{"id":8588,"date":"2023-08-18T10:54:45","date_gmt":"2023-08-18T07:54:45","guid":{"rendered":"https:\/\/urbancare.clinic\/a-drug-prescribed-for-weight-loss-could-help-improve-associative-learning-in-people-with-obesity\/"},"modified":"2023-08-18T10:54:45","modified_gmt":"2023-08-18T07:54:45","slug":"un-farmaco-prescritto-per-la-perdita-di-peso-potrebbe-aiutare-a-migliorare-lapprendimento-associativo-nelle-persone-obese","status":"publish","type":"post","link":"https:\/\/urbancare.clinic\/it\/un-farmaco-prescritto-per-la-perdita-di-peso-potrebbe-aiutare-a-migliorare-lapprendimento-associativo-nelle-persone-obese\/","title":{"rendered":"Un farmaco prescritto per la perdita di peso potrebbe aiutare a migliorare l'apprendimento associativo nelle persone con obesit\u00e0"},"content":{"rendered":"
<\/div>\n

Un farmaco prescritto per la perdita di peso e il diabete di tipo 2 pu\u00f2 migliorare l'apprendimento associativo nelle persone con obesit\u00e0, secondo uno studio recente.<\/p>\n

L'apprendimento associativo \u00e8 il processo mediante il quale gli esseri viventi apprendono connessioni<\/a> tra le cose che accadono intorno a loro. Coinvolge sia le modifiche dei comportamenti esistenti sia lo sviluppo di nuovi comportamenti.<\/p>\n

I ricercatori del Max Planck Institute for Metabolism Research hanno valutato come cambia l'apprendimento associativo nelle persone con ridotta sensibilit\u00e0 all'insulina associata all'obesit\u00e0. Hanno studiato i comportamenti di apprendimento associati in due gruppi di partecipanti; uno con peso normale, che aveva un'elevata sensibilit\u00e0 all'insulina e l'altro con ridotta sensibilit\u00e0 all'insulina dovuta all'obesit\u00e0. Il team ha scoperto che la ridotta sensibilit\u00e0 all'insulina dovuta all'obesit\u00e0 compromette l'apprendimento associativo.<\/p>\n

Ai partecipanti del gruppo obeso \u00e8 stato somministrato un placebo o liraglutide \u2013 a farmaco dimagrante<\/a> prescritto per l'obesit\u00e0 e il diabete di tipo 2.<\/p>\n

Con una singola dose di liraglutide, l'apprendimento associativo alterato nelle persone obese pu\u00f2 essere invertito e riportato agli stessi livelli di persone con peso normale, secondo i risultati, pubblicati sulla rivista Nature Metabolism.<\/p>\n

\u201cQuesti risultati sono di fondamentale importanza. Mostriamo qui che i comportamenti di base come l'apprendimento associativo dipendono non solo dalle condizioni ambientali esterne ma anche dallo stato metabolico del corpo. Quindi, se qualcuno \u00e8 in sovrappeso o meno, determina anche come il cervello impara ad associare i segnali sensoriali e quale motivazione viene generata. La normalizzazione che abbiamo ottenuto con il farmaco nei soggetti con obesit\u00e0, quindi, si adatta agli studi che dimostrano che questi farmaci ripristinano una normale sensazione di saziet\u00e0, inducendo le persone a mangiare di meno e quindi a perdere peso", ha detto il leader dello studio Marc Tittgemeyer in un comunicato stampa<\/a>.<\/p>\n

Lo studio mostra come l'obesit\u00e0 pu\u00f2 alterare il cervello e come il processo pu\u00f2 essere modificato con i farmaci. I ricercatori hanno in programma di condurre ulteriori studi per capire come funziona liraglutide a livello molecolare<\/a>. Hanno anche in programma di esplorare se anche altri approcci come prove di perdita di peso e sensibilizzanti all'insulina possono portare a miglioramenti simili.<\/p>\n

