{"id":7750,"date":"2023-04-05T12:21:32","date_gmt":"2023-04-05T09:21:32","guid":{"rendered":"https:\/\/urbancare.clinic\/new-shape-shifting-antibiotics-could-help-tackle-drug-resistant-viruses-researchers-suggest\/"},"modified":"2023-04-07T13:35:08","modified_gmt":"2023-04-07T10:35:08","slug":"de-nouveaux-antibiotiques-qui-changent-de-forme-pourraient-aider-a-lutter-contre-les-virus-resistants-aux-medicaments-suggerent-les-chercheurs","status":"publish","type":"post","link":"https:\/\/urbancare.clinic\/fr\/new-shape-shifting-antibiotics-could-help-tackle-drug-resistant-viruses-researchers-suggest\/","title":{"rendered":"De nouveaux antibiotiques m\u00e9tamorphes pourraient aider \u00e0 lutter contre les virus r\u00e9sistants aux m\u00e9dicaments, sugg\u00e8rent des chercheurs"},"content":{"rendered":"<p>Outre les \u00e9pisodes de grippe saisonni\u00e8re, les infections bact\u00e9riennes et virales ont \u00e9t\u00e9 la principale cause de d\u00e9c\u00e8s pendant la pand\u00e9mie. La saison de la grippe commence g\u00e9n\u00e9ralement \u00e0 l&#039;automne et dure jusqu&#039;au printemps. Lors de son apparition, les humains sont expos\u00e9s \u00e0 des dizaines de bact\u00e9ries qui peuvent causer des maladies graves.<\/p>\n<p>La gravit\u00e9 des sympt\u00f4mes de la grippe conduit souvent \u00e0 une surutilisation des antibiotiques, qui \u00e0 son tour entra\u00eene la croissance de certaines bact\u00e9ries r\u00e9sistantes. Cela peut rendre l&#039;attaque bact\u00e9rienne encore plus difficile \u00e0 g\u00e9rer. Compte tenu de cela, l&#039;Organisation mondiale de la sant\u00e9 a pr\u00e9sent\u00e9 la r\u00e9sistance des bact\u00e9ries comme l&#039;un des probl\u00e8mes de sant\u00e9 urgents auxquels le monde est actuellement confront\u00e9.<\/p>\n<p>Cependant, le professeur John E. Moses du Cold Spring Harbor Laboratory (CSHL) a fait une d\u00e9couverte \u00e9tonnante qui vise \u00e0 inverser cette crise et \u00e0 faire en sorte que les superbact\u00e9ries r\u00e9sistantes aux m\u00e9dicaments n&#039;aient plus le dessus sur les patients gripp\u00e9s.<\/p>\n<p>Moses a d\u00e9velopp\u00e9 un antibiotique qui peut changer de forme tout seul en r\u00e9arrangeant ses atomes.<\/p>\n<p>L&#039;id\u00e9e lui est venue apr\u00e8s avoir observ\u00e9 le fonctionnement des chars militaires - rotation de leurs tourelles et mouvements agiles, ce qui est un r\u00e9flexe aigu aux menaces possibles, selon <a href=\"https:\/\/www.newswise.com\/articles\/new-shape-shifting-antibiotics-could-fight-deadly-infections\" target=\"_blank\" rel=\"noopener nofollow\">Nouvelles avis\u00e9es<\/a>. Des ann\u00e9es apr\u00e8s avoir analys\u00e9 les chars militaires, Moses a d\u00e9couvert le bullval\u00e8ne, une mol\u00e9cule fluxionnelle caract\u00e9ris\u00e9e par des arrangements atomiques \u00e0 changement de position. Ledit attribut de ses atomes donne \u00e0 la mol\u00e9cule des millions de configurations, exactement la fluidit\u00e9 que Mo\u00efse recherchait dans ses recherches.<\/p>\n<p>Moses a ensuite \u00e9tudi\u00e9 la vancomycine, un m\u00e9dicament contre lequel de nombreux virus, dont le SARM, le VRSA et l&#039;ERV, sont devenus immunis\u00e9s. La vancomycine est un antibiotique puissant utilis\u00e9 depuis longtemps pour traiter des affections telles que les infections cutan\u00e9es et la m\u00e9ningite. Moses pensait qu&#039;il pouvait am\u00e9liorer les performances antibact\u00e9riennes du m\u00e9dicament en le combinant avec du bullval\u00e8ne. Au cours du processus, il a eu recours au prix Nobel <a rel=\"noopener nofollow\" href=\"https:\/\/en.wikipedia.org\/wiki\/Click_chemistry\" target=\"_blank\">cliquez sur la chimie<\/a> m\u00e9thode, notant qu&#039;elle rend la r\u00e9action plus efficace pour une utilisation \u00e0 grande \u00e9chelle.<\/p>\n<p>&quot;La chimie du clic est g\u00e9niale&quot;, a d\u00e9clar\u00e9 Moses, qui a appris les m\u00e9canismes de la m\u00e9thode du laur\u00e9at du prix Nobel K. Barry Sharpless. &quot;Cela vous donne la certitude et la meilleure chance que vous ayez de faire des choses complexes.&quot;<\/p>\n<p>Avec l&#039;aide de cette technique, Moses et ses coll\u00e8gues ont propos\u00e9 un nouvel antibiotique avec deux &quot;ogives&quot; de vancomycine et un centre bullval\u00e8ne fluctuant, <a rel=\"noopener nofollow\" href=\"https:\/\/www.biospace.com\/article\/releases\/new-shape-shifting-antibiotics-could-fight-deadly-infections\/\" target=\"_blank\">Bioespace<\/a> signal\u00e9.