{"id":7525,"date":"2023-02-03T12:57:52","date_gmt":"2023-02-03T09:57:52","guid":{"rendered":"https:\/\/urbancare.clinic\/prescribing-medication-dosage-according-to-dna-profile-lowers-side-effects-by-30-study\/"},"modified":"2023-02-03T12:57:52","modified_gmt":"2023-02-03T09:57:52","slug":"la-prescrizione-del-dosaggio-dei-farmaci-in-base-al-profilo-del-dna-riduce-gli-effetti-collaterali-secondo-30-studi","status":"publish","type":"post","link":"https:\/\/urbancare.clinic\/it\/la-prescrizione-del-dosaggio-dei-farmaci-in-base-al-profilo-del-dna-riduce-gli-effetti-collaterali-secondo-30-studi\/","title":{"rendered":"La prescrizione del dosaggio dei farmaci in base al profilo del DNA riduce gli effetti collaterali di 30%: studio"},"content":{"rendered":"
<\/div>\n

Un nuovo studio ha dimostrato che la prescrizione del dosaggio dei farmaci in base al DNA del paziente pu\u00f2 ridurre gli effetti collaterali di 30%, una cifra significativa.<\/p>\n

Lo studio internazionale \u00e8 stato condotto dal Leiden University Medical Center (LUMC) e i risultati sono stati pubblicati sulla rivista The Lancet.<\/p>\n

"L'approccio unico per la prescrizione dei farmaci \u00e8 obsoleto", ha affermato LUMC in a dichiarazione<\/a>.<\/p>\n

Il modo in cui le persone rispondono ai farmaci varia notevolmente a causa delle differenze nelle informazioni genetiche delle persone. Ad esempio, alcune persone metabolizzano i farmaci pi\u00f9 velocemente, rendendo necessario un dosaggio pi\u00f9 elevato per un trattamento efficace. NLTimes<\/a> segnalato.<\/p>\n

<\/div>\n

"Un trattamento personalizzato \u00e8 quindi auspicabile", afferma l'ospedale universitario.<\/p>\n

I ricercatori hanno creato un pass per i farmaci con DNA che associa il dosaggio dei farmaci influenzato dal DNA in base al profilo DNA di un paziente. Durante la scansione del pass, medici e farmacisti vengono informati sulla dose ottimale del farmaco che sarebbe appropriata per la persona da curare. <\/p>\n

Per lo studio, i ricercatori hanno arruolato circa 7.000 pazienti provenienti da sette paesi europei per testare il pass. Ad ogni partecipante \u00e8 stato prescritto un farmaco la cui elaborazione \u00e8 influenzata dal DNA. Lo studio \u00e8 stato limitato a 39 farmaci selezionati da una miriade di specializzazioni mediche, tra cui oncologia, cardiologia, psichiatria e medicina generale. I partecipanti sono stati divisi in due gruppi: met\u00e0 ha utilizzato il dosaggio standard del medicinale, mentre agli altri \u00e8 stato aggiustato il dosaggio in base al passaggio del DNA, secondo il punto vendita.<\/p>\n

Prima di iniziare il programma terapeutico, \u00e8 stato mappato il DNA di ciascun paziente. Esaminando 12 geni specifici, i ricercatori hanno scoperto che 50 tipi di varianti genetiche influenzavano il funzionamento dei 39 farmaci selezionati. Dopo 12 settimane, ai pazienti \u00e8 stato chiesto un feedback da parte di un infermiere specializzato in merito alla prevalenza di effetti collaterali, come diarrea, anemia, dolore ai nervi o perdita del gusto.<\/p>\n

"Lo studio Lancet ha rilevato che i pazienti che utilizzano attivamente il farmaco e le cui dosi sono adattate in base al loro DNA, sperimentano meno effetti collaterali gravi 30% rispetto ai pazienti a cui \u00e8 stata prescritta una dose standard di medicinale", si legge nella dichiarazione.<\/p>\n

Inoltre, i pazienti erano soddisfatti nell\u2019usare il pass poich\u00e9 sentivano di avere pi\u00f9 controllo e di essere coinvolti nel loro trattamento.<\/p>\n

\u201cPer la prima volta abbiamo dimostrato che una strategia 'su misura' funziona su larga scala nella pratica clinica. Ora ci sono prove sufficienti per procedere con l\u2019implementazione\u201d, ha affermato Henk-Jan Guchelaar, professore di farmacia clinica alla LUMC e coordinatore dello studio.<\/p>\n

\u201cCi\u00f2 significa che il prossimo passo per noi sar\u00e0 iniziare a utilizzare il DNA farmaco<\/a> superato", ha aggiunto Jesse Swen, professore di farmacia clinica e ricercatore principale.<\/p>\n

Guchelaar e Swen ritengono che il passaggio del DNA dovrebbe far parte delle cure standard.<\/p>\n

"Vogliamo procedere verso la mappatura del DNA di ogni paziente che si rivolge alla farmacia", ha osservato Guchelaar. \u201cIn questo modo possiamo rendere il trattamento pi\u00f9 efficace e sicuro per ciascun paziente\u201d.<\/p>\n

Fonte quotidiana medica<\/a><\/p>\n

","protected":false},"excerpt":{"rendered":"

"L'approccio unico per la prescrizione dei farmaci \u00e8 obsoleto", ha affermato il Leiden University Medical Center in una nota.<\/p>","protected":false},"author":2,"featured_media":7526,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"Default","format":"standard","meta":{"fifu_image_url":"https:\/\/urbancare.clinic\/wp-content\/uploads\/2023\/02\/prescribing-medication-dosage-according-to-dna-profile-lowers-side-effects-by-30-study.jpg","fifu_image_alt":"","footnotes":""},"categories":[27],"tags":[],"class_list":["post-7525","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blog"],"yoast_head":"\nPrescribing Medication Dosage According To DNA Profile Lowers Side Effects By 30%: Study - Urban Care Clinic<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/urbancare.clinic\/it\/la-prescrizione-del-dosaggio-dei-farmaci-in-base-al-profilo-del-dna-riduce-gli-effetti-collaterali-secondo-30-studi\/\" \/>\n<meta property=\"og:locale\" content=\"it_IT\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Prescribing Medication Dosage According To DNA Profile Lowers Side Effects By 30%: Study - 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