{"id":8319,"date":"2023-06-13T10:02:48","date_gmt":"2023-06-13T07:02:48","guid":{"rendered":"https:\/\/urbancare.clinic\/why-is-weight-loss-hard-for-obese-people-study-explains-reason\/"},"modified":"2023-06-13T10:02:48","modified_gmt":"2023-06-13T07:02:48","slug":"pourquoi-la-perte-de-poids-est-elle-difficile-pour-les-personnes-obeses-une-etude-explique-la-raison","status":"publish","type":"post","link":"https:\/\/urbancare.clinic\/fr\/pourquoi-la-perte-de-poids-est-elle-difficile-pour-les-personnes-obeses-une-etude-explique-la-raison\/","title":{"rendered":"Pourquoi la perte de poids est-elle difficile pour les personnes ob\u00e8ses ? Une \u00e9tude explique la raison"},"content":{"rendered":"<p>Perdre du poids et maintenir la perte de poids est toujours difficile pour les personnes ob\u00e8ses. Une \u00e9tude r\u00e9cente a expliqu\u00e9 comment les r\u00e9ponses c\u00e9r\u00e9brales des personnes en surpoids fonctionnent diff\u00e9remment en r\u00e9ponse au sucre et aux graisses, ce qui rend la perte de poids difficile.<\/p>\n<p>Les conclusions de la <a rel=\"noopener nofollow\" href=\"https:\/\/www.nature.com\/articles\/s42255-023-00816-9.epdf?sharing_token=liw89VwU9-jQHHBr5eY9tdRgN0jAjWel9jnR3ZoTv0M1SadTImevZtbaTQ0zrz0bHR-l_kFBGfPLzIqJZudrjrKDKf6W2s8_vtlPvT25PJ1GUdNaWTyzHUYEj_xeSrWlRPRB5lJs5_PoIBcO9HB7Wy1q3RBBF2ybRmkW-e-FGzVOPpT1iagk6opfit7llTVf0e7hc2oitOk5Se2ZWbaK072zNf6O_KJuk9jHw4Ix_Fg%3D&amp;tracking_referrer=www.usnews.com\" target=\"_blank\">\u00e9tude<\/a>, publi\u00e9 dans la revue Nature Metabolism, a expliqu\u00e9 comment l&#039;ob\u00e9sit\u00e9 faisait perdre l&#039;alignement du cerveau avec ce qui se passait dans l&#039;intestin.<\/p>\n<p>\u00ab Notre interpr\u00e9tation est qu&#039;il y a une d\u00e9tection des nutriments g\u00e9n\u00e9ralement r\u00e9duite chez les personnes ob\u00e8ses. Cela pourrait aider \u00e0 expliquer pourquoi la perte de poids et le maintien de la perte de poids sont si difficiles \u00bb, a d\u00e9clar\u00e9 la chercheuse principale, la Dre Mireille Serlie. <a rel=\"noopener nofollow\" href=\"https:\/\/www.usnews.com\/news\/health-news\/articles\/2023-06-12\/obesity-might-permanently-blunt-brains-responses-to-sugary-fatty-foods\" target=\"_blank\">a dit<\/a>.<\/p>\n<p>L&#039;\u00e9tude a \u00e9valu\u00e9 30 adultes ayant un poids corporel sain et 30 ob\u00e8ses. Les r\u00e9ponses c\u00e9r\u00e9brales des participants au sucre et aux graisses ont \u00e9t\u00e9 captur\u00e9es apr\u00e8s que les nutriments aient \u00e9t\u00e9 livr\u00e9s directement dans l&#039;intestin.<\/p>\n<p>Les participants maigres ont montr\u00e9 des sch\u00e9mas sp\u00e9cifiques d&#039;activit\u00e9 c\u00e9r\u00e9brale lorsque les nutriments ont \u00e9t\u00e9 d\u00e9livr\u00e9s, alors que ceux-ci \u00e9taient &quot;gravement alt\u00e9r\u00e9s&quot; chez les personnes ob\u00e8ses. Les participants en surpoids avaient \u00e9galement une moindre lib\u00e9ration de dopamine par le striatum du cerveau responsable de la r\u00e9gulation des habitudes alimentaires.<\/p>\n<p>M\u00eame apr\u00e8s avoir perdu 10% de leur poids avec un r\u00e9gime hypocalorique pendant trois mois, les r\u00e9ponses c\u00e9r\u00e9brales des participants ob\u00e8ses ne se sont pas invers\u00e9es.<\/p>\n<p>Les chercheurs pensent que la signalisation nutritive alt\u00e9r\u00e9e n&#039;est pas permanente et peut \u00eatre r\u00e9cup\u00e9r\u00e9e avec plus de temps et une perte de poids soutenue.<\/p>\n<p>Des exp\u00e9riences ant\u00e9rieures sur des animaux de laboratoire ont indiqu\u00e9 la <a rel=\"nofollow\" href=\"https:\/\/www.medicaldaily.com\/why-does-stress-make-us-crave-comfort-food-tips-prevent-emotional-eating-470084\">cerveau<\/a> ont r\u00e9pondu \u00e0 la pr\u00e9sence de nutriments dans l&#039;intestin m\u00eame sans l&#039;exp\u00e9rience sensorielle de manger.