{"id":8496,"date":"2023-07-18T10:56:23","date_gmt":"2023-07-18T07:56:23","guid":{"rendered":"https:\/\/urbancare.clinic\/a-step-closer-to-an-anti-aging-pill-harvard-researchers-find-age-reversing-chemical-cocktails\/"},"modified":"2023-07-18T10:56:23","modified_gmt":"2023-07-18T07:56:23","slug":"un-pas-de-plus-vers-une-pilule-anti-age-des-chercheurs-de-harvard-decouvrent-des-cocktails-chimiques-anti-age","status":"publish","type":"post","link":"https:\/\/urbancare.clinic\/fr\/un-pas-de-plus-vers-une-pilule-anti-age-des-chercheurs-de-harvard-decouvrent-des-cocktails-chimiques-anti-age\/","title":{"rendered":"Un pas de plus vers une pilule anti-\u00e2ge\u00a0? Des chercheurs de Harvard d\u00e9couvrent des cocktails chimiques anti-\u00e2ge"},"content":{"rendered":"
<\/div>\n

Les scientifiques se sont lanc\u00e9s dans une course pour trouver une pilule \u00ab\u00a0fontaine de jouvence\u00a0\u00bb susceptible d\u2019augmenter la long\u00e9vit\u00e9 ou d\u2019inverser le vieillissement. Sommes-nous d\u00e9j\u00e0 l\u00e0? On dirait que nous sommes un pas de plus vers l\u2019\u00e9lixir de vie toujours insaisissable.<\/p>\n

Dans ce qui pourrait \u00eatre une d\u00e9couverte r\u00e9volutionnaire, un groupe de chercheurs de Harvard a identifi\u00e9 six cocktails chimiques qui, selon eux, peuvent inverser le processus de vieillissement des cellules cutan\u00e9es humaines et de souris.<\/p>\n

\u00ab Nous sommes reconnaissants de partager notre derni\u00e8re publication : nous avons d\u00e9j\u00e0 montr\u00e9 que l'inversion de l'\u00e2ge est possible en utilisant la th\u00e9rapie g\u00e9nique pour activer les g\u00e8nes embryonnaires. Nous montrons maintenant que c'est possible avec des cocktails chimiques, une \u00e9tape vers un rajeunissement abordable du corps entier \u00bb, a tweet\u00e9 le Dr David Sinclair, biologiste mol\u00e9culaire \u00e0 la Harvard Medical School et co-auteur de l'\u00e9tude.<\/p>\n

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\n
\n
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Nous sommes reconnaissants de partager notre derni\u00e8re publication\u00a0: Nous avons d\u00e9j\u00e0 montr\u00e9 que l'inversion de l'\u00e2ge est possible en utilisant la th\u00e9rapie g\u00e9nique pour activer les g\u00e8nes embryonnaires. Nous montrons maintenant que c'est possible avec les cocktails chimiques, une \u00e9tape vers un rajeunissement complet du corps \u00e0 un prix abordable 1\/17 https:\/\/t.co\/J9c01lv5FQ<\/a><\/p>\n

\u2013 David Sinclair (@davidasinclair) 12 juillet 2023<\/a><\/p><\/blockquote>\n<\/div>\n<\/div>\n<\/figure>\n

\u00ab Nous identifions six cocktails chimiques qui, en moins d\u2019une semaine et sans compromettre l\u2019identit\u00e9 cellulaire, restaurent un profil de transcription jeune \u00e0 l\u2019\u00e9chelle du g\u00e9nome et inversent l\u2019\u00e2ge transcriptomique. Ainsi, le rajeunissement par inversion de l\u2019\u00e2ge peut \u00eatre obtenu non seulement par des moyens g\u00e9n\u00e9tiques, mais \u00e9galement chimiques \u00bb, ont \u00e9crit les chercheurs dans l\u2019\u00e9tude publi\u00e9e dans la revue Aging.<\/p>\n

