{"id":8319,"date":"2023-06-13T10:02:48","date_gmt":"2023-06-13T07:02:48","guid":{"rendered":"https:\/\/urbancare.clinic\/why-is-weight-loss-hard-for-obese-people-study-explains-reason\/"},"modified":"2023-06-13T10:02:48","modified_gmt":"2023-06-13T07:02:48","slug":"perche-la-perdita-di-peso-e-difficile-per-le-persone-obese-lo-studio-spiega-il-motivo","status":"publish","type":"post","link":"https:\/\/urbancare.clinic\/it\/perche-la-perdita-di-peso-e-difficile-per-le-persone-obese-lo-studio-spiega-il-motivo\/","title":{"rendered":"Perch\u00e9 la perdita di peso \u00e8 difficile per le persone obese? Lo studio spiega la ragione"},"content":{"rendered":"<p>Perdere peso e mantenere la perdita di peso \u00e8 sempre difficile per le persone con obesit\u00e0. Uno studio recente ha spiegato come le risposte cerebrali nelle persone in sovrappeso funzionino in modo diverso in risposta a zuccheri e grassi, rendendo la perdita di peso un viaggio difficile.<\/p>\n<p>I riscontri del <a rel=\"noopener nofollow\" href=\"https:\/\/www.nature.com\/articles\/s42255-023-00816-9.epdf?sharing_token=liw89VwU9-jQHHBr5eY9tdRgN0jAjWel9jnR3ZoTv0M1SadTImevZtbaTQ0zrz0bHR-l_kFBGfPLzIqJZudrjrKDKf6W2s8_vtlPvT25PJ1GUdNaWTyzHUYEj_xeSrWlRPRB5lJs5_PoIBcO9HB7Wy1q3RBBF2ybRmkW-e-FGzVOPpT1iagk6opfit7llTVf0e7hc2oitOk5Se2ZWbaK072zNf6O_KJuk9jHw4Ix_Fg%3D&amp;tracking_referrer=www.usnews.com\" target=\"_blank\">studio<\/a>, pubblicato sulla rivista Nature Metabolism, ha spiegato come l&#039;obesit\u00e0 abbia fatto perdere al cervello l&#039;allineamento con ci\u00f2 che stava accadendo nell&#039;intestino.<\/p>\n<p>\u201cLa nostra interpretazione \u00e8 che c&#039;\u00e8 una percezione dei nutrienti generalmente ridotta nelle persone con obesit\u00e0. Potrebbe aiutare a spiegare perch\u00e9 la perdita di peso e il mantenimento della perdita di peso sono cos\u00ec difficili &quot;, la ricercatrice senior Dr. Mireille Serlie <a rel=\"noopener nofollow\" href=\"https:\/\/www.usnews.com\/news\/health-news\/articles\/2023-06-12\/obesity-might-permanently-blunt-brains-responses-to-sugary-fatty-foods\" target=\"_blank\">disse<\/a>.<\/p>\n<p>Lo studio ha valutato 30 adulti con un peso corporeo sano e 30 con obesit\u00e0. Le risposte cerebrali dei partecipanti allo zucchero e al grasso sono state catturate dopo che i nutrienti sono stati consegnati direttamente all&#039;intestino.<\/p>\n<p>I partecipanti magri hanno mostrato modelli specifici di attivit\u00e0 cerebrale quando sono stati forniti i nutrienti, mentre questi erano &quot;gravemente compromessi&quot; nelle persone obese. I partecipanti che erano in sovrappeso avevano anche un minore rilascio di dopamina dallo striato del cervello responsabile della regolazione delle abitudini alimentari.<\/p>\n<p>Anche dopo aver perso 10% del loro peso con una dieta ipocalorica per tre mesi, le risposte cerebrali dei partecipanti obesi non si sono invertite.<\/p>\n<p>I ricercatori ritengono che la segnalazione dei nutrienti alterata non sia permanente e possa essere recuperata con pi\u00f9 tempo e una perdita di peso sostenuta.<\/p>\n<p>Precedenti esperimenti su animali da laboratorio indicavano il <a rel=\"nofollow\" href=\"https:\/\/www.medicaldaily.com\/why-does-stress-make-us-crave-comfort-food-tips-prevent-emotional-eating-470084\">cervello<\/a> ha risposto alla presenza di nutrienti nell&#039;intestino anche senza l&#039;esperienza sensoriale del mangiare.