<\/p>\n<p>&quot;Le bond en avant dans cette \u00e9tude est qu&#039;ils montrent que cela se produit \u00e9galement chez les humains, mais la r\u00e9ponse est compl\u00e8tement \u00e9mouss\u00e9e chez les personnes ob\u00e8ses&quot;, a d\u00e9clar\u00e9 Alexandra DiFeliceantonio, co-auteur de l&#039;\u00e9tude.<\/p>\n<p>La signalisation des nutriments entre l&#039;intestin et le cerveau aide les gens \u00e0 choisir ce qu&#039;ils mangent, mais la signalisation est \u00ab bris\u00e9e d&#039;une certaine mani\u00e8re \u00bb en raison de l&#039;ob\u00e9sit\u00e9, a ajout\u00e9 DiFeliceantonio.<\/p>\n<p>Pendant ce temps, les chercheurs n&#039;ont pas pu d\u00e9terminer exactement quand la signalisation devient alt\u00e9r\u00e9e ni comment.<\/p>\n<p>Selon l&#039;\u00e9tude, le secret d&#039;une perte de poids durable ne r\u00e9side pas toujours dans la \u00ab\u00a0volont\u00e9\u00a0\u00bb de poursuivre le r\u00e9gime, car les personnes ob\u00e8ses luttent constamment non seulement contre les tentations de la malbouffe bon march\u00e9 et facilement disponible, mais aussi contre un \u00ab\u00a0cerveau affam\u00e9\u00a0\u00bb qui rend les changements de r\u00e9gime et la perte de poids difficiles.<\/p>\n<p>\u00abJe pense que les gens sont bl\u00e2m\u00e9s. Ce n&#039;est pas une question de volont\u00e9. C&#039;est un vrai combat. Et nous commen\u00e7ons \u00e0 comprendre pourquoi les gens luttent \u00bb, a d\u00e9clar\u00e9 Serlie.<\/p>\n<p>Cependant, gr\u00e2ce \u00e0 l&#039;alimentation, aux changements de mode de vie et aux m\u00e9dicaments, les chercheurs esp\u00e8rent trouver un moyen de corriger la signalisation des nutriments \u00e0 l&#039;avenir.<\/p>\n<figure class=\"imageBox\">\n<div class=\"innerBox\"><picture class=\"mapping-embed\" width=\"736\" height=\"552\"><source type=\"image\/webp\" media=\"(min-width: 1100px)\" sizes=\"736px\" srcset=\"https:\/\/d.medicaldaily.com\/en\/full\/445610\/burger.webp?w=736&amp;f=990f4970890e24283f85ffb6eb2bfb48 736w\"><source type=\"image\/jpeg\" media=\"(min-width: 1100px)\" sizes=\"736px\" srcset=\"https:\/\/urbancare.clinic\/wp-content\/uploads\/2023\/06\/why-is-weight-loss-hard-for-obese-people-study-explains-reason.jpg 736w\"><source type=\"image\/webp\" media=\"(min-width: 768px)\" sizes=\"1000px\" srcset=\"https:\/\/d.medicaldaily.com\/en\/full\/445610\/burger.webp?w=1100&amp;f=d0344a1848f73f5887983c12133460d2 1100w\"><source type=\"image\/jpeg\" media=\"(min-width: 768px)\" sizes=\"1000px\" srcset=\"https:\/\/d.medicaldaily.com\/en\/full\/445610\/burger.jpg?w=1100&amp;f=d0344a1848f73f5887983c12133460d2 1100w\"><source type=\"image\/webp\" media=\"(min-width: 480px)\" sizes=\"736px\" srcset=\"https:\/\/d.medicaldaily.com\/en\/full\/445610\/burger.webp?w=736&amp;f=990f4970890e24283f85ffb6eb2bfb48 736w\"><source type=\"image\/jpeg\" media=\"(min-width: 480px)\" sizes=\"736px\" srcset=\"https:\/\/urbancare.clinic\/wp-content\/uploads\/2023\/06\/why-is-weight-loss-hard-for-obese-people-study-explains-reason.jpg 736w\"><source type=\"image\/webp\" media=\"(min-width: 0px)\" sizes=\"480px\" srcset=\"https:\/\/d.medicaldaily.com\/en\/full\/445610\/burger.webp?w=480&amp;f=2fdd49a08c05dcdaae5a4b7e8e4e04d3 480w\"><source type=\"image\/jpeg\" media=\"(min-width: 0px)\" sizes=\"480px\" srcset=\"https:\/\/d.medicaldaily.com\/en\/full\/445610\/burger.jpg?w=480&amp;f=2fdd49a08c05dcdaae5a4b7e8e4e04d3 480w\"><source type=\"image\/webp\" srcset=\"https:\/\/d.medicaldaily.com\/en\/full\/445610\/burger.webp?w=736&amp;f=990f4970890e24283f85ffb6eb2bfb48\"><img loading=\"lazy\" decoding=\"async\" class=\"mapping-embed imgPhoto\" id=\"i445610\" src=\"https:\/\/urbancare.clinic\/wp-content\/uploads\/2023\/06\/why-is-weight-loss-hard-for-obese-people-study-explains-reason.jpg\" alt=\"burger\" width=\"736\" height=\"552\" style=\"display:none\"><\/picture><\/div><figcaption class=\"caption\">\n<span class=\"cap\">Une \u00e9tude r\u00e9cente explique comment les r\u00e9ponses c\u00e9r\u00e9brales des personnes en surpoids fonctionnent diff\u00e9remment en r\u00e9ponse au sucre et aux graisses, ce qui rend la perte de poids difficile.