{"id":8643,"date":"2023-09-15T13:20:23","date_gmt":"2023-09-15T10:20:23","guid":{"rendered":"https:\/\/urbancare.clinic\/us-surgeons-report-longest-successful-pig-to-human-kidney-transplant\/"},"modified":"2023-09-15T13:20:23","modified_gmt":"2023-09-15T10:20:23","slug":"i-chirurghi-americani-segnalano-il-trapianto-di-rene-da-maiale-a-uomo-piu-duraturo-e-riuscito","status":"publish","type":"post","link":"https:\/\/urbancare.clinic\/it\/i-chirurghi-americani-segnalano-il-trapianto-di-rene-da-maiale-a-uomo-piu-duraturo-e-riuscito\/","title":{"rendered":"I chirurghi statunitensi riferiscono del trapianto di rene da maiale a uomo con successo pi\u00f9 lungo"},"content":{"rendered":"
<\/div>\n

I chirurghi statunitensi che hanno trapiantato un rene di maiale geneticamente modificato in un paziente cerebralmente morto hanno annunciato gioved\u00ec di aver terminato il loro esperimento dopo un record di 61 giorni.<\/p>\n

L\u2019ultima procedura sperimentale fa parte di un campo di ricerca in crescita volto a far avanzare i trapianti tra specie, testando principalmente la tecnica su corpi che sono stati donati alla scienza.<\/p>\n

Ci sono pi\u00f9 di 103.000 persone in attesa di trapianto di organi negli Stati Uniti, 88.000 delle quali necessitano di reni.<\/p>\n

"Abbiamo imparato molto in questi ultimi due mesi di attenta osservazione e analisi, e ci sono ottimi motivi per essere fiduciosi per il futuro", ha affermato Robert Montgomery, direttore del Langone Transplant Institute della New York University, che ha guidato l'intervento chirurgico in Luglio.<\/p>\n

Si \u00e8 trattato del quinto cosiddetto xenotrapianto eseguito da Montgomery, che ha anche effettuato il primo trapianto di rene di maiale geneticamente modificato nel settembre 2021.<\/p>\n

I tessuti raccolti durante lo studio indicavano che era iniziato un lieve processo di rigetto, che richiedeva l'intensificazione dei farmaci immunosoppressori.<\/p>\n

"Eliminando" il gene responsabile di una biomolecola chiamata alfa-gal - un bersaglio primario per gli anticorpi umani vaganti - il team di Langone della New York University \u00e8 riuscito a fermare il rigetto immediato.<\/p>\n

Il maiale donatore in questo esperimento proveniva da un allevamento coltivato dalla societ\u00e0 biotecnologica Revivicor con sede in Virginia.<\/p>\n

La mandria \u00e8 stata approvata anche dalla Food and Drug Administration come fonte di carne per le persone con ipersensibilit\u00e0 alla molecola alfa-gal, un'allergia causata da alcune punture di zecca.<\/p>\n

Questi maiali sono allevati, non clonati, il che significa che il processo pu\u00f2 essere scalato pi\u00f9 facilmente.<\/p>\n

Le prime ricerche sugli xenotrapianti si concentravano sul prelievo di organi dai primati: ad esempio, un cuore di babbuino fu trapiantato in una neonata conosciuta come "Baby Fae" nel 1984, ma sopravvisse solo 20 giorni.<\/p>\n

Gli sforzi attuali si concentrano sui maiali, che si ritiene siano donatori ideali per gli esseri umani a causa delle dimensioni dei loro organi, della loro rapida crescita, delle grandi cucciolate e del fatto che sono gi\u00e0 allevati come fonte di cibo.<\/p>\n

Nel gennaio 2022, i chirurghi della University of Maryland Medical School hanno effettuato il primo trapianto da maiale a uomo al mondo su un paziente vivente, questa volta coinvolgendo un cuore.<\/p>\n

Mor\u00ec due mesi dopo il traguardo, accusando successivamente la presenza di citomegalovirus suino nell'organo.<\/p>\n

La settimana scorsa, gli scienziati cinesi hanno pubblicato un articolo in cui dimostravano di essere riusciti a ottenere reni ibridi tra maiale e uomo in embrioni di maiale, un approccio alternativo che ha anche il potenziale per contribuire un giorno ad affrontare la carenza di donazioni di organi.<\/p>\n

