{"id":9220,"date":"2023-12-29T08:10:06","date_gmt":"2023-12-29T05:10:06","guid":{"rendered":"https:\/\/urbancare.clinic\/an-alternative-approach-to-treat-obesity-scientists-develop-vibrating-ingestible-capsule-that-makes-you-feel-full\/"},"modified":"2023-12-29T08:10:06","modified_gmt":"2023-12-29T05:10:06","slug":"une-approche-alternative-pour-traiter-lobesite-les-scientifiques-developpent-une-capsule-ingerable-vibrante-qui-vous-rassasie","status":"publish","type":"post","link":"https:\/\/urbancare.clinic\/fr\/an-alternative-approach-to-treat-obesity-scientists-develop-vibrating-ingestible-capsule-that-makes-you-feel-full\/","title":{"rendered":"Une approche alternative pour traiter l\u2019ob\u00e9sit\u00e9 ? Des scientifiques d\u00e9veloppent une capsule vibrante et ing\u00e9rable qui vous rassasie"},"content":{"rendered":"
<\/div>\n

Les chercheurs ont d\u00e9velopp\u00e9 une capsule ing\u00e9rable qui, lorsqu'elle est ing\u00e9r\u00e9e avant un repas, vibre dans l'estomac, envoyant des signaux au cerveau pour cr\u00e9er une sensation illusoire de sati\u00e9t\u00e9 et l'inciter \u00e0 arr\u00eater de manger. La nouvelle capsule pourrait appara\u00eetre comme un moyen peu invasif et rentable de traiter l\u2019ob\u00e9sit\u00e9.<\/p>\n

Chercheurs du Massachusetts Institute of Technology test\u00e9<\/a> la nouvelle capsule sur des animaux et a d\u00e9couvert que, administr\u00e9e 20 minutes avant de manger, elle stimulait la lib\u00e9ration d'hormones signalant la sati\u00e9t\u00e9 et r\u00e9duisait la consommation alimentaire de l'animal d'environ 40%. Les r\u00e9sultats ont \u00e9t\u00e9 publi\u00e9s dans la revue Science Advances.<\/p>\n

\u00ab Pour quelqu'un qui souhaite perdre du poids ou contr\u00f4ler son app\u00e9tit, il peut \u00eatre pris avant chaque repas. Cela pourrait \u00eatre vraiment int\u00e9ressant dans le sens o\u00f9 cela fournirait une option qui pourrait minimiser les effets secondaires que nous observons avec les autres traitements pharmacologiques \u00bb, a d\u00e9clar\u00e9 l'auteur principal Shriya Srinivasan, de l'Universit\u00e9 Harvard, dans un article. communiqu\u00e9 de presse<\/a>.<\/p>\n

Boire un verre d\u2019eau avant un repas permet d\u2019avoir moins faim. En effet, lorsque l\u2019estomac est plein de liquide, les m\u00e9canor\u00e9cepteurs de la muqueuse de l\u2019estomac envoient des signaux au cerveau, ce qui provoque une sensation de sati\u00e9t\u00e9. Les chercheurs ont travaill\u00e9 sur cette id\u00e9e et test\u00e9 si une capsule ing\u00e9rable qui vibre dans l\u2019estomac pouvait \u00e9tirer artificiellement les m\u00e9canor\u00e9cepteurs et cr\u00e9er la m\u00eame sensation de sati\u00e9t\u00e9.<\/p>\n

\u00ab Lorsque l\u2019estomac se distend, des cellules sp\u00e9cialis\u00e9es appel\u00e9es m\u00e9canor\u00e9cepteurs d\u00e9tectent cet \u00e9tirement et envoient des signaux au cerveau via le nerf vague. En cons\u00e9quence, le cerveau stimule la production d\u2019insuline, ainsi que d\u2019hormones telles que le peptide C, le Pyy et le GLP-1. Toutes ces hormones agissent ensemble pour aider les gens \u00e0 dig\u00e9rer leurs aliments, \u00e0 se sentir rassasi\u00e9s et \u00e0 arr\u00eater de manger. Dans le m\u00eame temps, les niveaux de ghr\u00e9line, une hormone favorisant la faim, diminuent \u00bb, expliquent les chercheurs.<\/p>\n