<\/span><br \/>\n<span class=\"credit\">Pixabay<\/span><br \/>\n<\/figcaption><\/figure>\n<p>Publi\u00e9 par Medicaldaily.com<\/p>\n<p><a href=\"https:\/\/www.medicaldaily.com\/why-weight-loss-hard-obese-people-study-explains-reason-470091\">Source quotidienne m\u00e9dicale<\/a><\/p>\n<p>","protected":false},"excerpt":{"rendered":"<p>Perdre du poids et maintenir la perte de poids est toujours difficile pour les personnes ob\u00e8ses. Une \u00e9tude r\u00e9cente a expliqu\u00e9 comment les r\u00e9ponses c\u00e9r\u00e9brales des personnes en surpoids fonctionnent diff\u00e9remment en r\u00e9ponse au sucre et aux graisses, ce qui rend la perte de poids difficile.<\/p>\n<p>Les conclusions de la <a rel=\"noopener nofollow\" href=\"https:\/\/www.nature.com\/articles\/s42255-023-00816-9.epdf?sharing_token=liw89VwU9-jQHHBr5eY9tdRgN0jAjWel9jnR3ZoTv0M1SadTImevZtbaTQ0zrz0bHR-l_kFBGfPLzIqJZudrjrKDKf6W2s8_vtlPvT25PJ1GUdNaWTyzHUYEj_xeSrWlRPRB5lJs5_PoIBcO9HB7Wy1q3RBBF2ybRmkW-e-FGzVOPpT1iagk6opfit7llTVf0e7hc2oitOk5Se2ZWbaK072zNf6O_KJuk9jHw4Ix_Fg%3D&amp;tracking_referrer=www.usnews.com\" target=\"_blank\">\u00e9tude<\/a>, publi\u00e9 dans la revue Nature Metabolism, a expliqu\u00e9 comment l&#039;ob\u00e9sit\u00e9 faisait perdre l&#039;alignement du cerveau avec ce qui se passait dans l&#039;intestin.<\/p>\n<p>\u00ab Notre interpr\u00e9tation est qu&#039;il y a une d\u00e9tection des nutriments g\u00e9n\u00e9ralement r\u00e9duite chez les personnes ob\u00e8ses. Cela pourrait aider \u00e0 expliquer pourquoi la perte de poids et le maintien de la perte de poids sont si difficiles \u00bb, a d\u00e9clar\u00e9 la chercheuse principale, la Dre Mireille Serlie. <a rel=\"noopener nofollow\" href=\"https:\/\/www.usnews.com\/news\/health-news\/articles\/2023-06-12\/obesity-might-permanently-blunt-brains-responses-to-sugary-fatty-foods\" target=\"_blank\">a dit<\/a>.<\/p>\n<p>L&#039;\u00e9tude a \u00e9valu\u00e9 30 adultes ayant un poids corporel sain et 30 ob\u00e8ses. Les r\u00e9ponses c\u00e9r\u00e9brales des participants au sucre et aux graisses ont \u00e9t\u00e9 captur\u00e9es apr\u00e8s que les nutriments aient \u00e9t\u00e9 livr\u00e9s directement dans l&#039;intestin.<\/p>\n<p>Les participants maigres ont montr\u00e9 des sch\u00e9mas sp\u00e9cifiques d&#039;activit\u00e9 c\u00e9r\u00e9brale lorsque les nutriments ont \u00e9t\u00e9 d\u00e9livr\u00e9s, alors que ceux-ci \u00e9taient &quot;gravement alt\u00e9r\u00e9s&quot; chez les personnes ob\u00e8ses. Les participants en surpoids avaient \u00e9galement une moindre lib\u00e9ration de dopamine par le striatum du cerveau responsable de la r\u00e9gulation des habitudes alimentaires.<\/p>\n<p>M\u00eame apr\u00e8s avoir perdu 10% de leur poids avec un r\u00e9gime hypocalorique pendant trois mois, les r\u00e9ponses c\u00e9r\u00e9brales des participants ob\u00e8ses ne se sont pas invers\u00e9es.<\/p>\n<p>Les chercheurs pensent que la signalisation nutritive alt\u00e9r\u00e9e n&#039;est pas permanente et peut \u00eatre r\u00e9cup\u00e9r\u00e9e avec plus de temps et une perte de poids soutenue.<\/p>\n<p>Des exp\u00e9riences ant\u00e9rieures sur des animaux de laboratoire ont indiqu\u00e9 la <a rel=\"nofollow\" href=\"https:\/\/www.medicaldaily.com\/why-does-stress-make-us-crave-comfort-food-tips-prevent-emotional-eating-470084\">cerveau<\/a> ont r\u00e9pondu \u00e0 la pr\u00e9sence de nutriments dans l&#039;intestin m\u00eame sans l&#039;exp\u00e9rience sensorielle de manger.