{"id":9269,"date":"2024-01-24T12:38:52","date_gmt":"2024-01-24T09:38:52","guid":{"rendered":"https:\/\/urbancare.clinic\/can-chocolate-coated-insulin-pills-replace-needles-animal-study-shows-promising-results-for-diabetes-patients\/"},"modified":"2024-01-24T12:38:52","modified_gmt":"2024-01-24T09:38:52","slug":"les-pilules-dinsuline-enrobees-de-chocolat-peuvent-elles-remplacer-les-aiguilles-une-etude-animale-montre-des-resultats-prometteurs-pour-les-patients-diabetiques","status":"publish","type":"post","link":"https:\/\/urbancare.clinic\/fr\/can-chocolate-coated-insulin-pills-replace-needles-animal-study-shows-promising-results-for-diabetes-patients\/","title":{"rendered":"Les pilules d\u2019insuline enrob\u00e9es de chocolat peuvent-elles remplacer les aiguilles ? Une \u00e9tude animale montre des r\u00e9sultats prometteurs pour les patients diab\u00e9tiques"},"content":{"rendered":"
<\/div>\n

Existe-t-il une alternative indolore aux injections d\u2019insuline ? De bonnes nouvelles pourraient se profiler \u00e0 l\u2019horizon pour les personnes atteintes de diab\u00e8te, car les r\u00e9sultats d\u2019une r\u00e9cente \u00e9tude animale sugg\u00e8rent qu\u2019une pilule d\u2019insuline \u00e0 avaler gliss\u00e9e dans un morceau de chocolat pourrait remplacer les injections d\u2019insuline douloureuses \u00e0 l\u2019avenir.<\/p>\n

Environ 425 millions de personnes dans le monde souffrent de diab\u00e8te et 75 millions d\u2019entre elles d\u00e9pendent d\u2019injections d\u2019insuline pour g\u00e9rer leur glyc\u00e9mie.<\/p>\n

Des scientifiques de l'Universit\u00e9 de Troms\u00f8 (UiT) de l'Universit\u00e9 arctique de Norv\u00e8ge ont explor\u00e9 des alternatives aux injections d'insuline et d\u00e9velopp\u00e9 une pilule encapsul\u00e9e avec de minuscules nano-porteurs d'insuline con\u00e7us pour \u00eatre administr\u00e9s directement au foie.<\/p>\n

\u00ab Cette fa\u00e7on de prendre l\u2019insuline est plus pr\u00e9cise car elle d\u00e9livre l\u2019insuline rapidement aux zones du corps qui en ont le plus besoin. Lorsque vous prenez de l\u2019insuline avec une seringue, elle se propage dans tout le corps et peut provoquer des effets secondaires ind\u00e9sirables. \u00bb a dit<\/a> Peter McCourt de l'UiT The Arctic University of Norwegian, chercheur \u00e0 l'origine de l'\u00e9tude publi\u00e9e dans la revue Nature Nanotechnology.<\/p>\n

Contrairement \u00e0 de nombreux m\u00e9dicaments qui peuvent \u00eatre aval\u00e9s, l\u2019insuline doit \u00eatre inject\u00e9e, car elle se d\u00e9compose dans l\u2019estomac avant d\u2019atteindre le foie. Cependant, les chercheurs ont r\u00e9solu l\u2019obstacle en cr\u00e9ant une couche protectrice qui ne peut se d\u00e9composer dans le foie que lorsque le taux de sucre dans le sang est \u00e9lev\u00e9.<\/p>\n

"Nous avons cr\u00e9\u00e9 un rev\u00eatement pour prot\u00e9ger l'insuline de la d\u00e9gradation par l'acide gastrique et les enzymes digestives lors de son passage dans le syst\u00e8me digestif, la gardant en s\u00e9curit\u00e9 jusqu'\u00e0 ce qu'elle atteigne sa destination, \u00e0 savoir le foie", a expliqu\u00e9 McCourt.<\/p>\n

