{"id":8643,"date":"2023-09-15T13:20:23","date_gmt":"2023-09-15T10:20:23","guid":{"rendered":"https:\/\/urbancare.clinic\/us-surgeons-report-longest-successful-pig-to-human-kidney-transplant\/"},"modified":"2023-09-15T13:20:23","modified_gmt":"2023-09-15T10:20:23","slug":"des-chirurgiens-americains-rapportent-que-la-greffe-de-rein-dun-porc-a-un-humain-a-ete-la-plus-longue-reussite","status":"publish","type":"post","link":"https:\/\/urbancare.clinic\/fr\/des-chirurgiens-americains-rapportent-que-la-greffe-de-rein-dun-porc-a-un-humain-a-ete-la-plus-longue-reussite\/","title":{"rendered":"Des chirurgiens am\u00e9ricains signalent la plus longue transplantation r\u00e9ussie de rein de porc \u00e0 humain"},"content":{"rendered":"<div><img decoding=\"async\" src=\"https:\/\/urbancare.clinic\/wp-content\/uploads\/2023\/09\/us-surgeons-report-longest-successful-pig-to-human-kidney-transplant.jpg\" class=\"ff-og-image-inserted\" style=\"display:none\"><\/div>\n<p>Des chirurgiens am\u00e9ricains qui ont transplant\u00e9 un rein de porc g\u00e9n\u00e9tiquement modifi\u00e9 chez un patient en \u00e9tat de mort c\u00e9r\u00e9brale ont annonc\u00e9 jeudi avoir mis fin \u00e0 leur exp\u00e9rience apr\u00e8s une dur\u00e9e record de 61 jours.<\/p>\n<p>La derni\u00e8re proc\u00e9dure exp\u00e9rimentale fait partie d\u2019un domaine de recherche en pleine croissance visant \u00e0 faire progresser les transplantations entre esp\u00e8ces, testant principalement la technique sur des corps donn\u00e9s \u00e0 la science.<\/p>\n<p>Aux \u00c9tats-Unis, plus de 103 000 personnes attendent une greffe d\u2019organe, dont 88 000 ont besoin de reins.<\/p>\n<p>&quot;Nous avons beaucoup appris au cours de ces deux derniers mois d&#039;observation et d&#039;analyse \u00e9troites, et il y a de grandes raisons d&#039;esp\u00e9rer pour l&#039;avenir&quot;, a d\u00e9clar\u00e9 Robert Montgomery, directeur du Langone Transplant Institute de l&#039;Universit\u00e9 de New York, qui a dirig\u00e9 l&#039;op\u00e9ration en Juillet.<\/p>\n<p>Il s&#039;agit de la cinqui\u00e8me x\u00e9notransplantation r\u00e9alis\u00e9e par Montgomery, qui a \u00e9galement r\u00e9alis\u00e9 la premi\u00e8re greffe de rein de porc g\u00e9n\u00e9tiquement modifi\u00e9 au monde en septembre 2021.<\/p>\n<p>Les tissus collect\u00e9s au cours de l&#039;\u00e9tude ont indiqu\u00e9 qu&#039;un l\u00e9ger processus de rejet avait commenc\u00e9, n\u00e9cessitant une intensification des m\u00e9dicaments immunosuppresseurs.<\/p>\n<p>En \u00ab \u00e9liminant \u00bb le g\u00e8ne responsable d\u2019une biomol\u00e9cule appel\u00e9e alpha-gal \u2013 une cible privil\u00e9gi\u00e9e des anticorps humains itin\u00e9rants \u2013 l\u2019\u00e9quipe de NYU Langone a pu arr\u00eater le rejet imm\u00e9diat.<\/p>\n<p>Le porc donneur de cette exp\u00e9rience provenait d&#039;un troupeau cultiv\u00e9 par la soci\u00e9t\u00e9 de biotechnologie Revivicor, bas\u00e9e en Virginie.<\/p>\n<p>Le troupeau a \u00e9galement \u00e9t\u00e9 approuv\u00e9 par la Food and Drug Administration comme source de viande pour les personnes pr\u00e9sentant une hypersensibilit\u00e9 \u00e0 la mol\u00e9cule alpha-gal, une allergie provoqu\u00e9e par certaines piq\u00fbres de tiques.<\/p>\n<p>Ces porcs sont \u00e9lev\u00e9s et non clon\u00e9s, ce qui signifie que le processus peut \u00eatre plus facilement \u00e9tendu.<\/p>\n<p>Les premi\u00e8res recherches sur la x\u00e9notransplantation se sont concentr\u00e9es sur le pr\u00e9l\u00e8vement d\u2019organes sur des primates \u2013 par exemple, un c\u0153ur de babouin a \u00e9t\u00e9 transplant\u00e9 chez un nouveau-n\u00e9 connu sous le nom de \u00ab Baby Fae \u00bb en 1984, mais celui-ci n\u2019a surv\u00e9cu que 20 jours.<\/p>\n<p>Les efforts actuels se concentrent sur les porcs, consid\u00e9r\u00e9s comme des donneurs id\u00e9aux pour les humains en raison de la taille de leurs organes, de leur croissance rapide et de leurs port\u00e9es importantes, ainsi que du fait qu&#039;ils sont d\u00e9j\u00e0 \u00e9lev\u00e9s comme source de nourriture.<\/p>\n<p>En janvier 2022, des chirurgiens de la facult\u00e9 de m\u00e9decine de l&#039;Universit\u00e9 du Maryland ont r\u00e9alis\u00e9 la premi\u00e8re transplantation porc-humain au monde sur un patient vivant, impliquant cette fois un c\u0153ur.