<\/p>\n<p>&quot;Le bond en avant dans cette \u00e9tude est qu&#039;ils montrent que cela se produit \u00e9galement chez les humains, mais la r\u00e9ponse est compl\u00e8tement \u00e9mouss\u00e9e chez les personnes ob\u00e8ses&quot;, a d\u00e9clar\u00e9 Alexandra DiFeliceantonio, co-auteur de l&#039;\u00e9tude.<\/p>\n<p>La signalisation des nutriments entre l&#039;intestin et le cerveau aide les gens \u00e0 choisir ce qu&#039;ils mangent, mais la signalisation est \u00ab bris\u00e9e d&#039;une certaine mani\u00e8re \u00bb en raison de l&#039;ob\u00e9sit\u00e9, a ajout\u00e9 DiFeliceantonio.<\/p>\n<p>Pendant ce temps, les chercheurs n&#039;ont pas pu d\u00e9terminer exactement quand la signalisation devient alt\u00e9r\u00e9e ni comment.<\/p>\n<p>Selon l&#039;\u00e9tude, le secret d&#039;une perte de poids durable ne r\u00e9side pas toujours dans la \u00ab\u00a0volont\u00e9\u00a0\u00bb de poursuivre le r\u00e9gime, car les personnes ob\u00e8ses luttent constamment non seulement contre les tentations de la malbouffe bon march\u00e9 et facilement disponible, mais aussi contre un \u00ab\u00a0cerveau affam\u00e9\u00a0\u00bb qui rend les changements de r\u00e9gime et la perte de poids difficiles.<\/p>\n<p>\u00abJe pense que les gens sont bl\u00e2m\u00e9s. Ce n&#039;est pas une question de volont\u00e9. C&#039;est un vrai combat. Et nous commen\u00e7ons \u00e0 comprendre pourquoi les gens luttent \u00bb, a d\u00e9clar\u00e9 Serlie.<\/p>\n<p>Cependant, gr\u00e2ce \u00e0 l&#039;alimentation, aux changements de mode de vie et aux m\u00e9dicaments, les chercheurs esp\u00e8rent trouver un moyen de corriger la signalisation des nutriments \u00e0 l&#039;avenir.<\/p>\n<figure class=\"imageBox\">\n<div class=\"innerBox\"><img loading=\"lazy\" decoding=\"async\" class=\"mapping-embed imgPhoto\" id=\"i445610\" src=\"https:\/\/urbancare.clinic\/wp-content\/uploads\/2023\/06\/why-is-weight-loss-hard-for-obese-people-study-explains-reason.jpg\" alt=\"burger\" width=\"736\" height=\"552\"><\/div><figcaption class=\"caption\">\n<span class=\"cap\">Une \u00e9tude r\u00e9cente explique comment les r\u00e9ponses c\u00e9r\u00e9brales des personnes en surpoids fonctionnent diff\u00e9remment en r\u00e9ponse au sucre et aux graisses, ce qui rend la perte de poids difficile.<\/span><br \/>\n<span class=\"credit\">Pixabay<\/span><br \/>\n<\/figcaption><\/figure>\n<p>Publi\u00e9 par Medicaldaily.com<\/p>","protected":false},"author":2,"featured_media":8320,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"Default","format":"standard","meta":{"fifu_image_url":"https:\/\/urbancare.clinic\/wp-content\/uploads\/2023\/06\/why-is-weight-loss-hard-for-obese-people-study-explains-reason.jpg","fifu_image_alt":"","footnotes":""},"categories":[27],"tags":[],"class_list":["post-8319","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blog"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.6 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Why Is Weight Loss Hard For Obese People? Study Explains Reason - Urban Care Clinic<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/urbancare.clinic\/fr\/pourquoi-la-perte-de-poids-est-elle-difficile-pour-les-personnes-obeses-une-etude-explique-la-raison\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Why Is Weight Loss Hard For Obese People? Study Explains Reason - Urban Care Clinic\" \/>\n<meta property=\"og:description\" content=\"Losing weight and maintaining weight loss is always difficult for people with obesity. A recent study explained how the brain responses in overweight people function differently in response to sugar and fat, making weight loss a tough journey.The findings of the study, published in the journal Nature Metabolism, explained how obesity caused the brain to lose alignment with what was happening in the gut.