{"id":7637,"date":"2022-11-22T13:00:22","date_gmt":"2022-11-22T10:00:22","guid":{"rendered":"https:\/\/urbancare.clinic\/clinicopathological-and-prognostic-values-of-pd-l1-expression-in-oesophageal-squamous-cell-carcinoma-a-meta-analysis-of-31-studies-with-5368-patients\/"},"modified":"2022-11-22T13:00:22","modified_gmt":"2022-11-22T10:00:22","slug":"valeurs-clinicopathologiques-et-pronostiques-de-lexpression-de-pd-l1-dans-le-carcinome-epidermoide-de-loesophage-meta-analyse-de-31-etudes-portant-sur-5-368-patients","status":"publish","type":"post","link":"https:\/\/urbancare.clinic\/fr\/clinicopathological-and-prognostic-values-of-pd-l1-expression-in-oesophageal-squamous-cell-carcinoma-a-meta-analysis-of-31-studies-with-5368-patients\/","title":{"rendered":"Valeurs clinicopathologiques et pronostiques de l&#039;expression de PD-L1 dans le carcinome \u00e9pidermo\u00efde de l&#039;\u0153sophage\u00a0: une m\u00e9ta-analyse de 31\u00a0\u00e9tudes portant sur 5\u00a0368\u00a0patients"},"content":{"rendered":"<div><img decoding=\"async\" src=\"https:\/\/urbancare.clinic\/wp-content\/uploads\/2023\/02\/clinicopathological-and-prognostic-values-of-pd-l1-expression-in-oesophageal-squamous-cell-carcinoma-a-meta-analysis-of-31-studies-with-5368-patients.jpg\" class=\"ff-og-image-inserted\" style=\"display:none\"><\/div>\n<p><span class=\"highwire-journal-article-marker-start\"><\/span><\/p>\n<div class=\"section abstract\" id=\"abstract-1\" readability=\"39\">\n<h2>Abstrait<\/h2>\n<p id=\"p-1\">Plusieurs inhibiteurs de points de contr\u00f4le immunitaires ciblant le ligand de mort programm\u00e9e 1 (PD-L1)\/mort programm\u00e9e 1 ont r\u00e9ussi \u00e0 am\u00e9liorer le pronostic du carcinome \u00e9pidermo\u00efde de l&#039;\u0153sophage (ESCC) avec une approbation dans certains pays. Cependant, on ne sait pas encore si l&#039;expression de PD-L1 est associ\u00e9e au degr\u00e9 de b\u00e9n\u00e9fice et une norme unifi\u00e9e d&#039;anticorps et de valeur seuil de d\u00e9tection de PD-L1 fait \u00e9galement d\u00e9faut. La m\u00e9ta-analyse actuelle visait alors \u00e0 explorer l&#039;association entre l&#039;expression de PD-L1 et les caract\u00e9ristiques clinicopathologiques ainsi que le pronostic dans l&#039;ESCC.<\/p>\n<p id=\"p-2\">Une recherche syst\u00e9matique dans les bases de donn\u00e9es PubMed, Embase, Cochrane Library et Web of Science a \u00e9t\u00e9 effectu\u00e9e jusqu&#039;au 30 mars 2021. La corr\u00e9lation entre l&#039;expression de PD-L1 et les caract\u00e9ristiques clinicopathologiques, ainsi que le pronostic dans l&#039;ESCC, a \u00e9t\u00e9 estim\u00e9e avec le mod\u00e8le \u00e0 effets al\u00e9atoires.<\/p>\n<p id=\"p-3\">Un total de 5368 patients issus de 31 \u00e9tudes r\u00e9trospectives ont \u00e9t\u00e9 recrut\u00e9s. La surexpression de PD-L1 \u00e9tait significativement associ\u00e9e aux m\u00e9tastases ganglionnaires (OR 1,342, 95% IC 0,995 \u00e0 1,809, p = 0,050) et aux m\u00e9tastases \u00e0 distance (OR 1,516, 95% IC 1,001 \u00e0 2,294, p = 0,050). Le RR combin\u00e9 a montr\u00e9 que la surexpression de PD-L1 \u00e9tait significativement corr\u00e9l\u00e9e \u00e0 une faible survie globale (SG) des patients atteints d&#039;ESCC (RR 1,306, IC 95% 1,108 \u00e0 1,539, p&lt;0,010) mais pas \u00e0 la survie sans maladie (DFS) (RR 1,180, 95% IC 0,937 \u00e0 1,487, p=0,160). L&#039;h\u00e9t\u00e9rog\u00e9n\u00e9it\u00e9 a diminu\u00e9 de mani\u00e8re significative dans les analyses de sous-groupes. La surexpression de PD-L1 \u00e9tait associ\u00e9e \u00e0 une mauvaise SSM au seuil de \u22651% (HR 1,642, 95% IC 1,367 \u00e0 1,973, p&lt;0,010\u00a0; I<sup>2<\/sup>=0%) et SG pire au seuil de \u226510% (HR 1,575, 95% IC 1,175 \u00e0 2,111, p&lt;0,010\u00a0; I<sup>2<\/sup>=0%).<\/p>\n<p id=\"p-4\">La surexpression de PD-L1 \u00e9tait corr\u00e9l\u00e9e aux ganglions lymphatiques et aux m\u00e9tastases \u00e0 distance ainsi qu&#039;\u00e0 la faible survie des ESCC.