L'\u00e9tude a \u00e9valu\u00e9 l'impact d'un pr\u00e9paration de drogue<\/a> qui contient l'hormone de croissance metformine et un m\u00e9dicament qui active la prot\u00e9ine kinase activ\u00e9e par une enzyme (AMPK) dans le rajeunissement des muscles \u00e2g\u00e9s, des tissus h\u00e9patiques et d'autres organes.<\/p>\n

"Des \u00e9tudes sur le nerf optique, les tissus c\u00e9r\u00e9braux, les reins et les muscles ont montr\u00e9 des r\u00e9sultats prometteurs, avec une vision am\u00e9lior\u00e9e et une dur\u00e9e de vie prolong\u00e9e chez la souris et, r\u00e9cemment, en avril de cette ann\u00e9e, une vision am\u00e9lior\u00e9e chez les singes", a d\u00e9clar\u00e9 le Dr Sinclair. a dit<\/a>.<\/p>\n

L\u2019\u00e9quipe a affirm\u00e9 avoir trouv\u00e9 des effets anti-\u00e2ge avec les six combinaisons. L\u2019impact d\u2019un traitement de quatre jours utilisant ces cocktails \u00e9tait comparable au changement total observ\u00e9 apr\u00e8s un an de traitement r\u00e9g\u00e9n\u00e9rateur dans une \u00e9tude historique de 2019.<\/p>\n

"Cette nouvelle d\u00e9couverte offre la possibilit\u00e9 d'inverser le vieillissement avec une seule pilule, avec des applications allant de l'am\u00e9lioration de la vue au traitement efficace des maladies li\u00e9es \u00e0 l'\u00e2ge", a ajout\u00e9 le Dr Sinclair.<\/p>\n

Cependant, certains chercheurs accueillent ces r\u00e9sultats avec une pointe de scepticisme. Matt Kaeberlein, biog\u00e9rontologue, a d\u00e9clar\u00e9 Terre<\/a> qu'il ne s'agit que d'une \u00e9tude pr\u00e9liminaire et que les chercheurs devraient valider au moins une des concoctions dans un mod\u00e8le animal pour son efficacit\u00e9 sur les param\u00e8tres de sant\u00e9 li\u00e9s \u00e0 l'\u00e2ge ou \u00e0 la dur\u00e9e de vie.<\/p>\n

Le Dr Charles Brenner, chercheur en m\u00e9tabolisme, a exprim\u00e9 ses inqui\u00e9tudes quant \u00e0 la s\u00e9curit\u00e9 des m\u00e9dicaments utilis\u00e9s dans les cocktails. "Ceux-ci ne sont g\u00e9n\u00e9ralement pas s\u00fbrs seuls ou en combinaison", a d\u00e9clar\u00e9 Brenner.<\/p>\n

Publi\u00e9 par Medicaldaily.com<\/p>\n

Source quotidienne m\u00e9dicale<\/a><\/p>\n

","protected":false},"excerpt":{"rendered":"

<\/div>\n

Les scientifiques se sont lanc\u00e9s dans une course pour trouver une pilule \u00ab\u00a0fontaine de jouvence\u00a0\u00bb susceptible d\u2019augmenter la long\u00e9vit\u00e9 ou d\u2019inverser le vieillissement. Sommes-nous d\u00e9j\u00e0 l\u00e0? On dirait que nous sommes un pas de plus vers l\u2019\u00e9lixir de vie toujours insaisissable.<\/p>\n

Dans ce qui pourrait \u00eatre une d\u00e9couverte r\u00e9volutionnaire, un groupe de chercheurs de Harvard a identifi\u00e9 six cocktails chimiques qui, selon eux, peuvent inverser le processus de vieillissement des cellules cutan\u00e9es humaines et de souris.<\/p>\n