L\u2019\u00e9quipe de recherche a con\u00e7u une capsule de la taille d\u2019une multivitamine, aliment\u00e9e par une petite pile \u00e0 l\u2019oxyde d\u2019argent. Une fois la capsule ing\u00e9r\u00e9e, les liquides gastriques dissolvent la membrane qui la recouvre, compl\u00e8tent le circuit \u00e9lectronique et activent le moteur vibrant.<\/p>\n

Au cours d\u2019essais sur des animaux, les chercheurs ont remarqu\u00e9 que lorsque l\u2019appareil vibrait, les niveaux d\u2019hormones imitaient de pr\u00e8s les tendances observ\u00e9es apr\u00e8s un repas r\u00e9gulier. Il n\u2019y avait aucun signe d\u2019obstruction, de perforation ou d\u2019autres impacts n\u00e9gatifs chez les animaux pendant que la pilule se trouvait dans leur tube digestif. Les pilules ont travers\u00e9 le tube digestif en quatre ou cinq jours.<\/p>\n

La version actuelle de la pilule peut vibrer pendant environ 30 minutes apr\u00e8s avoir atteint l\u2019estomac. Les chercheurs pr\u00e9voient de l'\u00e9tendre sur des p\u00e9riodes plus longues et de tester la possibilit\u00e9 de l'activer et de le d\u00e9sactiver sans fil.<\/p>\n

Les chercheurs esp\u00e8rent que la nouvelle pilule pourrait constituer une alternative plus s\u00fbre aux m\u00e9thodes actuelles de traitement de l\u2019ob\u00e9sit\u00e9 en cas d\u2019\u00e9chec du r\u00e9gime et de l\u2019exercice. De nombreuses interventions m\u00e9dicales existantes, telles que le pontage gastrique et les ballons gastriques, sont souvent consid\u00e9r\u00e9es comme invasives et ne sont pas largement recommand\u00e9es pour des raisons de s\u00e9curit\u00e9. Bien que des m\u00e9dicaments comme les agonistes du GLP-1 puissent aider \u00e0 perdre du poids, beaucoup d\u2019entre eux n\u00e9cessitent une injection, ce qui les rend moins pratiques et inabordables pour beaucoup.<\/p>\n

\u00ab Pour de nombreuses populations, certaines des th\u00e9rapies les plus efficaces contre l\u2019ob\u00e9sit\u00e9 sont tr\u00e8s co\u00fbteuses. \u00c0 grande \u00e9chelle, notre appareil pourrait \u00eatre fabriqu\u00e9 \u00e0 un prix assez rentable. J'aimerais voir comment cela transformerait les soins et la th\u00e9rapie pour les personnes travaillant dans des contextes de sant\u00e9 mondiaux qui n'ont peut-\u00eatre pas acc\u00e8s \u00e0 certaines des options les plus sophistiqu\u00e9es ou les plus co\u00fbteuses disponibles aujourd'hui \u00bb, a d\u00e9clar\u00e9 Srinivasan.<\/p>\n

Source quotidienne m\u00e9dicale<\/a><\/p>\n

","protected":false},"excerpt":{"rendered":"

<\/div>\n

Les chercheurs ont d\u00e9velopp\u00e9 une capsule ing\u00e9rable qui, lorsqu'elle est ing\u00e9r\u00e9e avant un repas, vibre dans l'estomac, envoyant des signaux au cerveau pour cr\u00e9er une sensation illusoire de sati\u00e9t\u00e9 et l'inciter \u00e0 arr\u00eater de manger. La nouvelle capsule pourrait appara\u00eetre comme un moyen peu invasif et rentable de traiter l\u2019ob\u00e9sit\u00e9.<\/p>\n

