{"id":7937,"date":"2023-04-19T12:38:20","date_gmt":"2023-04-19T09:38:20","guid":{"rendered":"https:\/\/urbancare.clinic\/irregular-sleeping-habits-can-lead-to-potentially-fatal-lung-disease-study\/"},"modified":"2023-05-23T17:33:58","modified_gmt":"2023-05-23T14:33:58","slug":"des-habitudes-de-sommeil-irregulieres-peuvent-conduire-a-une-etude-sur-une-maladie-pulmonaire-potentiellement-mortelle","status":"publish","type":"post","link":"https:\/\/urbancare.clinic\/fr\/irregular-sleeping-habits-can-lead-to-potentially-fatal-lung-disease-study\/","title":{"rendered":"Des habitudes de sommeil irr\u00e9guli\u00e8res peuvent entra\u00eener une maladie pulmonaire potentiellement mortelle : \u00e9tude"},"content":{"rendered":"<p>Ne pas suivre un horaire de sommeil r\u00e9gulier peut entra\u00eener des maladies pulmonaires mortelles, selon une nouvelle \u00e9tude.<\/p>\n<p>L&#039;\u00e9tude, publi\u00e9e dans la revue <a rel=\"noopener nofollow\" href=\"https:\/\/www.nature.com\/articles\/s41467-023-36896-0\" target=\"_blank\">Communications naturelles<\/a>, a not\u00e9 que des habitudes de sommeil irr\u00e9guli\u00e8res peuvent affecter n\u00e9gativement l&#039;horloge biologique naturelle du corps (\u00e9galement connue sous le nom d&#039;horloge circadienne), ce qui peut entra\u00eener des cicatrices pulmonaires ou une fibrose pulmonaire, une maladie potentiellement mortelle dans laquelle le tissu conjonctif s&#039;accumule dans les poumons, les durcissant et provoquant des difficult\u00e9s respiratoires.<\/p>\n<p>Cela se r\u00e9sume \u00e0 une prot\u00e9ine associ\u00e9e \u00e0 l\u2019horloge circadienne appel\u00e9e REV-ERB\u03b1, une prot\u00e9ine du rythme circadien qui r\u00e9gule la production de collag\u00e8ne dans le corps. Le manque de REV-ERB\u03b1 peut contribuer \u00e0 stimuler la production de collag\u00e8ne, ce qui, \u00e0 son tour, peut provoquer le durcissement des tissus pulmonaires et \u00e9ventuellement la fibrose.<\/p>\n<p>L&#039;\u00e9quipe \u00e0 l&#039;origine de l&#039;\u00e9tude, dirig\u00e9e par Irfan Rahman, Ph.D., professeur doyen de m\u00e9decine environnementale au centre m\u00e9dical de l&#039;Universit\u00e9 de Rochester, a d\u00e9couvert de faibles niveaux de REV-ERB\u03b1 et des niveaux accrus de collag\u00e8ne et de lysyl oxydase dans des \u00e9chantillons de poumons de fibrose pulmonaire. patients, selon <a rel=\"noopener nofollow\" href=\"https:\/\/www.hindustantimes.com\/lifestyle\/health\/lung-health-is-affected-by-irregular-sleep-patterns-study-101681812485747.html\" target=\"_blank\">Temps de l&#039;Hindoustan<\/a>.<\/p>\n<p>Dans une \u00e9tude sur un mod\u00e8le murin, les chercheurs ont d\u00e9couvert que le REV-ERB\u03b1 fluctue tout au long de la journ\u00e9e, culminant \u00e0 midi et diminuant pendant la nuit. Lorsqu&#039;ils ont subi une blessure la nuit, les mod\u00e8les de souris ont montr\u00e9 des augmentations plus importantes de la lysyl oxydase et des prot\u00e9ines de collag\u00e8ne, des l\u00e9sions pulmonaires plus importantes et des taux de survie inf\u00e9rieurs par rapport aux souris bless\u00e9es pendant la journ\u00e9e.<\/p>\n<p>Rahman a d\u00e9clar\u00e9 que les employ\u00e9s de nuit sont plus expos\u00e9s \u00e0 cette maladie. \u00ab Le travail de nuit se produit g\u00e9n\u00e9ralement vers minuit, lorsque l&#039;expression de REV-ERB\u03b1 est au plus bas \u00bb, explique-t-il. &quot;Nos r\u00e9sultats sugg\u00e8rent que l&#039;activation de REV-ERB\u03b1 la nuit offre moins de protection contre la fibrose pulmonaire.&quot;<\/p>\n<p>Qixin Wang, Ph.D., chercheur postdoctoral travaillant dans le laboratoire de Rahman, a d\u00e9clar\u00e9 dans l&#039;\u00e9tude que le march\u00e9 manquait suffisamment <a href=\"https:\/\/www.medicaldaily.com\/3d-imaging-technique-pulmonary-fibrosis-lung-disease-382910\" rel=\"nofollow\">fibrose<\/a> m\u00e9dicaments, et avec la nouvelle \u00e9tude, les scientifiques visent \u00e0 d\u00e9velopper de nouveaux m\u00e9dicaments pour mieux traiter la maladie pulmonaire.