\u00ab Nous sommes reconnaissants de partager notre derni\u00e8re publication : nous avons d\u00e9j\u00e0 montr\u00e9 que l'inversion de l'\u00e2ge est possible en utilisant la th\u00e9rapie g\u00e9nique pour activer les g\u00e8nes embryonnaires. Nous montrons maintenant que c'est possible avec des cocktails chimiques, une \u00e9tape vers un rajeunissement abordable du corps entier \u00bb, a tweet\u00e9 le Dr David Sinclair, biologiste mol\u00e9culaire \u00e0 la Harvard Medical School et co-auteur de l'\u00e9tude.<\/p>\n

\n
\n
\n
\n

Nous sommes reconnaissants de partager notre derni\u00e8re publication\u00a0: Nous avons d\u00e9j\u00e0 montr\u00e9 que l'inversion de l'\u00e2ge est possible en utilisant la th\u00e9rapie g\u00e9nique pour activer les g\u00e8nes embryonnaires. Nous montrons maintenant que c'est possible avec les cocktails chimiques, une \u00e9tape vers un rajeunissement complet du corps \u00e0 un prix abordable 1\/17 https:\/\/t.co\/J9c01lv5FQ<\/a><\/p>\n

\u2013 David Sinclair (@davidasinclair) 12 juillet 2023<\/a><\/p><\/blockquote>\n<\/div>\n<\/div>\n<\/figure>\n

\u00ab Nous identifions six cocktails chimiques qui, en moins d\u2019une semaine et sans compromettre l\u2019identit\u00e9 cellulaire, restaurent un profil de transcription jeune \u00e0 l\u2019\u00e9chelle du g\u00e9nome et inversent l\u2019\u00e2ge transcriptomique. Ainsi, le rajeunissement par inversion de l\u2019\u00e2ge peut \u00eatre obtenu non seulement par des moyens g\u00e9n\u00e9tiques, mais \u00e9galement chimiques \u00bb, ont \u00e9crit les chercheurs dans l\u2019\u00e9tude publi\u00e9e dans la revue Aging.<\/p>\n

L'\u00e9tude a \u00e9valu\u00e9 l'impact d'un pr\u00e9paration de drogue<\/a> qui contient l'hormone de croissance metformine et un m\u00e9dicament qui active la prot\u00e9ine kinase activ\u00e9e par une enzyme (AMPK) dans le rajeunissement des muscles \u00e2g\u00e9s, des tissus h\u00e9patiques et d'autres organes.<\/p>\n

"Des \u00e9tudes sur le nerf optique, les tissus c\u00e9r\u00e9braux, les reins et les muscles ont montr\u00e9 des r\u00e9sultats prometteurs, avec une vision am\u00e9lior\u00e9e et une dur\u00e9e de vie prolong\u00e9e chez la souris et, r\u00e9cemment, en avril de cette ann\u00e9e, une vision am\u00e9lior\u00e9e chez les singes", a d\u00e9clar\u00e9 le Dr Sinclair. a dit<\/a>.<\/p>\n

L\u2019\u00e9quipe a affirm\u00e9 avoir trouv\u00e9 des effets anti-\u00e2ge avec les six combinaisons. L\u2019impact d\u2019un traitement de quatre jours utilisant ces cocktails \u00e9tait comparable au changement total observ\u00e9 apr\u00e8s un an de traitement r\u00e9g\u00e9n\u00e9rateur dans une \u00e9tude historique de 2019.<\/p>\n

"Cette nouvelle d\u00e9couverte offre la possibilit\u00e9 d'inverser le vieillissement avec une seule pilule, avec des applications allant de l'am\u00e9lioration de la vue au traitement efficace des maladies li\u00e9es \u00e0 l'\u00e2ge", a ajout\u00e9 le Dr Sinclair.<\/p>\n

Cependant, certains chercheurs accueillent ces r\u00e9sultats avec une pointe de scepticisme. Matt Kaeberlein, biog\u00e9rontologue, a d\u00e9clar\u00e9 Terre<\/a> qu'il ne s'agit que d'une \u00e9tude pr\u00e9liminaire et que les chercheurs devraient valider au moins une des concoctions dans un mod\u00e8le animal pour son efficacit\u00e9 sur les param\u00e8tres de sant\u00e9 li\u00e9s \u00e0 l'\u00e2ge ou \u00e0 la dur\u00e9e de vie.<\/p>\n