Chercheurs du Massachusetts Institute of Technology test\u00e9<\/a> la nouvelle capsule sur des animaux et a d\u00e9couvert que, administr\u00e9e 20 minutes avant de manger, elle stimulait la lib\u00e9ration d'hormones signalant la sati\u00e9t\u00e9 et r\u00e9duisait la consommation alimentaire de l'animal d'environ 40%. Les r\u00e9sultats ont \u00e9t\u00e9 publi\u00e9s dans la revue Science Advances.<\/p>\n

\u00ab Pour quelqu'un qui souhaite perdre du poids ou contr\u00f4ler son app\u00e9tit, il peut \u00eatre pris avant chaque repas. Cela pourrait \u00eatre vraiment int\u00e9ressant dans le sens o\u00f9 cela fournirait une option qui pourrait minimiser les effets secondaires que nous observons avec les autres traitements pharmacologiques \u00bb, a d\u00e9clar\u00e9 l'auteur principal Shriya Srinivasan, de l'Universit\u00e9 Harvard, dans un article. communiqu\u00e9 de presse<\/a>.<\/p>\n

Boire un verre d\u2019eau avant un repas permet d\u2019avoir moins faim. En effet, lorsque l\u2019estomac est plein de liquide, les m\u00e9canor\u00e9cepteurs de la muqueuse de l\u2019estomac envoient des signaux au cerveau, ce qui provoque une sensation de sati\u00e9t\u00e9. Les chercheurs ont travaill\u00e9 sur cette id\u00e9e et test\u00e9 si une capsule ing\u00e9rable qui vibre dans l\u2019estomac pouvait \u00e9tirer artificiellement les m\u00e9canor\u00e9cepteurs et cr\u00e9er la m\u00eame sensation de sati\u00e9t\u00e9.<\/p>\n

\u00ab Lorsque l\u2019estomac se distend, des cellules sp\u00e9cialis\u00e9es appel\u00e9es m\u00e9canor\u00e9cepteurs d\u00e9tectent cet \u00e9tirement et envoient des signaux au cerveau via le nerf vague. En cons\u00e9quence, le cerveau stimule la production d\u2019insuline, ainsi que d\u2019hormones telles que le peptide C, le Pyy et le GLP-1. Toutes ces hormones agissent ensemble pour aider les gens \u00e0 dig\u00e9rer leurs aliments, \u00e0 se sentir rassasi\u00e9s et \u00e0 arr\u00eater de manger. Dans le m\u00eame temps, les niveaux de ghr\u00e9line, une hormone favorisant la faim, diminuent \u00bb, expliquent les chercheurs.<\/p>\n

L\u2019\u00e9quipe de recherche a con\u00e7u une capsule de la taille d\u2019une multivitamine, aliment\u00e9e par une petite pile \u00e0 l\u2019oxyde d\u2019argent. Une fois la capsule ing\u00e9r\u00e9e, les liquides gastriques dissolvent la membrane qui la recouvre, compl\u00e8tent le circuit \u00e9lectronique et activent le moteur vibrant.<\/p>\n

Au cours d\u2019essais sur des animaux, les chercheurs ont remarqu\u00e9 que lorsque l\u2019appareil vibrait, les niveaux d\u2019hormones imitaient de pr\u00e8s les tendances observ\u00e9es apr\u00e8s un repas r\u00e9gulier. Il n\u2019y avait aucun signe d\u2019obstruction, de perforation ou d\u2019autres impacts n\u00e9gatifs chez les animaux pendant que la pilule se trouvait dans leur tube digestif. Les pilules ont travers\u00e9 le tube digestif en quatre ou cinq jours.<\/p>\n

La version actuelle de la pilule peut vibrer pendant environ 30 minutes apr\u00e8s avoir atteint l\u2019estomac. Les chercheurs pr\u00e9voient de l'\u00e9tendre sur des p\u00e9riodes plus longues et de tester la possibilit\u00e9 de l'activer et de le d\u00e9sactiver sans fil.<\/p>\n