<\/p>\n<\/div>\n<ul class=\"kwd-group\">\n<li class=\"kwd\">maladie oesophagienne<\/li>\n<li class=\"kwd\">\u00e9pid\u00e9miologie<\/li>\n<li class=\"kwd\">\u00e9pid\u00e9miologie<\/li>\n<li class=\"kwd\">immunologie<\/li>\n<\/ul>\n<p><span class=\"highwire-journal-article-marker-end\"><\/span><a href=\"http:\/\/pmj.bmj.com\/cgi\/content\/short\/98\/1166\/948?rss=1\">Source quotidienne m\u00e9dicale<\/a><\/p>\n<p>","protected":false},"excerpt":{"rendered":"<p>Plusieurs inhibiteurs de points de contr\u00f4le immunitaires ciblant le ligand de mort programm\u00e9e 1 (PD-L1)\/mort programm\u00e9e 1 ont r\u00e9ussi \u00e0 am\u00e9liorer le pronostic du carcinome \u00e9pidermo\u00efde de l&#039;\u0153sophage (ESCC) avec une approbation dans certains pays. Cependant, on ne sait pas encore si l&#039;expression de PD-L1 est associ\u00e9e au degr\u00e9 de b\u00e9n\u00e9fice et une norme unifi\u00e9e d&#039;anticorps et de valeur seuil de d\u00e9tection de PD-L1 fait \u00e9galement d\u00e9faut. La m\u00e9ta-analyse actuelle visait alors \u00e0 explorer l&#039;association entre l&#039;expression de PD-L1 et les caract\u00e9ristiques clinicopathologiques ainsi que le pronostic dans l&#039;ESCC.<\/p>\n<p>Une recherche syst\u00e9matique dans les bases de donn\u00e9es PubMed, Embase, Cochrane Library et Web of Science a \u00e9t\u00e9 effectu\u00e9e jusqu&#039;au 30 mars 2021. La corr\u00e9lation entre l&#039;expression de PD-L1 et les caract\u00e9ristiques clinicopathologiques, ainsi que le pronostic dans l&#039;ESCC, a \u00e9t\u00e9 estim\u00e9e avec le mod\u00e8le \u00e0 effets al\u00e9atoires.<\/p>\n<p>Au total, 5 368 patients issus de 31 \u00e9tudes r\u00e9trospectives ont \u00e9t\u00e9 recrut\u00e9s. La surexpression de PD-L1 \u00e9tait significativement associ\u00e9e aux m\u00e9tastases ganglionnaires (OR 1,342, IC 95% 0,995 \u00e0 1,809, p = 0,050) et aux m\u00e9tastases \u00e0 distance (OR 1,516, IC 95% 1,001 \u00e0 2,294, p = 0,050). Le HR group\u00e9 a montr\u00e9 que la surexpression de PD-L1 \u00e9tait significativement corr\u00e9l\u00e9e \u00e0 une faible survie globale (OS) des patients atteints de carcinome \u00e9pidermo\u00efde \u0153sophagien (ESCC) (HR 1,306, IC 95% 1,108 \u00e0 1,539, p &lt; 0,010) mais pas \u00e0 la survie sans maladie (DFS) (HR 1,180, IC 95% 0,937 \u00e0 1,487, p = 0,160). L&#039;h\u00e9t\u00e9rog\u00e9n\u00e9it\u00e9 a diminu\u00e9 de mani\u00e8re significative dans les analyses de sous-groupes. La surexpression de PD-L1 a \u00e9t\u00e9 associ\u00e9e \u00e0 une faible DFS au point limite de \u2265 1% (HR 1,642, 95% IC 1,367 \u00e0 1,973, p &lt; 0,010 ; I<sup>2<\/sup>=0%) et une SG pire au point limite de \u226510% (HR 1,575, IC 95% 1,175 \u00e0 2,111, p&lt;0,010 ; I<sup>2<\/sup>=0%).<\/p>\n<p>La surexpression de PD-L1 \u00e9tait corr\u00e9l\u00e9e aux ganglions lymphatiques et aux m\u00e9tastases \u00e0 distance ainsi qu&#039;\u00e0 la faible survie des ESCC.<\/p>","protected":false},"author":2,"featured_media":7638,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"Default","format":"standard","meta":{"page_builder":"","fifu_image_url":"https:\/\/urbancare.clinic\/wp-content\/uploads\/2023\/02\/clinicopathological-and-prognostic-values-of-pd-l1-expression-in-oesophageal-squamous-cell-carcinoma-a-meta-analysis-of-31-studies-with-5368-patients.jpg","fifu_image_alt":"","footnotes":""},"categories":[185],"tags":[],"class_list":["post-7637","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-research-medical-articles"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Clinicopathological and prognostic values of PD-L1 expression in oesophageal squamous cell carcinoma: a meta-analysis of 31 studies with 5368 patients - Urban Care Clinic<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/urbancare.clinic\/fr\/valeurs-clinicopathologiques-et-pronostiques-de-lexpression-de-pd-l1-dans-le-carcinome-epidermoide-de-loesophage-meta-analyse-de-31-etudes-portant-sur-5-368-patients\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Clinicopathological and prognostic values of PD-L1 expression in oesophageal squamous cell carcinoma: a meta-analysis of 31 studies with 5368 patients - Urban Care Clinic\" \/>\n<meta property=\"og:description\" content=\"Several immune checkpoint inhibitors targeting programmed death ligand 1 (PD-L1)\/programmed death 1 have successfully improved the prognosis of oesophageal squamous cell carcinoma (ESCC) with approval in certain countries. 