Le Dr Charles Brenner, chercheur en m\u00e9tabolisme, a exprim\u00e9 ses inqui\u00e9tudes quant \u00e0 la s\u00e9curit\u00e9 des m\u00e9dicaments utilis\u00e9s dans les cocktails. "Ceux-ci ne sont g\u00e9n\u00e9ralement pas s\u00fbrs seuls ou en combinaison", a d\u00e9clar\u00e9 Brenner.<\/p>\n

Publi\u00e9 par Medicaldaily.com<\/p>","protected":false},"author":2,"featured_media":8497,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"Default","format":"standard","meta":{"fifu_image_url":"https:\/\/urbancare.clinic\/wp-content\/uploads\/2023\/07\/a-step-closer-to-an-anti-aging-pill-harvard-researchers-find-age-reversing-chemical-cocktails.jpg","fifu_image_alt":"","footnotes":""},"categories":[27],"tags":[],"class_list":["post-8496","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blog"],"yoast_head":"\nA Step Closer To An Anti-Aging Pill? Harvard Researchers Find Age-Reversing Chemical Cocktails - Urban Care Clinic<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/urbancare.clinic\/fr\/un-pas-de-plus-vers-une-pilule-anti-age-des-chercheurs-de-harvard-decouvrent-des-cocktails-chimiques-anti-age\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"A Step Closer To An Anti-Aging Pill? Harvard Researchers Find Age-Reversing Chemical Cocktails - Urban Care Clinic\" \/>\n<meta property=\"og:description\" content=\"Scientists have been in a race to find a "fountain of youth" pill that has the potential to increase longevity or reverse aging. Are we there yet? Looks like we are a step closer to the ever-elusive elixir of life.In what could be a groundbreaking discovery, a group of researchers from Harvard has identified six chemical cocktails that they say can reverse the aging process in both human and mouse skin cells."Grateful to share our latest publication: We've previously shown age reversal is possible using gene therapy to turn on embryonic genes. Now we show it's possible with chemical cocktails, a step towards affordable whole-body rejuvenation," tweeted Dr. David Sinclair, a molecular biologist at Harvard Medical School and co-author of the study.Grateful to share our latest publication: We\u2019ve previously shown age reversal is possible using gene therapy to turn on embryonic genes. Now we show it\u2019s possible with chemical cocktails, a step towards affordable whole-body rejuvenation 1\/17 https:\/\/t.co\/J9c01lv5FQ\u2014 David Sinclair (@davidasinclair) July 12, 2023 "We identify six chemical cocktails, which, in less than a week and without compromising cellular identity, restore a youthful genome-wide transcript profile and reverse transcriptomic age. Thus, rejuvenation by age reversal can be achieved, not only by genetic, but also chemical means, " the researchers wrote in the study published in the journal Aging.The study evaluated the impact of a drug concoction that contains the growth hormone metformin and a drug that activates the enzyme-activated protein kinase (AMPK) in the rejuvenation of aged muscles, liver tissue and other organs."Studies on the optic nerve, brain tissue, kidney and muscle have shown promising results, with improved vision and extended lifespan in mice and, recently, in April of this year, improved vision in monkeys," Dr. Sinclair said.The team claimed they found age-reversing effects with all six combinations. The impact of a four-day treatment using the cocktails was comparable to the total change seen after a year of a regenerative treatment in a landmark study from 2019."This new discovery offers the potential to reverse aging with a single pill, with applications ranging from improving eyesight to effectively treating age-related diseases," Dr. Sinclair added.However, some researchers receive the findings with a pinch of skepticism. Matt Kaeberlein, a biogerontologist, told Earth that it is just a preliminary study and the researchers should validate at least one of the