{"id":7637,"date":"2022-11-22T13:00:22","date_gmt":"2022-11-22T10:00:22","guid":{"rendered":"https:\/\/urbancare.clinic\/clinicopathological-and-prognostic-values-of-pd-l1-expression-in-oesophageal-squamous-cell-carcinoma-a-meta-analysis-of-31-studies-with-5368-patients\/"},"modified":"2022-11-22T13:00:22","modified_gmt":"2022-11-22T10:00:22","slug":"valori-clinicopatologici-e-prognostici-dellespressione-di-pd-l1-nel-carcinoma-esofageo-a-cellule-squamose-una-meta-analisi-di-31-studi-con-5368-pazienti","status":"publish","type":"post","link":"https:\/\/urbancare.clinic\/it\/clinicopathological-and-prognostic-values-of-pd-l1-expression-in-oesophageal-squamous-cell-carcinoma-a-meta-analysis-of-31-studies-with-5368-patients\/","title":{"rendered":"Valori clinicopatologici e prognostici dell&#039;espressione di PD-L1 nel carcinoma a cellule squamose dell&#039;esofago: una meta-analisi di 31 studi con 5368 pazienti"},"content":{"rendered":"<div><img decoding=\"async\" src=\"https:\/\/urbancare.clinic\/wp-content\/uploads\/2023\/02\/clinicopathological-and-prognostic-values-of-pd-l1-expression-in-oesophageal-squamous-cell-carcinoma-a-meta-analysis-of-31-studies-with-5368-patients.jpg\" class=\"ff-og-image-inserted\" style=\"display:none\"><\/div>\n<p><span class=\"highwire-journal-article-marker-start\"><\/span><\/p>\n<div class=\"section abstract\" id=\"abstract-1\" readability=\"39\">\n<h2>Astratto<\/h2>\n<p id=\"p-1\">Diversi inibitori del checkpoint immunitario mirati al ligando della morte programmata 1 (PD-L1)\/morte programmata 1 hanno migliorato con successo la prognosi del carcinoma a cellule squamose dell&#039;esofago (ESCC) con l&#039;approvazione in alcuni paesi. Tuttavia, non \u00e8 ancora chiaro se l&#039;espressione di PD-L1 sia associata al grado di beneficio e manca anche uno standard unificato di anticorpi e un valore di cut-off per il rilevamento di PD-L1. L&#039;attuale meta-analisi mirava quindi a esplorare l&#039;associazione tra l&#039;espressione di PD-L1 e le caratteristiche clinicopatologiche, nonch\u00e9 la prognosi nell&#039;ESCC.<\/p>\n<p id=\"p-2\">Fino al 30 marzo 2021 \u00e8 stata eseguita una ricerca sistematica sui database PubMed, Embase, Cochrane Library e Web of Science. La correlazione tra l&#039;espressione di PD-L1 e le caratteristiche clinicopatologiche, nonch\u00e9 la prognosi nell&#039;ESCC, \u00e8 stata stimata con il modello a effetti casuali.<\/p>\n<p id=\"p-3\">Sono stati arruolati un totale di 5368 pazienti provenienti da 31 studi retrospettivi. La sovraespressione di PD-L1 era significativamente associata a metastasi linfonodali (OR 1.342, 95% CI da 0.995 a 1.809, p=0.050) e metastasi a distanza (OR 1.516, 95% CI da 1.001 a 2.294, p=0.050). L&#039;HR raggruppato ha mostrato che la sovraespressione di PD-L1 era significativamente correlata con la scarsa sopravvivenza globale (OS) dei pazienti con ESCC (HR 1.306, 95% CI da 1.108 a 1.539, p&lt;0.010) ma non con la sopravvivenza libera da malattia (DFS) (HR 1.180, 95% CI da 0,937 a 1,487, p=0,160). L&#039;eterogeneit\u00e0 \u00e8 diminuita significativamente nelle analisi dei sottogruppi. La sovraespressione di PD-L1 era associata a scarsa DFS al cut-off di \u22651% (HR 1,642, 95% CI da 1,367 a 1,973, p&lt;0,010; I<sup>2<\/sup>=0%) e OS peggiore al cut-off di \u226510% (HR 1,575, 95% CI da 1,175 a 2,111, p&lt;0,010; I<sup>2<\/sup>=0%).<\/p>\n<p id=\"p-4\">La sovraespressione di PD-L1 era correlata con linfonodi e metastasi a distanza, nonch\u00e9 con una scarsa sopravvivenza dell&#039;ESCC.<\/p>\n<\/div>\n<ul class=\"kwd-group\">\n<li class=\"kwd\">malattia esofagea<\/li>\n<li class=\"kwd\">epidemiologia<\/li>\n<li class=\"kwd\">epidemiologia<\/li>\n<li class=\"kwd\">immunologia<\/li>\n<\/ul>\n<p><span class=\"highwire-journal-article-marker-end\"><\/span><a href=\"http:\/\/pmj.bmj.com\/cgi\/content\/short\/98\/1166\/948?rss=1\">Fonte quotidiana medica<\/a><\/p>\n<p>","protected":false},"excerpt":{"rendered":"<p>Diversi inibitori del checkpoint immunitario mirati al ligando della morte programmata 1 (PD-L1)\/morte programmata 1 hanno migliorato con successo la prognosi del carcinoma a cellule squamose dell&#039;esofago (ESCC) con l&#039;approvazione in alcuni paesi. Tuttavia, non \u00e8 ancora chiaro se l&#039;espressione di PD-L1 sia associata al grado di beneficio e manca anche uno standard unificato di anticorpi e un valore di cut-off per il rilevamento di PD-L1. L&#039;attuale meta-analisi mirava quindi a esplorare l&#039;associazione tra l&#039;espressione di PD-L1 e le caratteristiche clinicopatologiche, nonch\u00e9 la prognosi nell&#039;ESCC.