<\/p>\n<p>&quot;Il salto in avanti in questo studio \u00e8 che stanno dimostrando che ci\u00f2 sta accadendo anche negli esseri umani, ma la risposta \u00e8 completamente attenuata nelle persone con obesit\u00e0&quot;, ha detto Alexandra DiFeliceantonio, coautrice dello studio.<\/p>\n<p>La segnalazione dei nutrienti tra l&#039;intestino e il cervello aiuta le persone a scegliere cosa mangiare, ma la segnalazione \u00e8 &quot;in qualche modo interrotta&quot; a causa dell&#039;obesit\u00e0, ha aggiunto DiFeliceantonio.<\/p>\n<p>Nel frattempo, i ricercatori non sono stati in grado di determinare quando esattamente la segnalazione viene compromessa o come.<\/p>\n<p>Secondo lo studio, il segreto per una perdita di peso duratura non sta sempre nella \u201cforza di volont\u00e0\u201d per continuare la dieta, poich\u00e9 le persone obese combattono costantemente non solo le tentazioni di cibo spazzatura a buon mercato e facilmente disponibile, ma anche un \u201ccervello affamato\u201d che rende difficili i cambiamenti nella dieta e la perdita di peso.<\/p>\n<p>\u201cPenso che le persone vengano incolpate. Non si tratta di forza di volont\u00e0. \u00c8 una vera lotta. E stiamo iniziando a capire perch\u00e9 le persone lottano&quot;, ha detto Serlie.<\/p>\n<p>Tuttavia, attraverso la dieta, i cambiamenti nello stile di vita e i farmaci, i ricercatori sperano di trovare un modo per correggere la segnalazione dei nutrienti in futuro.<\/p>\n<figure class=\"imageBox\">\n<div class=\"innerBox\"><picture class=\"mapping-embed\" width=\"736\" height=\"552\"><source type=\"image\/webp\" media=\"(min-width: 1100px)\" sizes=\"736px\" srcset=\"https:\/\/d.medicaldaily.com\/en\/full\/445610\/burger.webp?w=736&amp;f=990f4970890e24283f85ffb6eb2bfb48 736w\"><source type=\"image\/jpeg\" media=\"(min-width: 1100px)\" sizes=\"736px\" srcset=\"https:\/\/urbancare.clinic\/wp-content\/uploads\/2023\/06\/why-is-weight-loss-hard-for-obese-people-study-explains-reason.jpg 736w\"><source type=\"image\/webp\" media=\"(min-width: 768px)\" sizes=\"1000px\" srcset=\"https:\/\/d.medicaldaily.com\/en\/full\/445610\/burger.webp?w=1100&amp;f=d0344a1848f73f5887983c12133460d2 1100w\"><source type=\"image\/jpeg\" media=\"(min-width: 768px)\" sizes=\"1000px\" srcset=\"https:\/\/d.medicaldaily.com\/en\/full\/445610\/burger.jpg?w=1100&amp;f=d0344a1848f73f5887983c12133460d2 1100w\"><source type=\"image\/webp\" media=\"(min-width: 480px)\" sizes=\"736px\" srcset=\"https:\/\/d.medicaldaily.com\/en\/full\/445610\/burger.webp?w=736&amp;f=990f4970890e24283f85ffb6eb2bfb48 736w\"><source type=\"image\/jpeg\" media=\"(min-width: 480px)\" sizes=\"736px\" srcset=\"https:\/\/urbancare.clinic\/wp-content\/uploads\/2023\/06\/why-is-weight-loss-hard-for-obese-people-study-explains-reason.jpg 736w\"><source type=\"image\/webp\" media=\"(min-width: 0px)\" sizes=\"480px\" srcset=\"https:\/\/d.medicaldaily.com\/en\/full\/445610\/burger.webp?w=480&amp;f=2fdd49a08c05dcdaae5a4b7e8e4e04d3 480w\"><source type=\"image\/jpeg\" media=\"(min-width: 0px)\" sizes=\"480px\" srcset=\"https:\/\/d.medicaldaily.com\/en\/full\/445610\/burger.jpg?w=480&amp;f=2fdd49a08c05dcdaae5a4b7e8e4e04d3 480w\"><source type=\"image\/webp\" srcset=\"https:\/\/d.medicaldaily.com\/en\/full\/445610\/burger.webp?w=736&amp;f=990f4970890e24283f85ffb6eb2bfb48\"><img loading=\"lazy\" decoding=\"async\" class=\"mapping-embed imgPhoto\" id=\"i445610\" src=\"https:\/\/urbancare.clinic\/wp-content\/uploads\/2023\/06\/why-is-weight-loss-hard-for-obese-people-study-explains-reason.jpg\" alt=\"burger\" width=\"736\" height=\"552\" style=\"display:none\"><\/picture><\/div><figcaption class=\"caption\">\n<span class=\"cap\">Uno studio recente spiega come le risposte cerebrali nelle persone in sovrappeso funzionino in modo diverso in risposta a zuccheri e grassi, rendendo la perdita di peso un viaggio difficile.