{"id":7937,"date":"2023-04-19T12:38:20","date_gmt":"2023-04-19T09:38:20","guid":{"rendered":"https:\/\/urbancare.clinic\/irregular-sleeping-habits-can-lead-to-potentially-fatal-lung-disease-study\/"},"modified":"2023-05-23T17:33:58","modified_gmt":"2023-05-23T14:33:58","slug":"abitudini-di-sonno-irregolari-possono-portare-a-uno-studio-di-malattie-polmonari-potenzialmente-fatali","status":"publish","type":"post","link":"https:\/\/urbancare.clinic\/it\/irregular-sleeping-habits-can-lead-to-potentially-fatal-lung-disease-study\/","title":{"rendered":"Abitudini di sonno irregolari possono portare a malattie polmonari potenzialmente fatali: studio"},"content":{"rendered":"<p>Non seguire un programma di sonno regolare pu\u00f2 provocare malattie polmonari mortali, ha scoperto un nuovo studio.<\/p>\n<p>Lo studio, pubblicato sulla rivista <a rel=\"noopener nofollow\" href=\"https:\/\/www.nature.com\/articles\/s41467-023-36896-0\" target=\"_blank\">Comunicazioni sulla natura<\/a>, hanno osservato che modelli di sonno irregolari possono influenzare negativamente l&#039;orologio biologico naturale del corpo (noto anche come orologio circadiano), che pu\u00f2 portare a cicatrici polmonari o fibrosi polmonare, una malattia potenzialmente mortale in cui il tessuto connettivo si accumula nei polmoni, indurendoli e provocando difficolt\u00e0 respiratorie.<\/p>\n<p>Si tratta di una proteina associata all&#039;orologio circadiano chiamata REV-ERB\u03b1, una proteina del ritmo circadiano che regola la produzione di collagene nel corpo. La mancanza di REV-ERB\u03b1 pu\u00f2 aiutare ad aumentare la produzione di collagene che, a sua volta, pu\u00f2 causare l\u2019indurimento dei tessuti polmonari e infine la fibrosi.<\/p>\n<p>Il team dietro lo studio, guidato da Irfan Rahman, Ph.D., professore di medicina ambientale presso il Medical Center dell&#039;Universit\u00e0 di Rochester, ha riscontrato bassi livelli di REV-ERB\u03b1 e livelli aumentati di collagene e lisil ossidasi in campioni polmonari di fibrosi polmonare pazienti, secondo <a rel=\"noopener nofollow\" href=\"https:\/\/www.hindustantimes.com\/lifestyle\/health\/lung-health-is-affected-by-irregular-sleep-patterns-study-101681812485747.html\" target=\"_blank\">Tempi dell&#039;Hindustan<\/a>.<\/p>\n<p>In uno studio su un modello murino, i ricercatori hanno scoperto che REV-ERB\u03b1 fluttua durante il giorno, raggiungendo il picco a mezzogiorno e diminuendo durante la notte. Quando veniva subito un infortunio durante la notte, i modelli di topo mostravano aumenti maggiori della lisil ossidasi e delle proteine del collagene, un danno polmonare pi\u00f9 ampio e tassi di sopravvivenza pi\u00f9 bassi rispetto ai topi danneggiati durante il giorno.<\/p>\n<p>Rahman ha detto che i dipendenti del turno di notte sono pi\u00f9 a rischio di questa condizione. &quot;Il lavoro del turno di notte avviene solitamente intorno a mezzanotte, quando l&#039;espressione di REV-ERB\u03b1 \u00e8 al minimo&quot;, ha spiegato. \u201cI nostri risultati suggeriscono che l\u2019attivazione di REV-ERB\u03b1 durante la notte fornisce una minore protezione contro la fibrosi polmonare\u201d.<\/p>\n<p>Qixin Wang, Ph.D., un ricercatore post-dottorato che lavora nel laboratorio di Rahman, ha affermato nello studio che al mercato mancano abbastanza <a href=\"https:\/\/www.medicaldaily.com\/3d-imaging-technique-pulmonary-fibrosis-lung-disease-382910\" rel=\"nofollow\">fibrosi<\/a> farmaci e, con il nuovo studio, gli scienziati mirano a sviluppare nuovi farmaci per trattare meglio la condizione polmonare.