"Cela signifie que lorsque la glyc\u00e9mie est \u00e9lev\u00e9e, il y a une lib\u00e9ration rapide d'insuline et, plus important encore, lorsque la glyc\u00e9mie est basse, aucune insuline n'est lib\u00e9r\u00e9e", a d\u00e9clar\u00e9 Nicholas J. Hunt de l'Universit\u00e9 de Sydney, chercheur qui a co- a dirig\u00e9 le projet.<\/p>\n

"Afin de rendre l'insuline orale agr\u00e9able au go\u00fbt, nous l'avons incorpor\u00e9e dans du chocolat sans sucre, cette approche a \u00e9t\u00e9 bien accueillie", a ajout\u00e9 Hunt.<\/p>\n

Selon Hunt, les pilules offrent une m\u00e9thode plus pratique et plus conviviale pour g\u00e9rer le diab\u00e8te et r\u00e9duisent le risque d\u2019hypoglyc\u00e9mie. La technique permet la lib\u00e9ration contr\u00f4l\u00e9e de l'insuline en fonction des besoins du patient, contrairement aux injections o\u00f9 toute l'insuline est lib\u00e9r\u00e9e en une seule fois.<\/p>\n

Les chercheurs ont d\u00e9clar\u00e9 que la technique d'administration d'insuline de la pilule fonctionne de la m\u00eame mani\u00e8re que l'insuline agit chez les personnes en bonne sant\u00e9 et qu'elle aura moins d'effets secondaires.<\/p>\n

\u00abLorsque vous injectez de l'insuline sous la peau avec une seringue, une bien plus grande quantit\u00e9 d'insuline va aux muscles et aux tissus adipeux, ce qui se produirait normalement si elle \u00e9tait lib\u00e9r\u00e9e par le pancr\u00e9as, ce qui peut entra\u00eener une accumulation de graisses. Cela peut \u00e9galement entra\u00eener une hypoglyc\u00e9mie, ce qui peut \u00eatre dangereux pour les personnes diab\u00e9tiques. Avec la nouvelle m\u00e9thode, ces effets secondaires seront moins nombreux. De plus, vous n\u2019avez pas besoin de vous piquer avec une aiguille et vous pouvez prendre les m\u00e9dicaments dont vous avez besoin de mani\u00e8re un peu plus discr\u00e8te. De plus, cette forme d\u2019insuline n\u2019a pas besoin d\u2019\u00eatre r\u00e9frig\u00e9r\u00e9e \u00bb, ont indiqu\u00e9 les chercheurs.<\/p>\n

L'insuline orale a \u00e9t\u00e9 test\u00e9e sur des n\u00e9matodes, des souris et des rats diab\u00e9tiques. Dans un essai r\u00e9cent, des chercheurs les ont test\u00e9s sur 20 babouins en bonne sant\u00e9 et ont constat\u00e9 que leur taux de sucre dans le sang \u00e9tait r\u00e9duit.<\/p>\n

Les essais sur l\u2019homme d\u00e9buteront en 2025 et les chercheurs esp\u00e8rent que le nouveau m\u00e9dicament pourrait \u00eatre disponible dans deux \u00e0 trois ans.<\/p>\n

Source quotidienne m\u00e9dicale<\/a><\/p>\n

","protected":false},"excerpt":{"rendered":"

<\/div>\n

Existe-t-il une alternative indolore aux injections d\u2019insuline ? De bonnes nouvelles pourraient se profiler \u00e0 l\u2019horizon pour les personnes atteintes de diab\u00e8te, car les r\u00e9sultats d\u2019une r\u00e9cente \u00e9tude animale sugg\u00e8rent qu\u2019une pilule d\u2019insuline \u00e0 avaler gliss\u00e9e dans un morceau de chocolat pourrait remplacer les injections d\u2019insuline douloureuses \u00e0 l\u2019avenir.<\/p>\n

