{"id":8631,"date":"2023-09-08T10:17:04","date_gmt":"2023-09-08T07:17:04","guid":{"rendered":"https:\/\/urbancare.clinic\/breast-cancer-and-pregnancy-study-explains-why-older-first-time-moms-are-at-higher-risk\/"},"modified":"2023-09-08T10:17:04","modified_gmt":"2023-09-08T07:17:04","slug":"lo-studio-sul-cancro-al-seno-e-sulla-gravidanza-spiega-perche-le-mamme-piu-anziane-per-la-prima-volta-corrono-un-rischio-piu-elevato","status":"publish","type":"post","link":"https:\/\/urbancare.clinic\/it\/lo-studio-sul-cancro-al-seno-e-sulla-gravidanza-spiega-perche-le-mamme-piu-anziane-per-la-prima-volta-corrono-un-rischio-piu-elevato\/","title":{"rendered":"Cancro al seno e gravidanza: uno studio spiega perch\u00e9 le mamme anziane per la prima volta corrono un rischio maggiore"},"content":{"rendered":"
<\/div>\n

Esiste una connessione intricata tra cancro al seno e gravidanza. In uno studio, i ricercatori spiegano perch\u00e9 le donne che diventano madri per la prima volta pi\u00f9 tardi nella vita hanno un rischio a lungo termine pi\u00f9 elevato di cancro al seno rispetto a quelle che diventano mamme precocemente.<\/p>\n

Gli studi dimostrano che le giovani madri per la prima volta, quelle che hanno meno di 24 anni durante la loro gravidanza iniziale, sperimentano un rischio a lungo termine sostanzialmente inferiore di tumore al seno<\/a> (circa 20-35%) rispetto alle donne che non hanno avuto figli.<\/p>\n

Tuttavia, con l\u2019aumentare dell\u2019et\u00e0 delle madri per la prima volta, aumenta progressivamente anche il rischio di cancro al seno, con un picco di rischio di 5% ogni cinque anni.<\/p>\n

\u201cNegli ultimi decenni, le donne hanno iniziato ad avere figli pi\u00f9 tardi a causa dei cambiamenti sociali e delle preferenze personali. Precedenti ricerche hanno scoperto che questo \u00e8 associato a un aumento del rischio di cancro al seno\u201d, ha affermato nel comunicato stampa la dott.ssa Biancastella Cereser, autrice principale dello studio.<\/p>\n

\u201cLa nostra ricerca approfondisce i misteri genetici che governano questo rischio. Abbiamo scoperto che il seno umano, come altri organi, accumula mutazioni con l\u2019et\u00e0, ma anche che la gravidanza ha un effetto aggiuntivo, nel senso che le donne anziane che madri per la prima volta potrebbero avere maggiori probabilit\u00e0 di sviluppare cambiamenti dannosi nelle cellule del seno rispetto ad altre donne. ", ha detto Cereser.<\/p>\n

Nell'ultimo studio, pubblicato su rivista<\/a> Nature Communications, i ricercatori hanno analizzato i cambiamenti cellulari e genetici che avvengono nelle cellule sane del seno mentre si trasformano canceroso<\/a>. Dopo aver sequenziato 29 tessuti mammari sani congelati di donatori, il team ha scoperto che con l\u2019et\u00e0 questi tessuti mammari sani accumulano mutazioni, al ritmo di circa 15 mutazioni ogni anno. Sebbene la maggior parte di queste mutazioni non influenzi i geni e non causino il cancro, con il passare del tempo aumenta la possibilit\u00e0 di avere mutazioni driver associate al cancro.<\/p>\n

\u201cQuesto potrebbe non essere sufficiente a causare il cancro da solo. Ma la gravidanza potrebbe rappresentare un \u201cdoppio smacco\u201d, perch\u00e9 induce una rapida espansione delle cellule del seno, in preparazione all\u2019allattamento al seno. Se le cellule che ospitano mutazioni driver si replicassero e si espandessero, potrebbero avere un vantaggio competitivo rispetto alle cellule vicine non mutate, portando potenzialmente a un effetto incontrollato e, infine, creando un tumore canceroso\u201d, ha spiegato Cereser.<\/p>\n

Pubblicato da Medicaldaily.com<\/p>\n

Fonte quotidiana medica<\/a><\/p>\n

","protected":false},"excerpt":{"rendered":"

<\/div>\n

Esiste una connessione intricata tra cancro al seno e gravidanza. In uno studio, i ricercatori spiegano perch\u00e9 le donne che diventano madri per la prima volta pi\u00f9 tardi nella vita hanno un rischio a lungo termine pi\u00f9 elevato di cancro al seno rispetto a quelle che diventano mamme precocemente.<\/p>\n

Gli studi dimostrano che le giovani madri per la prima volta, quelle che hanno meno di 24 anni durante la loro gravidanza iniziale, sperimentano un rischio a lungo termine sostanzialmente inferiore di tumore al seno<\/a> (circa 20-35%) rispetto alle donne che non hanno avuto figli.<\/p>\n

Tuttavia, con l\u2019aumentare dell\u2019et\u00e0 delle madri per la prima volta, aumenta progressivamente anche il rischio di cancro al seno, con un picco di rischio di 5% ogni cinque anni.<\/p>\n

