{"id":7746,"date":"2023-04-04T13:20:36","date_gmt":"2023-04-04T10:20:36","guid":{"rendered":"https:\/\/urbancare.clinic\/minnesota-man-dies-of-rabies-despite-receiving-post-exposure-treatment\/"},"modified":"2023-04-04T13:20:36","modified_gmt":"2023-04-04T10:20:36","slug":"un-homme-du-minnesota-meurt-de-la-rage-malgre-un-traitement-post-exposition","status":"publish","type":"post","link":"https:\/\/urbancare.clinic\/fr\/un-homme-du-minnesota-meurt-de-la-rage-malgre-un-traitement-post-exposition\/","title":{"rendered":"Un homme du Minnesota meurt de la rage malgr\u00e9 un traitement post-exposition"},"content":{"rendered":"

Un homme de 84 ans du Minnesota serait d\u00e9c\u00e9d\u00e9 des suites de la rage malgr\u00e9 un traitement post-exposition appropri\u00e9.<\/p>\n

Dans un rapport de cas r\u00e9cemment publi\u00e9 dans Maladies infectieuses cliniques<\/a>, les experts ont discut\u00e9 de ce qui est arriv\u00e9 \u00e0 l'homme \u00e2g\u00e9 et de ce qui pourrait \u00eatre responsable de sa disparition, m\u00eame s'il avait re\u00e7u le traitement appropri\u00e9 contre le virus.<\/p>\n

Selon les auteurs, le patient est d\u00e9c\u00e9d\u00e9 en janvier 2021, six mois apr\u00e8s avoir \u00e9t\u00e9 mordu par une chauve-souris enrag\u00e9e. Avant cela, aucune prophylaxie post-exposition (PPE) contre la rage n\u2019avait \u00e9t\u00e9 document\u00e9e chez l\u2019homme aux \u00c9tats-Unis \u00e0 l\u2019aide de vaccins modernes issus de cultures cellulaires.<\/p>\n

Les scientifiques ont utilis\u00e9 diff\u00e9rentes m\u00e9thodes pour rechercher la cause de cette infection r\u00e9volutionnaire. Ils ont examin\u00e9 les dossiers m\u00e9dicaux, les r\u00e9sultats de laboratoire et les conclusions de l'autopsie. Ils ont \u00e9galement effectu\u00e9 un s\u00e9quen\u00e7age du g\u00e9nome entier pour comparer les s\u00e9quences du virus du patient et de la chauve-souris. Des \u00e9chantillons d\u2019immunoglobulines antirabiques restantes ont m\u00eame \u00e9t\u00e9 examin\u00e9s pour d\u00e9terminer leur activit\u00e9.<\/p>\n

Les auteurs ont d\u00e9couvert que le patient souffrait d\u2019une \u00ab gammapathie monoclonale non reconnue de signification inconnue \u00bb. Ils ont \u00e9galement not\u00e9 que les anticorps anti-virus pr\u00e9sents dans le s\u00e9rum et le liquide c\u00e9phalo-rachidien du patient n'\u00e9taient pas neutralisants.<\/p>\n

\u00ab Il s\u2019agit du premier cas signal\u00e9 d\u2019\u00e9chec d\u2019un traitement prophylactique appropri\u00e9 contre la rage depuis le d\u00e9but d\u2019un tel traitement. Ce malheureux individu souffrait d\u2019un d\u00e9ficit immunitaire non reconnu qui a probablement contribu\u00e9 \u00e0 cet \u00e9chec \u00bb, a d\u00e9clar\u00e9 le Dr Aaron Glatt, qui ne faisait pas partie du rapport. Fox News num\u00e9rique<\/a>.<\/p>\n

Glatt est le chef du service des maladies infectieuses \u00e0 l'h\u00f4pital Mount Sinai South Nassau \u00e0 Long Island, New York. Il a assur\u00e9 que la th\u00e9rapie PEP est tr\u00e8s efficace dans la pr\u00e9vention de la rage lorsqu'elle est administr\u00e9e au bon moment, c'est-\u00e0-dire avant l'apparition des sympt\u00f4mes.<\/p>\n

\u00ab L\u2019\u00e9chec du vaccin primaire m\u00e9di\u00e9 par l\u2019h\u00f4te, attribu\u00e9 \u00e0 une immunit\u00e9 affaiblie jusqu\u2019alors non reconnue, est l\u2019explication la plus probable de cette infection r\u00e9volutionnaire. Les cliniciens devraient envisager de mesurer les titres d\u2019anticorps neutralisant la rage apr\u00e8s la fin de la PEP en cas de suspicion d\u2019immunod\u00e9pression \u00bb, ont conclu les auteurs.<\/p>\n

Outre le probl\u00e8me d\u2019immunit\u00e9, l\u2019homme qui s\u2019est r\u00e9veill\u00e9 le 27 juillet 2020 lorsqu\u2019une chauve-souris lui a mordu la main droite souffrait \u00e9galement d\u2019une maladie coronarienne, d\u2019un diab\u00e8te de type 2 contr\u00f4l\u00e9, d\u2019hypertension, d\u2019hyperlipid\u00e9mie, d\u2019une maladie r\u00e9nale chronique et d\u2019une hypertrophie de la prostate.<\/p>\n

Selon le Centres pour le Contr\u00f4le et la Pr\u00e9vention des catastrophes<\/a> (CDC), environ 59 000 personnes meurent chaque ann\u00e9e de la rage dans le monde. Aux \u00c9tats-Unis, les cas de rage humaine sont consid\u00e9r\u00e9s comme rares, avec seulement 1 \u00e0 3 cas signal\u00e9s chaque ann\u00e9e. Cependant, entre 30 000 et 60 000<\/a> La population du pays re\u00e7oit une PPE chaque ann\u00e9e.<\/p>\n

\n
\"Chauve-souris<\/picture><\/div>
\nLa rage des chauves-souris vampires touche des milliers de personnes en Am\u00e9rique latine, contribuant \u00e0 960 d\u00e9c\u00e8s pour 100 000 habitants.<\/span>
\nUwe Schmidt\/Wikimedia Commons<\/span>
\n<\/figcaption><\/figure>\n

Source quotidienne m\u00e9dicale<\/a><\/p>\n

","protected":false},"excerpt":{"rendered":"

Un expert a d\u00e9clar\u00e9 que l\u2019homme souffrait d\u2019un d\u00e9ficit immunitaire non reconnu qui a conduit \u00e0 l\u2019\u00e9chec du vaccin.<\/p>","protected":false},"author":2,"featured_media":7747,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"Default","format":"standard","meta":{"fifu_image_url":"https:\/\/urbancare.clinic\/wp-content\/uploads\/2023\/04\/minnesota-man-dies-of-rabies-despite-receiving-post-exposure-treatment.jpg","fifu_image_alt":"","footnotes":""},"categories":[27],"tags":[],"class_list":["post-7746","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blog"],"yoast_head":"\nMinnesota Man Dies Of Rabies Despite Receiving Post-Exposure Treatment - Urban Care Clinic<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/urbancare.clinic\/fr\/un-homme-du-minnesota-meurt-de-la-rage-malgre-un-traitement-post-exposition\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Minnesota Man Dies Of Rabies Despite Receiving Post-Exposure Treatment - 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