concoctions in an animal model for its effectiveness in age-related health metrics or lifespan.Dr. Charles Brenner, a metabolism researcher, raised concerns about the safety of the drugs used in the cocktails. "These are generally not safe alone or in a combination," Brenner said.Published by Medicaldaily.com\" \/>\n<meta property=\"og:url\" content=\"https:\/\/urbancare.clinic\/fr\/un-pas-de-plus-vers-une-pilule-anti-age-des-chercheurs-de-harvard-decouvrent-des-cocktails-chimiques-anti-age\/\" \/>\n<meta property=\"og:site_name\" content=\"Urban Care Clinic\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/urbancarezanzibar\" \/>\n<meta property=\"article:published_time\" content=\"2023-07-18T07:56:23+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/urbancare.clinic\/wp-content\/uploads\/2023\/07\/a-step-closer-to-an-anti-aging-pill-harvard-researchers-find-age-reversing-chemical-cocktails.jpg\" \/>\n<meta name=\"author\" content=\"Urban Care Clinic\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:image\" content=\"https:\/\/urbancare.clinic\/wp-content\/uploads\/2023\/07\/a-step-closer-to-an-anti-aging-pill-harvard-researchers-find-age-reversing-chemical-cocktails.jpg\" \/>\n<meta name=\"twitter:label1\" content=\"\u00c9crit par\" \/>\n\t<meta name=\"twitter:data1\" content=\"Urban Care Clinic\" \/>\n\t<meta name=\"twitter:label2\" content=\"Dur\u00e9e de lecture estim\u00e9e\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/urbancare.clinic\/a-step-closer-to-an-anti-aging-pill-harvard-researchers-find-age-reversing-chemical-cocktails\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/urbancare.clinic\/a-step-closer-to-an-anti-aging-pill-harvard-researchers-find-age-reversing-chemical-cocktails\/\"},\"author\":{\"name\":\"Urban Care Clinic\",\"@id\":\"https:\/\/urbancare.clinic\/#\/schema\/person\/f286c4d84be896d302aceda3ed7e789c\"},\"headline\":\"A Step Closer To An Anti-Aging Pill? 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Des chercheurs de Harvard d\u00e9couvrent des cocktails chimiques anti-\u00e2ge - Urban Care Clinic","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/urbancare.clinic\/fr\/un-pas-de-plus-vers-une-pilule-anti-age-des-chercheurs-de-harvard-decouvrent-des-cocktails-chimiques-anti-age\/","og_locale":"fr_FR","og_type":"article","og_title":"A Step Closer To An Anti-Aging Pill? Harvard Researchers Find Age-Reversing Chemical Cocktails - Urban Care Clinic","og_description":"Scientists have been in a race to find a \"fountain of youth\" pill that has the potential to increase longevity or reverse aging. Are we there yet? Looks like we are a step closer to the ever-elusive elixir of life.In what could be a groundbreaking discovery, a group of researchers from Harvard has identified six chemical cocktails that they say can reverse the aging process in both human and mouse skin cells.\"Grateful to share our latest publication: We've previously shown age reversal is possible using gene therapy to turn on embryonic genes. Now we show it's possible with chemical cocktails, a step towards affordable whole-body rejuvenation,\" tweeted Dr. David Sinclair, a molecular biologist at Harvard Medical School and co-author of the study.Grateful to share our latest publication: We\u2019ve previously shown age reversal is possible using gene therapy to turn on embryonic genes. Now we show it\u2019s possible with chemical cocktails, a step towards affordable whole-body rejuvenation 1\/17 https:\/\/t.co\/J9c01lv5FQ\u2014 David Sinclair (@davidasinclair) July 12, 2023 \"We identify six chemical cocktails, which, in less than a week and without compromising cellular identity, restore a youthful genome-wide transcript profile and reverse transcriptomic age. Thus, rejuvenation by age reversal can be achieved, not only by genetic, but also chemical means, \" the researchers wrote in the study published in the journal Aging.The study evaluated the impact of a drug concoction that contains the growth hormone metformin and a drug that activates the enzyme-activated protein kinase (AMPK) in the rejuvenation of aged muscles, liver tissue and other organs.