{"id":9269,"date":"2024-01-24T12:38:52","date_gmt":"2024-01-24T09:38:52","guid":{"rendered":"https:\/\/urbancare.clinic\/can-chocolate-coated-insulin-pills-replace-needles-animal-study-shows-promising-results-for-diabetes-patients\/"},"modified":"2024-01-24T12:38:52","modified_gmt":"2024-01-24T09:38:52","slug":"le-pillole-di-insulina-ricoperte-di-cioccolato-possono-sostituire-gli-aghi-uno-studio-sugli-animali-mostra-risultati-promettenti-per-i-pazienti-diabetici","status":"publish","type":"post","link":"https:\/\/urbancare.clinic\/it\/can-chocolate-coated-insulin-pills-replace-needles-animal-study-shows-promising-results-for-diabetes-patients\/","title":{"rendered":"Le pillole di insulina ricoperte di cioccolato possono sostituire gli aghi? Uno studio sugli animali mostra risultati promettenti per i pazienti diabetici"},"content":{"rendered":"
<\/div>\n

Esiste un\u2019alternativa indolore alle iniezioni di insulina? Buone notizie potrebbero essere all\u2019orizzonte per le persone con diabete, poich\u00e9 i risultati di un recente studio sugli animali suggeriscono che una pillola di insulina da deglutire nascosta in un pezzo di cioccolato potrebbe sostituire in futuro le dolorose iniezioni di insulina.<\/p>\n

Circa 425 milioni di persone nel mondo soffrono di diabete e 75 milioni di loro dipendono dalle iniezioni di insulina per gestire i livelli di zucchero nel sangue.<\/p>\n

Scienziati dell\u2019Universit\u00e0 di Troms\u00f8 (UiT) dell\u2019Universit\u00e0 Artica della Norvegia hanno esplorato alternative alle iniezioni di insulina e hanno sviluppato una pillola incapsulata con minuscoli nano-vettori di insulina progettati per la somministrazione diretta al fegato.<\/p>\n

\u201cQuesto modo di assumere l\u2019insulina \u00e8 pi\u00f9 preciso perch\u00e9 trasporta rapidamente l\u2019insulina nelle aree del corpo che ne hanno pi\u00f9 bisogno. Quando prendi l\u2019insulina con una siringa, questa si diffonde in tutto il corpo dove pu\u00f2 causare effetti collaterali indesiderati\u201d, disse<\/a> Peter McCourt della UiT The Arctic University of Norvegia, ricercatore dietro lo studio pubblicato sulla rivista Nature Nanotechnology.<\/p>\n

A differenza di molti medicinali che possono essere ingeriti, l\u2019insulina deve essere iniettata poich\u00e9 si decompone nello stomaco prima di raggiungere il fegato. Tuttavia, i ricercatori hanno risolto l\u2019ostacolo creando un rivestimento protettivo che pu\u00f2 rompersi nel fegato solo quando i livelli di zucchero nel sangue sono elevati.<\/p>\n

"Abbiamo creato un rivestimento per proteggere l'insulina dalla degradazione degli acidi dello stomaco e degli enzimi digestivi nel suo percorso attraverso il sistema digestivo, mantenendola al sicuro fino a raggiungere la sua destinazione, vale a dire il fegato", ha spiegato McCourt.<\/p>\n

"Ci\u00f2 significa che quando lo zucchero nel sangue \u00e8 alto, c'\u00e8 un rapido rilascio di insulina e, cosa ancora pi\u00f9 importante, quando lo zucchero nel sangue \u00e8 basso, non viene rilasciata insulina", ha affermato Nicholas J. Hunt dell'Universit\u00e0 di Sydney, un ricercatore che ha collaborato alla ricerca. ha guidato il progetto.<\/p>\n

"Per rendere appetibile l'insulina orale, l'abbiamo incorporata nel cioccolato senza zucchero e questo approccio \u00e8 stato ben accolto", ha aggiunto Hunt.<\/p>\n

