{"id":8202,"date":"2023-05-19T03:24:07","date_gmt":"2023-05-19T00:24:07","guid":{"rendered":"https:\/\/urbancare.clinic\/who-wants-vaccine-manufacturers-to-ditch-original-strain-in-updated-formulations\/"},"modified":"2023-05-23T17:29:53","modified_gmt":"2023-05-23T14:29:53","slug":"che-vuole-che-i-produttori-di-vaccini-abbandonino-il-ceppo-originale-in-formulazioni-aggiornate","status":"publish","type":"post","link":"https:\/\/urbancare.clinic\/it\/who-wants-vaccine-manufacturers-to-ditch-original-strain-in-updated-formulations\/","title":{"rendered":"L&#039;OMS vuole che i produttori di vaccini abbandonino il ceppo originale nelle formulazioni aggiornate"},"content":{"rendered":"<div><img decoding=\"async\" src=\"https:\/\/urbancare.clinic\/wp-content\/uploads\/2023\/05\/who-wants-vaccine-manufacturers-to-ditch-original-strain-in-updated-formulations.jpg\" class=\"ff-og-image-inserted\"  style=\"display:none\"><\/div>\n<p>L&#039;Organizzazione mondiale della sanit\u00e0 (OMS) ha rilasciato una dichiarazione sulla composizione antigenica dei vaccini COVID-19.<\/p>\n<p>L&#039;agenzia specializzata delle Nazioni Unite ha affermato gioved\u00ec che i produttori di vaccini dovrebbero progettare aggiornamenti che non prendano pi\u00f9 di mira il ceppo originale di SARS-CoV-2.<\/p>\n<p>&quot;Mentre i vaccini COVID-19 attualmente approvati, compresi quelli basati sul virus indice, continuano a fornire protezione contro malattie gravi, il TAG-CO-VAC consiglia di abbandonare l&#039;inclusione del virus indice nelle future formulazioni di vaccini COVID-19, &quot; IL <a rel=\"noopener nofollow\" href=\"https:\/\/www.who.int\/news\/item\/18-05-2023-statement-on-the-antigen-composition-of-covid-19-vaccines\" target=\"_blank\">L&#039;OMS ha dichiarato sul suo sito web<\/a>.<\/p>\n<p>TAG-CO-VAC \u00e8 il gruppo consultivo tecnico dell&#039;OMS sulla composizione del vaccino COVID-19. Il gruppo consultivo ha il compito di riunirsi regolarmente per valutare le implicazioni di nuove mutazioni per la composizione dell&#039;antigene dei futuri vaccini.<\/p>\n<p>Per quest&#039;anno, TAG-CO-VAC dovrebbe riunirsi almeno due volte. Il primo \u00e8 stato programmato per maggio e un follow-up dovrebbe essere fatto circa sei mesi dopo. Il gruppo si \u00e8 riunito ufficialmente l&#039;11 e il 12 maggio per discutere gli ultimi dati sulle varianti di SARS-CoV-2 circolanti e sulla composizione del vaccino.<\/p>\n<p>L&#039;anno scorso, <a rel=\"noopener nofollow\" href=\"https:\/\/www.who.int\/news\/item\/17-06-2022-interim-statement-on--the-composition-of-current-COVID-19-vaccines\" target=\"_blank\">dichiarato TAG-CO-VAC<\/a> che l&#039;obiettivo dell&#039;aggiornamento della composizione dell&#039;antigene del vaccino COVID-19 era quello di migliorare le risposte immunitarie indotte dal vaccino alle varianti di coronavirus attualmente in circolazione. Se il gruppo dovesse trovare la necessit\u00e0 di modificare le formulazioni, consiglierebbe all&#039;OMS di informare tutti i produttori di vaccini.<\/p>\n<p>L&#039;ultima raccomandazione del gruppo di abbandonare il ceppo originale nelle formulazioni future \u00e8 dovuta a diversi motivi. Uno dei quali ha a che fare con il virus indice e altri ceppi precedenti che non circolano pi\u00f9 negli esseri umani. Un altro motivo \u00e8 il modo in cui il ceppo originale suscita livelli non rilevabili o molto bassi di anticorpi neutralizzanti contro le varianti pi\u00f9 recenti.<\/p>\n<p>Il terzo motivo addotto dal gruppo ha a che fare con la concentrazione della composizione. Includendo il virus indice nei vaccini e nei richiami bivalenti o multivalenti, la concentrazione dei nuovi antigeni bersaglio pu\u00f2 essere inferiore. Ci\u00f2 diminuisce l&#039;entit\u00e0 della risposta immunitaria umorale contro le varianti attualmente in circolazione.<\/p>\n<p>TAG-CO-VAC ha riconosciuto i limiti dei dati disponibili su tempistica, mutazioni specifiche, caratteristiche antigeniche e potenziali rischi per la salute pubblica delle varianti future. Anche le informazioni sulla reattivit\u00e0 crociata delle risposte immunitarie provocate dai ceppi pi\u00f9 recenti sono limitate. Nel frattempo, i dati sui vaccini candidati contro il lignaggio discendente XBB.1 sono ancora limitati ai modelli animali.