<\/p>\n<p>Il est d\u00e9c\u00e9d\u00e9 deux mois apr\u00e8s ce jalon, la pr\u00e9sence du cytom\u00e9galovirus porcin dans l&#039;organe \u00e9tant ensuite imput\u00e9e.<\/p>\n<p>La semaine derni\u00e8re, des scientifiques chinois ont publi\u00e9 un article d\u00e9montrant qu&#039;ils avaient r\u00e9ussi \u00e0 cr\u00e9er des reins hybrides de porc et d&#039;humain sur des embryons de porc, une approche alternative qui pourrait \u00e9galement un jour contribuer \u00e0 r\u00e9soudre la p\u00e9nurie de dons d&#039;organes.<\/p>\n<p>Mais cette d\u00e9couverte soul\u00e8ve des questions \u00e9thiques, d&#039;autant plus que certaines cellules humaines ont \u00e9galement \u00e9t\u00e9 trouv\u00e9es dans le cerveau des porcs, selon les experts.<\/p>\n<p>Publi\u00e9 par Medicaldaily.com<\/p>\n<p><a href=\"https:\/\/www.medicaldaily.com\/us-surgeons-report-longest-successful-pig-human-kidney-transplant-470809\">Source quotidienne m\u00e9dicale<\/a><\/p>\n<p>","protected":false},"excerpt":{"rendered":"<div><img decoding=\"async\" src=\"https:\/\/urbancare.clinic\/wp-content\/uploads\/2023\/09\/us-surgeons-report-longest-successful-pig-to-human-kidney-transplant.jpg\" class=\"ff-og-image-inserted\"><\/div>\n<p>Des chirurgiens am\u00e9ricains qui ont transplant\u00e9 un rein de porc g\u00e9n\u00e9tiquement modifi\u00e9 chez un patient en \u00e9tat de mort c\u00e9r\u00e9brale ont annonc\u00e9 jeudi avoir mis fin \u00e0 leur exp\u00e9rience apr\u00e8s une dur\u00e9e record de 61 jours.<\/p>\n<p>La derni\u00e8re proc\u00e9dure exp\u00e9rimentale fait partie d\u2019un domaine de recherche en pleine croissance visant \u00e0 faire progresser les transplantations entre esp\u00e8ces, testant principalement la technique sur des corps donn\u00e9s \u00e0 la science.<\/p>\n<p>Aux \u00c9tats-Unis, plus de 103 000 personnes attendent une greffe d\u2019organe, dont 88 000 ont besoin de reins.<\/p>\n<p>&quot;Nous avons beaucoup appris au cours de ces deux derniers mois d&#039;observation et d&#039;analyse \u00e9troites, et il y a de grandes raisons d&#039;esp\u00e9rer pour l&#039;avenir&quot;, a d\u00e9clar\u00e9 Robert Montgomery, directeur du Langone Transplant Institute de l&#039;Universit\u00e9 de New York, qui a dirig\u00e9 l&#039;op\u00e9ration en Juillet.<\/p>\n<p>Il s&#039;agit de la cinqui\u00e8me x\u00e9notransplantation r\u00e9alis\u00e9e par Montgomery, qui a \u00e9galement r\u00e9alis\u00e9 la premi\u00e8re greffe de rein de porc g\u00e9n\u00e9tiquement modifi\u00e9 au monde en septembre 2021.<\/p>\n<p>Les tissus collect\u00e9s au cours de l&#039;\u00e9tude ont indiqu\u00e9 qu&#039;un l\u00e9ger processus de rejet avait commenc\u00e9, n\u00e9cessitant une intensification des m\u00e9dicaments immunosuppresseurs.<\/p>\n<p>En \u00ab \u00e9liminant \u00bb le g\u00e8ne responsable d\u2019une biomol\u00e9cule appel\u00e9e alpha-gal \u2013 une cible privil\u00e9gi\u00e9e des anticorps humains itin\u00e9rants \u2013 l\u2019\u00e9quipe de NYU Langone a pu arr\u00eater le rejet imm\u00e9diat.<\/p>\n<p>Le porc donneur de cette exp\u00e9rience provenait d&#039;un troupeau cultiv\u00e9 par la soci\u00e9t\u00e9 de biotechnologie Revivicor, bas\u00e9e en Virginie.<\/p>\n<p>Le troupeau a \u00e9galement \u00e9t\u00e9 approuv\u00e9 par la Food and Drug Administration comme source de viande pour les personnes pr\u00e9sentant une hypersensibilit\u00e9 \u00e0 la mol\u00e9cule alpha-gal, une allergie provoqu\u00e9e par certaines piq\u00fbres de tiques.<\/p>\n<p>Ces porcs sont \u00e9lev\u00e9s et non clon\u00e9s, ce qui signifie que le processus peut \u00eatre plus facilement \u00e9tendu.<\/p>\n<p>Les premi\u00e8res recherches sur la x\u00e9notransplantation se sont concentr\u00e9es sur le pr\u00e9l\u00e8vement d\u2019organes sur des primates \u2013 par exemple, un c\u0153ur de babouin a \u00e9t\u00e9 transplant\u00e9 chez un nouveau-n\u00e9 connu sous le nom de \u00ab Baby Fae \u00bb en 1984, mais celui-ci n\u2019a surv\u00e9cu que 20 jours.<\/p>\n<p>Les efforts actuels se concentrent sur les porcs, consid\u00e9r\u00e9s comme des donneurs id\u00e9aux pour les humains en raison de la taille de leurs organes, de leur croissance rapide et de leurs port\u00e9es importantes, ainsi que du fait qu&#039;ils sont d\u00e9j\u00e0 \u00e9lev\u00e9s comme source de nourriture.