\u201cMentre \u00e8 incoraggiante che i farmaci disponibili abbiano un effetto positivo sull'attivit\u00e0 cerebrale nell'obesit\u00e0, \u00e8 allarmante che i cambiamenti nelle prestazioni cerebrali si verifichino anche nei giovani con obesit\u00e0 senza altre condizioni mediche. La prevenzione dell'obesit\u00e0 dovrebbe svolgere un ruolo molto pi\u00f9 importante nel nostro sistema sanitario in futuro. I farmaci per tutta la vita sono l'opzione meno preferita rispetto alla prevenzione primaria dell'obesit\u00e0 e delle complicanze associate", ha affermato Ruth Han\u00dfen, prima autrice dello studio e medico presso l'ospedale universitario di Colonia.<\/p>\n

Pubblicato da Medicaldaily.com<\/p>\n

Fonte quotidiana medica<\/a><\/p>\n

","protected":false},"excerpt":{"rendered":"

<\/div>\n

Un farmaco prescritto per la perdita di peso e il diabete di tipo 2 pu\u00f2 migliorare l'apprendimento associativo nelle persone con obesit\u00e0, secondo uno studio recente.<\/p>\n

L'apprendimento associativo \u00e8 il processo mediante il quale gli esseri viventi apprendono connessioni<\/a> tra le cose che accadono intorno a loro. Coinvolge sia le modifiche dei comportamenti esistenti sia lo sviluppo di nuovi comportamenti.<\/p>\n

I ricercatori del Max Planck Institute for Metabolism Research hanno valutato come cambia l'apprendimento associativo nelle persone con ridotta sensibilit\u00e0 all'insulina associata all'obesit\u00e0. Hanno studiato i comportamenti di apprendimento associati in due gruppi di partecipanti; uno con peso normale, che aveva un'elevata sensibilit\u00e0 all'insulina e l'altro con ridotta sensibilit\u00e0 all'insulina dovuta all'obesit\u00e0. Il team ha scoperto che la ridotta sensibilit\u00e0 all'insulina dovuta all'obesit\u00e0 compromette l'apprendimento associativo.<\/p>\n

Ai partecipanti del gruppo obeso \u00e8 stato somministrato un placebo o liraglutide \u2013 a farmaco dimagrante<\/a> prescritto per l'obesit\u00e0 e il diabete di tipo 2.<\/p>\n

Con una singola dose di liraglutide, l'apprendimento associativo alterato nelle persone obese pu\u00f2 essere invertito e riportato agli stessi livelli di persone con peso normale, secondo i risultati, pubblicati sulla rivista Nature Metabolism.<\/p>\n

\u201cQuesti risultati sono di fondamentale importanza. Mostriamo qui che i comportamenti di base come l'apprendimento associativo dipendono non solo dalle condizioni ambientali esterne ma anche dallo stato metabolico del corpo. Quindi, se qualcuno \u00e8 in sovrappeso o meno, determina anche come il cervello impara ad associare i segnali sensoriali e quale motivazione viene generata. La normalizzazione che abbiamo ottenuto con il farmaco nei soggetti con obesit\u00e0, quindi, si adatta agli studi che dimostrano che questi farmaci ripristinano una normale sensazione di saziet\u00e0, inducendo le persone a mangiare di meno e quindi a perdere peso", ha detto il leader dello studio Marc Tittgemeyer in un comunicato stampa<\/a>.<\/p>\n

Lo studio mostra come l'obesit\u00e0 pu\u00f2 alterare il cervello e come il processo pu\u00f2 essere modificato con i farmaci. I ricercatori hanno in programma di condurre ulteriori studi per capire come funziona liraglutide a livello molecolare<\/a>. Hanno anche in programma di esplorare se anche altri approcci come prove di perdita di peso e sensibilizzanti all'insulina possono portare a miglioramenti simili.<\/p>\n