Secondo Hunt, le pillole offrono un metodo pi\u00f9 pratico e adatto al paziente per gestire il diabete e ridurre il rischio di ipoglicemia. La tecnica consente il rilascio controllato di insulina in base alle esigenze del paziente, a differenza delle iniezioni in cui tutta l'insulina viene rilasciata in un'unica iniezione.<\/p>\n

I ricercatori hanno affermato che la tecnica di somministrazione dell'insulina con la pillola funziona in modo simile a come funziona l'insulina nelle persone sane e avr\u00e0 meno effetti collaterali.<\/p>\n

\u201cQuando si inietta l\u2019insulina sotto la pelle con una siringa, molta pi\u00f9 insulina va ai muscoli e ai tessuti adiposi di quanto accadrebbe normalmente se fosse rilasciata dal pancreas, il che pu\u00f2 portare all\u2019accumulo di grassi. Pu\u00f2 anche portare all\u2019ipoglicemia, che pu\u00f2 essere potenzialmente pericolosa per le persone con diabete. Con il nuovo metodo ci saranno meno effetti collaterali di questo tipo. Inoltre, non \u00e8 necessario pungersi con un ago e puoi prendere la medicina di cui hai bisogno in modo un po' pi\u00f9 discreto. Inoltre, questa forma di insulina non necessita di essere refrigerata\u201d, hanno affermato i ricercatori.<\/p>\n

L'insulina orale \u00e8 stata testata su nematodi, topi e ratti affetti da diabete. In un recente studio, i ricercatori li hanno testati su 20 babbuini sani e hanno scoperto che avevano livelli di zucchero nel sangue ridotti.<\/p>\n

Gli studi sull\u2019uomo inizieranno nel 2025 e i ricercatori sperano che il nuovo medicinale possa essere disponibile per l\u2019uso entro due o tre anni.<\/p>\n

Fonte quotidiana medica<\/a><\/p>\n

","protected":false},"excerpt":{"rendered":"

<\/div>\n

Esiste un\u2019alternativa indolore alle iniezioni di insulina? Buone notizie potrebbero essere all\u2019orizzonte per le persone con diabete, poich\u00e9 i risultati di un recente studio sugli animali suggeriscono che una pillola di insulina da deglutire nascosta in un pezzo di cioccolato potrebbe sostituire in futuro le dolorose iniezioni di insulina.<\/p>\n

Circa 425 milioni di persone nel mondo soffrono di diabete e 75 milioni di loro dipendono dalle iniezioni di insulina per gestire i livelli di zucchero nel sangue.<\/p>\n

Scienziati dell\u2019Universit\u00e0 di Troms\u00f8 (UiT) dell\u2019Universit\u00e0 Artica della Norvegia hanno esplorato alternative alle iniezioni di insulina e hanno sviluppato una pillola incapsulata con minuscoli nano-vettori di insulina progettati per la somministrazione diretta al fegato.<\/p>\n

\u201cQuesto modo di assumere l\u2019insulina \u00e8 pi\u00f9 preciso perch\u00e9 trasporta rapidamente l\u2019insulina nelle aree del corpo che ne hanno pi\u00f9 bisogno. Quando prendi l\u2019insulina con una siringa, questa si diffonde in tutto il corpo dove pu\u00f2 causare effetti collaterali indesiderati\u201d, disse<\/a> Peter McCourt della UiT The Arctic University of Norvegia, ricercatore dietro lo studio pubblicato sulla rivista Nature Nanotechnology.<\/p>\n

A differenza di molti medicinali che possono essere ingeriti, l\u2019insulina deve essere iniettata poich\u00e9 si decompone nello stomaco prima di raggiungere il fegato. Tuttavia, i ricercatori hanno risolto l\u2019ostacolo creando un rivestimento protettivo che pu\u00f2 rompersi nel fegato solo quando i livelli di zucchero nel sangue sono elevati.<\/p>\n

"Abbiamo creato un rivestimento per proteggere l'insulina dalla degradazione degli acidi dello stomaco e degli enzimi digestivi nel suo percorso attraverso il sistema digestivo, mantenendola al sicuro fino a raggiungere la sua destinazione, vale a dire il fegato", ha spiegato McCourt.<\/p>\n

