{"id":7318,"date":"2023-01-20T12:55:34","date_gmt":"2023-01-20T09:55:34","guid":{"rendered":"https:\/\/urbancare.clinic\/hiv-vaccine-in-late-stage-trial-fails-extending-wait-for-effective-jab\/"},"modified":"2023-01-20T12:55:34","modified_gmt":"2023-01-20T09:55:34","slug":"il-vaccino-contro-lhiv-in-fase-avanzata-di-sperimentazione-fallisce-prolungando-lattesa-per-un-vaccino-efficace","status":"publish","type":"post","link":"https:\/\/urbancare.clinic\/it\/hiv-vaccine-in-late-stage-trial-fails-extending-wait-for-effective-jab\/","title":{"rendered":"Il vaccino contro l&#039;HIV in fase avanzata di sperimentazione fallisce, prolungando l&#039;attesa per un vaccino efficace"},"content":{"rendered":"<div><img decoding=\"async\" src=\"https:\/\/urbancare.clinic\/wp-content\/uploads\/2023\/01\/hiv-vaccine-in-late-stage-trial-fails-extending-wait-for-effective-jab.jpg\" class=\"ff-og-image-inserted\" style=\"display:none\"><\/div>\n<p>L\u2019unico vaccino contro l\u2019HIV in fase avanzata di sperimentazione ha fallito. La triste notizia \u00e8 un freno agli sforzi concertati di controllo dell\u2019HIV.&nbsp;<\/p>\n<p>L&#039;annuncio \u00e8 stato fatto mercoled\u00ec dai ricercatori coinvolti, <a href=\"https:\/\/www.nbcnews.com\/nbc-out\/out-health-and-wellness\/another-major-hiv-vaccine-trial-fails-rcna66324\" rel=\"nofollow noopener\" target=\"_blank\">NBCNews<\/a> segnalato. La sperimentazione del vaccino sul prodotto denominato Mosaico \u00e8 stata una partnership pubblico-privata tra il governo degli Stati Uniti e il colosso farmaceutico Janssen.<\/p>\n<p>Lo studio, avviato nel 2019, \u00e8 stato condotto in otto paesi in Europa e nelle Americhe, compresi gli Stati Uniti. Quasi 3.900 uomini che hanno rapporti sessuali con uomini e persone transgender sono stati reclutati per lo studio e sono stati tutti considerati a maggior rischio di HIV.<\/p>\n<p>Un comitato indipendente di monitoraggio dei dati e della sicurezza ha esaminato i risultati dello studio e non ha trovato alcun collegamento tra il vaccino e il tasso di acquisizione dell&#039;HIV. Di conseguenza, i ricercatori hanno deciso di interrompere il loro lavoro.<\/p>\n<div id=\"dfp-ad-oop2\" class=\"dfp-tag-wrapper\"> <\/div>\n<p>&quot;\u00c8 ovviamente deludente&quot;, ha detto il dottor Anthony Fauci, ex capo dell&#039;Istituto nazionale per le allergie e le malattie infettive (NIAID) e partner integrale dello studio, secondo la notizia. Ha aggiunto che &quot;ci sono molti altri approcci&quot; presi in considerazione nel campo della ricerca sul vaccino contro l&#039;HIV che ritiene promettenti.<\/p>\n<p>&quot;Non penso che le persone dovrebbero arrendersi nel campo del vaccino contro l&#039;HIV&quot;, ha detto Fauci.<\/p>\n<p>Questo fallimento non sorprende, secondo gli esperti. Anche un vaccino simile in uno studio clinico separato chiamato Imbokodo ha fallito&nbsp;<a href=\"https:\/\/www.nih.gov\/news-events\/news-releases\/hiv-vaccine-candidate-does-not-sufficiently-protect-women-against-hiv-infection\" rel=\"nofollow noopener\" target=\"_blank\">nell&#039;agosto 2021<\/a>. Il vaccino \u00e8 stato testato tra le donne in Africa. Secondo un portavoce dell&#039;agenzia, il NIAID aveva speso $56 milioni in totale per i due studi.