{"id":7021,"date":"2022-12-22T13:03:40","date_gmt":"2022-12-22T10:03:40","guid":{"rendered":"https:\/\/www.medicaldaily.com\/6-neurogenerative-diseases-have-common-and-unique-cellular-signposts-study-467615"},"modified":"2022-12-22T14:43:03","modified_gmt":"2022-12-22T11:43:03","slug":"magonjwa-6-ya-mfumo-wa-neva-yana-matokeo-ya-utafiti-ya-alama-za-seli-za-kawaida-na-za-kipekee","status":"publish","type":"post","link":"https:\/\/urbancare.clinic\/sw\/6-neurogenerative-diseases-have-common-and-unique-cellular-signposts-study-finds\/","title":{"rendered":"Magonjwa 6 ya Neurogenerative Yana Alama za Kawaida na za Kipekee za Seli, Matokeo ya Utafiti"},"content":{"rendered":"
<\/div>\n

Utafiti uligundua kuwa magonjwa mengi ya mfumo wa neva yana michakato ya kawaida na ya kipekee isiyofanya kazi ya seli.<\/p>\n

Magonjwa sita ya neurodegenerative ambayo yalionyesha hali hii ya kawaida, ni pamoja na amyotrophic lateral sclerosis au ugonjwa wa Lou Gehrig, ugonjwa wa Alzeima, ataksia ya Friedreich, shida ya akili ya frontotemporal, ugonjwa wa Huntington, na ugonjwa wa Parkinson.<\/p>\n

Kwa ajili ya utafiti, iliyochapishwa katika Alzheimers & Dementia: Jarida la Chama cha Alzheimer's<\/a>,<\/a> <\/em>watafiti walipeleka uchanganuzi wa kujifunza kwa mashine ya RNA kutoka kwa sampuli za damu. Sampuli za damu zilichukuliwa kutoka kwa hifadhidata inayopatikana kwa umma iitwayo Gene Expression Omnibus. Timu ya utafiti kisha ililinganisha magonjwa mengi ili kutambua viashirio vya RNA vinavyotokea katika magonjwa kadhaa ya mfumo wa neva na yale ambayo ni ya kipekee kwa kila ugonjwa.<\/p>\n

Utafiti huo ulipata alama nane za kawaida kati ya magonjwa sita ya neurodegenerative. Hizi ni udhibiti wa maandishi, uharibifu wa granulation (unaohusishwa na mchakato wa kuvimba), mwitikio wa kinga, usanisi wa protini, kifo cha seli au apoptosis, vipengele vya cytoskeletal, ubiquity\/proteasome (sehemu ya uharibifu wa protini), na mitochondrial complexes (kusimamia matumizi ya nishati katika seli), kulingana na NewsMedical<\/a>.<\/p>\n

<\/div>\n

Dysfunctions hizi nane za seli huhusishwa na patholojia zinazotambulika katika ubongo kwa kila ugonjwa. Kando na hizi nane, utafiti pia ulipata alama za kipekee kwa kila ugonjwa.<\/p>\n

Kwa mfano, nakala zinazohusiana na mchakato unaojulikana kama udhibiti wa spliceosome ziligunduliwa katika kesi ya ugonjwa wa Alzheimer.<\/a><\/p>\n

"Inaonekana kwamba magonjwa mengi ya mfumo wa neva huhifadhi michakato sawa ya kimsingi isiyofanya kazi ya seli. Tofauti kati ya magonjwa inaweza kuwa muhimu katika kugundua udhaifu wa aina ya seli na shabaha za matibabu kwa kila ugonjwa," mwandishi wa kwanza wa utafiti huo, Carol Huseby, mtafiti katika Kituo cha Utafiti wa Magonjwa ya Neurodegenerative cha ASU-Banner, alisema, chombo kiliripoti.<\/p>\n

Kulingana na Umoja wa Mataifa, idadi ya vifo ulimwenguni kutokana na magonjwa yote ya mfumo wa neva kwa pamoja inaweza kuwa watu bilioni 1, kulingana na duka.<\/p>\n

Kinyume na hali hii, hitaji la mbinu mpya za utambuzi wa mapema, matibabu bora, na hata njia za kuzuia ni kubwa.<\/p>\n

Nakala za RNA zilizotolewa kutoka kwa damu hutolewa kwa kanuni ya kujifunza kwa mashine, inayojulikana kama Random Forest, ambayo kisha huchanganua data na kulinganisha matokeo na mifumo inayojulikana inayohusishwa na njia za kibayolojia zinazohusishwa na magonjwa.<\/p>\n

Aina zingine za kawaida za upimaji mara nyingi hazina maelezo ya kina, ni ghali, ni vamizi, na zinazohitaji nguvu kazi. Kinyume chake, uchunguzi kupitia damu nzima ni mbadala wa gharama nafuu. Inaweza kukusanywa kwa urahisi kwa wagonjwa katika hatua zote za maisha.<\/p>\n

Zaidi ya hayo, mabadiliko katika matokeo ya damu yanaweza kufuatiliwa, ambayo inaweza kusaidia kufuatilia maendeleo ya ugonjwa.<\/p>\n

Utafiti huo unafungua uwezekano kwamba mabadiliko ya RNA ya kawaida katika magonjwa mengi yanaweza baadaye kuendeleza kuwa magonjwa ya neurodegenerative ya mtu binafsi. Hata hivyo, utaratibu nyuma ya jambo hili bado ni siri.<\/p>\n

Chanzo cha matibabu cha kila siku<\/a><\/p>\n

","protected":false},"excerpt":{"rendered":"

Kulingana na Umoja wa Mataifa, idadi ya vifo duniani kutokana na magonjwa yote ya mfumo wa neva kwa pamoja inaweza kuwa watu bilioni 1.<\/p>","protected":false},"author":2,"featured_media":7022,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"page_builder":"","fifu_image_url":"https:\/\/urbancare.clinic\/wp-content\/uploads\/2022\/12\/6-neurogenerative-diseases-have-common-and-unique-cellular-signposts-study-finds.jpg","fifu_image_alt":"","footnotes":""},"categories":[121],"tags":[],"class_list":["post-7021","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-health-articles"],"yoast_head":"\n6 Neurogenerative Diseases Have Common And Unique Cellular Signposts, Study Finds - Urban Care Clinic<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/urbancare.clinic\/sw\/magonjwa-6-ya-mfumo-wa-neva-yana-matokeo-ya-utafiti-ya-alama-za-seli-za-kawaida-na-za-kipekee\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"6 Neurogenerative Diseases Have Common And Unique Cellular Signposts, Study Finds - 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