{"id":7081,"date":"2022-12-29T13:12:32","date_gmt":"2022-12-29T10:12:32","guid":{"rendered":"https:\/\/www.medicaldaily.com\/scientists-develop-blood-test-alzheimers-diagnosis-467657"},"modified":"2022-12-29T13:12:32","modified_gmt":"2022-12-29T10:12:32","slug":"gli-scienziati-sviluppano-un-esame-del-sangue-per-la-diagnosi-dellalzheimer","status":"publish","type":"post","link":"https:\/\/urbancare.clinic\/it\/scientists-develop-blood-test-for-alzheimers-diagnosis\/","title":{"rendered":"Gli scienziati sviluppano un esame del sangue per la diagnosi di Alzheimer"},"content":{"rendered":"
<\/div>\n

Gli scienziati hanno creato un esame del sangue radicale per rilevare la malattia di Alzheimer. Secondo quanto riferito, questo esame del sangue ha un vantaggio rispetto ad altri esami del sangue sul campo.<\/p>\n

L'Alzheimer \u00e8 una malattia neurodegenerativa ed \u00e8 la forma pi\u00f9 comune di demenza, ma la sua diagnosi \u00e8 una sfida, soprattutto durante la fase iniziale della malattia.<\/p>\n

Per una diagnosi di successo, si raccomanda il rilevamento di tre marcatori distinti. Questi includono un accumulo eccessivo di proteine amiloide e tau, nonch\u00e9 una perdita lenta e progressiva di cellule neuronali in regioni specifiche del cervello.<\/p>\n

Attualmente, la diagnosi della malattia di Alzheimer comporta costose scansioni cerebrali e una dolorosa puntura lombare Il guardiano<\/a>. Pertanto, la necessit\u00e0 di una diagnosi pi\u00f9 semplice tramite esame del sangue \u00e8 ovvia.<\/p>\n

<\/div>\n

L'imaging cerebrale non solo \u00e8 costoso, ma richiede lunghi tempi di attesa per la programmazione.<\/p>\n

\u201cMolti pazienti, anche negli Stati Uniti, non hanno accesso agli scanner MRI e PET. L\u2019accessibilit\u00e0 \u00e8 una questione importante\u201d, ha affermato il prof. Thomas Karikari dell\u2019Universit\u00e0 di Pittsburgh, in Pennsylvania, USA, coautore dello studio pubblicato sulla rivista Cervello<\/a>, disse.<\/p>\n

La puntura lombare \u00e8 una procedura molto dolorosa che viene utilizzata per estrarre il liquido cerebrospinale (CSF) dal midollo spinale. Si pu\u00f2 anche manifestare mal di testa o mal di schiena dopo la procedura.<\/p>\n

Oltre ad essere indolori e facilmente disponibili, gli esami del sangue aiutano anche a individuare precocemente la malattia, che a sua volta porter\u00e0 all\u2019inizio tempestivo del trattamento.<\/p>\n

"Un esame del sangue \u00e8 pi\u00f9 economico, pi\u00f9 sicuro e pi\u00f9 facile da somministrare e pu\u00f2 migliorare la fiducia clinica nella diagnosi dell'Alzheimer e nella selezione dei partecipanti per la sperimentazione clinica e il monitoraggio della malattia", ha affermato Karikari, secondo quanto riportato dal quotidiano.<\/p>\n

Sebbene gli attuali esami del sangue possano rilevare livelli anomali di proteine amiloide e tau, individuare i marcatori del danno alle cellule nervose specifico del cervello si \u00e8 rivelato difficile. \u00c8 qui che l\u2019esame del sangue sviluppato da Karikari e dal suo team differisce. Il gruppo di ricerca ha sviluppato un esame del sangue basato su anticorpi che rileva una particolare forma di proteina tau chiamata tau derivata dal cervello. Questa proteina \u00e8 specifica della malattia di Alzheimer.<\/p>\n

Per lo studio, i ricercatori hanno testato 600 pazienti affetti da diversi stadi di Alzheimer. Hanno scoperto che i livelli di tau derivata dal cervello erano commisurati ai livelli di tau nel liquido cerebrospinale. Inoltre, l'esame del sangue potrebbe distinguere l'Alzheimer da altre malattie neurodegenerative.<\/p>\n

Lo studio ha scoperto che i livelli di proteine hanno mostrato anche una forte associazione con la gravit\u00e0 delle placche amiloidi e dei grovigli di tau nel tessuto cerebrale prelevato da persone morte a causa del morbo di Alzheimer.<\/p>\n

Il monitoraggio dei livelli di tau cerebrale nel sangue potrebbe aiutare a creare sperimentazioni cliniche efficienti per i trattamenti dell'Alzheimer, sperava Karikari.<\/p>\n

Uno studio separato ha scoperto varianti genetiche rare e dannose<\/a> che aumentano il rischio di malattia di Alzheimer.<\/p>\n

"I nostri risultati forniscono ulteriori prove del ruolo importante dell'elaborazione della proteina precursore dell'amiloide-\u03b2, dell'aggregazione dell'amiloide-\u03b2, del metabolismo dei lipidi e della funzione microgliale nell'AD", hanno scritto gli autori nel loro articolo.<\/p>\n

Utilizzando l'analisi del carico basata sui geni al posto dei pi\u00f9 comuni studi di associazione sull'intero genoma (GWAS), i ricercatori hanno trovato un forte legame tra varianti rare e dannose in ATP8B4 e ABCA1 con rischio di AD e un segnale in ADAM10, nonch\u00e9 varianti rare -carico di varianti nei geni RIN3, CLU, ZCWPW1 e ACE, secondo GenEngNews.<\/p>\n

Fonte quotidiana medica<\/a><\/p>\n

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