Les chercheurs esp\u00e8rent que la nouvelle pilule pourrait constituer une alternative plus s\u00fbre aux m\u00e9thodes actuelles de traitement de l\u2019ob\u00e9sit\u00e9 en cas d\u2019\u00e9chec du r\u00e9gime et de l\u2019exercice. De nombreuses interventions m\u00e9dicales existantes, telles que le pontage gastrique et les ballons gastriques, sont souvent consid\u00e9r\u00e9es comme invasives et ne sont pas largement recommand\u00e9es pour des raisons de s\u00e9curit\u00e9. Bien que des m\u00e9dicaments comme les agonistes du GLP-1 puissent aider \u00e0 perdre du poids, beaucoup d\u2019entre eux n\u00e9cessitent une injection, ce qui les rend moins pratiques et inabordables pour beaucoup.<\/p>\n

\u00ab Pour de nombreuses populations, certaines des th\u00e9rapies les plus efficaces contre l\u2019ob\u00e9sit\u00e9 sont tr\u00e8s co\u00fbteuses. \u00c0 grande \u00e9chelle, notre appareil pourrait \u00eatre fabriqu\u00e9 \u00e0 un prix assez rentable. J'aimerais voir comment cela transformerait les soins et la th\u00e9rapie pour les personnes travaillant dans des contextes de sant\u00e9 mondiaux qui n'ont peut-\u00eatre pas acc\u00e8s \u00e0 certaines des options les plus sophistiqu\u00e9es ou les plus co\u00fbteuses disponibles aujourd'hui \u00bb, a d\u00e9clar\u00e9 Srinivasan.<\/p>","protected":false},"author":2,"featured_media":9221,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"Default","format":"standard","meta":{"page_builder":"","fifu_image_url":"https:\/\/urbancare.clinic\/wp-content\/uploads\/2024\/01\/an-alternative-approach-to-treat-obesity-scientists-develop-vibrating-ingestible-capsule-that-makes-you-feel-full.jpg","fifu_image_alt":"","footnotes":""},"categories":[27],"tags":[],"class_list":["post-9220","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blog"],"yoast_head":"\nAn Alternative Approach To Treat Obesity? Scientists Develop Vibrating, Ingestible Capsule That Makes You Feel Full - Urban Care Clinic<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/urbancare.clinic\/fr\/une-approche-alternative-pour-traiter-lobesite-les-scientifiques-developpent-une-capsule-ingerable-vibrante-qui-vous-rassasie\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"An Alternative Approach To Treat Obesity? Scientists Develop Vibrating, Ingestible Capsule That Makes You Feel Full - Urban Care Clinic\" \/>\n<meta property=\"og:description\" content=\"Researchers have developed an ingestible capsule, which when ingested before a meal, vibrates in the stomach, sending signals to the brain to create an illusory sense of fullness and trick it to stop eating. The new capsule could emerge as a minimally invasive and cost-effective way to treat obesity.Researchers from the Massachusetts Institute of Technology tested the new capsule on animals and found that when given 20 minutes before eating, it stimulated the release of hormones that signal satiety and reduced the animal's food intake by about 40%. The results were published in the journal Science Advances."For somebody who wants to lose weight or control their appetite, it could be taken before each meal. This could be really interesting in that it would provide an option that could minimize the side effects that we see with the other pharmacological treatments out there," lead author Shriya Srinivasan, from Harvard University, said in a news release.Drinking a glass of water before a meal makes you feel less hungry. This is because when the stomach is full of liquid, the mechanoreceptors of the stomach lining send signals to the brain, making you feel satiated. Researchers worked on this idea and tested if an ingestible capsule that vibrates within the stomach could artificially stretch the mechanoreceptors and create the same sense of fullness."When the stomach becomes distended, specialized cells called mechanoreceptors sense that stretching and send signals to the brain via the vagus nerve. As a result, the brain stimulates the production of insulin, as well as hormones such as C-peptide, Pyy and GLP-1. All of these hormones work together to help people digest their food, feel full, and stop eating. At the same time, levels of ghrelin, a hunger-promoting hormone, go down," researchers explained.The research team designed a capsule about the size of a multivitamin, powered by