Environ 425 millions de personnes dans le monde souffrent de diab\u00e8te et 75 millions d\u2019entre elles d\u00e9pendent d\u2019injections d\u2019insuline pour g\u00e9rer leur glyc\u00e9mie.<\/p>\n

Des scientifiques de l'Universit\u00e9 de Troms\u00f8 (UiT) de l'Universit\u00e9 arctique de Norv\u00e8ge ont explor\u00e9 des alternatives aux injections d'insuline et d\u00e9velopp\u00e9 une pilule encapsul\u00e9e avec de minuscules nano-porteurs d'insuline con\u00e7us pour \u00eatre administr\u00e9s directement au foie.<\/p>\n

\u00ab Cette fa\u00e7on de prendre l\u2019insuline est plus pr\u00e9cise car elle d\u00e9livre l\u2019insuline rapidement aux zones du corps qui en ont le plus besoin. Lorsque vous prenez de l\u2019insuline avec une seringue, elle se propage dans tout le corps et peut provoquer des effets secondaires ind\u00e9sirables. \u00bb a dit<\/a> Peter McCourt de l'UiT The Arctic University of Norwegian, chercheur \u00e0 l'origine de l'\u00e9tude publi\u00e9e dans la revue Nature Nanotechnology.<\/p>\n

Contrairement \u00e0 de nombreux m\u00e9dicaments qui peuvent \u00eatre aval\u00e9s, l\u2019insuline doit \u00eatre inject\u00e9e, car elle se d\u00e9compose dans l\u2019estomac avant d\u2019atteindre le foie. Cependant, les chercheurs ont r\u00e9solu l\u2019obstacle en cr\u00e9ant une couche protectrice qui ne peut se d\u00e9composer dans le foie que lorsque le taux de sucre dans le sang est \u00e9lev\u00e9.<\/p>\n

"Nous avons cr\u00e9\u00e9 un rev\u00eatement pour prot\u00e9ger l'insuline de la d\u00e9gradation par l'acide gastrique et les enzymes digestives lors de son passage dans le syst\u00e8me digestif, la gardant en s\u00e9curit\u00e9 jusqu'\u00e0 ce qu'elle atteigne sa destination, \u00e0 savoir le foie", a expliqu\u00e9 McCourt.<\/p>\n

"Cela signifie que lorsque la glyc\u00e9mie est \u00e9lev\u00e9e, il y a une lib\u00e9ration rapide d'insuline et, plus important encore, lorsque la glyc\u00e9mie est basse, aucune insuline n'est lib\u00e9r\u00e9e", a d\u00e9clar\u00e9 Nicholas J. Hunt de l'Universit\u00e9 de Sydney, chercheur qui a co- a dirig\u00e9 le projet.<\/p>\n

"Afin de rendre l'insuline orale agr\u00e9able au go\u00fbt, nous l'avons incorpor\u00e9e dans du chocolat sans sucre, cette approche a \u00e9t\u00e9 bien accueillie", a ajout\u00e9 Hunt.<\/p>\n

Selon Hunt, les pilules offrent une m\u00e9thode plus pratique et plus conviviale pour g\u00e9rer le diab\u00e8te et r\u00e9duisent le risque d\u2019hypoglyc\u00e9mie. La technique permet la lib\u00e9ration contr\u00f4l\u00e9e de l'insuline en fonction des besoins du patient, contrairement aux injections o\u00f9 toute l'insuline est lib\u00e9r\u00e9e en une seule fois.<\/p>\n

Les chercheurs ont d\u00e9clar\u00e9 que la technique d'administration d'insuline de la pilule fonctionne de la m\u00eame mani\u00e8re que l'insuline agit chez les personnes en bonne sant\u00e9 et qu'elle aura moins d'effets secondaires.<\/p>\n