<\/span><br \/>\n<span class=\"credit\">Pixabay<\/span><br \/>\n<\/figcaption><\/figure>\n<p>Pubblicato da Medicaldaily.com<\/p>\n<p><a href=\"https:\/\/www.medicaldaily.com\/why-weight-loss-hard-obese-people-study-explains-reason-470091\">Fonte quotidiana medica<\/a><\/p>\n<p>","protected":false},"excerpt":{"rendered":"<p>Perdere peso e mantenere la perdita di peso \u00e8 sempre difficile per le persone con obesit\u00e0. Uno studio recente ha spiegato come le risposte cerebrali nelle persone in sovrappeso funzionino in modo diverso in risposta a zuccheri e grassi, rendendo la perdita di peso un viaggio difficile.<\/p>\n<p>I riscontri del <a rel=\"noopener nofollow\" href=\"https:\/\/www.nature.com\/articles\/s42255-023-00816-9.epdf?sharing_token=liw89VwU9-jQHHBr5eY9tdRgN0jAjWel9jnR3ZoTv0M1SadTImevZtbaTQ0zrz0bHR-l_kFBGfPLzIqJZudrjrKDKf6W2s8_vtlPvT25PJ1GUdNaWTyzHUYEj_xeSrWlRPRB5lJs5_PoIBcO9HB7Wy1q3RBBF2ybRmkW-e-FGzVOPpT1iagk6opfit7llTVf0e7hc2oitOk5Se2ZWbaK072zNf6O_KJuk9jHw4Ix_Fg%3D&amp;tracking_referrer=www.usnews.com\" target=\"_blank\">studio<\/a>, pubblicato sulla rivista Nature Metabolism, ha spiegato come l&#039;obesit\u00e0 abbia fatto perdere al cervello l&#039;allineamento con ci\u00f2 che stava accadendo nell&#039;intestino.<\/p>\n<p>\u201cLa nostra interpretazione \u00e8 che c&#039;\u00e8 una percezione dei nutrienti generalmente ridotta nelle persone con obesit\u00e0. Potrebbe aiutare a spiegare perch\u00e9 la perdita di peso e il mantenimento della perdita di peso sono cos\u00ec difficili &quot;, la ricercatrice senior Dr. Mireille Serlie <a rel=\"noopener nofollow\" href=\"https:\/\/www.usnews.com\/news\/health-news\/articles\/2023-06-12\/obesity-might-permanently-blunt-brains-responses-to-sugary-fatty-foods\" target=\"_blank\">disse<\/a>.<\/p>\n<p>Lo studio ha valutato 30 adulti con un peso corporeo sano e 30 con obesit\u00e0. Le risposte cerebrali dei partecipanti allo zucchero e al grasso sono state catturate dopo che i nutrienti sono stati consegnati direttamente all&#039;intestino.<\/p>\n<p>I partecipanti magri hanno mostrato modelli specifici di attivit\u00e0 cerebrale quando sono stati forniti i nutrienti, mentre questi erano &quot;gravemente compromessi&quot; nelle persone obese. I partecipanti che erano in sovrappeso avevano anche un minore rilascio di dopamina dallo striato del cervello responsabile della regolazione delle abitudini alimentari.<\/p>\n<p>Anche dopo aver perso 10% del loro peso con una dieta ipocalorica per tre mesi, le risposte cerebrali dei partecipanti obesi non si sono invertite.<\/p>\n<p>I ricercatori ritengono che la segnalazione dei nutrienti alterata non sia permanente e possa essere recuperata con pi\u00f9 tempo e una perdita di peso sostenuta.<\/p>\n<p>Precedenti esperimenti su animali da laboratorio indicavano il <a rel=\"nofollow\" href=\"https:\/\/www.medicaldaily.com\/why-does-stress-make-us-crave-comfort-food-tips-prevent-emotional-eating-470084\">cervello<\/a> ha risposto alla presenza di nutrienti nell&#039;intestino anche senza l&#039;esperienza sensoriale del mangiare.<\/p>\n<p>&quot;Il salto in avanti in questo studio \u00e8 che stanno dimostrando che ci\u00f2 sta accadendo anche negli esseri umani, ma la risposta \u00e8 completamente attenuata nelle persone con obesit\u00e0&quot;, ha detto Alexandra DiFeliceantonio, coautrice dello studio.