a small silver oxide battery. After the capsule gets ingested, the gastric fluids dissolve the membrane that covers it, complete the electronic circuit and activate the vibrating motor.During animal trials, researchers noticed that when the device was vibrating, hormone levels closely mimicked the patterns seen after a regular meal. There were no signs of obstruction, perforation or other negative impacts in animals while the pill was in their digestive tract. The pills passed through the digestive tract within four or five days.The current version of the pill can vibrate for about 30 minutes after reaching the stomach. Researchers plan to extend it for longer periods and test the possibility of activating and deactivating it wirelessly.Researchers hope the new pill could work as a safer alternative to the current methods of treating obesity when diet and exercise fail. Many existing medical interventions such as gastric bypass surgery and gastric balloons are often considered invasive and are not widely recommended due to safety concerns. While drugs like GLP-1 agonists can help in weight loss, many of them require injection, making them less convenient and unaffordable for many."For a lot of populations, some of the more effective therapies for obesity are very costly. At scale, our device could be manufactured at a pretty cost-effective price point. I'd love to see how this would transform care and therapy for people in global health settings who may not have access to some of the more sophisticated or expensive options that are available today," Srinivasan said.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/urbancare.clinic\/fr\/une-approche-alternative-pour-traiter-lobesite-les-scientifiques-developpent-une-capsule-ingerable-vibrante-qui-vous-rassasie\/\" \/>\n<meta property=\"og:site_name\" content=\"Urban Care Clinic\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/urbancarezanzibar\" \/>\n<meta property=\"article:published_time\" content=\"2023-12-29T05:10:06+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/urbancare.clinic\/wp-content\/uploads\/2024\/01\/an-alternative-approach-to-treat-obesity-scientists-develop-vibrating-ingestible-capsule-that-makes-you-feel-full.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1024\" \/>\n\t<meta property=\"og:image:height\" content=\"1024\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Urban Care Clinic\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"\u00c9crit par\" \/>\n\t<meta name=\"twitter:data1\" content=\"Urban Care Clinic\" \/>\n\t<meta name=\"twitter:label2\" content=\"Dur\u00e9e de lecture estim\u00e9e\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/urbancare.clinic\\\/an-alternative-approach-to-treat-obesity-scientists-develop-vibrating-ingestible-capsule-that-makes-you-feel-full\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/urbancare.clinic\\\/an-alternative-approach-to-treat-obesity-scientists-develop-vibrating-ingestible-capsule-that-makes-you-feel-full\\\/\"},\"author\":{\"name\":\"Urban Care Clinic\",\"@id\":\"https:\\\/\\\/urbancare.clinic\\\/#\\\/schema\\\/person\\\/a304a61bcf298680ee41e2e9ae193930\"},\"headline\":\"An Alternative Approach To Treat Obesity? 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Des scientifiques d\u00e9veloppent une capsule vibrante et ing\u00e9rable qui vous rassasie - Urban Care Clinic","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/urbancare.clinic\/fr\/une-approche-alternative-pour-traiter-lobesite-les-scientifiques-developpent-une-capsule-ingerable-vibrante-qui-vous-rassasie\/","og_locale":"fr_FR","og_type":"article","og_title":"An Alternative Approach To Treat Obesity? Scientists Develop Vibrating, Ingestible Capsule That Makes You Feel Full - Urban Care Clinic","og_description":"Researchers have developed an ingestible capsule, which when ingested before a meal, vibrates in the stomach, sending signals to the brain to create an illusory sense of fullness and trick it to stop eating. The new capsule could emerge as a minimally invasive and cost-effective way to treat obesity.Researchers from the Massachusetts Institute of Technology tested the new capsule on animals and found that when given 20 minutes before eating, it stimulated the release of hormones that signal satiety and reduced the animal's food intake by about 40%. The results were published in the journal Science Advances.