\u00abLorsque vous injectez de l'insuline sous la peau avec une seringue, une bien plus grande quantit\u00e9 d'insuline va aux muscles et aux tissus adipeux, ce qui se produirait normalement si elle \u00e9tait lib\u00e9r\u00e9e par le pancr\u00e9as, ce qui peut entra\u00eener une accumulation de graisses. Cela peut \u00e9galement entra\u00eener une hypoglyc\u00e9mie, ce qui peut \u00eatre dangereux pour les personnes diab\u00e9tiques. Avec la nouvelle m\u00e9thode, ces effets secondaires seront moins nombreux. De plus, vous n\u2019avez pas besoin de vous piquer avec une aiguille et vous pouvez prendre les m\u00e9dicaments dont vous avez besoin de mani\u00e8re un peu plus discr\u00e8te. De plus, cette forme d\u2019insuline n\u2019a pas besoin d\u2019\u00eatre r\u00e9frig\u00e9r\u00e9e \u00bb, ont indiqu\u00e9 les chercheurs.<\/p>\n

L'insuline orale a \u00e9t\u00e9 test\u00e9e sur des n\u00e9matodes, des souris et des rats diab\u00e9tiques. Dans un essai r\u00e9cent, des chercheurs les ont test\u00e9s sur 20 babouins en bonne sant\u00e9 et ont constat\u00e9 que leur taux de sucre dans le sang \u00e9tait r\u00e9duit.<\/p>\n