<\/p>\n<p>Nonostante i limiti, il gruppo consultivo ha affermato di continuare a incoraggiare il futuro sviluppo di vaccini COVID-19 che migliorano l&#039;immunit\u00e0 delle mucose per una migliore protezione contro le infezioni virali e riducono la trasmissione di SARS-CoV-2, specialmente nel <a rel=\"nofollow\" href=\"https:\/\/www.medicaldaily.com\/how-stay-safe-post-pandemic-era-469772\">epoca post pandemia<\/a>.<\/p>\n<p>Pubblicato da Medicaldaily.com<\/p>\n<p><a href=\"https:\/\/www.medicaldaily.com\/who-wants-vaccine-manufacturers-ditch-original-strain-updated-formulations-469822\">Fonte quotidiana medica<\/a><\/p>\n<p>","protected":false},"excerpt":{"rendered":"<div><img decoding=\"async\" src=\"https:\/\/urbancare.clinic\/wp-content\/uploads\/2023\/05\/who-wants-vaccine-manufacturers-to-ditch-original-strain-in-updated-formulations.jpg\" class=\"ff-og-image-inserted\"><\/div>\n<p>L&#039;Organizzazione mondiale della sanit\u00e0 (OMS) ha rilasciato una dichiarazione sulla composizione antigenica dei vaccini COVID-19.<\/p>\n<p>L&#039;agenzia specializzata delle Nazioni Unite ha affermato gioved\u00ec che i produttori di vaccini dovrebbero progettare aggiornamenti che non prendano pi\u00f9 di mira il ceppo originale di SARS-CoV-2.<\/p>\n<p>&quot;Mentre i vaccini COVID-19 attualmente approvati, compresi quelli basati sul virus indice, continuano a fornire protezione contro malattie gravi, il TAG-CO-VAC consiglia di abbandonare l&#039;inclusione del virus indice nelle future formulazioni di vaccini COVID-19, &quot; IL <a rel=\"noopener nofollow\" href=\"https:\/\/www.who.int\/news\/item\/18-05-2023-statement-on-the-antigen-composition-of-covid-19-vaccines\" target=\"_blank\">L&#039;OMS ha dichiarato sul suo sito web<\/a>.<\/p>\n<p>TAG-CO-VAC \u00e8 il gruppo consultivo tecnico dell&#039;OMS sulla composizione del vaccino COVID-19. Il gruppo consultivo ha il compito di riunirsi regolarmente per valutare le implicazioni di nuove mutazioni per la composizione dell&#039;antigene dei futuri vaccini.<\/p>\n<p>Per quest&#039;anno, TAG-CO-VAC dovrebbe riunirsi almeno due volte. Il primo \u00e8 stato programmato per maggio e un follow-up dovrebbe essere fatto circa sei mesi dopo. Il gruppo si \u00e8 riunito ufficialmente l&#039;11 e il 12 maggio per discutere gli ultimi dati sulle varianti di SARS-CoV-2 circolanti e sulla composizione del vaccino.<\/p>\n<p>L&#039;anno scorso, <a rel=\"noopener nofollow\" href=\"https:\/\/www.who.int\/news\/item\/17-06-2022-interim-statement-on--the-composition-of-current-COVID-19-vaccines\" target=\"_blank\">dichiarato TAG-CO-VAC<\/a> che l&#039;obiettivo dell&#039;aggiornamento della composizione dell&#039;antigene del vaccino COVID-19 era quello di migliorare le risposte immunitarie indotte dal vaccino alle varianti di coronavirus attualmente in circolazione. Se il gruppo dovesse trovare la necessit\u00e0 di modificare le formulazioni, consiglierebbe all&#039;OMS di informare tutti i produttori di vaccini.<\/p>\n<p>L&#039;ultima raccomandazione del gruppo di abbandonare il ceppo originale nelle formulazioni future \u00e8 dovuta a diversi motivi. Uno dei quali ha a che fare con il virus indice e altri ceppi precedenti che non circolano pi\u00f9 negli esseri umani. Un altro motivo \u00e8 il modo in cui il ceppo originale suscita livelli non rilevabili o molto bassi di anticorpi neutralizzanti contro le varianti pi\u00f9 recenti.<\/p>\n<p>Il terzo motivo addotto dal gruppo ha a che fare con la concentrazione della composizione. Includendo il virus indice nei vaccini e nei richiami bivalenti o multivalenti, la concentrazione dei nuovi antigeni bersaglio pu\u00f2 essere inferiore. Ci\u00f2 diminuisce l&#039;entit\u00e0 della risposta immunitaria umorale contro le varianti attualmente in circolazione.<\/p>\n<p>TAG-CO-VAC ha riconosciuto i limiti dei dati disponibili su tempistica, mutazioni specifiche, caratteristiche antigeniche e potenziali rischi per la salute pubblica delle varianti future. Anche le informazioni sulla reattivit\u00e0 crociata delle risposte immunitarie provocate dai ceppi pi\u00f9 recenti sono limitate. Nel frattempo, i dati sui vaccini candidati contro il lignaggio discendente XBB.1 sono ancora limitati ai modelli animali.