\"For somebody who wants to lose weight or control their appetite, it could be taken before each meal. This could be really interesting in that it would provide an option that could minimize the side effects that we see with the other pharmacological treatments out there,\" lead author Shriya Srinivasan, from Harvard University, said in a news release.Drinking a glass of water before a meal makes you feel less hungry. This is because when the stomach is full of liquid, the mechanoreceptors of the stomach lining send signals to the brain, making you feel satiated. Researchers worked on this idea and tested if an ingestible capsule that vibrates within the stomach could artificially stretch the mechanoreceptors and create the same sense of fullness.\"When the stomach becomes distended, specialized cells called mechanoreceptors sense that stretching and send signals to the brain via the vagus nerve. As a result, the brain stimulates the production of insulin, as well as hormones such as C-peptide, Pyy and GLP-1. All of these hormones work together to help people digest their food, feel full, and stop eating. At the same time, levels of ghrelin, a hunger-promoting hormone, go down,\" researchers explained.The research team designed a capsule about the size of a multivitamin, powered by a small silver oxide battery. After the capsule gets ingested, the gastric fluids dissolve the membrane that covers it, complete the electronic circuit and activate the vibrating motor.During animal trials, researchers noticed that when the device was vibrating, hormone levels closely mimicked the patterns seen after a regular meal. There were no signs of obstruction, perforation or other negative impacts in animals while the pill was in their digestive tract. The pills passed through the digestive tract within four or five days.The current version of the pill can vibrate for about 30 minutes after reaching the stomach. Researchers plan to extend it for longer periods and test the possibility of activating and deactivating it wirelessly.Researchers hope the new pill could work as a safer alternative to the current methods of treating obesity when diet and exercise fail. Many existing medical interventions such as gastric bypass surgery and gastric balloons are often considered invasive and are not widely recommended due to safety concerns. While drugs like GLP-1 agonists can help in weight loss, many of them require injection, making them less convenient and unaffordable for many.\"For a lot of populations, some of the more effective therapies for obesity are very costly. At scale, our device could be manufactured at a pretty cost-effective price point. I'd love to see how this would transform care and therapy for people in global health settings who may not have access to some of the more sophisticated or expensive options that are available today,\" Srinivasan said.","og_url":"https:\/\/urbancare.clinic\/fr\/une-approche-alternative-pour-traiter-lobesite-les-scientifiques-developpent-une-capsule-ingerable-vibrante-qui-vous-rassasie\/","og_site_name":"Urban Care Clinic","article_publisher":"https:\/\/www.facebook.com\/urbancarezanzibar","article_published_time":"2023-12-29T05:10:06+00:00","og_image":[{"url":"https:\/\/urbancare.clinic\/wp-content\/uploads\/2024\/01\/an-alternative-approach-to-treat-obesity-scientists-develop-vibrating-ingestible-capsule-that-makes-you-feel-full.jpg","width":1024,"height":1024,"type":"image\/jpeg"}],"author":"Urban Care Clinic","twitter_card":"summary_large_image","twitter_misc":{"\u00c9crit par":"Urban Care Clinic","Dur\u00e9e de lecture estim\u00e9e":"3 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/urbancare.clinic\/an-alternative-approach-to-treat-obesity-scientists-develop-vibrating-ingestible-capsule-that-makes-you-feel-full\/#article","isPartOf":{"@id":"https:\/\/urbancare.clinic\/an-alternative-approach-to-treat-obesity-scientists-develop-vibrating-ingestible-capsule-that-makes-you-feel-full\/"},"author":{"name":"Urban Care Clinic","@id":"https:\/\/urbancare.clinic\/#\/schema\/person\/a304a61bcf298680ee41e2e9ae193930"},"headline":"An Alternative Approach To Treat Obesity? 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