\"Studies on the optic nerve, brain tissue, kidney and muscle have shown promising results, with improved vision and extended lifespan in mice and, recently, in April of this year, improved vision in monkeys,\" Dr. Sinclair said.The team claimed they found age-reversing effects with all six combinations. The impact of a four-day treatment using the cocktails was comparable to the total change seen after a year of a regenerative treatment in a landmark study from 2019.\"This new discovery offers the potential to reverse aging with a single pill, with applications ranging from improving eyesight to effectively treating age-related diseases,\" Dr. Sinclair added.However, some researchers receive the findings with a pinch of skepticism. Matt Kaeberlein, a biogerontologist, told Earth that it is just a preliminary study and the researchers should validate at least one of the concoctions in an animal model for its effectiveness in age-related health metrics or lifespan.Dr. Charles Brenner, a metabolism researcher, raised concerns about the safety of the drugs used in the cocktails. \"These are generally not safe alone or in a combination,\" Brenner said.Published by Medicaldaily.com","og_url":"https:\/\/urbancare.clinic\/fr\/un-pas-de-plus-vers-une-pilule-anti-age-des-chercheurs-de-harvard-decouvrent-des-cocktails-chimiques-anti-age\/","og_site_name":"Urban Care Clinic","article_publisher":"https:\/\/www.facebook.com\/urbancarezanzibar","article_published_time":"2023-07-18T07:56:23+00:00","og_image":[{"url":"https:\/\/urbancare.clinic\/wp-content\/uploads\/2023\/07\/a-step-closer-to-an-anti-aging-pill-harvard-researchers-find-age-reversing-chemical-cocktails.jpg","type":"","width":"","height":""}],"author":"Urban Care Clinic","twitter_card":"summary_large_image","twitter_image":"https:\/\/urbancare.clinic\/wp-content\/uploads\/2023\/07\/a-step-closer-to-an-anti-aging-pill-harvard-researchers-find-age-reversing-chemical-cocktails.jpg","twitter_misc":{"\u00c9crit par":"Urban Care Clinic","Dur\u00e9e de lecture estim\u00e9e":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/urbancare.clinic\/a-step-closer-to-an-anti-aging-pill-harvard-researchers-find-age-reversing-chemical-cocktails\/#article","isPartOf":{"@id":"https:\/\/urbancare.clinic\/a-step-closer-to-an-anti-aging-pill-harvard-researchers-find-age-reversing-chemical-cocktails\/"},"author":{"name":"Urban Care Clinic","@id":"https:\/\/urbancare.clinic\/#\/schema\/person\/f286c4d84be896d302aceda3ed7e789c"},"headline":"A Step Closer To An Anti-Aging Pill? Harvard Researchers Find Age-Reversing Chemical Cocktails","datePublished":"2023-07-18T07:56:23+00:00","mainEntityOfPage":{"@id":"https:\/\/urbancare.clinic\/a-step-closer-to-an-anti-aging-pill-harvard-researchers-find-age-reversing-chemical-cocktails\/"},"wordCount":463,"publisher":{"@id":"https:\/\/urbancare.clinic\/#organization"},"image":{"@id":"https:\/\/urbancare.clinic\/a-step-closer-to-an-anti-aging-pill-harvard-researchers-find-age-reversing-chemical-cocktails\/#primaryimage"},"thumbnailUrl":"https:\/\/urbancare.clinic\/wp-content\/uploads\/2023\/07\/a-step-closer-to-an-anti-aging-pill-harvard-researchers-find-age-reversing-chemical-cocktails.jpg","articleSection":["Medical Daily"],"inLanguage":"fr-FR"},{"@type":"WebPage","@id":"https:\/\/urbancare.clinic\/a-step-closer-to-an-anti-aging-pill-harvard-researchers-find-age-reversing-chemical-cocktails\/","url":"https:\/\/urbancare.clinic\/a-step-closer-to-an-anti-aging-pill-harvard-researchers-find-age-reversing-chemical-cocktails\/","name":"Un pas de plus vers une pilule anti-\u00e2ge ? 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