<\/p>\n<p>&quot;Actuellement, il n&#039;existe que deux m\u00e9dicaments approuv\u00e9s par la FDA pour traiter la fibrose, et ils ne font que retarder le processus, ils ne gu\u00e9rissent pas la maladie&quot;, a d\u00e9clar\u00e9 Wang. &quot;Les m\u00e9dicaments activant REV-ERB\u03b1 pourraient servir de th\u00e9rapies potentielles pour aider \u00e0 pr\u00e9venir la fibrose et arr\u00eater le processus pathologique.&quot;<\/p>\n<figure class=\"imageBox\">\n<div class=\"innerBox\"><picture class=\"mapping-embed\" width=\"736\" height=\"490\"><source type=\"image\/webp\" media=\"(min-width: 1100px)\" sizes=\"736px\" srcset=\"https:\/\/d.medicaldaily.com\/en\/full\/432161\/lungs.webp?w=736&amp;f=4b353c8bd15aeedc2e11df1d1589b9c0 736w\"><source type=\"image\/jpeg\" media=\"(min-width: 1100px)\" sizes=\"736px\" srcset=\"https:\/\/urbancare.clinic\/wp-content\/uploads\/2023\/04\/irregular-sleeping-habits-can-lead-to-potentially-fatal-lung-disease-study.jpg 736w\"><source type=\"image\/webp\" media=\"(min-width: 768px)\" sizes=\"1000px\" srcset=\"https:\/\/d.medicaldaily.com\/en\/full\/432161\/lungs.webp?w=1100&amp;f=03619962be1fcf7e51628052d46f5219 1100w\"><source type=\"image\/jpeg\" media=\"(min-width: 768px)\" sizes=\"1000px\" srcset=\"https:\/\/d.medicaldaily.com\/en\/full\/432161\/lungs.jpg?w=1100&amp;f=03619962be1fcf7e51628052d46f5219 1100w\"><source type=\"image\/webp\" media=\"(min-width: 480px)\" sizes=\"640px\" srcset=\"https:\/\/d.medicaldaily.com\/en\/full\/432161\/lungs.webp?w=640&amp;f=dc06f1e9516bd73edcc9cb88a457e479 640w\"><source type=\"image\/jpeg\" media=\"(min-width: 480px)\" sizes=\"640px\" srcset=\"https:\/\/d.medicaldaily.com\/en\/full\/432161\/lungs.jpg?w=640&amp;f=dc06f1e9516bd73edcc9cb88a457e479 640w\"><source type=\"image\/webp\" media=\"(min-width: 0px)\" sizes=\"480px\" srcset=\"https:\/\/d.medicaldaily.com\/en\/full\/432161\/lungs.webp?w=480&amp;f=33593576f0e006f0323e8740a45cf6d9 480w\"><source type=\"image\/jpeg\" media=\"(min-width: 0px)\" sizes=\"480px\" srcset=\"https:\/\/d.medicaldaily.com\/en\/full\/432161\/lungs.jpg?w=480&amp;f=33593576f0e006f0323e8740a45cf6d9 480w\"><source type=\"image\/webp\" srcset=\"https:\/\/d.medicaldaily.com\/en\/full\/432161\/lungs.webp?w=736&amp;f=4b353c8bd15aeedc2e11df1d1589b9c0\"><img loading=\"lazy\" decoding=\"async\" class=\"mapping-embed imgPhoto\" id=\"i432161\" src=\"https:\/\/urbancare.clinic\/wp-content\/uploads\/2023\/04\/irregular-sleeping-habits-can-lead-to-potentially-fatal-lung-disease-study.jpg\" alt=\"Poumons\" width=\"736\" height=\"490\" style=\"display:none\"><\/picture><\/div><figcaption class=\"caption\">\n<span class=\"cap\">Les principales caract\u00e9ristiques des maladies pulmonaires auto-immunes sont l\u2019inflammation et la cicatrisation. <\/span><br \/>\n<span class=\"credit\">Pixabay<\/span><br \/>\n<\/figcaption><\/figure>\n<p><a href=\"https:\/\/www.medicaldaily.com\/irregular-sleeping-habits-can-lead-potentially-fatal-lung-disease-study-469458\">Source quotidienne m\u00e9dicale<\/a><\/p>\n<p>","protected":false},"excerpt":{"rendered":"<p>Le manque de sommeil perturbe la production d&#039;une prot\u00e9ine de l&#039;horloge biologique appel\u00e9e REV-ERB\u03b1, qui peut provoquer une fibrose pulmonaire.<\/p>","protected":false},"author":2,"featured_media":7938,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"page_builder":"","fifu_image_url":"https:\/\/urbancare.clinic\/wp-content\/uploads\/2023\/04\/irregular-sleeping-habits-can-lead-to-potentially-fatal-lung-disease-study.jpg","fifu_image_alt":"","footnotes":""},"categories":[27],"tags":[203],"class_list":["post-7937","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blog","tag-sleep"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Irregular Sleeping Habits Can Lead To Potentially Fatal Lung Disease: Study - Urban Care Clinic<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" 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