Les essais sur l\u2019homme d\u00e9buteront en 2025 et les chercheurs esp\u00e8rent que le nouveau m\u00e9dicament pourrait \u00eatre disponible dans deux \u00e0 trois ans.<\/p>","protected":false},"author":2,"featured_media":9270,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"Default","format":"standard","meta":{"page_builder":"","fifu_image_url":"https:\/\/urbancare.clinic\/wp-content\/uploads\/2024\/01\/can-chocolate-coated-insulin-pills-replace-needles-animal-study-shows-promising-results-for-diabetes-patients.jpg","fifu_image_alt":"","footnotes":""},"categories":[27],"tags":[],"class_list":["post-9269","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blog"],"yoast_head":"\nCan Chocolate-Coated Insulin Pills Replace Needles? Animal Study Shows Promising Results For Diabetes Patients - Urban Care Clinic<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/urbancare.clinic\/fr\/les-pilules-dinsuline-enrobees-de-chocolat-peuvent-elles-remplacer-les-aiguilles-une-etude-animale-montre-des-resultats-prometteurs-pour-les-patients-diabetiques\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Can Chocolate-Coated Insulin Pills Replace Needles? Animal Study Shows Promising Results For Diabetes Patients - Urban Care Clinic\" \/>\n<meta property=\"og:description\" content=\"Is there a pain-free alternative to insulin shots? Good news might be on the horizon for people with diabetes, as findings of a recent animal study suggest that a swallowable insulin pill tucked in a piece of chocolate might replace painful insulin shots in the future.Around 425 million people in the world have diabetes and 75 million of them depend on insulin injections to manage their blood sugar levels.Scientists from the University of Troms\u00f8 (UiT) The Arctic University of Norway explored alternatives to insulin shots and developed an encapsulated pill with tiny nano-carriers of insulin designed for direct delivery to the liver."This way of taking insulin is more precise because it delivers the insulin rapidly to the areas of the body that need it most. When you take insulin with a syringe, it is spread throughout the body where it can cause unwanted side effects," said Peter McCourt from UiT The Arctic University of Norway, a researcher behind the study published in the journal Nature Nanotechnology.Unlike many medicines that can be swallowed, insulin has to be injected, as it breaks down in the stomach before it reaches the liver. However, researchers solved the hurdle by creating a protective coating that can only break down in the liver when the blood sugar levels are high."We have created a coating to protect the insulin from being broken down by stomach acid and digestive enzymes on its way through the digestive system, keeping it safe until it reaches its destination, namely the liver," McCourt explained."This means that when blood sugar is high, there is a rapid release of insulin, and even more importantly when blood sugar is low, no insulin is released," said Nicholas J. Hunt from the University of Sydney, a researcher who co-led the project."In order to make the oral insulin palatable we incorporated it into sugar-free chocolate, this approach was well received," Hunt added.According to Hunt, the pills offer a more practical and patient-friendly method of managing diabetes and reduce the risk of hypoglycemia. The technique allows the controlled release of insulin based on the patient's requirements, unlike injections where all the insulin is released in one shot.The researchers said the pill's insulin delivery technique works similarly to how insulin works in healthy people and will have fewer side effects."When you inject insulin under the skin with a syringe, far more of it goes to the muscles and to adipose tissues that would normally happen if it was released from the pancreas, which can lead to the accumulation of fats. It can also lead to hypoglycemia, which can potentially be dangerous for people with diabetes. With the new method, there will be fewer such side effects. In addition, you do not need to stab yourself with a needle and you can take the medicine you need in a slightly more discreet way. Also, this form of insulin does not need to be refrigerated," the researchers said.The oral insulin has been tested on nematodes, mice and rats that have diabetes. In a recent trial, researchers tested them on 20 healthy baboons and found them to have reduced blood sugar levels.The human trials will begin in 2025, and researchers hope the new medicine could be available for use in two to three years.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/urbancare.clinic\/fr\/les-pilules-dinsuline-enrobees-de-chocolat-peuvent-elles-remplacer-les-aiguilles-une-etude-animale-montre-des-resultats-prometteurs-pour-les-patients-diabetiques\/\" \/>\n<meta property=\"og:site_name\" content=\"Urban Care Clinic\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/urbancarezanzibar\" \/>\n<meta property=\"article:published_time\" content=\"2024-01-24T09:38:52+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/urbancare.clinic\/wp-content\/uploads\/2024\/01\/can-chocolate-coated-insulin-pills-replace-needles-animal-study-shows-promising-results-for-diabetes-patients.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1024\" \/>\n\t<meta property=\"og:image:height\" content=\"1024\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Urban Care Clinic\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"\u00c9crit par\" \/>\n\t<meta name=\"twitter:data1\" content=\"Urban Care Clinic\" \/>\n\t<meta name=\"twitter:label2\" content=\"Dur\u00e9e de lecture estim\u00e9e\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/urbancare.clinic\\\/can-chocolate-coated-insulin-pills-replace-needles-animal-study-shows-promising-results-for-diabetes-patients\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/urbancare.clinic\\\/can-chocolate-coated-insulin-pills-replace-needles-animal-study-shows-promising-results-for-diabetes-patients\\\/\"},\"author\":{\"name\":\"Urban Care Clinic\",\"@id\":\"https:\\\/\\\/urbancare.clinic\\\/#\\\/schema\\\/person\\\/a304a61bcf298680ee41e2e9ae193930\"},\"headline\":\"Can Chocolate-Coated Insulin Pills Replace Needles? 