<\/p>\n<p>En janvier 2022, des chirurgiens de la facult\u00e9 de m\u00e9decine de l&#039;Universit\u00e9 du Maryland ont r\u00e9alis\u00e9 la premi\u00e8re transplantation porc-humain au monde sur un patient vivant, impliquant cette fois un c\u0153ur.<\/p>\n<p>Il est d\u00e9c\u00e9d\u00e9 deux mois apr\u00e8s ce jalon, la pr\u00e9sence du cytom\u00e9galovirus porcin dans l&#039;organe \u00e9tant ensuite imput\u00e9e.<\/p>\n<p>La semaine derni\u00e8re, des scientifiques chinois ont publi\u00e9 un article d\u00e9montrant qu&#039;ils avaient r\u00e9ussi \u00e0 cr\u00e9er des reins hybrides de porc et d&#039;humain sur des embryons de porc, une approche alternative qui pourrait \u00e9galement un jour contribuer \u00e0 r\u00e9soudre la p\u00e9nurie de dons d&#039;organes.<\/p>\n<p>Mais cette d\u00e9couverte soul\u00e8ve des questions \u00e9thiques, d&#039;autant plus que certaines cellules humaines ont \u00e9galement \u00e9t\u00e9 trouv\u00e9es dans le cerveau des porcs, selon les experts.<\/p>\n<p>Publi\u00e9 par Medicaldaily.com<\/p>","protected":false},"author":2,"featured_media":8644,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"Default","format":"standard","meta":{"fifu_image_url":"https:\/\/urbancare.clinic\/wp-content\/uploads\/2023\/09\/us-surgeons-report-longest-successful-pig-to-human-kidney-transplant.jpg","fifu_image_alt":"","footnotes":""},"categories":[27],"tags":[],"class_list":["post-8643","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blog"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.6 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>US Surgeons Report Longest Successful Pig-To-Human Kidney Transplant - Urban Care Clinic<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/urbancare.clinic\/fr\/des-chirurgiens-americains-rapportent-que-la-greffe-de-rein-dun-porc-a-un-humain-a-ete-la-plus-longue-reussite\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"US Surgeons Report Longest Successful Pig-To-Human Kidney Transplant - Urban Care Clinic\" \/>\n<meta property=\"og:description\" content=\"U.S. surgeons who transplanted a genetically modified pig kidney into a brain-dead patient announced Thursday they had ended their experiment after a record-breaking 61 days.The latest experimental procedure is part of a growing field of research aimed at advancing cross-species transplants, mainly testing the technique on bodies that have been donated for science.There are more than 103,000 people waiting for organ transplants in the United States, 88,000 of whom need kidneys.&quot;We have learned a great deal throughout these past two months of close observation and analysis, and there is great reason to be hopeful for the future,&quot; said Robert Montgomery, director of the New York University Langone Transplant Institute, who led the surgery in July.It was the fifth so-called xenotransplant performed by Montgomery, who also carried out the world&#039;s first genetically modified pig kidney transplant in September 2021.Tissue collected during the study indicated a mild rejection process had begun, requiring intensification of immunosuppression medication.By &quot;knocking out&quot; the gene responsible for a biomolecule called alpha-gal -- a prime target for roving human antibodies -- the NYU Langone team were able to stop immediate rejection.The donor pig in this experiment came from a herd cultivated by Virginia-based biotech company Revivicor.The herd has also been approved by the Food and Drug Administration as a source of meat for people with hypersensitivity to the alpha-gal molecule, an allergy caused by some tick bites.These pigs are bred, not cloned, meaning the process can be more easily scaled.Early xenotransplantation research focused on harvesting organs from primates -- for example, a baboon heart was transplanted into a newborn known as &quot;Baby Fae&quot; in 1984, but she survived only 20 days.Current efforts focus on pigs, which are thought to be ideal donors for humans because of their organ size, their rapid growth and large litters, and the fact they are already raised as a food source.In January 2022, surgeons at the University of Maryland Medical School carried out the world&#039;s first pig-to-human transplant on a living patient -- this time