{"id":7750,"date":"2023-04-05T12:21:32","date_gmt":"2023-04-05T09:21:32","guid":{"rendered":"https:\/\/urbancare.clinic\/new-shape-shifting-antibiotics-could-help-tackle-drug-resistant-viruses-researchers-suggest\/"},"modified":"2023-04-07T13:35:08","modified_gmt":"2023-04-07T10:35:08","slug":"nuovi-antibiotici-mutaforma-potrebbero-aiutare-a-combattere-i-virus-resistenti-ai-farmaci-suggeriscono-i-ricercatori","status":"publish","type":"post","link":"https:\/\/urbancare.clinic\/it\/new-shape-shifting-antibiotics-could-help-tackle-drug-resistant-viruses-researchers-suggest\/","title":{"rendered":"Nuovi antibiotici mutaforma potrebbero aiutare a contrastare i virus resistenti ai farmaci, suggeriscono i ricercatori"},"content":{"rendered":"<p>A parte gli episodi di influenza stagionale, le infezioni batteriche e virali sono state la principale causa di morte durante la pandemia. La stagione influenzale inizia generalmente durante l&#039;autunno e dura fino alla primavera. Durante la sua insorgenza, gli esseri umani sono esposti a decine di batteri che possono causare gravi malattie.<\/p>\n<p>La gravit\u00e0 dei sintomi influenzali porta spesso a un uso eccessivo di antibiotici, che a sua volta fa s\u00ec che alcuni batteri crescano resistenti ad essi. Pu\u00f2 rendere l&#039;assalto batterico ancora pi\u00f9 difficile da affrontare. In considerazione di ci\u00f2, l&#039;Organizzazione mondiale della sanit\u00e0 ha pubblicizzato la resistenza ai batteri come uno dei problemi sanitari urgenti che il mondo deve affrontare in questo momento.<\/p>\n<p>Tuttavia, il professor John E. Moses del Cold Spring Harbor Laboratory (CSHL) ha fatto una scoperta sorprendente che mira a invertire questa crisi e garantire che i superbatteri resistenti ai farmaci non ottengano pi\u00f9 il meglio dai malati di influenza.<\/p>\n<p>Moses ha sviluppato un antibiotico che pu\u00f2 cambiare forma da solo riorganizzando i suoi atomi.<\/p>\n<p>L&#039;idea gli \u00e8 venuta dopo aver osservato come funzionano i carri armati militari: ruotare le loro torrette e movimenti agili che \u00e8 un riflesso acuto di possibili minacce, secondo <a href=\"https:\/\/www.newswise.com\/articles\/new-shape-shifting-antibiotics-could-fight-deadly-infections\" target=\"_blank\" rel=\"noopener nofollow\">Saggio di notizie<\/a>. Anni dopo aver analizzato i carri armati, Moses venne a conoscenza del bullvalene, una molecola flussiale caratterizzata da disposizioni atomiche a scambio di posizione. Il suddetto attributo dei suoi atomi conferisce alla molecola milioni di configurazioni, esattamente la fluidit\u00e0 che Mos\u00e8 cercava nella sua ricerca.<\/p>\n<p>Moses ha quindi studiato la vancomicina, un medicinale a cui sono diventati immuni molti virus tra cui MRSA, VRSA e VRE. La vancomicina \u00e8 un potente antibiotico che \u00e8 stato a lungo usato per trattare condizioni come infezioni della pelle e meningite. Moses credeva di poter migliorare le prestazioni antibatteriche del farmaco combinandolo con il bullvalene. Durante il processo, ha fatto ricorso al premio Nobel <a rel=\"noopener nofollow\" href=\"https:\/\/en.wikipedia.org\/wiki\/Click_chemistry\" target=\"_blank\">fai clic su chimica<\/a> metodo, osservando che rende la reazione pi\u00f9 efficiente per un uso su larga scala.<\/p>\n<p>&quot;La chimica dei clic \u00e8 fantastica&quot;, ha detto Moses, che ha appreso i meccanismi del metodo dal premio Nobel K. Barry Sharpless. &quot;Ti d\u00e0 certezza e la migliore possibilit\u00e0 che hai di fare cose complesse.&quot;<\/p>\n<p>Con l&#039;aiuto di questa tecnica, Moses e i suoi collaboratori trovarono un nuovo antibiotico con due &quot;testate&quot; di vancomicina e un centro di bullvalene fluttuante, <a rel=\"noopener nofollow\" href=\"https:\/\/www.biospace.com\/article\/releases\/new-shape-shifting-antibiotics-could-fight-deadly-infections\/\" target=\"_blank\">Biospazio<\/a> segnalato.