{"id":7051,"date":"2022-12-23T12:51:18","date_gmt":"2022-12-23T09:51:18","guid":{"rendered":"https:\/\/www.medicaldaily.com\/common-acne-treatment-adolescents-can-have-long-term-effects-skeletal-system-467625"},"modified":"2022-12-23T12:51:18","modified_gmt":"2022-12-23T09:51:18","slug":"il-trattamento-comune-dellacne-negli-adolescenti-puo-avere-effetti-a-lungo-termine-sul-sistema-scheletrico","status":"publish","type":"post","link":"https:\/\/urbancare.clinic\/it\/common-acne-treatment-in-adolescents-can-have-long-term-effects-on-skeletal-system-study\/","title":{"rendered":"Il trattamento comune dell'acne negli adolescenti pu\u00f2 avere effetti a lungo termine sul sistema scheletrico: studio"},"content":{"rendered":"
<\/div>\n

Gli adolescenti affetti da acne potrebbero dover pensarci due volte prima di iniziare un comune trattamento antibiotico inteso a risolvere i problemi della pelle. Un nuovo studio ha scoperto che il trattamento antibiotico pu\u00f2 alterare il sistema scheletrico con effetti a lungo termine.<\/p>\n

Lo studio, pubblicato nel Approfondimento del Journal of Clinical Investigation (JCI).<\/a>, hanno dimostrato che l'uso topico a lungo termine di un antibiotico sistemico, la minociclina, pu\u00f2 avere effetti indesiderati durante lo sviluppo osseo dell'adolescente.<\/p>\n

Il trattamento con minociclina pu\u00f2 durare fino a due anni. Questo antibiotico altera il microbioma intestinale, la popolazione di microrganismi che vivono nell\u2019intestino.<\/p>\n

I ricercatori della Medical University of South Carolina (MUSC) hanno scoperto una forte correlazione tra la composizione del microbioma intestinale e la sana maturazione scheletrica.<\/p>\n

<\/div>\n

Per lo studio, il gruppo di ricerca ha somministrato una dose adeguata di minociclina ai topi durante la fase di crescita puberale\/postpuberale, che \u00e8 l\u2019et\u00e0 equivalente all\u2019adolescenza negli esseri umani.<\/p>\n

Nello studio \u00e8 stato riscontrato che, sebbene la terapia con minociclina non abbia causato alcun effetto citotossico o indotto una risposta proinfiammatoria, ha modificato la composizione del microbioma intestinale, portando a una diminuzione dell\u2019accumulo di massa ossea e a una maturazione scheletrica inefficiente.<\/p>\n

"Ci sono cambiamenti sostenuti nel microbioma intestinale in seguito alla terapia sistemica con minociclina a lungo termine che portano a una ridotta maturazione ossea", ha riferito il primo autore, Matthew Carson, del laboratorio Novince. SciTechDaily<\/a>.<\/p>\n

"Da un punto di vista clinico, non solo il trattamento con minociclina causa cambiamenti allo scheletro in maturazione, ma anche il microbioma e lo scheletro non sono in grado di riprendersi completamente dopo la terapia antibiotica", Chad Novince, ricercatore principale e professore associato presso il Dipartimento di Scienze della salute orale aggiunto presso la Facolt\u00e0 di Odontoiatria.<\/p>\n

La minociclina appartiene alla classe degli antibiotici delle tetracicline. Questo gruppo comprende anche antibiotici come la tetraciclina, la doxiciclina e la sareciclina. Questi antibiotici agiscono ostruendo la crescita e la diffusione dei batteri. In caso di acne<\/a>, uccidono i batteri che infettano i pori e riducono alcune sostanze oleose naturali che causano l'acne.<\/p>\n

"La cosa veramente interessante \u00e8 che se si provocano cambiamenti nel microbioma durante questa fase adolescenziale, quando il microbiota sta ancora progredendo verso uno stato adulto stabile, si avranno effetti profondi sullo scheletro in maturazione", ha detto Carson, secondo lo sbocco.<\/p>\n

\u00c8 interessante notare che il team ha scoperto che i cambiamenti nel microbioma intestinale dovuti alla minociclina hanno influenzato anche la comunicazione tra il fegato e l\u2019intestino tenue, che avviene attraverso molecole chiamate acidi biliari.<\/p>\n

"Gli acidi biliari non erano stati precedentemente considerati importanti molecole di comunicazione tra l'intestino e lo scheletro", ha detto Novince, secondo il quotidiano. \u201cCambiando il microbioma intestinale, la composizione degli acidi biliari viene alterata, il che influenza la fisiologia dell\u2019ospite, compresa la maturazione scheletrica\u201d.<\/p>\n

Il microbioma intestinale alterato ha creato un diverso pool di acidi biliari. Questi diversi tipi di acidi biliari non sono riusciti ad attivare le cellule che formano l\u2019osso chiamate osteoblasti, che, a loro volta, hanno ridotto la formazione e la mineralizzazione dell\u2019osso di oltre 30%.<\/p>\n

"Si trattava di una scienza veramente collaborativa, che \u00e8 dove penso che ci troviamo oggi", ha detto Novince. \u201cPer promuovere una scienza ad alto impatto, \u00e8 necessario coinvolgere esperti provenienti da diverse professioni e discipline. Abbiamo avuto la fortuna di avere una squadra davvero forte. \u00c8 stato divertente \u2013 tutto \u00e8 stato emozionante!\u201d<\/p>\n

Fonte quotidiana medica<\/a><\/p>\n

","protected":false},"excerpt":{"rendered":"

Nello studio \u00e8 stato riscontrato che la terapia con minociclina ha modificato la composizione del microbioma intestinale, portando a una diminuzione dell\u2019accumulo di massa ossea e a una maturazione scheletrica inefficiente.<\/p>","protected":false},"author":2,"featured_media":7052,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"Default","format":"standard","meta":{"page_builder":"","fifu_image_url":"https:\/\/urbancare.clinic\/wp-content\/uploads\/2022\/12\/common-acne-treatment-in-adolescents-can-have-long-term-effects-on-skeletal-system-study.jpg","fifu_image_alt":"","footnotes":""},"categories":[27],"tags":[],"class_list":["post-7051","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blog"],"yoast_head":"\nCommon Acne Treatment In Adolescents Can Have Long-Term Effects On Skeletal System: Study - Urban Care Clinic<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, 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