"Ci\u00f2 significa che quando lo zucchero nel sangue \u00e8 alto, c'\u00e8 un rapido rilascio di insulina e, cosa ancora pi\u00f9 importante, quando lo zucchero nel sangue \u00e8 basso, non viene rilasciata insulina", ha affermato Nicholas J. Hunt dell'Universit\u00e0 di Sydney, un ricercatore che ha collaborato alla ricerca. ha guidato il progetto.<\/p>\n

"Per rendere appetibile l'insulina orale, l'abbiamo incorporata nel cioccolato senza zucchero e questo approccio \u00e8 stato ben accolto", ha aggiunto Hunt.<\/p>\n

Secondo Hunt, le pillole offrono un metodo pi\u00f9 pratico e adatto al paziente per gestire il diabete e ridurre il rischio di ipoglicemia. La tecnica consente il rilascio controllato di insulina in base alle esigenze del paziente, a differenza delle iniezioni in cui tutta l'insulina viene rilasciata in un'unica iniezione.<\/p>\n

I ricercatori hanno affermato che la tecnica di somministrazione dell'insulina con la pillola funziona in modo simile a come funziona l'insulina nelle persone sane e avr\u00e0 meno effetti collaterali.<\/p>\n

\u201cQuando si inietta l\u2019insulina sotto la pelle con una siringa, molta pi\u00f9 insulina va ai muscoli e ai tessuti adiposi di quanto accadrebbe normalmente se fosse rilasciata dal pancreas, il che pu\u00f2 portare all\u2019accumulo di grassi. Pu\u00f2 anche portare all\u2019ipoglicemia, che pu\u00f2 essere potenzialmente pericolosa per le persone con diabete. Con il nuovo metodo ci saranno meno effetti collaterali di questo tipo. Inoltre, non \u00e8 necessario pungersi con un ago e puoi prendere la medicina di cui hai bisogno in modo un po' pi\u00f9 discreto. Inoltre, questa forma di insulina non necessita di essere refrigerata\u201d, hanno affermato i ricercatori.<\/p>\n

L'insulina orale \u00e8 stata testata su nematodi, topi e ratti affetti da diabete. In un recente studio, i ricercatori li hanno testati su 20 babbuini sani e hanno scoperto che avevano livelli di zucchero nel sangue ridotti.<\/p>\n