<\/p>\n<p>Moses si \u00e8 avvalso dell&#039;aiuto della dottoressa Tatiana Soares da-Costa dell&#039;Universit\u00e0 di Adelaide per testare il potenziale del farmaco. Come parte del test, ha somministrato il farmaco a larve di falena della cera infette da VRE, che sono comunemente usate per testare gli antibiotici. Il risultato ha indicato che l&#039;antibiotico mutaforma ha mostrato una promessa migliore della vancomicina nell&#039;eliminare l&#039;infezione mortale.<\/p>\n<p>&quot;Se potessimo inventare molecole che significano la differenza tra la vita e la morte&quot;, ha detto, &quot;sarebbe il pi\u00f9 grande risultato di sempre&quot;.<\/p>\n<figure class=\"imageBox\">\n<div class=\"innerBox\"><picture class=\"mapping-embed\" width=\"736\" height=\"405\"><source type=\"image\/webp\" media=\"(min-width: 1100px)\" sizes=\"736px\" srcset=\"https:\/\/d.medicaldaily.com\/en\/full\/435719\/bacteria.webp?w=736&amp;f=6ebb050345fdc9e2fdfd4894d69afd42 736w\"><source type=\"image\/jpeg\" media=\"(min-width: 1100px)\" sizes=\"736px\" srcset=\"https:\/\/urbancare.clinic\/wp-content\/uploads\/2023\/04\/new-shape-shifting-antibiotics-could-help-tackle-drug-resistant-viruses-researchers-suggest.jpg 736w\"><source type=\"image\/webp\" media=\"(min-width: 768px)\" sizes=\"1000px\" srcset=\"https:\/\/d.medicaldaily.com\/en\/full\/435719\/bacteria.webp?w=1100&amp;f=af8d8273e37e58aff79237c7dd06c845 1100w\"><source type=\"image\/jpeg\" media=\"(min-width: 768px)\" sizes=\"1000px\" srcset=\"https:\/\/d.medicaldaily.com\/en\/full\/435719\/bacteria.jpg?w=1100&amp;f=af8d8273e37e58aff79237c7dd06c845 1100w\"><source type=\"image\/webp\" media=\"(min-width: 480px)\" sizes=\"736px\" srcset=\"https:\/\/d.medicaldaily.com\/en\/full\/435719\/bacteria.webp?w=736&amp;f=6ebb050345fdc9e2fdfd4894d69afd42 736w\"><source type=\"image\/jpeg\" media=\"(min-width: 480px)\" sizes=\"736px\" srcset=\"https:\/\/urbancare.clinic\/wp-content\/uploads\/2023\/04\/new-shape-shifting-antibiotics-could-help-tackle-drug-resistant-viruses-researchers-suggest.jpg 736w\"><source type=\"image\/webp\" media=\"(min-width: 0px)\" sizes=\"480px\" srcset=\"https:\/\/d.medicaldaily.com\/en\/full\/435719\/bacteria.webp?w=480&amp;f=becd8390b8d454893b9da94ceb9f08a4 480w\"><source type=\"image\/jpeg\" media=\"(min-width: 0px)\" sizes=\"480px\" srcset=\"https:\/\/d.medicaldaily.com\/en\/full\/435719\/bacteria.jpg?w=480&amp;f=becd8390b8d454893b9da94ceb9f08a4 480w\"><source type=\"image\/webp\" srcset=\"https:\/\/d.medicaldaily.com\/en\/full\/435719\/bacteria.webp?w=736&amp;f=6ebb050345fdc9e2fdfd4894d69afd42\"><img loading=\"lazy\" decoding=\"async\" class=\"mapping-embed imgPhoto\" id=\"i435719\" src=\"https:\/\/urbancare.clinic\/wp-content\/uploads\/2023\/04\/new-shape-shifting-antibiotics-could-help-tackle-drug-resistant-viruses-researchers-suggest.jpg\" alt=\"batteri\" width=\"736\" height=\"405\" style=\"display:none\"><\/picture><\/div><figcaption class=\"caption\">\n<span class=\"cap\">La comunit\u00e0 scientifica continua a cercare trattamenti efficaci per combattere la crescente resistenza agli antibiotici in tutto il mondo.<\/span><br \/>\n<span class=\"credit\">Pixabay<\/span><br \/>\n<\/figcaption><\/figure>\n<p><a href=\"https:\/\/www.medicaldaily.com\/new-shape-shifting-antibiotics-could-help-tackle-drug-resistant-viruses-researchers-suggest-469289\">Fonte quotidiana medica<\/a><\/p>\n<p>","protected":false},"excerpt":{"rendered":"<p>Gli scienziati hanno utilizzato il metodo della chimica del clic vincitore del premio Nobel per sviluppare l&#039;antibiotico rivoluzionario.<\/p>","protected":false},"author":2,"featured_media":7751,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"page_builder":"","fifu_image_url":"https:\/\/urbancare.clinic\/wp-content\/uploads\/2023\/04\/new-shape-shifting-antibiotics-could-help-tackle-drug-resistant-viruses-researchers-suggest.jpg","fifu_image_alt":"","footnotes":""},"categories":[27,185],"tags":[],"class_list":["post-7750","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blog","category-research-medical-articles"],"yoast_head":"<!-- This site is optimized 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