{"id":7517,"date":"2023-02-01T12:52:21","date_gmt":"2023-02-01T09:52:21","guid":{"rendered":"https:\/\/urbancare.clinic\/novel-ultrasound-technique-releases-hidden-neurodegenerative-markers-in-blood\/"},"modified":"2023-02-01T12:52:21","modified_gmt":"2023-02-01T09:52:21","slug":"una-nuova-tecnica-ad-ultrasuoni-rilascia-marcatori-neurodegenerativi-nascosti-nel-sangue","status":"publish","type":"post","link":"https:\/\/urbancare.clinic\/it\/una-nuova-tecnica-ad-ultrasuoni-rilascia-marcatori-neurodegenerativi-nascosti-nel-sangue\/","title":{"rendered":"Una nuova tecnica ad ultrasuoni rilascia marcatori neurodegenerativi nascosti nel sangue"},"content":{"rendered":"
<\/div>\n

I ricercatori hanno scoperto che una tecnica ad ultrasuoni focalizzati, nota come sonobiopsia, pu\u00f2 rilasciare pi\u00f9 biomarcatori di disturbi neurodegenerativi nel sangue per facilitare la diagnosi delle malattie.<\/p>\n

Lo studio, pubblicato marted\u00ec sulla rivista Radiologia<\/a>, hanno scoperto un metodo non invasivo per rilevare biomarcatori nel sangue che in precedenza erano limitati dalla barriera ematoencefalica.<\/p>\n

Lo studio ha scoperto che la biopsia liquida mediata da ultrasuoni focalizzati in un modello murino ha rilasciato pi\u00f9 proteine tau e un altro biomarcatore nel sangue che senza di essa. Molti disturbi neurodegenerativi, compreso il morbo di Alzheimer, sono caratterizzati dalla presenza di proteine tau nel cervello.<\/p>\n

Nella sonobiopsia, gli ultrasuoni focalizzati vengono utilizzati per individuare una posizione precisa nel cervello.<\/p>\n

<\/div>\n

\u201cUna volta localizzati, i ricercatori iniettano microbolle nel sangue che viaggiano verso il tessuto bersaglio degli ultrasuoni e pulsano, aprendo in modo sicuro la barriera emato-encefalica. Le aperture temporanee consentono ai biomarcatori, come le proteine tau e la proteina della catena leggera dei neurofilamenti (NfL), entrambi indicativi di disturbi neurodegenerativi, di passare attraverso la barriera emato-encefalica e di essere rilasciati nel sangue\u201d, hanno scritto i ricercatori in un articolo. comunicato stampa.<\/a><\/p>\n

Il metodo viene pubblicizzato come il primo metodo non invasivo e mirato per la diagnosi e il monitoraggio dei disturbi neurodegenerativi mediante la tecnica degli ultrasuoni.<\/p>\n

Nello studio, sono stati raccolti campioni di sangue da topi giovani con proteine tau anormali nel cervello, o tauopatia, che erano stati sottoposti a sonobiopsia o erano nel gruppo di controllo.<\/p>\n

Dopo l'analisi, si \u00e8 visto che la sonobiopsia ha portato ad un aumento di 1,7 volte dei livelli di proteina tau pTau-181 fosforilata normalizzata e ad un aumento di 1,4 volte di pTau-231 normalizzato rispetto al gruppo di topi di controllo.<\/p>\n

Successivamente, i ricercatori hanno nuovamente condotto una sonobiopsia, questa volta prendendo di mira l\u2019ippocampo o la corteccia cerebrale nei primi stadi neurodegenerativi del modello tauopatico. Sono stati raccolti e analizzati campioni di sangue prima e dopo la sonobiopsia. La sonobiopsia mirata ha mostrato un aumento di 2,3 volte della proteina NfL, un biomarcatore secondario per le malattie neurodegenerative, nel gruppo della sonobiopsia.<\/p>\n

"Nel nostro studio di prova, abbiamo cercato di determinare se la sonobiopsia \u00e8 in grado di rilasciare specie tau fosforilate e NfL nel flusso sanguigno aprendo la barriera emato-encefalica", Hong Chen, professore associato di ingegneria biomedica presso la McKelvey School of Ingegneria e di radioterapia oncologica nella Facolt\u00e0 di Medicina, si legge nel comunicato stampa. \u201cQuesta dimostrazione ha dimostrato che la sonobiopsia ha migliorato significativamente il rilascio delle proteine pTau e di un marcatore secondario di neurodegenerazione nel flusso sanguigno per la diagnosi non invasiva delle malattie neurodegenerative\u201d.<\/p>\n

In un'altra dimostrazione di ingegno, un diverso gruppo di scienziati ha creato un oggetto innovativo \u201cpatch intelligente\u201d,<\/a> utilizzando la tecnologia dei microaghi, in grado di rilevare i segni premonitori dell'Alzheimer in soli sei minuti, prima ancora che si manifestino i sintomi. Il dispositivo creato dagli scienziati dell'Universit\u00e0 di Swansea cerca biomarcatori infiammatori di malattie neurologiche e pu\u00f2 individuarli con grande precisione.<\/p>\n

Fonte quotidiana medica<\/a><\/p>\n

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Il metodo viene pubblicizzato come il primo metodo non invasivo e mirato per la diagnosi e il monitoraggio dei disturbi neurodegenerativi mediante la tecnica degli ultrasuoni.<\/p>","protected":false},"author":2,"featured_media":7518,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"Default","format":"standard","meta":{"fifu_image_url":"https:\/\/urbancare.clinic\/wp-content\/uploads\/2023\/02\/novel-ultrasound-technique-releases-hidden-neurodegenerative-markers-in-blood.jpg","fifu_image_alt":"","footnotes":""},"categories":[27],"tags":[],"class_list":["post-7517","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blog"],"yoast_head":"\nNovel Ultrasound Technique Releases Hidden Neurodegenerative Markers In Blood - Urban Care Clinic<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/urbancare.clinic\/it\/una-nuova-tecnica-ad-ultrasuoni-rilascia-marcatori-neurodegenerativi-nascosti-nel-sangue\/\" \/>\n<meta property=\"og:locale\" content=\"it_IT\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Novel Ultrasound Technique Releases Hidden Neurodegenerative Markers In Blood - 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