<\/p>\n<p>&quot;Attualmente, ci sono solo due farmaci approvati dalla FDA per il trattamento della fibrosi, e ritardano solo il processo, non curano la malattia&quot;, ha detto Wang. \u201cI farmaci che attivano REV-ERB\u03b1 potrebbero servire come potenziali terapie per aiutare a prevenire la fibrosi e arrestare il processo patologico\u201d.<\/p>\n<figure class=\"imageBox\">\n<div class=\"innerBox\"><picture class=\"mapping-embed\" width=\"736\" height=\"490\"><source type=\"image\/webp\" media=\"(min-width: 1100px)\" sizes=\"736px\" srcset=\"https:\/\/d.medicaldaily.com\/en\/full\/432161\/lungs.webp?w=736&amp;f=4b353c8bd15aeedc2e11df1d1589b9c0 736w\"><source type=\"image\/jpeg\" media=\"(min-width: 1100px)\" sizes=\"736px\" srcset=\"https:\/\/urbancare.clinic\/wp-content\/uploads\/2023\/04\/irregular-sleeping-habits-can-lead-to-potentially-fatal-lung-disease-study.jpg 736w\"><source type=\"image\/webp\" media=\"(min-width: 768px)\" sizes=\"1000px\" srcset=\"https:\/\/d.medicaldaily.com\/en\/full\/432161\/lungs.webp?w=1100&amp;f=03619962be1fcf7e51628052d46f5219 1100w\"><source type=\"image\/jpeg\" media=\"(min-width: 768px)\" sizes=\"1000px\" srcset=\"https:\/\/d.medicaldaily.com\/en\/full\/432161\/lungs.jpg?w=1100&amp;f=03619962be1fcf7e51628052d46f5219 1100w\"><source type=\"image\/webp\" media=\"(min-width: 480px)\" sizes=\"640px\" srcset=\"https:\/\/d.medicaldaily.com\/en\/full\/432161\/lungs.webp?w=640&amp;f=dc06f1e9516bd73edcc9cb88a457e479 640w\"><source type=\"image\/jpeg\" media=\"(min-width: 480px)\" sizes=\"640px\" srcset=\"https:\/\/d.medicaldaily.com\/en\/full\/432161\/lungs.jpg?w=640&amp;f=dc06f1e9516bd73edcc9cb88a457e479 640w\"><source type=\"image\/webp\" media=\"(min-width: 0px)\" sizes=\"480px\" srcset=\"https:\/\/d.medicaldaily.com\/en\/full\/432161\/lungs.webp?w=480&amp;f=33593576f0e006f0323e8740a45cf6d9 480w\"><source type=\"image\/jpeg\" media=\"(min-width: 0px)\" sizes=\"480px\" srcset=\"https:\/\/d.medicaldaily.com\/en\/full\/432161\/lungs.jpg?w=480&amp;f=33593576f0e006f0323e8740a45cf6d9 480w\"><source type=\"image\/webp\" srcset=\"https:\/\/d.medicaldaily.com\/en\/full\/432161\/lungs.webp?w=736&amp;f=4b353c8bd15aeedc2e11df1d1589b9c0\"><img loading=\"lazy\" decoding=\"async\" class=\"mapping-embed imgPhoto\" id=\"i432161\" src=\"https:\/\/urbancare.clinic\/wp-content\/uploads\/2023\/04\/irregular-sleeping-habits-can-lead-to-potentially-fatal-lung-disease-study.jpg\" alt=\"Polmoni\" width=\"736\" height=\"490\" style=\"display:none\"><\/picture><\/div><figcaption class=\"caption\">\n<span class=\"cap\">Le caratteristiche principali della malattia polmonare autoimmune sono l\u2019infiammazione e le cicatrici. <\/span><br \/>\n<span class=\"credit\">Pixabay<\/span><br \/>\n<\/figcaption><\/figure>\n<p><a href=\"https:\/\/www.medicaldaily.com\/irregular-sleeping-habits-can-lead-potentially-fatal-lung-disease-study-469458\">Fonte quotidiana medica<\/a><\/p>\n<p>","protected":false},"excerpt":{"rendered":"<p>La mancanza di sonno provoca l&#039;interruzione della produzione di una proteina dell&#039;orologio biologico chiamata REV-ERB\u03b1, che pu\u00f2 causare fibrosi polmonare.<\/p>","protected":false},"author":2,"featured_media":7938,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"page_builder":"","fifu_image_url":"https:\/\/urbancare.clinic\/wp-content\/uploads\/2023\/04\/irregular-sleeping-habits-can-lead-to-potentially-fatal-lung-disease-study.jpg","fifu_image_alt":"","footnotes":""},"categories":[27],"tags":[203],"class_list":["post-7937","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blog","tag-sleep"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.4 - 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