Ma lo sviluppo ha sollevato questioni etiche, soprattutto perch\u00e9 alcune cellule umane sono state trovate anche nel cervello dei maiali, hanno detto gli esperti.<\/p>\n

Pubblicato da Medicaldaily.com<\/p>\n

Fonte quotidiana medica<\/a><\/p>\n

","protected":false},"excerpt":{"rendered":"

<\/div>\n

I chirurghi statunitensi che hanno trapiantato un rene di maiale geneticamente modificato in un paziente cerebralmente morto hanno annunciato gioved\u00ec di aver terminato il loro esperimento dopo un record di 61 giorni.<\/p>\n

L\u2019ultima procedura sperimentale fa parte di un campo di ricerca in crescita volto a far avanzare i trapianti tra specie, testando principalmente la tecnica su corpi che sono stati donati alla scienza.<\/p>\n

Ci sono pi\u00f9 di 103.000 persone in attesa di trapianto di organi negli Stati Uniti, 88.000 delle quali necessitano di reni.<\/p>\n

"Abbiamo imparato molto in questi ultimi due mesi di attenta osservazione e analisi, e ci sono ottimi motivi per essere fiduciosi per il futuro", ha affermato Robert Montgomery, direttore del Langone Transplant Institute della New York University, che ha guidato l'intervento chirurgico in Luglio.<\/p>\n

Si \u00e8 trattato del quinto cosiddetto xenotrapianto eseguito da Montgomery, che ha anche effettuato il primo trapianto di rene di maiale geneticamente modificato nel settembre 2021.<\/p>\n

I tessuti raccolti durante lo studio indicavano che era iniziato un lieve processo di rigetto, che richiedeva l'intensificazione dei farmaci immunosoppressori.<\/p>\n

"Eliminando" il gene responsabile di una biomolecola chiamata alfa-gal - un bersaglio primario per gli anticorpi umani vaganti - il team di Langone della New York University \u00e8 riuscito a fermare il rigetto immediato.<\/p>\n

Il maiale donatore in questo esperimento proveniva da un allevamento coltivato dalla societ\u00e0 biotecnologica Revivicor con sede in Virginia.<\/p>\n

La mandria \u00e8 stata approvata anche dalla Food and Drug Administration come fonte di carne per le persone con ipersensibilit\u00e0 alla molecola alfa-gal, un'allergia causata da alcune punture di zecca.<\/p>\n

Questi maiali sono allevati, non clonati, il che significa che il processo pu\u00f2 essere scalato pi\u00f9 facilmente.<\/p>\n

Le prime ricerche sugli xenotrapianti si concentravano sul prelievo di organi dai primati: ad esempio, un cuore di babbuino fu trapiantato in una neonata conosciuta come "Baby Fae" nel 1984, ma sopravvisse solo 20 giorni.<\/p>\n

Gli sforzi attuali si concentrano sui maiali, che si ritiene siano donatori ideali per gli esseri umani a causa delle dimensioni dei loro organi, della loro rapida crescita, delle grandi cucciolate e del fatto che sono gi\u00e0 allevati come fonte di cibo.<\/p>\n

Nel gennaio 2022, i chirurghi della University of Maryland Medical School hanno effettuato il primo trapianto da maiale a uomo al mondo su un paziente vivente, questa volta coinvolgendo un cuore.<\/p>\n

Mor\u00ec due mesi dopo il traguardo, accusando successivamente la presenza di citomegalovirus suino nell'organo.<\/p>\n

La settimana scorsa, gli scienziati cinesi hanno pubblicato un articolo in cui dimostravano di essere riusciti a ottenere reni ibridi tra maiale e uomo in embrioni di maiale, un approccio alternativo che ha anche il potenziale per contribuire un giorno ad affrontare la carenza di donazioni di organi.<\/p>\n

Ma lo sviluppo ha sollevato questioni etiche, soprattutto perch\u00e9 alcune cellule umane sono state trovate anche nel cervello dei maiali, hanno detto gli esperti.<\/p>\n