<\/p>\n<p>Nonostante i limiti, il gruppo consultivo ha affermato di continuare a incoraggiare il futuro sviluppo di vaccini COVID-19 che migliorano l&#039;immunit\u00e0 delle mucose per una migliore protezione contro le infezioni virali e riducono la trasmissione di SARS-CoV-2, specialmente nel <a rel=\"nofollow\" href=\"https:\/\/www.medicaldaily.com\/how-stay-safe-post-pandemic-era-469772\">epoca post pandemia<\/a>.<\/p>\n<p>Pubblicato da Medicaldaily.com<\/p>","protected":false},"author":2,"featured_media":8203,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"page_builder":"","fifu_image_url":"https:\/\/urbancare.clinic\/wp-content\/uploads\/2023\/05\/who-wants-vaccine-manufacturers-to-ditch-original-strain-in-updated-formulations.jpg","fifu_image_alt":"","footnotes":""},"categories":[27],"tags":[193],"class_list":["post-8202","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blog","tag-vaccination"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>WHO Wants Vaccine Manufacturers To Ditch Original Strain In Updated Formulations - Urban Care Clinic<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/urbancare.clinic\/it\/che-vuole-che-i-produttori-di-vaccini-abbandonino-il-ceppo-originale-in-formulazioni-aggiornate\/\" \/>\n<meta property=\"og:locale\" content=\"it_IT\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"WHO Wants Vaccine Manufacturers To Ditch Original Strain In Updated Formulations - Urban Care Clinic\" \/>\n<meta property=\"og:description\" content=\"The World Health Organization (WHO) has issued a statement on the antigen composition of the COVID-19 vaccines.The specialized agency of the United Nations said Thursday that vaccine manufacturers should design updates that no longer target the original strain of SARS-CoV-2.&quot;While currently approved COVID-19 vaccines, including those based on the index virus, continue to provide protection against severe disease, the TAG-CO-VAC advises moving away from the inclusion of the index virus in future formulations of COVID-19 vaccines,&quot; the WHO stated on its website.TAG-CO-VAC is the WHO&#039;s Technical Advisory Group on COVID-19 Vaccine Composition. The advisory group is tasked to convene regularly to assess the implications of newer mutations for the antigen composition of future vaccines.For this year, TAG-CO-VAC is expected to meet at least twice. The first one was scheduled in May, and a follow-up should be done about six months later. The group officially convened on May 11-12 to discuss the latest data on circulating SARS-CoV-2 variants and vaccine composition.Last year, TAG-CO-VAC stated that the objective of updating the COVID-19 vaccine antigen composition was to enhance vaccine-induced immune responses to currently circulating coronavirus variants. Should the group find the need to change formulations, it would advise the WHO to inform all vaccine manufacturers.The latest recommendation of the group to ditch the original strain in future formulations is due to several reasons. One of which has to do with the index virus and other earlier strains no longer circulating in humans. Another reason is how the original strain elicits undetectable or very low levels of neutralizing antibodies against the newer variants.The third reason cited by the group has something to do with the concentration of the composition. By including the index virus in the bivalent or multivalent vaccines and boosters, the concentration of the new target antigens may be lower. This decreases the magnitude of the humoral immune response against the currently circulating variants.TAG-CO-VAC acknowledged the limitations of the available data on the timing, specific mutations, antigenic characteristics and potential public health risks of future variants. Information on the cross-reactivity of immune responses elicited by newer strains is also limited. Meanwhile, data on candidate vaccines against XBB.1 descendent lineage are still limited to animal models.Despite the limitations, the advisory group said it continues to encourage the future development of COVID-19 vaccines that enhance mucosal immunity for improved protection against viral infection