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Une \u00e9tude animale montre des r\u00e9sultats prometteurs pour les patients diab\u00e9tiques - Urban Care Clinic","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/urbancare.clinic\/fr\/les-pilules-dinsuline-enrobees-de-chocolat-peuvent-elles-remplacer-les-aiguilles-une-etude-animale-montre-des-resultats-prometteurs-pour-les-patients-diabetiques\/","og_locale":"fr_FR","og_type":"article","og_title":"Can Chocolate-Coated Insulin Pills Replace Needles? Animal Study Shows Promising Results For Diabetes Patients - Urban Care Clinic","og_description":"Is there a pain-free alternative to insulin shots? Good news might be on the horizon for people with diabetes, as findings of a recent animal study suggest that a swallowable insulin pill tucked in a piece of chocolate might replace painful insulin shots in the future.Around 425 million people in the world have diabetes and 75 million of them depend on insulin injections to manage their blood sugar levels.Scientists from the University of Troms\u00f8 (UiT) The Arctic University of Norway explored alternatives to insulin shots and developed an encapsulated pill with tiny nano-carriers of insulin designed for direct delivery to the liver.\"This way of taking insulin is more precise because it delivers the insulin rapidly to the areas of the body that need it most. When you take insulin with a syringe, it is spread throughout the body where it can cause unwanted side effects,\" said Peter McCourt from UiT The Arctic University of Norway, a researcher behind the study published in the journal Nature Nanotechnology.Unlike many medicines that can be swallowed, insulin has to be injected, as it breaks down in the stomach before it reaches the liver. However, researchers solved the hurdle by creating a protective coating that can only break down in the liver when the blood sugar levels are high.\"We have created a coating to protect the insulin from being broken down by stomach acid and digestive enzymes on its way through the digestive system, keeping it safe until it reaches its destination, namely the liver,\" McCourt explained.\"This means that when blood sugar is high, there is a rapid release of insulin, and even more importantly when blood sugar is low, no insulin is released,\" said Nicholas J. Hunt from the University of Sydney, a researcher who co-led the project.\"In order to make the oral insulin palatable we incorporated it into sugar-free chocolate, this approach was well received,\" Hunt added.According to Hunt, the pills offer a more practical and patient-friendly method of managing diabetes and reduce the risk of hypoglycemia. The technique allows the controlled release of insulin based on the patient's requirements, unlike injections where all the insulin is released in one shot.The researchers said the pill's insulin delivery technique works similarly to how insulin works in healthy people and will have fewer side effects.\"When you inject insulin under the skin with a syringe, far more of it goes to the muscles and to adipose tissues that would normally happen if it was released from the pancreas, which can lead to the accumulation of fats. It can also lead to hypoglycemia, which can potentially be dangerous for people with diabetes. With the new method, there will be fewer such side effects. In addition, you do not need to stab yourself with a needle and you can take the medicine you need in a slightly more discreet way. Also, this form of insulin does not need to be refrigerated,\" the researchers said.The oral insulin has been tested on nematodes, mice and rats that have diabetes. In a recent trial, researchers tested them on 20 healthy baboons and found them to have reduced blood sugar levels.The human trials will begin in 2025, and researchers hope the new medicine could be available for use in two to three years.","og_url":"https:\/\/urbancare.clinic\/fr\/les-pilules-dinsuline-enrobees-de-chocolat-peuvent-elles-remplacer-les-aiguilles-une-etude-animale-montre-des-resultats-prometteurs-pour-les-patients-diabetiques\/","og_site_name":"Urban Care Clinic","article_publisher":"https:\/\/www.facebook.com\/urbancarezanzibar","article_published_time":"2024-01-24T09:38:52+00:00","og_image":[{"url":"https:\/\/urbancare.clinic\/wp-content\/uploads\/2024\/01\/can-chocolate-coated-insulin-pills-replace-needles-animal-study-shows-promising-results-for-diabetes-patients.jpg","width":1024,"height":1024,"type":"image\/jpeg"}],"author":"Urban Care Clinic","twitter_card":"summary_large_image","twitter_misc":{"\u00c9crit par":"Urban Care Clinic","Dur\u00e9e de lecture estim\u00e9e":"3 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/urbancare.clinic\/can-chocolate-coated-insulin-pills-replace-needles-animal-study-shows-promising-results-for-diabetes-patients\/#article","isPartOf":{"@id":"https:\/\/urbancare.clinic\/can-chocolate-coated-insulin-pills-replace-needles-animal-study-shows-promising-results-for-diabetes-patients\/"},"author":{"name":"Urban Care Clinic","@id":"https:\/\/urbancare.clinic\/#\/schema\/person\/a304a61bcf298680ee41e2e9ae193930"},"headline":"Can Chocolate-Coated Insulin Pills Replace Needles? 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