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The pooled HR showed that PD-L1 overexpression was significantly correlated with poor overall survival (OS) of patients with ESCC (HR 1.306, 95% CI 1.108 to 1.539, p&lt;0.010) but not disease-free survival (DFS) (HR 1.180, 95% CI 0.937 to 1.487, p=0.160). Heterogeneity decreased significantly in subgroup analyses. The overexpression of PD-L1 was associated with poor DFS at the cut-off point of &ge;1% (HR 1.642, 95% CI 1.367 to 1.973, p&lt;0.010; I2=0%) and worse OS at the cut-off point of &ge;10% (HR 1.575, 95% CI 1.175 to 2.111, p&lt;0.010; I2=0%). 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Clinic","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/urbancare.clinic\/fr\/valeurs-clinicopathologiques-et-pronostiques-de-lexpression-de-pd-l1-dans-le-carcinome-epidermoide-de-loesophage-meta-analyse-de-31-etudes-portant-sur-5-368-patients\/","og_locale":"fr_FR","og_type":"article","og_title":"Clinicopathological and prognostic values of PD-L1 expression in oesophageal squamous cell carcinoma: a meta-analysis of 31 studies with 5368 patients - Urban Care Clinic","og_description":"Several immune checkpoint inhibitors targeting programmed death ligand 1 (PD-L1)\/programmed death 1 have successfully improved the prognosis of oesophageal squamous cell carcinoma (ESCC) with approval in certain countries. However, whether the expression of PD-L1 is associated with the degree of benefit is unclear yet and a unified standard of antibody and cut-off value of PD-L1 detection is also lacking. The current meta-analysis then aimed to explore the association between PD-L1 expression and clinicopathological features as well as prognosis in ESCC. A systematic search on PubMed, Embase, Cochrane Library and Web of Science databases was performed up to 30 March 2021. The correlation between PD-L1 expression and clinicopathological features, as well as prognosis in ESCC, was estimated with the random-effects model. A total of 5368 patients from 31 retrospective studies were enrolled. The overexpression of PD-L1 was significantly associated with lymph node metastasis (OR 1.342, 95% CI 0.995 to 1.809, p=0.050) and distant metastasis (OR 1.516, 95% CI 1.001 to 2.294, p=0.050). The pooled HR showed that PD-L1 overexpression was significantly correlated with poor overall survival (OS) of patients with ESCC (HR 1.306, 95% CI 1.108 to 1.539, p&lt;0.010) but not disease-free survival (DFS) (HR 1.180, 95% CI 0.937 to 1.487, p=0.160). Heterogeneity decreased significantly in subgroup analyses. The overexpression of PD-L1 was associated with poor DFS at the cut-off point of &ge;1% (HR 1.642, 95% CI 1.367 to 1.973, p&lt;0.010; I2=0%) and worse OS at the cut-off point of &ge;10% (HR 1.575, 95% CI 1.175 to 2.111, p&lt;0.010; I2=0%). The overexpression of PD-L1 was correlated with lymph node and distant metastasis as well as poor survival of ESCC.","og_url":"https:\/\/urbancare.clinic\/fr\/valeurs-clinicopathologiques-et-pronostiques-de-lexpression-de-pd-l1-dans-le-carcinome-epidermoide-de-loesophage-meta-analyse-de-31-etudes-portant-sur-5-368-patients\/","og_site_name":"Urban Care Clinic","article_publisher":"https:\/\/www.facebook.com\/urbancarezanzibar","article_published_time":"2022-11-22T10:00:22+00:00","og_image":[{"url":"https:\/\/urbancare.clinic\/wp-content\/uploads\/2023\/02\/clinicopathological-and-prognostic-values-of-pd-l1-expression-in-oesophageal-squamous-cell-carcinoma-a-meta-analysis-of-31-studies-with-5368-patients.jpg","width":1024,"height":1024,"type":"image\/jpeg"}],"author":"Urban Care Clinic","twitter_card":"summary_large_image","twitter_misc":{"\u00c9crit par":"Urban Care Clinic","Dur\u00e9e de lecture estim\u00e9e":"1 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