{"id":7543,"date":"2022-11-22T13:00:22","date_gmt":"2022-11-22T10:00:22","guid":{"rendered":"https:\/\/urbancare.clinic\/warfarin-induced-skin-necrosis\/"},"modified":"2023-05-23T17:37:36","modified_gmt":"2023-05-23T14:37:36","slug":"necrosis-ya-ngozi-iliyosababishwa-na-warfarin","status":"publish","type":"post","link":"https:\/\/urbancare.clinic\/sw\/warfarin-induced-skin-necrosis\/","title":{"rendered":"Warfarin iliyosababishwa na necrosis ya ngozi"},"content":{"rendered":"<div><img decoding=\"async\" src=\"https:\/\/urbancare.clinic\/wp-content\/uploads\/2023\/02\/warfarin-induced-skin-necrosis.jpg\" class=\"ff-og-image-inserted\"  style=\"display:none\"><\/div>\n<p>Ikiwa ungependa kutumia tena makala yoyote au yote haya tafadhali tumia kiungo kilicho hapa chini kitakachokupeleka kwenye huduma ya RightsLink ya Kituo cha Kusafisha Hakimiliki. Utaweza kupata bei ya haraka na ruhusa ya papo hapo ya kutumia tena maudhui kwa njia nyingi tofauti.<\/p>\n<p><a href=\"http:\/\/pmj.bmj.com\/cgi\/content\/short\/98\/1166\/e41?rss=1\">Chanzo cha matibabu cha kila siku<\/a><\/p>\n<p>","protected":false},"excerpt":{"rendered":"<p>Warfarin, upanga maradufu haisaidii tu katika kuzuia damu kuganda kwa kuzuia sababu tegemezi za kuganda kwa vitamini K lakini pia huzuia ugandaji wa damu kwa kuzuia protini C na protini S. Nusu ya maisha ya protini C na S ni mafupi kuliko sababu tegemezi za kuganda kwa vitamini K. ukolezi wa plasma hupungua kwa kasi. Ikianza peke yake mgonjwa yuko katika hatari ya kupatwa na nekrosisi ya ngozi iliyotokana na warfarini, jambo linaloweza kuwa mbaya ingawa ni tatizo adimu (0.01%\u20130.1%) kwa kawaida hutokea siku 2-5 baada ya kuanza kwa matibabu ya warfarini.<\/p>\n<p>Mzee wa miaka 63 hivi karibuni aligundua ugonjwa wa moyo wa rheumatic na stenosis kali ya mitral iliyotolewa na historia ya siku 2 ya kupungua kwa pato la mkojo. Alianza kutumia warfarin 5 mg mara moja kwa siku na furosemide 20 mg mara mbili kwa siku wiki 2 zilizopita. Uchunguzi wa kimwili ulionyesha kiwango cha mapigo ya 98 bpm, shinikizo la damu la 140\/88 mm Hg, kiwango cha kupumua cha 26 pumzi \/ min. Kusisimka kwa moyo kulionyesha mdundo usio wa kawaida\u2026.<\/p>","protected":false},"author":2,"featured_media":7544,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"page_builder":"","fifu_image_url":"https:\/\/urbancare.clinic\/wp-content\/uploads\/2023\/02\/warfarin-induced-skin-necrosis.jpg","fifu_image_alt":"","footnotes":""},"categories":[185],"tags":[198],"class_list":["post-7543","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-research-medical-articles","tag-blood-pressure"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Warfarin induced skin necrosis - Urban Care Clinic<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/urbancare.clinic\/sw\/necrosis-ya-ngozi-iliyosababishwa-na-warfarin\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Warfarin induced skin necrosis - Urban Care Clinic\" \/>\n<meta property=\"og:description\" content=\"Warfarin, a double sword not only helps in anticoagulation by inhibition of vitamin K dependent clotting factors but also prevents clot lysis by inhibiting protein C and protein S. The half-life of protein C and S is shorter than vitamin K dependent clotting factors hence its plasma concentration falls faster. If started alone the patient is at risk of developing warfarin induced skin necrosis, a potentially disastrous although a rare complication (0.01%&ndash;0.1%) usually occurring 2&ndash;5 days after initiation of warfarin therapy. A 63-year-old man recently diagnosed rheumatic heart disease with severe mitral stenosis presented with a 2-day history of decreased urine output. He was started on tablet warfarin 5 mg once a day and tablet furosemide 20 mg two times a day 2 weeks ago. Physical examination showed pulse rate of 98 bpm, blood pressure of 140\/88 mm Hg, respiratory rate of 26 breaths\/min. Cardiac auscultation showed irregular rhythm....\" \/>\n<meta property=\"og:url\" content=\"https:\/\/urbancare.clinic\/sw\/necrosis-ya-ngozi-iliyosababishwa-na-warfarin\/\" \/>\n<meta property=\"og:site_name\" content=\"Urban Care Clinic\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/urbancarezanzibar\" \/>\n<meta property=\"article:published_time\" content=\"2022-11-22T10:00:22+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-05-23T14:37:36+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/urbancare.clinic\/wp-content\/uploads\/2023\/02\/warfarin-induced-skin-necrosis.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1024\" \/>\n\t<meta property=\"og:image:height\" content=\"1024\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Urban Care Clinic\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Urban Care Clinic\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/urbancare.clinic\\\/warfarin-induced-skin-necrosis\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/urbancare.clinic\\\/warfarin-induced-skin-necrosis\\\/\"},\"author\":{\"name\":\"Urban Care Clinic\",\"@id\":\"https:\\\/\\\/urbancare.clinic\\\/#\\\/schema\\\/person\\\/a304a61bcf298680ee41e2e9ae193930\"},\"headline\":\"Warfarin induced skin necrosis\",\"datePublished\":\"2022-11-22T10:00:22+00:00\",\"dateModified\":\"2023-05-23T14:37:36+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/urbancare.clinic\\\/warfarin-induced-skin-necrosis\\\/\"},\"wordCount\":55,\"publisher\":{\"@id\":\"https:\\\/\\\/urbancare.clinic\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/urbancare.clinic\\\/warfarin-induced-skin-necrosis\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/urbancare.clinic\\\/wp-content\\\/uploads\\\/2023\\\/02\\\/warfarin-induced-skin-necrosis.jpg\",\"keywords\":[\"Blood Pressure\"],\"articleSection\":[\"Research Articles\"],\"inLanguage\":\"sw\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/urbancare.clinic\\\/warfarin-induced-skin-necrosis\\\/\",\"url\":\"https:\\\/\\\/urbancare.clinic\\\/warfarin-induced-skin-necrosis\\\/\",\"name\":\"Warfarin induced skin necrosis - 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