{"id":7557,"date":"2023-02-09T12:57:32","date_gmt":"2023-02-09T09:57:32","guid":{"rendered":"https:\/\/urbancare.clinic\/ashkenazi-jews-susceptible-to-rare-genetic-disease-that-protects-them-from-tb-study\/"},"modified":"2023-02-09T12:57:32","modified_gmt":"2023-02-09T09:57:32","slug":"gli-ebrei-ashkenaziti-sono-soggetti-a-una-rara-malattia-genetica-che-li-protegge-dallo-studio-della-tubercolosi","status":"publish","type":"post","link":"https:\/\/urbancare.clinic\/it\/ashkenazi-jews-susceptible-to-rare-genetic-disease-that-protects-them-from-tb-study\/","title":{"rendered":"Ebrei ashkenaziti sensibili alla malattia genetica rara che li protegge dalla tubercolosi: studio"},"content":{"rendered":"
<\/div>\n

Per un colpo di fortuna, gli scienziati hanno scoperto che una rara malattia genetica che colpisce pi\u00f9 comunemente gli ebrei ashkenaziti li protegge anche dalla tubercolosi.<\/p>\n

Nello studio, pubblicato sulla rivista PNAS<\/a>, i ricercatori hanno scoperto che la malattia di Gaucher (pronunciata go-SHAY), una malattia lisosomiale, offre una protezione involontaria contro la tubercolosi.<\/p>\n

Secondo una stima, circa 10,6 milioni di persone<\/a> in tutto il mondo si sono ammalati di tubercolosi (TBC) e 1,6 milioni di persone sono morte a causa della malattia nel 2021.<\/p>\n

Tuttavia, il 95% delle persone infette dal batterio della tubercolosi non si ammala. Il sistema immunitario di questi individui riesce a uccidere con successo l\u2019agente patogeno.<\/p>\n

<\/div>\n

\u201cIo e i miei colleghi siamo interessati a ci\u00f2 che rende alcune persone suscettibili alla tubercolosi, mentre altre sembrano essere protette. Usiamo il pesce zebra per studiare la malattia, poich\u00e9 il loro sistema immunitario condivide molte somiglianze con quello umano ed \u00e8 possibile manipolare i loro geni in laboratorio", Lalita Ramakrishnan, professoressa di microbiologia, Universit\u00e0 di Cambridge, e Laura Whitworth, Group Laboratory Il direttore del Dipartimento di Medicina dell'Universit\u00e0 di Cambridge ha dichiarato: ScienceAlert<\/a> segnalato.<\/p>\n

La malattia di Gaucher \u00e8 una malattia genetica rara che colpisce in modo sproporzionato gli ebrei ashkenaziti, con circa uno su 800 nascite<\/a>. Ma la malattia pu\u00f2 colpire chiunque. La malattia presenta sintomi relativamente lievi, tra cui ingrossamento della milza e del fegato e anemia.<\/p>\n

Gli enzimi presenti nei lisosomi delle cellule scompongono il materiale indesiderato come proteine e grassi. La riduzione di questi enzimi pu\u00f2 portare ad un accumulo di materiale tossico.<\/p>\n

Questo accumulo \u00e8 molto dannoso per il normale funzionamento delle cellule chiamate macrofagi.<\/p>\n

\u201cUn tipo di cellula vulnerabile a questo accumulo \u00e8 il macrofago, una cellula che 'mangia' materiale tossico, inclusi batteri e prodotti di scarto. Nei disordini lisosomiali, i macrofagi si muovono lentamente e si ingrandiscono perch\u00e9 accumulano materiale non digerito nei loro lisosomi, rendendoli meno capaci di combattere le infezioni\u201d, hanno detto gli autori.<\/p>\n

Quando i ricercatori hanno modificato geneticamente il pesce zebra sul modello della malattia di Gaucher, hanno scoperto che il pesce diventava \u201cresistente alla tubercolosi, piuttosto che suscettibile\u201d.<\/p>\n

\u201cLa ragione di questa resistenza alle infezioni \u00e8 dovuta alla sostanza chimica grassa che si accumula nei macrofagi nella malattia di Gaucher. Si \u00e8 scoperto che questa sostanza chimica grassa agisce come un solvente in grado di uccidere i batteri della tubercolosi in pochi minuti distruggendo le loro pareti cellulari\u201d, hanno spiegato i ricercatori.<\/p>\n

Gli ebrei ashkenaziti attraversarono secoli di persecuzioni, vivendo nei ghetti e spostandosi da un paese all'altro. Da TBC<\/a> si diffonde pi\u00f9 rapidamente nelle condizioni di vita pi\u00f9 povere e nelle aree densamente popolate, gli ebrei devono essere stati altamente esposti alla tubercolosi.<\/p>\n

\u201cQuesti pesci ci hanno inconsapevolmente trascinati in un dibattito in corso sulla genetica umana per decenni<\/a>: gli ebrei ashkenaziti \u2013 che sappiamo corrono un rischio molto maggiore di contrarre la malattia di Gaucher \u2013 hanno in qualche modo meno probabilit\u00e0 di contrarre l\u2019infezione da tubercolosi? La risposta sembra essere s\u00ec\u201d, hanno concluso i ricercatori.<\/p>\n

Fonte quotidiana medica<\/a><\/p>\n

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Secondo una stima, nel 2021 circa 10,6 milioni di persone in tutto il mondo si sono ammalate di tubercolosi (TBC) e 1,6 milioni di persone sono morte a causa della malattia.<\/p>","protected":false},"author":2,"featured_media":7558,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"Default","format":"standard","meta":{"page_builder":"","fifu_image_url":"https:\/\/urbancare.clinic\/wp-content\/uploads\/2023\/02\/ashkenazi-jews-susceptible-to-rare-genetic-disease-that-protects-them-from-tb-study.jpg","fifu_image_alt":"","footnotes":""},"categories":[27],"tags":[],"class_list":["post-7557","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blog"],"yoast_head":"\nAshkenazi Jews Susceptible To Rare Genetic Disease That Protects Them From TB: Study - Urban Care Clinic<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/urbancare.clinic\/it\/gli-ebrei-ashkenaziti-sono-soggetti-a-una-rara-malattia-genetica-che-li-protegge-dallo-studio-della-tubercolosi\/\" \/>\n<meta property=\"og:locale\" content=\"it_IT\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Ashkenazi Jews Susceptible To Rare Genetic Disease That Protects Them From TB: Study - 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