\u201cMentre \u00e8 incoraggiante che i farmaci disponibili abbiano un effetto positivo sull'attivit\u00e0 cerebrale nell'obesit\u00e0, \u00e8 allarmante che i cambiamenti nelle prestazioni cerebrali si verifichino anche nei giovani con obesit\u00e0 senza altre condizioni mediche. La prevenzione dell'obesit\u00e0 dovrebbe svolgere un ruolo molto pi\u00f9 importante nel nostro sistema sanitario in futuro. I farmaci per tutta la vita sono l'opzione meno preferita rispetto alla prevenzione primaria dell'obesit\u00e0 e delle complicanze associate", ha affermato Ruth Han\u00dfen, prima autrice dello studio e medico presso l'ospedale universitario di Colonia.<\/p>\n

Pubblicato da Medicaldaily.com<\/p>","protected":false},"author":2,"featured_media":8589,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"Default","format":"standard","meta":{"fifu_image_url":"https:\/\/urbancare.clinic\/wp-content\/uploads\/2023\/08\/a-drug-prescribed-for-weight-loss-could-help-improve-associative-learning-in-people-with-obesity.jpg","fifu_image_alt":"","footnotes":""},"categories":[27],"tags":[],"class_list":["post-8588","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blog"],"yoast_head":"\nA Drug Prescribed For Weight Loss Could Help Improve Associative Learning In People With Obesity - Urban Care Clinic<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/urbancare.clinic\/it\/un-farmaco-prescritto-per-la-perdita-di-peso-potrebbe-aiutare-a-migliorare-lapprendimento-associativo-nelle-persone-obese\/\" \/>\n<meta property=\"og:locale\" content=\"it_IT\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"A Drug Prescribed For Weight Loss Could Help Improve Associative Learning In People With Obesity - Urban Care Clinic\" \/>\n<meta property=\"og:description\" content=\"A drug prescribed for weight loss and type 2 diabetes may improve associative learning in people with obesity, a recent study has found.Associative learning is the process by which living things learn about the connections between things happening around them. It involves both modifications of existing behaviors and the development of new behaviors.Researchers from Max Planck Institute for Metabolism Research evaluated how associative learning changes in people with impaired insulin sensitivity associated with obesity. They studied associated learning behaviors in two groups of participants; one with normal weight, who had high insulin sensitivity, and the other with reduced insulin sensitivity from obesity. The team found that reduced insulin sensitivity from obesity impairs associative learning.The participants in the obese group were either given a placebo or liraglutide \u2013 a weight loss drug prescribed for obesity and type 2 diabetes.With a single dose of liraglutide, the impaired associative learning in obese people can be reversed and brought back to the levels same as that of people with normal weight, according to the findings, published in the journal Nature Metabolism."These findings are of fundamental importance. We show here that basic behaviors such as associative learning depend not only on external environmental conditions but also on the body's metabolic state. So, whether someone has overweight or not also determines how the brain learns to associate sensory signals and what motivation is generated. The normalization we achieved with the drug in subjects with obesity, therefore, fits with studies showing that these drugs restore a normal feeling of satiety, causing people to eat less and therefore lose weight," study leader Marc Tittgemeyer said in a news release.The study shows how obesity can alter the brain and how the process can be modified with medication. The researchers plan to carry out further studies to understand how liraglutide works at a molecular level. They also plan to explore if other approaches such as weight loss trials and insulin sensitizers can also bring in similar improvements."While it is encouraging that available drugs have a positive effect on brain activity in obesity, it is alarming that changes in brain performance occur even in young people with obesity without other medical conditions. Obesity prevention should play a much greater role in our healthcare system in the future. Lifelong medication is the less preferred option in comparison to primary prevention of obesity and associated complications," said Ruth Han\u00dfen, first author of the study and a physician at the University Hospital of Cologne.Published by Medicaldaily.com\" \/>\n<meta property=\"og:url\" content=\"https:\/\/urbancare.clinic\/it\/un-farmaco-prescritto-per-la-perdita-di-peso-potrebbe-aiutare-a-migliorare-lapprendimento-associativo-nelle-persone-obese\/\" \/>\n<meta property=\"og:site_name\" content=\"Urban Care