Gli studi sull\u2019uomo inizieranno nel 2025 e i ricercatori sperano che il nuovo medicinale possa essere disponibile per l\u2019uso entro due o tre anni.<\/p>","protected":false},"author":2,"featured_media":9270,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"Default","format":"standard","meta":{"page_builder":"","fifu_image_url":"https:\/\/urbancare.clinic\/wp-content\/uploads\/2024\/01\/can-chocolate-coated-insulin-pills-replace-needles-animal-study-shows-promising-results-for-diabetes-patients.jpg","fifu_image_alt":"","footnotes":""},"categories":[27],"tags":[],"class_list":["post-9269","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blog"],"yoast_head":"\nCan Chocolate-Coated Insulin Pills Replace Needles? Animal Study Shows Promising Results For Diabetes Patients - Urban Care Clinic<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/urbancare.clinic\/it\/le-pillole-di-insulina-ricoperte-di-cioccolato-possono-sostituire-gli-aghi-uno-studio-sugli-animali-mostra-risultati-promettenti-per-i-pazienti-diabetici\/\" \/>\n<meta property=\"og:locale\" content=\"it_IT\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Can Chocolate-Coated Insulin Pills Replace Needles? Animal Study Shows Promising Results For Diabetes Patients - Urban Care Clinic\" \/>\n<meta property=\"og:description\" content=\"Is there a pain-free alternative to insulin shots? Good news might be on the horizon for people with diabetes, as findings of a recent animal study suggest that a swallowable insulin pill tucked in a piece of chocolate might replace painful insulin shots in the future.Around 425 million people in the world have diabetes and 75 million of them depend on insulin injections to manage their blood sugar levels.Scientists from the University of Troms\u00f8 (UiT) The Arctic University of Norway explored alternatives to insulin shots and developed an encapsulated pill with tiny nano-carriers of insulin designed for direct delivery to the liver."This way of taking insulin is more precise because it delivers the insulin rapidly to the areas of the body that need it most. When you take insulin with a syringe, it is spread throughout the body where it can cause unwanted side effects," said Peter McCourt from UiT The Arctic University of Norway, a researcher behind the study published in the journal Nature Nanotechnology.Unlike many medicines that can be swallowed, insulin has to be injected, as it breaks down in the stomach before it reaches the liver. However, researchers solved the hurdle by creating a protective coating that can only break down in the liver when the blood sugar levels are high."We have created a coating to protect the insulin from being broken down by stomach acid and digestive enzymes on its way through the digestive system, keeping it safe until it reaches its destination, namely the liver," McCourt explained."This means that when blood sugar is high, there is a rapid release of insulin, and even more importantly when blood sugar is low, no insulin is released," said Nicholas J. Hunt from the University of Sydney, a researcher who co-led the project."In order to make the oral insulin palatable we incorporated it into sugar-free chocolate, this approach was well received," Hunt added.According to Hunt, the pills offer a more practical and patient-friendly method of managing diabetes and reduce the risk of hypoglycemia. The technique allows the controlled release of insulin based on the patient's requirements, unlike injections where all the insulin is released in one shot.The researchers said the pill's insulin delivery technique works similarly to how insulin works in healthy people and will have fewer side effects."When you inject insulin under the skin with a syringe, far more of it goes to the muscles and to adipose tissues that would normally happen if it was released from the pancreas, which can lead to the accumulation of fats. It can also lead to hypoglycemia, which can potentially be dangerous for people with diabetes. With the new method, there will be fewer such side effects. In addition, you do not need to stab yourself with a needle and you can take the medicine you need in a slightly more discreet way. Also, this form of insulin does not need to be refrigerated," the researchers said.The oral insulin has been tested on nematodes, mice and rats that have diabetes. In a recent trial, researchers tested them on 20 healthy baboons and found them to have reduced blood sugar levels.The human trials will begin in 2025, and researchers hope the new medicine could be available for use in two to three years.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/urbancare.clinic\/it\/le-pillole-di-insulina-ricoperte-di-cioccolato-possono-sostituire-gli-aghi-uno-studio-sugli-animali-mostra-risultati-promettenti-per-i-pazienti-diabetici\/\" \/>\n<meta property=\"og:site_name\" content=\"Urban Care Clinic\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/urbancarezanzibar\" \/>\n<meta property=\"article:published_time\" content=\"2024-01-24T09:38:52+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/urbancare.clinic\/wp-content\/uploads\/2024\/01\/can-chocolate-coated-insulin-pills-replace-needles-animal-study-shows-promising-results-for-diabetes-patients.