{"id":7577,"date":"2023-02-14T12:52:11","date_gmt":"2023-02-14T09:52:11","guid":{"rendered":"https:\/\/urbancare.clinic\/cocaine-addiction-causes-faster-biological-aging-of-the-brain-study-finds\/"},"modified":"2023-02-14T12:52:11","modified_gmt":"2023-02-14T09:52:11","slug":"secondo-uno-studio-la-dipendenza-da-cocaina-provoca-un-invecchiamento-biologico-piu-rapido-del-cervello","status":"publish","type":"post","link":"https:\/\/urbancare.clinic\/it\/secondo-uno-studio-la-dipendenza-da-cocaina-provoca-un-invecchiamento-biologico-piu-rapido-del-cervello\/","title":{"rendered":"La dipendenza da cocaina provoca un invecchiamento biologico pi\u00f9 rapido del cervello, secondo uno studio"},"content":{"rendered":"
<\/div>\n

Un nuovo studio ha scoperto che la dipendenza da cocaina pu\u00f2 far \u201cinvecchiare\u201d il cervello pi\u00f9 velocemente. Lo studio si aggiunge ai molti danni gi\u00e0 associati al disturbo da uso di cocaina.<\/p>\n

Lo studio, pubblicato in Frontiere in psichiatria<\/a>, hanno analizzato i tessuti cerebrali umani post mortem di persone che avevano una dipendenza da cocaina e di quelle che non ne avevano. <\/p>\n

\u00c8 stato scoperto che le persone con disturbo da uso di cocaina accumulano cambiamenti nel DNA nel cervello associati all\u2019invecchiamento biologico a un ritmo accelerato.<\/p>\n

Secondo una stima, una persona su cinque<\/a> chi fa uso di cocaina sviluppa una dipendenza negli Stati Uniti<\/p>\n

<\/div>\n

Ci sono modifiche non codificanti nel DNA all'interno delle cellule del cervello, che influenzano il meccanismo di accensione e spegnimento dei geni. Chiamati cambiamenti epigenetici, questi modelli sono stati analizzati nello studio dai ricercatori in una regione del cervello chiamata Area 9 di Brodmann, ScienceAlert<\/a> segnalato.<\/p>\n

L'area 9 di Brodmann (BA9) \u00e8 situata nella corteccia prefrontale e fa parte del cervello dietro la fronte. Si ritiene che BA9 regoli l'autoconsapevolezza e il controllo inibitorio, entrambi aspetti influenzati dai disturbi da uso di sostanze.<\/p>\n

Nello studio, i ricercatori hanno confrontato i livelli di metilazione del DNA nei campioni di tessuto cerebrale di 21 persone, rispettivamente di coloro che avevano disturbi da uso di cocaina e di quelli che non lo avevano. La metilazione del DNA \u00e8 un cambiamento chimico accumularsi con l'et\u00e0<\/a> e nelle malattie legate all\u2019et\u00e0.<\/p>\n

Nella regione BA9, i consumatori di cocaina avevano segmenti di DNA pieni di gruppi metilici, ha scoperto lo studio.<\/p>\n

"Abbiamo rilevato una tendenza verso un pi\u00f9 forte invecchiamento biologico del cervello negli individui con disturbo da uso di cocaina rispetto agli individui senza disturbo da uso di cocaina", ha detto Stephanie Witt, autrice senior dello studio e biologa molecolare presso l'Istituto centrale di salute mentale in Germania. "Ci\u00f2 potrebbe essere causato da processi patologici legati alla cocaina nel cervello, come l'infiammazione o la morte cellulare", ha aggiunto Witt.<\/p>\n

I due geni che hanno mostrato i maggiori cambiamenti nella metilazione del DNA in questo studio erano quelli che, secondo ricerche precedenti, regolano gli aspetti comportamentali dell'assunzione di cocaina nei roditori, secondo quanto riportato.<\/p>\n

"Poich\u00e9 la stima dell'et\u00e0 biologica \u00e8 un concetto molto recente nella ricerca sulle dipendenze ed \u00e8 influenzata da molti fattori, sono necessari ulteriori studi per indagare su questo fenomeno, con campioni di dimensioni pi\u00f9 ampie di quelle possibili in questo caso", ha ammesso Witt.<\/p>\n

Un'altra sostanza che inizia con la lettera C ha l'effetto opposto sul cervello. Un recente studio di revisione della letteratura ha rilevato i componenti eugenolo, cinnamaldeide e acido cinnamico della cannella alterare positivamente la funzione cognitiva<\/a>N. Alcuni studi hanno anche riferito che i componenti della spezia prevengono e riducono il deterioramento delle funzioni cognitive. <\/p>\n

Inoltre, vi sono prove scientifiche che la cannella abbia anche propriet\u00e0 antiossidanti, antinfiammatorie e antitumorali Medical Xpress<\/a>. <\/p>\n

Fonte quotidiana medica<\/a><\/p>\n

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