&quot;Our interpretation is, there&#039;s a generally reduced nutrient-sensing in people with obesity. It could help explain why weight loss and weight-loss maintenance are so hard,&quot; senior researcher Dr. Mireille Serlie said.The study evaluated 30 adults with a healthy body weight and 30 with obesity. The brain responses of the participants to sugar and fat were captured after the nutrients were delivered directly to the gut.The lean participants showed specific patterns of brain activity when the nutrients were delivered, while these were &quot;severely impaired&quot; in obese people. The participants who were overweight also had a lesser release of dopamine from the striatum of the brain responsible for regulating eating habits.Even after shedding 10% of their weight on a reduced-calorie diet for three months, the brain responses of the obese participants did not reverse.Researchers believe that impaired nutrient signaling is not permanent and can be regained with more time and sustained weight loss.Earlier experiments on lab animals indicated the brain responded to the presence of nutrients in the gut even without the sensory experience of eating.&quot;The leap forward in this study is that they&#039;re showing this is happening in humans, too, but the response is completely blunted in people with obesity,&quot; Alexandra DiFeliceantonio, a co-author of the study, said.The nutrient signaling between the gut and the brain helps people choose what they eat, but the signaling is &quot;broken in some way&quot; due to obesity, DiFeliceantonio added.Meanwhile, the researchers could not determine when exactly the signaling becomes impaired or how.According to the study, the secret to lasting weight loss is not always about the &quot;willpower&quot; to continue the diet, as obese people are constantly fighting not only the temptations of cheap, readily available junk food, but also a &quot;hungry brain&quot; that makes diet changes and weight loss difficult.&quot;I do think people get blamed. This is not about willpower. It&#039;s a real struggle. And we&#039;re starting to understand why people struggle,&quot; Serlie said.However, through diet, lifestyle changes, and medications the researchers hope to find a way to correct the nutrient signaling in the future. A recent study explains how the brain responses in overweight people function differently in response to sugar and fat, making weight loss a tough journey. Pixabay Published by Medicaldaily.com\" \/>\n<meta property=\"og:url\" content=\"https:\/\/urbancare.clinic\/fr\/pourquoi-la-perte-de-poids-est-elle-difficile-pour-les-personnes-obeses-une-etude-explique-la-raison\/\" \/>\n<meta property=\"og:site_name\" content=\"Urban Care Clinic\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/urbancarezanzibar\" \/>\n<meta property=\"article:published_time\" content=\"2023-06-13T07:02:48+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/urbancare.clinic\/wp-content\/uploads\/2023\/06\/why-is-weight-loss-hard-for-obese-people-study-explains-reason.jpg\" \/>\n<meta name=\"author\" content=\"Urban Care Clinic\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:image\" content=\"https:\/\/urbancare.clinic\/wp-content\/uploads\/2023\/06\/why-is-weight-loss-hard-for-obese-people-study-explains-reason.jpg\" \/>\n<meta name=\"twitter:label1\" content=\"\u00c9crit par\" \/>\n\t<meta name=\"twitter:data1\" content=\"Urban Care Clinic\" \/>\n\t<meta name=\"twitter:label2\" content=\"Dur\u00e9e de lecture estim\u00e9e\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/urbancare.clinic\/why-is-weight-loss-hard-for-obese-people-study-explains-reason\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/urbancare.clinic\/why-is-weight-loss-hard-for-obese-people-study-explains-reason\/\"},\"author\":{\"name\":\"Urban Care Clinic\",\"@id\":\"https:\/\/urbancare.clinic\/#\/schema\/person\/f286c4d84be896d302aceda3ed7e789c\"},\"headline\":\"Why Is Weight Loss Hard For Obese People? 