and reduce the transmission of SARS-CoV-2, especially in the post-pandemic era.Published by Medicaldaily.com\" \/>\n<meta property=\"og:url\" content=\"https:\/\/urbancare.clinic\/it\/che-vuole-che-i-produttori-di-vaccini-abbandonino-il-ceppo-originale-in-formulazioni-aggiornate\/\" \/>\n<meta property=\"og:site_name\" content=\"Urban Care Clinic\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/urbancarezanzibar\" \/>\n<meta property=\"article:published_time\" content=\"2023-05-19T00:24:07+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-05-23T14:29:53+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/urbancare.clinic\/wp-content\/uploads\/2023\/05\/who-wants-vaccine-manufacturers-to-ditch-original-strain-in-updated-formulations.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1024\" \/>\n\t<meta property=\"og:image:height\" content=\"1024\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Urban Care Clinic\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Scritto da\" \/>\n\t<meta name=\"twitter:data1\" content=\"Urban Care Clinic\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tempo di lettura stimato\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minuti\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/urbancare.clinic\\\/who-wants-vaccine-manufacturers-to-ditch-original-strain-in-updated-formulations\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/urbancare.clinic\\\/who-wants-vaccine-manufacturers-to-ditch-original-strain-in-updated-formulations\\\/\"},\"author\":{\"name\":\"Urban Care Clinic\",\"@id\":\"https:\\\/\\\/urbancare.clinic\\\/#\\\/schema\\\/person\\\/a304a61bcf298680ee41e2e9ae193930\"},\"headline\":\"WHO Wants Vaccine Manufacturers To Ditch Original Strain In Updated Formulations\",\"datePublished\":\"2023-05-19T00:24:07+00:00\",\"dateModified\":\"2023-05-23T14:29:53+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/urbancare.clinic\\\/who-wants-vaccine-manufacturers-to-ditch-original-strain-in-updated-formulations\\\/\"},\"wordCount\":429,\"publisher\":{\"@id\":\"https:\\\/\\\/urbancare.clinic\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/urbancare.clinic\\\/who-wants-vaccine-manufacturers-to-ditch-original-strain-in-updated-formulations\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/urbancare.clinic\\\/wp-content\\\/uploads\\\/2023\\\/05\\\/who-wants-vaccine-manufacturers-to-ditch-original-strain-in-updated-formulations.jpg\",\"keywords\":[\"Vaccination\"],\"articleSection\":[\"Medical Daily\"],\"inLanguage\":\"it-IT\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/urbancare.clinic\\\/who-wants-vaccine-manufacturers-to-ditch-original-strain-in-updated-formulations\\\/\",\"url\":\"https:\\\/\\\/urbancare.clinic\\\/who-wants-vaccine-manufacturers-to-ditch-original-strain-in-updated-formulations\\\/\",\"name\":\"WHO Wants Vaccine Manufacturers To Ditch Original Strain In Updated Formulations - 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Urban Care Clinic","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/urbancare.clinic\/it\/che-vuole-che-i-produttori-di-vaccini-abbandonino-il-ceppo-originale-in-formulazioni-aggiornate\/","og_locale":"it_IT","og_type":"article","og_title":"WHO Wants Vaccine Manufacturers To Ditch Original Strain In Updated Formulations - Urban Care Clinic","og_description":"The World Health Organization (WHO) has issued a statement on the antigen composition of the COVID-19 vaccines.The specialized agency of the United Nations said Thursday that vaccine manufacturers should design updates that no longer target the original strain of SARS-CoV-2.