\u201cNegli ultimi decenni, le donne hanno iniziato ad avere figli pi\u00f9 tardi a causa dei cambiamenti sociali e delle preferenze personali. Precedenti ricerche hanno scoperto che questo \u00e8 associato a un aumento del rischio di cancro al seno\u201d, ha affermato nel comunicato stampa la dott.ssa Biancastella Cereser, autrice principale dello studio.<\/p>\n

\u201cLa nostra ricerca approfondisce i misteri genetici che governano questo rischio. Abbiamo scoperto che il seno umano, come altri organi, accumula mutazioni con l\u2019et\u00e0, ma anche che la gravidanza ha un effetto aggiuntivo, nel senso che le donne anziane che madri per la prima volta potrebbero avere maggiori probabilit\u00e0 di sviluppare cambiamenti dannosi nelle cellule del seno rispetto ad altre donne. ", ha detto Cereser.<\/p>\n

Nell'ultimo studio, pubblicato su rivista<\/a> Nature Communications, i ricercatori hanno analizzato i cambiamenti cellulari e genetici che avvengono nelle cellule sane del seno mentre si trasformano canceroso<\/a>. Dopo aver sequenziato 29 tessuti mammari sani congelati di donatori, il team ha scoperto che con l\u2019et\u00e0 questi tessuti mammari sani accumulano mutazioni, al ritmo di circa 15 mutazioni ogni anno. Sebbene la maggior parte di queste mutazioni non influenzi i geni e non causino il cancro, con il passare del tempo aumenta la possibilit\u00e0 di avere mutazioni driver associate al cancro.<\/p>\n

\u201cQuesto potrebbe non essere sufficiente a causare il cancro da solo. Ma la gravidanza potrebbe rappresentare un \u201cdoppio smacco\u201d, perch\u00e9 induce una rapida espansione delle cellule del seno, in preparazione all\u2019allattamento al seno. Se le cellule che ospitano mutazioni driver si replicassero e si espandessero, potrebbero avere un vantaggio competitivo rispetto alle cellule vicine non mutate, portando potenzialmente a un effetto incontrollato e, infine, creando un tumore canceroso\u201d, ha spiegato Cereser.<\/p>\n

Pubblicato da Medicaldaily.com<\/p>","protected":false},"author":2,"featured_media":8632,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"Default","format":"standard","meta":{"fifu_image_url":"https:\/\/urbancare.clinic\/wp-content\/uploads\/2023\/09\/breast-cancer-and-pregnancy-study-explains-why-older-first-time-moms-are-at-higher-risk.jpg","fifu_image_alt":"","footnotes":""},"categories":[27],"tags":[],"class_list":["post-8631","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blog"],"yoast_head":"\nBreast Cancer And Pregnancy: Study Explains Why Older First-Time Moms Are At Higher Risk - Urban Care Clinic<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/urbancare.clinic\/it\/lo-studio-sul-cancro-al-seno-e-sulla-gravidanza-spiega-perche-le-mamme-piu-anziane-per-la-prima-volta-corrono-un-rischio-piu-elevato\/\" \/>\n<meta property=\"og:locale\" content=\"it_IT\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Breast Cancer And Pregnancy: Study Explains Why Older First-Time Moms Are At Higher Risk - Urban Care Clinic\" \/>\n<meta property=\"og:description\" content=\"There is an intricate connection between breast cancer and pregnancy. In a study, researchers explain why women who become first-time mothers later in life have a higher long-term risk of breast cancer than those who become moms early.Studies show that young first-time mothers, those who are below the age of 24 during their initial pregnancy, experience a substantially lower long-term risk of breast cancer (approximately 20-35%) compared to women who have not had kids.However, as the age of first-time mothers goes up, the breast cancer risk also progressively increases, with a 5% spike in risk every five years."In recent decades, women have begun having children later because of societal changes and personal preferences. Previous research has found that this is associated with a heightened breast cancer risk," Dr. Biancastella Cereser, a lead author of the study, said in the news release."Our own research delves into the genetic mysteries that govern this risk. We found that the human breast, like other organs, accumulates mutations with age, but also that pregnancy has an additional effect, meaning that older first-time mothers might have a higher chance of developing harmful changes in their breast cells compared to other women," Cereser said.In the latest study, published in the journal Nature Communications, researchers analyzed the cellular and genetic changes that happen to healthy breast cells as they turn cancerous. After sequencing 29 frozen healthy breast tissues from donors, the team found that with age, these healthy breast tissues accumulate mutations, at the rate of around 15 mutations every year. Although the majority of these mutations do not affect the genes and are not cancer-causing, with more time, there is a greater chance of having driver mutations associated with cancer."This might not be enough to cause cancer by itself. But, pregnancy could provide a 'double whammy', because it induces a rapid expansion of breast cells, in preparation for breastfeeding. 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We found that the human breast, like other organs, accumulates mutations with age, but also that pregnancy has an additional effect, meaning that older first-time mothers might have a higher chance of developing harmful changes in their breast cells compared to other women,\" Cereser said.In the latest study, published in the journal Nature Communications, researchers analyzed the cellular and genetic changes that happen to healthy breast cells as they turn cancerous. After sequencing 29 frozen healthy breast tissues from donors, the team found that with age, these healthy breast tissues accumulate mutations, at the rate of around 15 mutations every year. Although the majority of these mutations do not affect the genes and are not cancer-causing, with more time, there is a greater chance of having driver mutations associated with cancer.\"This might not be enough to cause cancer by itself. 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