<\/p>\n<p>I vaccini in entrambi gli studi utilizzavano un comune virus del raffreddore per fornire immunogeni a mosaico. Il presupposto era che l\u2019immunogeno avrebbe innescato una forte risposta immunitaria poich\u00e9 includeva materiale genetico proveniente da un mix di ceppi di HIV prevalenti in tutto il mondo,&nbsp;<a href=\"https:\/\/www.nih.gov\/news-events\/news-releases\/nih-partners-launch-hiv-vaccine-efficacy-study\" rel=\"nofollow noopener\" target=\"_blank\">secondo il National Institutes of Health<\/a>. Mosaico \u00e8 stato un passo avanti in quanto includeva un elemento aggiuntivo per ampliare la risposta immunitaria.&nbsp;<\/p>\n<p>Nello studio Mosaico, ai partecipanti di et\u00e0 compresa tra 18 e 60 anni sono state somministrate quattro iniezioni in un anno. A seguito dell&#039;analisi, il comitato di monitoraggio <a href=\"https:\/\/newatlas.com\/medical\/large-phase-3-hiv-vaccine-trial-fails-nih\/\" rel=\"nofollow noopener\" target=\"_blank\">non ho trovato alcuna differenza<\/a> nel tasso di acquisizione dell\u2019HIV tra i due gruppi: vaccino e placebo.<\/p>\n<p>Il fatto che il vaccino Mosaico abbia suscitato i cosiddetti anticorpi non neutralizzanti contro l\u2019HIV e non neutralizzanti si \u00e8 trasformato nella sua limitazione, ha osservato Fauci.<\/p>\n<p>\u201cSta diventando chiaro\u201d, ha detto, \u201cche i vaccini che non inducono anticorpi neutralizzanti non sono efficaci contro l\u2019HIV\u201d.<\/p>\n<p>Il fallimento del processo \u00e8 un \u201cforte promemoria di quanto sfuggente fosse un <a href=\"https:\/\/www.medicaldaily.com\/common-anti-viral-drugs-can-stop-hiv-transmission-mother-child-467581\">HIV<\/a> Il vaccino esiste davvero e perch\u00e9 questo tipo di ricerca continua ad essere importante\u201d, ha affermato Jennifer Kates, direttrice della politica sanitaria globale e dell\u2019HIV presso la Kaiser Family Foundation.<\/p>\n<p>\u201cFortunatamente, esistono gi\u00e0 una serie di interventi di prevenzione dell\u2019HIV altamente efficaci\u201d, ha aggiunto Kates. \u201cLa sfida \u00e8 ampliarli per raggiungere tutti coloro che sono a rischio\u201d.&nbsp;<\/p>\n<p><a href=\"https:\/\/www.medicaldaily.com\/hiv-vaccine-late-stage-trial-fails-extending-wait-effective-jab-467815?utm_source=Public&#038;utm_medium=Feed&#038;utm_campaign=Distribution\">Fonte quotidiana medica<\/a><\/p>\n<p>","protected":false},"excerpt":{"rendered":"<p>Il fallimento dello studio \u00e8 un \u201cforte promemoria di quanto sia sfuggente un vaccino contro l&#039;HIV e perch\u00e9 questo tipo di ricerca continua ad essere importante\u201d, ha affermato Jennifer Kates, direttrice della salute globale e delle politiche sull&#039;HIV presso la Kaiser Family Foundation.<\/p>","protected":false},"author":2,"featured_media":7319,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"Default","format":"standard","meta":{"page_builder":"","fifu_image_url":"https:\/\/urbancare.clinic\/wp-content\/uploads\/2023\/01\/hiv-vaccine-in-late-stage-trial-fails-extending-wait-for-effective-jab.jpg","fifu_image_alt":"","footnotes":""},"categories":[27],"tags":[],"class_list":["post-7318","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blog"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.4 - 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