<\/p>\n<p>La segnalazione dei nutrienti tra l&#039;intestino e il cervello aiuta le persone a scegliere cosa mangiare, ma la segnalazione \u00e8 &quot;in qualche modo interrotta&quot; a causa dell&#039;obesit\u00e0, ha aggiunto DiFeliceantonio.<\/p>\n<p>Nel frattempo, i ricercatori non sono stati in grado di determinare quando esattamente la segnalazione viene compromessa o come.<\/p>\n<p>Secondo lo studio, il segreto per una perdita di peso duratura non sta sempre nella \u201cforza di volont\u00e0\u201d per continuare la dieta, poich\u00e9 le persone obese combattono costantemente non solo le tentazioni di cibo spazzatura a buon mercato e facilmente disponibile, ma anche un \u201ccervello affamato\u201d che rende difficili i cambiamenti nella dieta e la perdita di peso.<\/p>\n<p>\u201cPenso che le persone vengano incolpate. Non si tratta di forza di volont\u00e0. \u00c8 una vera lotta. E stiamo iniziando a capire perch\u00e9 le persone lottano&quot;, ha detto Serlie.<\/p>\n<p>Tuttavia, attraverso la dieta, i cambiamenti nello stile di vita e i farmaci, i ricercatori sperano di trovare un modo per correggere la segnalazione dei nutrienti in futuro.<\/p>\n<figure class=\"imageBox\">\n<div class=\"innerBox\"><img loading=\"lazy\" decoding=\"async\" class=\"mapping-embed imgPhoto\" id=\"i445610\" src=\"https:\/\/urbancare.clinic\/wp-content\/uploads\/2023\/06\/why-is-weight-loss-hard-for-obese-people-study-explains-reason.jpg\" alt=\"burger\" width=\"736\" height=\"552\"><\/div><figcaption class=\"caption\">\n<span class=\"cap\">Uno studio recente spiega come le risposte cerebrali nelle persone in sovrappeso funzionino in modo diverso in risposta a zuccheri e grassi, rendendo la perdita di peso un viaggio difficile.<\/span><br \/>\n<span class=\"credit\">Pixabay<\/span><br \/>\n<\/figcaption><\/figure>\n<p>Pubblicato da Medicaldaily.com<\/p>","protected":false},"author":2,"featured_media":8320,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"Default","format":"standard","meta":{"fifu_image_url":"https:\/\/urbancare.clinic\/wp-content\/uploads\/2023\/06\/why-is-weight-loss-hard-for-obese-people-study-explains-reason.jpg","fifu_image_alt":"","footnotes":""},"categories":[27],"tags":[],"class_list":["post-8319","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blog"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.6 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Why Is Weight Loss Hard For Obese People? Study Explains Reason - Urban Care Clinic<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/urbancare.clinic\/it\/perche-la-perdita-di-peso-e-difficile-per-le-persone-obese-lo-studio-spiega-il-motivo\/\" \/>\n<meta property=\"og:locale\" content=\"it_IT\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Why Is Weight Loss Hard For Obese People? Study Explains Reason - Urban Care Clinic\" \/>\n<meta property=\"og:description\" content=\"Losing weight and maintaining weight loss is always difficult for people with obesity. A recent study explained how the brain responses in overweight people function differently in response to sugar and fat, making weight loss a tough journey.The findings of the study, published in the journal Nature Metabolism, explained how obesity caused the brain to lose alignment with what was happening in the gut.