\"While currently approved COVID-19 vaccines, including those based on the index virus, continue to provide protection against severe disease, the TAG-CO-VAC advises moving away from the inclusion of the index virus in future formulations of COVID-19 vaccines,\" the WHO stated on its website.TAG-CO-VAC is the WHO's Technical Advisory Group on COVID-19 Vaccine Composition. The advisory group is tasked to convene regularly to assess the implications of newer mutations for the antigen composition of future vaccines.For this year, TAG-CO-VAC is expected to meet at least twice. The first one was scheduled in May, and a follow-up should be done about six months later. The group officially convened on May 11-12 to discuss the latest data on circulating SARS-CoV-2 variants and vaccine composition.Last year, TAG-CO-VAC stated that the objective of updating the COVID-19 vaccine antigen composition was to enhance vaccine-induced immune responses to currently circulating coronavirus variants. Should the group find the need to change formulations, it would advise the WHO to inform all vaccine manufacturers.The latest recommendation of the group to ditch the original strain in future formulations is due to several reasons. One of which has to do with the index virus and other earlier strains no longer circulating in humans. Another reason is how the original strain elicits undetectable or very low levels of neutralizing antibodies against the newer variants.The third reason cited by the group has something to do with the concentration of the composition. By including the index virus in the bivalent or multivalent vaccines and boosters, the concentration of the new target antigens may be lower. This decreases the magnitude of the humoral immune response against the currently circulating variants.TAG-CO-VAC acknowledged the limitations of the available data on the timing, specific mutations, antigenic characteristics and potential public health risks of future variants. Information on the cross-reactivity of immune responses elicited by newer strains is also limited. Meanwhile, data on candidate vaccines against XBB.1 descendent lineage are still limited to animal models.Despite the limitations, the advisory group said it continues to encourage the future development of COVID-19 vaccines that enhance mucosal immunity for improved protection against viral infection and reduce the transmission of SARS-CoV-2, especially in the post-pandemic era.Published by Medicaldaily.com","og_url":"https:\/\/urbancare.clinic\/it\/che-vuole-che-i-produttori-di-vaccini-abbandonino-il-ceppo-originale-in-formulazioni-aggiornate\/","og_site_name":"Urban Care Clinic","article_publisher":"https:\/\/www.facebook.com\/urbancarezanzibar","article_published_time":"2023-05-19T00:24:07+00:00","article_modified_time":"2023-05-23T14:29:53+00:00","og_image":[{"url":"https:\/\/urbancare.clinic\/wp-content\/uploads\/2023\/05\/who-wants-vaccine-manufacturers-to-ditch-original-strain-in-updated-formulations.jpg","width":1024,"height":1024,"type":"image\/jpeg"}],"author":"Urban Care Clinic","twitter_card":"summary_large_image","twitter_misc":{"Scritto da":"Urban Care Clinic","Tempo di lettura stimato":"2 minuti"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/urbancare.clinic\/who-wants-vaccine-manufacturers-to-ditch-original-strain-in-updated-formulations\/#article","isPartOf":{"@id":"https:\/\/urbancare.clinic\/who-wants-vaccine-manufacturers-to-ditch-original-strain-in-updated-formulations\/"},"author":{"name":"Urban Care Clinic","@id":"https:\/\/urbancare.clinic\/#\/schema\/person\/a304a61bcf298680ee41e2e9ae193930"},"headline":"WHO Wants Vaccine Manufacturers To Ditch Original Strain In Updated Formulations","datePublished":"2023-05-19T00:24:07+00:00","dateModified":"2023-05-23T14:29:53+00:00","mainEntityOfPage":{"@id":"https:\/\/urbancare.clinic\/who-wants-vaccine-manufacturers-to-ditch-original-strain-in-updated-formulations\/"},"wordCount":429,"publisher":{"@id":"https:\/\/urbancare.clinic\/#organization"},"image":{"@id":"https:\/\/urbancare.clinic\/who-wants-vaccine-manufacturers-to-ditch-original-strain-in-updated-formulations\/#primaryimage"},"thumbnailUrl":"https:\/\/urbancare.clinic\/wp-content\/uploads\/2023\/05\/who-wants-vaccine-manufacturers-to-ditch-original-strain-in-updated-formulations.jpg","keywords":["Vaccination"],"articleSection":["Medical Daily"],"inLanguage":"it-IT"},{"@type":"WebPage","@id":"https:\/\/urbancare.clinic\/who-wants-vaccine-manufacturers-to-ditch-original-strain-in-updated-formulations\/","url":"https:\/\/urbancare.clinic\/who-wants-vaccine-manufacturers-to-ditch-original-strain-in-updated-formulations\/","name":"L&#039;OMS vuole che i produttori di vaccini abbandonino il ceppo originale in formulazioni aggiornate - 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