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1024\" \/>\n\t<meta property=\"og:image:height\" content=\"1024\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Urban Care Clinic\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Scritto da\" \/>\n\t<meta name=\"twitter:data1\" content=\"Urban Care Clinic\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tempo di lettura stimato\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minuti\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/urbancare.clinic\\\/can-chocolate-coated-insulin-pills-replace-needles-animal-study-shows-promising-results-for-diabetes-patients\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/urbancare.clinic\\\/can-chocolate-coated-insulin-pills-replace-needles-animal-study-shows-promising-results-for-diabetes-patients\\\/\"},\"author\":{\"name\":\"Urban Care Clinic\",\"@id\":\"https:\\\/\\\/urbancare.clinic\\\/#\\\/schema\\\/person\\\/a304a61bcf298680ee41e2e9ae193930\"},\"headline\":\"Can Chocolate-Coated Insulin Pills Replace Needles? 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Uno studio sugli animali mostra risultati promettenti per i pazienti diabetici - Urban Care Clinic","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/urbancare.clinic\/it\/le-pillole-di-insulina-ricoperte-di-cioccolato-possono-sostituire-gli-aghi-uno-studio-sugli-animali-mostra-risultati-promettenti-per-i-pazienti-diabetici\/","og_locale":"it_IT","og_type":"article","og_title":"Can Chocolate-Coated Insulin Pills Replace Needles? Animal Study Shows Promising Results For Diabetes Patients - Urban Care Clinic","og_description":"Is there a pain-free alternative to insulin shots? Good news might be on the horizon for people with diabetes, as findings of a recent animal study suggest that a swallowable insulin pill tucked in a piece of chocolate might replace painful insulin shots in the future.Around 425 million people in the world have diabetes and 75 million of them depend on insulin injections to manage their blood sugar levels.Scientists from the University of Troms\u00f8 (UiT) The Arctic University of Norway explored alternatives to insulin shots and developed an encapsulated pill with tiny nano-carriers of insulin designed for direct delivery to the liver.\"This way of taking insulin is more precise because it delivers the insulin rapidly to the areas of the body that need it most. When you take insulin with a syringe, it is spread throughout the body where it can cause unwanted side effects,\" said Peter McCourt from UiT The Arctic University of Norway, a researcher behind the study published in the journal Nature Nanotechnology.Unlike many medicines that can be swallowed, insulin has to be injected, as it breaks down in the stomach before it reaches the liver. However, researchers solved the hurdle by creating a protective coating that can only break down in the liver when the blood sugar levels are high.\"We have created a coating to protect the insulin from being broken down by stomach acid and digestive enzymes on its way through the digestive system, keeping it safe until it reaches its destination, namely the liver,\" McCourt explained.\"This means that when blood sugar is high, there is a rapid release of insulin, and even more importantly when blood sugar is low, no insulin is released,\" said Nicholas J. Hunt from the University of Sydney, a researcher who co-led the project.\"In order to make the oral insulin palatable we incorporated it into sugar-free chocolate, this approach was well received,\" Hunt added.According to Hunt, the pills offer a more practical and patient-friendly method of managing diabetes and reduce the risk of hypoglycemia. The technique allows the controlled release of insulin based on the patient's requirements, unlike injections where all the insulin is released in one shot.The researchers said the pill's insulin delivery technique works similarly to how insulin works in healthy people and will have fewer side effects.\"When you inject insulin under the skin with a syringe, far more of it goes to the muscles and to adipose tissues that would normally happen if it was released from the pancreas, which can lead to the accumulation of fats. It can also lead to hypoglycemia, which can potentially be dangerous for people with diabetes. With the new method, there will be fewer such side effects. In addition, you do not need to stab yourself with a needle and you can take the medicine you need in a slightly more discreet way. Also, this form of insulin does not need to be refrigerated,\" the researchers said.The oral insulin has been tested on nematodes, mice and rats that have diabetes. In a recent trial, researchers tested them on 20 healthy baboons and found them to have reduced blood sugar levels.The human trials will begin in 2025, and researchers hope the new medicine could be available for use in two to three years.","og_url":"https:\/\/urbancare.clinic\/it\/le-pillole-di-insulina-ricoperte-di-cioccolato-possono-sostituire-gli-aghi-uno-studio-sugli-animali-mostra-risultati-promettenti-per-i-pazienti-diabetici\/","og_site_name":"Urban Care Clinic","article_publisher":"https:\/\/www.facebook.com\/urbancarezanzibar","article_published_time":"2024-01-24T09:38:52+00:00","og_image":[{"url":"https:\/\/urbancare.clinic\/wp-content\/uploads\/2024\/01\/can-chocolate-coated-insulin-pills-replace-needles-animal-study-shows-promising-results-for-diabetes-patients.jpg","width":1024,"height":1024,"type":"image\/jpeg"}],"author":"Urban Care Clinic","twitter_card":"summary_large_image","twitter_misc":{"Scritto da":"Urban Care Clinic","Tempo di lettura stimato":"3 minuti"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/urbancare.clinic\/can-chocolate-coated-insulin-pills-replace-needles-animal-study-shows-promising-results-for-diabetes-patients\/#article","isPartOf":{"@id":"https:\/\/urbancare.clinic\/can-chocolate-coated-insulin-pills-replace-needles-animal-study-shows-promising-results-for-diabetes-patients\/"},"author":{"name":"Urban Care Clinic","@id":"https:\/\/urbancare.clinic\/#\/schema\/person\/a304a61bcf298680ee41e2e9ae193930"},"headline":"Can Chocolate-Coated Insulin Pills Replace Needles? 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