":"<p>Vizuizi kadhaa vya ukaguzi wa kinga vinavyolenga kano 1 ya kifo (PD-L1)\/kifo kilichoratibiwa 1 vimefanikiwa kuboresha ubashiri wa saratani ya umio ya squamous cell carcinoma (ESCC) kwa idhini katika nchi fulani. Hata hivyo, iwapo usemi wa PD-L1 unahusishwa na kiwango cha manufaa bado haijulikani wazi na kiwango cha umoja cha kingamwili na thamani iliyokatwa ya ugunduzi wa PD-L1 pia haipo. Uchambuzi wa sasa wa meta ulilenga kuchunguza uhusiano kati ya usemi wa PD-L1 na vipengele vya kiafya pamoja na ubashiri katika ESCC.<\/p>\n<p>Utafutaji wa kimfumo kwenye hifadhidata za PubMed, Embase, Maktaba ya Cochrane na Wavuti wa Sayansi ulifanyika hadi tarehe 30 Machi 2021. Uwiano kati ya usemi wa PD-L1 na vipengele vya kiafya, pamoja na ubashiri katika ESCC, ulikadiriwa kwa modeli ya madoido bila mpangilio.<\/p>\n<p>Jumla ya wagonjwa 5368 kutoka kwa masomo 31 ya nyuma waliandikishwa. Ufafanuzi wa kupita kiasi wa PD-L1 ulihusishwa kwa kiasi kikubwa na metastasis ya nodi za lymph (OR 1.342, 95% CI 0.995 hadi 1.809, p=0.050) na metastasis ya mbali (OR 1.516, 95% CI 1.001 hadi 2090, p=090). HR iliyojumuishwa ilionyesha kuwa usemi wa kupindukia wa PD-L1 ulihusiana kwa kiasi kikubwa na maisha duni ya jumla (OS) ya wagonjwa walio na ESCC (HR 1.306, 95% CI 1.108 hadi 1.539, p&lt;0.010) lakini sio kuishi bila magonjwa (DFS) (HR 1.180) (HR 1.180) 95% CI 0.937 hadi 1.487, p=0.160). Heterogeneity ilipungua kwa kiasi kikubwa katika uchanganuzi wa vikundi vidogo. Udhihirisho wa kupita kiasi wa PD-L1 ulihusishwa na DFS duni katika sehemu ya \u22651% (HR 1.642, 95% CI 1.367 hadi 1.973, p&lt;0.010; I<sup>2<\/sup>=0%) na Mfumo mbaya zaidi wa Uendeshaji katika sehemu iliyokatwa ya \u226510% (HR 1.575, 95% CI 1.175 hadi 2.111, p&lt;0.010; I<sup>2<\/sup>=0%).<\/p>\n<p>Ufafanuzi wa kupita kiasi wa PD-L1 ulihusishwa na nodi ya limfu na metastasis ya mbali pamoja na maisha duni ya ESCC.<\/p>","protected":false},"author":2,"featured_media":7638,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"Default","format":"standard","meta":{"page_builder":"","fifu_image_url":"https:\/\/urbancare.clinic\/wp-content\/uploads\/2023\/02\/clinicopathological-and-prognostic-values-of-pd-l1-expression-in-oesophageal-squamous-cell-carcinoma-a-meta-analysis-of-31-studies-with-5368-patients.jpg","fifu_image_alt":"","footnotes":""},"categories":[185],"tags":[],"class_list":["post-7637","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-research-medical-articles"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Clinicopathological and prognostic values of PD-L1 expression in oesophageal squamous cell carcinoma: a meta-analysis of 31 studies with 5368 patients - Urban Care Clinic<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/urbancare.clinic\/sw\/maadili-ya-kiafya-na-ya-ubashiri-ya-usemi-wa-pd-l1-katika-saratani-ya-umio-ya-squamous-kiini-uchambuzi-wa-meta-wa-masomo-31-na-wagonjwa-5368\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Clinicopathological and prognostic values of PD-L1 expression in oesophageal squamous cell carcinoma: a meta-analysis of 31 studies with 5368 patients - Urban Care Clinic\" \/>\n<meta property=\"og:description\" content=\"Several immune checkpoint inhibitors targeting programmed death ligand 1 (PD-L1)\/programmed death 1 have successfully improved the prognosis of oesophageal squamous cell carcinoma (ESCC) with approval in certain countries. However, whether the expression of PD-L1 is associated with the degree of benefit is unclear yet and a unified standard of antibody and cut-off value of PD-L1 detection is also lacking. The current meta-analysis then aimed to explore the association between PD-L1 expression and clinicopathological features as well as prognosis in ESCC. A systematic search on PubMed, Embase, Cochrane Library and Web of Science databases was performed up to 30 March 2021. The correlation between PD-L1 expression and clinicopathological features, as well as prognosis in ESCC, was estimated with the random-effects model. A total of 5368 patients from 31 retrospective studies were enrolled. The overexpression of PD-L1 was significantly associated with lymph node metastasis (OR 1.342, 95% CI 0.995 to 1.809, p=0.050) and distant metastasis (OR 1.516, 95% CI 1.001 to 2.294, p=0.050). The pooled HR showed that PD-L1 overexpression was significantly correlated with poor overall survival (OS) of patients with ESCC (HR 1.306, 95% CI 1.108 to 1.539, p&lt;0.010) but not disease-free survival (DFS) (HR 1.180, 95% CI 0.937 to 1.487, p=0.160). Heterogeneity decreased significantly in subgroup analyses. The overexpression of PD-L1 was associated with poor DFS at the cut-off point of &ge;1% (HR 1.642, 95% CI 1.367 to 1.973, p&lt;0.010; I2=0%) and worse OS at the cut-off point of &ge;10% (HR 1.575, 95% CI 1.175 to 2.111, p&lt;0.010; I2=0%). 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