<\/p>\n<p>Moses a demand\u00e9 l&#039;aide du Dr Tatiana Soares da-Costa de l&#039;Universit\u00e9 d&#039;Ad\u00e9la\u00efde pour tester le potentiel du m\u00e9dicament. Dans le cadre du test, il a administr\u00e9 le m\u00e9dicament \u00e0 des larves de teignes de la cire infect\u00e9es par les ERV, qui sont couramment utilis\u00e9es pour tester les antibiotiques. Le r\u00e9sultat a indiqu\u00e9 que l&#039;antibiotique \u00e0 changement de forme \u00e9tait plus prometteur que la vancomycine pour \u00e9liminer l&#039;infection mortelle.<\/p>\n<p>&quot;Si nous pouvons inventer des mol\u00e9cules qui signifient la diff\u00e9rence entre la vie et la mort&quot;, a-t-il d\u00e9clar\u00e9, &quot;ce serait la plus grande r\u00e9ussite de tous les temps.&quot;<\/p>\n<figure class=\"imageBox\">\n<div class=\"innerBox\"><picture class=\"mapping-embed\" width=\"736\" height=\"405\"><source type=\"image\/webp\" media=\"(min-width: 1100px)\" sizes=\"736px\" srcset=\"https:\/\/d.medicaldaily.com\/en\/full\/435719\/bacteria.webp?w=736&amp;f=6ebb050345fdc9e2fdfd4894d69afd42 736w\"><source type=\"image\/jpeg\" media=\"(min-width: 1100px)\" sizes=\"736px\" srcset=\"https:\/\/urbancare.clinic\/wp-content\/uploads\/2023\/04\/new-shape-shifting-antibiotics-could-help-tackle-drug-resistant-viruses-researchers-suggest.jpg 736w\"><source type=\"image\/webp\" media=\"(min-width: 768px)\" sizes=\"1000px\" srcset=\"https:\/\/d.medicaldaily.com\/en\/full\/435719\/bacteria.webp?w=1100&amp;f=af8d8273e37e58aff79237c7dd06c845 1100w\"><source type=\"image\/jpeg\" media=\"(min-width: 768px)\" sizes=\"1000px\" srcset=\"https:\/\/d.medicaldaily.com\/en\/full\/435719\/bacteria.jpg?w=1100&amp;f=af8d8273e37e58aff79237c7dd06c845 1100w\"><source type=\"image\/webp\" media=\"(min-width: 480px)\" sizes=\"736px\" srcset=\"https:\/\/d.medicaldaily.com\/en\/full\/435719\/bacteria.webp?w=736&amp;f=6ebb050345fdc9e2fdfd4894d69afd42 736w\"><source type=\"image\/jpeg\" media=\"(min-width: 480px)\" sizes=\"736px\" srcset=\"https:\/\/urbancare.clinic\/wp-content\/uploads\/2023\/04\/new-shape-shifting-antibiotics-could-help-tackle-drug-resistant-viruses-researchers-suggest.jpg 736w\"><source type=\"image\/webp\" media=\"(min-width: 0px)\" sizes=\"480px\" srcset=\"https:\/\/d.medicaldaily.com\/en\/full\/435719\/bacteria.webp?w=480&amp;f=becd8390b8d454893b9da94ceb9f08a4 480w\"><source type=\"image\/jpeg\" media=\"(min-width: 0px)\" sizes=\"480px\" srcset=\"https:\/\/d.medicaldaily.com\/en\/full\/435719\/bacteria.jpg?w=480&amp;f=becd8390b8d454893b9da94ceb9f08a4 480w\"><source type=\"image\/webp\" srcset=\"https:\/\/d.medicaldaily.com\/en\/full\/435719\/bacteria.webp?w=736&amp;f=6ebb050345fdc9e2fdfd4894d69afd42\"><img loading=\"lazy\" decoding=\"async\" class=\"mapping-embed imgPhoto\" id=\"i435719\" src=\"https:\/\/urbancare.clinic\/wp-content\/uploads\/2023\/04\/new-shape-shifting-antibiotics-could-help-tackle-drug-resistant-viruses-researchers-suggest.jpg\" alt=\"bact\u00e9ries\" width=\"736\" height=\"405\" style=\"display:none\"><\/picture><\/div><figcaption class=\"caption\">\n<span class=\"cap\">La communaut\u00e9 scientifique continue de rechercher des traitements efficaces pour lutter contre la r\u00e9sistance croissante aux antibiotiques dans le monde.<\/span><br \/>\n<span class=\"credit\">Pixabay<\/span><br \/>\n<\/figcaption><\/figure>\n<p><a href=\"https:\/\/www.medicaldaily.com\/new-shape-shifting-antibiotics-could-help-tackle-drug-resistant-viruses-researchers-suggest-469289\">Source quotidienne m\u00e9dicale<\/a><\/p>\n<p>","protected":false},"excerpt":{"rendered":"<p>Les scientifiques ont utilis\u00e9 la m\u00e9thode de chimie du clic r\u00e9compens\u00e9e par le prix Nobel pour d\u00e9velopper l&#039;antibiotique r\u00e9volutionnaire.<\/p>","protected":false},"author":2,"featured_media":7751,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"page_builder":"","fifu_image_url":"https:\/\/urbancare.clinic\/wp-content\/uploads\/2023\/04\/new-shape-shifting-antibiotics-could-help-tackle-drug-resistant-viruses-researchers-suggest.jpg","fifu_image_alt":"","footnotes":""},"categories":[27,185],"tags":[],"class_list":["post-7750","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blog","category-research-medical-articles"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>New Shape-Shifting Antibiotics Could Help Tackle Drug-Resistant Viruses, Researchers Suggest - Urban Care Clinic<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link 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