{"id":7557,"date":"2023-02-09T12:57:32","date_gmt":"2023-02-09T09:57:32","guid":{"rendered":"https:\/\/urbancare.clinic\/ashkenazi-jews-susceptible-to-rare-genetic-disease-that-protects-them-from-tb-study\/"},"modified":"2023-02-09T12:57:32","modified_gmt":"2023-02-09T09:57:32","slug":"wayahudi-wa-ashkenazi-wanaoshambuliwa-na-ugonjwa-adimu-wa-kijeni-unaowalinda-dhidi-ya-utafiti-wa-tb","status":"publish","type":"post","link":"https:\/\/urbancare.clinic\/sw\/wayahudi-wa-ashkenazi-wanaoshambuliwa-na-ugonjwa-adimu-wa-kijeni-unaowalinda-dhidi-ya-utafiti-wa-tb\/","title":{"rendered":"Wayahudi wa Ashkenazi Wanahusika na Ugonjwa Adimu wa Kinasaba Ambao Huwalinda Na Kifua Kikuu: Utafiti"},"content":{"rendered":"
<\/div>\n

Katika hali ya kusikitisha, wanasayansi wamegundua kwamba ugonjwa wa nadra wa kijeni unaoathiri zaidi Wayahudi wa Ashkenazi pia huwalinda kutokana na kifua kikuu.<\/p>\n

Katika utafiti huo, iliyochapishwa katika jarida PNAS<\/a>, watafiti waligundua ugonjwa wa Gaucher (hutamkwa go-SHAY), ugonjwa wa lysosomal, hutoa kinga dhidi ya TB bila kukusudia.<\/p>\n

Kulingana na makadirio, karibu Watu milioni 10.6<\/a> kote ulimwenguni waliugua kutokana na kifua kikuu (TB) na watu milioni 1.6 walikufa kutokana na ugonjwa huo mnamo 2021.<\/p>\n

Hata hivyo, 95% ya watu ambao wameambukizwa na bakteria ya TB hawaugui. Mfumo wa kinga katika watu hawa hufanikiwa kuua pathojeni.<\/p>\n

<\/div>\n

\u201cMimi na wenzangu tunavutiwa na kile kinachofanya baadhi ya watu kuathiriwa na TB, huku wengine wakionekana kulindwa. Tunatumia pundamilia kuchunguza ugonjwa huo, kwani mifumo yao ya kinga hushiriki mambo mengi yanayofanana na yale ya binadamu, na inawezekana kudhibiti jeni zao kwenye maabara,\u201d Lalita Ramakrishnan, Profesa, Microbiology, Chuo Kikuu cha Cambridge, na Laura Whitworth, Maabara ya Kikundi. Meneja, Idara ya Tiba, Chuo Kikuu cha Cambridge, pamoja alisema, SayansiAlert<\/a> taarifa.<\/p>\n

Ugonjwa wa Gaucher ni ugonjwa adimu wa kijeni unaoathiri Wayahudi wa Ashkenazi kwa njia isiyo sawa, na karibu. mmoja kati ya 800 waliozaliwa<\/a>. Lakini ugonjwa unaweza kuathiri mtu yeyote. Ugonjwa huo una dalili kidogo, ikiwa ni pamoja na wengu na ini iliyoenea, na upungufu wa damu.<\/p>\n

Vimeng'enya vilivyomo kwenye lysosomes za seli huvunja vitu visivyohitajika kama vile protini na mafuta. Kupungua kwa enzymes hizi kunaweza kusababisha mkusanyiko wa vitu vyenye sumu.<\/p>\n

Mkusanyiko huu unadhuru sana utendaji wa kawaida wa seli zinazoitwa macrophages.<\/p>\n

"Aina moja ya seli ambayo inaweza kuathiriwa na mkusanyiko huu ni macrophage, seli ambayo 'hula' vitu vyenye sumu, ikiwa ni pamoja na bakteria na bidhaa taka. Katika matatizo ya lysosomal, macrophages husonga polepole na kukua kwa sababu hujilimbikiza nyenzo ambazo hazijaingizwa katika lysosomes zao, na kuzifanya kuwa na uwezo mdogo wa kupambana na maambukizi, "waandishi walisema.<\/p>\n

Wakati watafiti walitengeneza vinasaba vya zebrafish kwa mfano wa ugonjwa wa Gaucher, walipata samaki hao "walistahimili TB, badala ya kushambuliwa."<\/p>\n

"Sababu ya upinzani huu dhidi ya maambukizi ilikuwa kwa sababu ya kemikali ya mafuta ambayo hujilimbikiza kwenye macrophages katika ugonjwa wa Gaucher. Kemikali hii yenye mafuta iligunduliwa kufanya kazi kama kiyeyusho ambacho kinaweza kuua bakteria wa TB ndani ya dakika chache kwa kuharibu kuta zao za seli,\u201d watafiti walieleza.<\/p>\n

Wayahudi wa Ashkenazi walipitia karne za mateso, wakiishi kwenye ghetto na kuhama kutoka nchi hadi nchi. Tangu TB<\/a> huenea kwa kasi katika hali duni ya maisha na maeneo yenye watu wengi, Wayahudi lazima wawe wameathiriwa sana na TB.<\/p>\n

\u201cSamaki hawa bila kujua walituingiza kwenye mjadala ambao umekuwa ukiendelea katika vinasaba vya binadamu kwa miongo kadhaa<\/a>: Je, Wayahudi wa Ashkenazi - ambao tunajua wako katika hatari kubwa zaidi ya ugonjwa wa Gaucher - uwezekano mdogo wa kupata maambukizi ya TB? Jibu linaonekana kuwa ndiyo,\u201d watafiti walihitimisha.<\/p>\n

Chanzo cha matibabu cha kila siku<\/a><\/p>\n

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Kulingana na makadirio, karibu watu milioni 10.6 kote ulimwenguni waliugua kutokana na kifua kikuu (TB) na watu milioni 1.6 walikufa kutokana na ugonjwa huo mnamo 2021.<\/p>","protected":false},"author":2,"featured_media":7558,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"Default","format":"standard","meta":{"fifu_image_url":"https:\/\/urbancare.clinic\/wp-content\/uploads\/2023\/02\/ashkenazi-jews-susceptible-to-rare-genetic-disease-that-protects-them-from-tb-study.jpg","fifu_image_alt":"","footnotes":""},"categories":[27],"tags":[],"class_list":["post-7557","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blog"],"yoast_head":"\nAshkenazi Jews Susceptible To Rare Genetic Disease That Protects Them From TB: Study - Urban Care Clinic<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/urbancare.clinic\/sw\/wayahudi-wa-ashkenazi-wanaoshambuliwa-na-ugonjwa-adimu-wa-kijeni-unaowalinda-dhidi-ya-utafiti-wa-tb\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Ashkenazi Jews Susceptible To Rare Genetic Disease That Protects Them From TB: Study - 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