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Une \u00e9tude explique la raison - Urban Care Clinic","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/urbancare.clinic\/fr\/pourquoi-la-perte-de-poids-est-elle-difficile-pour-les-personnes-obeses-une-etude-explique-la-raison\/","og_locale":"fr_FR","og_type":"article","og_title":"Why Is Weight Loss Hard For Obese People? Study Explains Reason - Urban Care Clinic","og_description":"Losing weight and maintaining weight loss is always difficult for people with obesity. A recent study explained how the brain responses in overweight people function differently in response to sugar and fat, making weight loss a tough journey.The findings of the study, published in the journal Nature Metabolism, explained how obesity caused the brain to lose alignment with what was happening in the gut.\"Our interpretation is, there's a generally reduced nutrient-sensing in people with obesity. It could help explain why weight loss and weight-loss maintenance are so hard,\" senior researcher Dr. Mireille Serlie said.The study evaluated 30 adults with a healthy body weight and 30 with obesity. The brain responses of the participants to sugar and fat were captured after the nutrients were delivered directly to the gut.The lean participants showed specific patterns of brain activity when the nutrients were delivered, while these were \"severely impaired\" in obese people. The participants who were overweight also had a lesser release of dopamine from the striatum of the brain responsible for regulating eating habits.Even after shedding 10% of their weight on a reduced-calorie diet for three months, the brain responses of the obese participants did not reverse.Researchers believe that impaired nutrient signaling is not permanent and can be regained with more time and sustained weight loss.Earlier experiments on lab animals indicated the brain responded to the presence of nutrients in the gut even without the sensory experience of eating.\"The leap forward in this study is that they're showing this is happening in humans, too, but the response is completely blunted in people with obesity,\" Alexandra DiFeliceantonio, a co-author of the study, said.The nutrient signaling between the gut and the brain helps people choose what they eat, but the signaling is \"broken in some way\" due to obesity, DiFeliceantonio added.Meanwhile, the researchers could not determine when exactly the signaling becomes impaired or how.According to the study, the secret to lasting weight loss is not always about the \"willpower\" to continue the diet, as obese people are constantly fighting not only the temptations of cheap, readily available junk food, but also a \"hungry brain\" that makes diet changes and weight loss difficult.\"I do think people get blamed. This is not about willpower. It's a real struggle. And we're starting to understand why people struggle,\" Serlie said.However, through diet, lifestyle changes, and medications the researchers hope to find a way to correct the nutrient signaling in the future. A recent study explains how the brain responses in overweight people function differently in response to sugar and fat, making weight loss a tough journey. 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