1.0Kliniki ya Huduma ya Mjinihttps://urbancare.clinic/swWarfarin induced skin necrosis - Urban Care Clinicrich600338<blockquote class="wp-embedded-content" data-secret="iwf3ULxYCV"><a href="https://urbancare.clinic/sw/warfarin-induced-skin-necrosis/">Warfarin iliyosababishwa na necrosis ya ngozi</a></blockquote><iframe sandbox="allow-scripts" security="restricted" src="https://urbancare.clinic/sw/warfarin-induced-skin-necrosis/embed/#?secret=iwf3ULxYCV" width="600" height="338" title="“Warfarin induced skin necrosis” — Urban Care Clinic" data-secret="iwf3ULxYCV" frameborder="0" marginwidth="0" marginheight="0" scrolling="no" class="wp-embedded-content"></iframe><script>
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</script>https://urbancare.clinic/wp-content/uploads/2023/02/warfarin-induced-skin-necrosis.jpg10241024Warfarin, a double sword not only helps in anticoagulation by inhibition of vitamin K dependent clotting factors but also prevents clot lysis by inhibiting protein C and protein S. The half-life of protein C and S is shorter than vitamin K dependent clotting factors hence its plasma concentration falls faster. If started alone the patient is at risk of developing warfarin induced skin necrosis, a potentially disastrous although a rare complication (0.01%–0.1%) usually occurring 2–5 days after initiation of warfarin therapy. A 63-year-old man recently diagnosed rheumatic heart disease with severe mitral stenosis presented with a 2-day history of decreased urine output. He was started on tablet warfarin 5 mg once a day and tablet furosemide 20 mg two times a day 2 weeks ago. Physical examination showed pulse rate of 98 bpm, blood pressure of 140/88 mm Hg, respiratory rate of 26 breaths/min. Cardiac auscultation showed irregular rhythm....