Pubblicato da Medicaldaily.com<\/p>","protected":false},"author":2,"featured_media":8644,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"Default","format":"standard","meta":{"fifu_image_url":"https:\/\/urbancare.clinic\/wp-content\/uploads\/2023\/09\/us-surgeons-report-longest-successful-pig-to-human-kidney-transplant.jpg","fifu_image_alt":"","footnotes":""},"categories":[27],"tags":[],"class_list":["post-8643","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blog"],"yoast_head":"\nUS Surgeons Report Longest Successful Pig-To-Human Kidney Transplant - Urban Care Clinic<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/urbancare.clinic\/it\/i-chirurghi-americani-segnalano-il-trapianto-di-rene-da-maiale-a-uomo-piu-duraturo-e-riuscito\/\" \/>\n<meta property=\"og:locale\" content=\"it_IT\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"US Surgeons Report Longest Successful Pig-To-Human Kidney Transplant - Urban Care Clinic\" \/>\n<meta property=\"og:description\" content=\"U.S. surgeons who transplanted a genetically modified pig kidney into a brain-dead patient announced Thursday they had ended their experiment after a record-breaking 61 days.The latest experimental procedure is part of a growing field of research aimed at advancing cross-species transplants, mainly testing the technique on bodies that have been donated for science.There are more than 103,000 people waiting for organ transplants in the United States, 88,000 of whom need kidneys."We have learned a great deal throughout these past two months of close observation and analysis, and there is great reason to be hopeful for the future," said Robert Montgomery, director of the New York University Langone Transplant Institute, who led the surgery in July.It was the fifth so-called xenotransplant performed by Montgomery, who also carried out the world's first genetically modified pig kidney transplant in September 2021.Tissue collected during the study indicated a mild rejection process had begun, requiring intensification of immunosuppression medication.By "knocking out" the gene responsible for a biomolecule called alpha-gal -- a prime target for roving human antibodies -- the NYU Langone team were able to stop immediate rejection.The donor pig in this experiment came from a herd cultivated by Virginia-based biotech company Revivicor.The herd has also been approved by the Food and Drug Administration as a source of meat for people with hypersensitivity to the alpha-gal molecule, an allergy caused by some tick bites.These pigs are bred, not cloned, meaning the process can be more easily scaled.Early xenotransplantation research focused on harvesting organs from primates -- for example, a baboon heart was transplanted into a newborn known as "Baby Fae" in 1984, but she survived only 20 days.Current efforts focus on pigs, which are thought to be ideal donors for humans because of their organ size, their rapid growth and large litters, and the fact they are already raised as a food source.In January 2022, surgeons at the University of Maryland Medical School carried out the world's first pig-to-human transplant on a living patient -- this time involving a heart.He died two months after the milestone, with the presence of porcine cytomegalovirus in the organ later blamed.Last week, Chinese scientists published a paper showing they had succeeded in hybrid pig-human kidneys in pig embryos, an alternative approach that also has the potential to one day help address organ donation shortages.But the development raised ethical issues -- especially since some human cells were also found in the pigs' brains, experts said.Published by Medicaldaily.com\" \/>\n<meta property=\"og:url\" content=\"https:\/\/urbancare.clinic\/it\/i-chirurghi-americani-segnalano-il-trapianto-di-rene-da-maiale-a-uomo-piu-duraturo-e-riuscito\/\" \/>\n<meta property=\"og:site_name\" content=\"Urban Care Clinic\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/urbancarezanzibar\" \/>\n<meta property=\"article:published_time\" content=\"2023-09-15T10:20:23+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/urbancare.clinic\/wp-content\/uploads\/2023\/09\/us-surgeons-report-longest-successful-pig-to-human-kidney-transplant.jpg\" \/>\n<meta name=\"author\" content=\"Urban Care Clinic\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:image\" content=\"https:\/\/urbancare.clinic\/wp-content\/uploads\/2023\/09\/us-surgeons-report-longest-successful-pig-to-human-kidney-transplant.jpg\" \/>\n<meta name=\"twitter:label1\" content=\"Scritto da\" \/>\n\t<meta name=\"twitter:data1\" content=\"Urban Care Clinic\" 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