&quot;Our interpretation is, there&#039;s a generally reduced nutrient-sensing in people with obesity. It could help explain why weight loss and weight-loss maintenance are so hard,&quot; senior researcher Dr. Mireille Serlie said.The study evaluated 30 adults with a healthy body weight and 30 with obesity. The brain responses of the participants to sugar and fat were captured after the nutrients were delivered directly to the gut.The lean participants showed specific patterns of brain activity when the nutrients were delivered, while these were &quot;severely impaired&quot; in obese people. The participants who were overweight also had a lesser release of dopamine from the striatum of the brain responsible for regulating eating habits.Even after shedding 10% of their weight on a reduced-calorie diet for three months, the brain responses of the obese participants did not reverse.Researchers believe that impaired nutrient signaling is not permanent and can be regained with more time and sustained weight loss.Earlier experiments on lab animals indicated the brain responded to the presence of nutrients in the gut even without the sensory experience of eating.&quot;The leap forward in this study is that they&#039;re showing this is happening in humans, too, but the response is completely blunted in people with obesity,&quot; Alexandra DiFeliceantonio, a co-author of the study, said.The nutrient signaling between the gut and the brain helps people choose what they eat, but the signaling is &quot;broken in some way&quot; due to obesity, DiFeliceantonio added.Meanwhile, the researchers could not determine when exactly the signaling becomes impaired or how.According to the study, the secret to lasting weight loss is not always about the &quot;willpower&quot; to continue the diet, as obese people are constantly fighting not only the temptations of cheap, readily available junk food, but also a &quot;hungry brain&quot; that makes diet changes and weight loss difficult.&quot;I do think people get blamed. This is not about willpower. It&#039;s a real struggle. And we&#039;re starting to understand why people struggle,&quot; Serlie said.However, through diet, lifestyle changes, and medications the researchers hope to find a way to correct the nutrient signaling in the future. A recent study explains how the brain responses in overweight people function differently in response to sugar and fat, making weight loss a tough journey. Pixabay Published by Medicaldaily.com\" \/>\n<meta property=\"og:url\" content=\"https:\/\/urbancare.clinic\/it\/perche-la-perdita-di-peso-e-difficile-per-le-persone-obese-lo-studio-spiega-il-motivo\/\" \/>\n<meta property=\"og:site_name\" content=\"Urban Care Clinic\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/urbancarezanzibar\" \/>\n<meta property=\"article:published_time\" content=\"2023-06-13T07:02:48+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/urbancare.clinic\/wp-content\/uploads\/2023\/06\/why-is-weight-loss-hard-for-obese-people-study-explains-reason.jpg\" \/>\n<meta name=\"author\" content=\"Urban Care Clinic\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:image\" content=\"https:\/\/urbancare.clinic\/wp-content\/uploads\/2023\/06\/why-is-weight-loss-hard-for-obese-people-study-explains-reason.jpg\" \/>\n<meta name=\"twitter:label1\" content=\"Scritto da\" \/>\n\t<meta name=\"twitter:data1\" content=\"Urban Care Clinic\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tempo di lettura stimato\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minuti\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/urbancare.clinic\/why-is-weight-loss-hard-for-obese-people-study-explains-reason\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/urbancare.clinic\/why-is-weight-loss-hard-for-obese-people-study-explains-reason\/\"},\"author\":{\"name\":\"Urban Care Clinic\",\"@id\":\"https:\/\/urbancare.clinic\/#\/schema\/person\/f286c4d84be896d302aceda3ed7e789c\"},\"headline\":\"Why Is Weight Loss Hard For Obese People? 