involving a heart.He died two months after the milestone, with the presence of porcine cytomegalovirus in the organ later blamed.Last week, Chinese scientists published a paper showing they had succeeded in hybrid pig-human kidneys in pig embryos, an alternative approach that also has the potential to one day help address organ donation 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humain - Urban Care Clinic","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/urbancare.clinic\/fr\/des-chirurgiens-americains-rapportent-que-la-greffe-de-rein-dun-porc-a-un-humain-a-ete-la-plus-longue-reussite\/","og_locale":"fr_FR","og_type":"article","og_title":"US Surgeons Report Longest Successful Pig-To-Human Kidney Transplant - Urban Care Clinic","og_description":"U.S. surgeons who transplanted a genetically modified pig kidney into a brain-dead patient announced Thursday they had ended their experiment after a record-breaking 61 days.The latest experimental procedure is part of a growing field of research aimed at advancing cross-species transplants, mainly testing the technique on bodies that have been donated for science.There are more than 103,000 people waiting for organ transplants in the United States, 88,000 of whom need kidneys.\"We have learned a great deal throughout these past two months of close observation and analysis, and there is great reason to be hopeful for the future,\" said Robert Montgomery, director of the New York University Langone Transplant Institute, who led the surgery in July.It was the fifth so-called xenotransplant performed by Montgomery, who also carried out the world's first genetically modified pig kidney transplant in September 2021.Tissue collected during the study indicated a mild rejection process had begun, requiring intensification of immunosuppression medication.By \"knocking out\" the gene responsible for a biomolecule called alpha-gal -- a prime target for roving human antibodies -- the NYU Langone team were able to stop immediate rejection.The donor pig in this experiment came from a herd cultivated by Virginia-based biotech company Revivicor.The herd has also been approved by the Food and Drug Administration as a source of meat for people with hypersensitivity to the alpha-gal molecule, an allergy caused by some tick bites.These pigs are bred, not cloned, meaning the process can be more easily scaled.Early xenotransplantation research focused on harvesting organs from primates -- for example, a baboon heart was transplanted into a newborn known as \"Baby Fae\" in 1984, but she survived only 20 days.Current efforts focus on pigs, which are thought to be ideal donors for humans because of their organ size, their rapid growth and large litters, and the fact they are already raised as a food source.In January 2022, surgeons at the University of Maryland Medical School carried out the world's first pig-to-human transplant on a living patient -- this time involving a heart.He died two months after the milestone, with the presence of porcine cytomegalovirus in the organ later blamed.Last week, Chinese scientists published a paper showing they had succeeded in hybrid pig-human kidneys in pig embryos, an alternative approach that also has the potential to one day help address organ donation shortages.But the development raised ethical issues -- especially since some human cells were also found in the pigs' brains, experts said.Published by Medicaldaily.com","og_url":"https:\/\/urbancare.clinic\/fr\/des-chirurgiens-americains-rapportent-que-la-greffe-de-rein-dun-porc-a-un-humain-a-ete-la-plus-longue-reussite\/","og_site_name":"Urban Care Clinic","article_publisher":"https:\/\/www.facebook.com\/urbancarezanzibar","article_published_time":"2023-09-15T10:20:23+00:00","og_image":[{"url":"https:\/\/urbancare.clinic\/wp-content\/uploads\/2023\/09\/us-surgeons-report-longest-successful-pig-to-human-kidney-transplant.jpg","type":"","width":"","height":""}],"author":"Urban Care Clinic","twitter_card":"summary_large_image","twitter_image":"https:\/\/urbancare.clinic\/wp-content\/uploads\/2023\/09\/us-surgeons-report-longest-successful-pig-to-human-kidney-transplant.jpg","twitter_misc":{"\u00c9crit par":"Urban Care Clinic","Dur\u00e9e de lecture 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