<\/p>\n<p>Fino al 30 marzo 2021 \u00e8 stata eseguita una ricerca sistematica sui database PubMed, Embase, Cochrane Library e Web of Science. La correlazione tra l&#039;espressione di PD-L1 e le caratteristiche clinicopatologiche, nonch\u00e9 la prognosi nell&#039;ESCC, \u00e8 stata stimata con il modello a effetti casuali.<\/p>\n<p>Sono stati arruolati 5368 pazienti da 31 studi retrospettivi. La sovraespressione di PD-L1 era significativamente associata a metastasi linfonodali (OR 1,342, 95% CI 0,995-1,809, p=0,050) e metastasi a distanza (OR 1,516, 95% CI 1,001-2,294, p=0,050). L&#039;HR aggregato ha mostrato che la sovraespressione di PD-L1 era significativamente correlata a una scarsa sopravvivenza complessiva (OS) dei pazienti con ESCC (HR 1,306, 95% CI 1,108-1,539, p&lt;0,010) ma non alla sopravvivenza libera da malattia (DFS) (HR 1,180, 95% CI 0,937-1,487, p=0,160). L&#039;eterogeneit\u00e0 \u00e8 diminuita significativamente nelle analisi dei sottogruppi. La sovraespressione di PD-L1 \u00e8 stata associata a una scarsa DFS al punto di cut-off di \u22651% (HR 1,642, 95% CI 1,367-1,973, p&lt;0,010; I<sup>2<\/sup>=0%) e peggiore OS al punto di cut-off di \u226510% (HR 1,575, 95% CI 1,175 a 2,111, p&lt;0,010; I<sup>2<\/sup>=0%).<\/p>\n<p>La sovraespressione di PD-L1 era correlata con linfonodi e metastasi a distanza, nonch\u00e9 con una scarsa sopravvivenza dell&#039;ESCC.<\/p>","protected":false},"author":2,"featured_media":7638,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"Default","format":"standard","meta":{"page_builder":"","fifu_image_url":"https:\/\/urbancare.clinic\/wp-content\/uploads\/2023\/02\/clinicopathological-and-prognostic-values-of-pd-l1-expression-in-oesophageal-squamous-cell-carcinoma-a-meta-analysis-of-31-studies-with-5368-patients.jpg","fifu_image_alt":"","footnotes":""},"categories":[185],"tags":[],"class_list":["post-7637","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-research-medical-articles"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Clinicopathological and prognostic values of PD-L1 expression in oesophageal squamous cell carcinoma: a meta-analysis of 31 studies with 5368 patients - Urban Care Clinic<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/urbancare.clinic\/it\/valori-clinicopatologici-e-prognostici-dellespressione-di-pd-l1-nel-carcinoma-esofageo-a-cellule-squamose-una-meta-analisi-di-31-studi-con-5368-pazienti\/\" \/>\n<meta property=\"og:locale\" content=\"it_IT\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Clinicopathological and prognostic values of PD-L1 expression in oesophageal squamous cell carcinoma: a meta-analysis of 31 studies with 5368 patients - Urban Care Clinic\" \/>\n<meta property=\"og:description\" content=\"Several immune checkpoint inhibitors targeting programmed death ligand 1 (PD-L1)\/programmed death 1 have successfully improved the prognosis of oesophageal squamous cell carcinoma (ESCC) with approval in certain countries. However, whether the expression of PD-L1 is associated with the degree of benefit is unclear yet and a unified standard of antibody and cut-off value of PD-L1 detection is also lacking. The current meta-analysis then aimed to explore the association between PD-L1 expression and clinicopathological features as well as prognosis in ESCC. A systematic search on PubMed, Embase, Cochrane Library and Web of Science databases was performed up to 30 March 2021. The correlation between PD-L1 expression and clinicopathological features, as well as prognosis in ESCC, was estimated with the random-effects model. A total of 5368 patients from 31 retrospective studies were enrolled. The overexpression of PD-L1 was significantly associated with lymph node metastasis (OR 1.342, 95% CI 0.995 to 1.809, p=0.050) and distant metastasis (OR 1.516, 95% CI 1.001 to 2.294, p=0.050). The pooled HR showed that PD-L1 overexpression was significantly correlated with poor overall survival (OS) of patients with ESCC (HR 1.306, 95% CI 1.108 to 1.539, p&lt;0.010) but not disease-free survival (DFS) (HR 1.180, 95% CI 0.937 to 1.487, p=0.160). Heterogeneity decreased significantly in subgroup analyses. The overexpression of PD-L1 was associated with poor DFS at the cut-off point of &ge;1% (HR 1.642, 95% CI 1.367 to 1.973, p&lt;0.010; I2=0%) and worse OS at the cut-off point of &ge;10% (HR 1.575, 95% CI 1.175 to 2.111, p&lt;0.010; I2=0%). 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