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Lo studio spiega la ragione - Urban Care Clinic","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/urbancare.clinic\/it\/perche-la-perdita-di-peso-e-difficile-per-le-persone-obese-lo-studio-spiega-il-motivo\/","og_locale":"it_IT","og_type":"article","og_title":"Why Is Weight Loss Hard For Obese People? Study Explains Reason - Urban Care Clinic","og_description":"Losing weight and maintaining weight loss is always difficult for people with obesity. A recent study explained how the brain responses in overweight people function differently in response to sugar and fat, making weight loss a tough journey.The findings of the study, published in the journal Nature Metabolism, explained how obesity caused the brain to lose alignment with what was happening in the gut.\"Our interpretation is, there's a generally reduced nutrient-sensing in people with obesity. It could help explain why weight loss and weight-loss maintenance are so hard,\" senior researcher Dr. Mireille Serlie said.The study evaluated 30 adults with a healthy body weight and 30 with obesity. The brain responses of the participants to sugar and fat were captured after the nutrients were delivered directly to the gut.The lean participants showed specific patterns of brain activity when the nutrients were delivered, while these were \"severely impaired\" in obese people. The participants who were overweight also had a lesser release of dopamine from the striatum of the brain responsible for regulating eating habits.Even after shedding 10% of their weight on a reduced-calorie diet for three months, the brain responses of the obese participants did not reverse.Researchers believe that impaired nutrient signaling is not permanent and can be regained with more time and sustained weight loss.Earlier experiments on lab animals indicated the brain responded to the presence of nutrients in the gut even without the sensory experience of eating.\"The leap forward in this study is that they're showing this is happening in humans, too, but the response is completely blunted in people with obesity,\" Alexandra DiFeliceantonio, a co-author of the study, said.The nutrient signaling between the gut and the brain helps people choose what they eat, but the signaling is \"broken in some way\" due to obesity, DiFeliceantonio added.Meanwhile, the researchers could not determine when exactly the signaling becomes impaired or how.According to the study, the secret to lasting weight loss is not always about the \"willpower\" to continue the diet, as obese people are constantly fighting not only the temptations of cheap, readily available junk food, but also a \"hungry brain\" that makes diet changes and weight loss difficult.\"I do think people get blamed. This is not about willpower. It's a real struggle. And we're starting to understand why people struggle,\" Serlie said.However, through diet, lifestyle changes, and medications the researchers hope to find a way to correct the nutrient signaling in the future. A recent study explains how the brain responses in overweight people function differently in response to sugar and fat, making weight loss a tough journey. 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