Clinic\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/urbancarezanzibar\" \/>\n<meta property=\"article:published_time\" content=\"2023-08-18T07:54:45+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/urbancare.clinic\/wp-content\/uploads\/2023\/08\/a-drug-prescribed-for-weight-loss-could-help-improve-associative-learning-in-people-with-obesity.jpg\" \/>\n<meta name=\"author\" content=\"Urban Care Clinic\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:image\" content=\"https:\/\/urbancare.clinic\/wp-content\/uploads\/2023\/08\/a-drug-prescribed-for-weight-loss-could-help-improve-associative-learning-in-people-with-obesity.jpg\" \/>\n<meta name=\"twitter:label1\" content=\"Scritto da\" \/>\n\t<meta name=\"twitter:data1\" content=\"Urban Care Clinic\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tempo di lettura stimato\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minuti\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/urbancare.clinic\/a-drug-prescribed-for-weight-loss-could-help-improve-associative-learning-in-people-with-obesity\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/urbancare.clinic\/a-drug-prescribed-for-weight-loss-could-help-improve-associative-learning-in-people-with-obesity\/\"},\"author\":{\"name\":\"Urban Care Clinic\",\"@id\":\"https:\/\/urbancare.clinic\/#\/schema\/person\/f286c4d84be896d302aceda3ed7e789c\"},\"headline\":\"A Drug Prescribed For Weight Loss Could Help Improve Associative Learning In People With Obesity\",\"datePublished\":\"2023-08-18T07:54:45+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/urbancare.clinic\/a-drug-prescribed-for-weight-loss-could-help-improve-associative-learning-in-people-with-obesity\/\"},\"wordCount\":438,\"publisher\":{\"@id\":\"https:\/\/urbancare.clinic\/#organization\"},\"image\":{\"@id\":\"https:\/\/urbancare.clinic\/a-drug-prescribed-for-weight-loss-could-help-improve-associative-learning-in-people-with-obesity\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/urbancare.clinic\/wp-content\/uploads\/2023\/08\/a-drug-prescribed-for-weight-loss-could-help-improve-associative-learning-in-people-with-obesity.jpg\",\"articleSection\":[\"Medical Daily\"],\"inLanguage\":\"it-IT\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/urbancare.clinic\/a-drug-prescribed-for-weight-loss-could-help-improve-associative-learning-in-people-with-obesity\/\",\"url\":\"https:\/\/urbancare.clinic\/a-drug-prescribed-for-weight-loss-could-help-improve-associative-learning-in-people-with-obesity\/\",\"name\":\"A Drug Prescribed For Weight Loss Could Help Improve Associative Learning In People With Obesity - 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Urban Care Clinic","og_description":"A drug prescribed for weight loss and type 2 diabetes may improve associative learning in people with obesity, a recent study has found.Associative learning is the process by which living things learn about the connections between things happening around them. It involves both modifications of existing behaviors and the development of new behaviors.Researchers from Max Planck Institute for Metabolism Research evaluated how associative learning changes in people with impaired insulin sensitivity associated with obesity. They studied associated learning behaviors in two groups of participants; one with normal weight, who had high insulin sensitivity, and the other with reduced insulin sensitivity from obesity. The team found that reduced insulin sensitivity from obesity impairs associative learning.The participants in the obese group were either given a placebo or liraglutide \u2013 a weight loss drug prescribed for obesity and type 2 diabetes.With a single dose of liraglutide, the impaired associative learning in obese people can be reversed and brought back to the levels same as that of people with normal weight, according to the findings, published in the journal Nature Metabolism.\"These findings are of fundamental importance. We show here that basic behaviors such as associative learning depend not only on external environmental conditions but also on the body's metabolic state. So, whether someone has overweight or not also determines how the brain learns to associate sensory signals and what motivation is generated. The normalization we achieved with the drug in subjects with obesity, therefore, fits with studies showing that these drugs restore a normal feeling of satiety, causing people to eat less and therefore lose weight,\" study leader Marc Tittgemeyer said in a news release.The study shows how obesity can alter the brain and how the process can be modified with medication. The researchers plan to carry out further studies to understand how liraglutide works at a molecular level. 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