{"id":7608,"date":"2022-11-22T13:00:22","date_gmt":"2022-11-22T10:00:22","guid":{"rendered":"https:\/\/urbancare.clinic\/low-level-of-complement-factor-h-increases-the-risk-of-cancer-related-death-in-patients-with-small-cell-lung-cancer\/"},"modified":"2023-05-23T17:38:32","modified_gmt":"2023-05-23T14:38:32","slug":"un-faible-niveau-de-facteur-h-du-complement-augmente-le-risque-de-deces-lie-au-cancer-chez-les-patients-atteints-dun-cancer-du-poumon-a-petites-cellules","status":"publish","type":"post","link":"https:\/\/urbancare.clinic\/fr\/low-level-of-complement-factor-h-increases-the-risk-of-cancer-related-death-in-patients-with-small-cell-lung-cancer\/","title":{"rendered":"Un faible taux de facteur H du compl\u00e9ment augmente le risque de d\u00e9c\u00e8s li\u00e9 au cancer chez les patients atteints d&#039;un cancer du poumon \u00e0 petites cellules"},"content":{"rendered":"<div><img decoding=\"async\" src=\"https:\/\/urbancare.clinic\/wp-content\/uploads\/2023\/02\/low-level-of-complement-factor-h-increases-the-risk-of-cancer-related-death-in-patients-with-small-cell-lung-cancer.jpg\" class=\"ff-og-image-inserted\"  style=\"display:none\"><\/div>\n<p>Si vous souhaitez r\u00e9utiliser tout ou partie de cet article, veuillez utiliser le lien ci-dessous qui vous m\u00e8nera au service RightsLink du Copyright Clearance Center. Vous pourrez obtenir un prix rapide et une autorisation instantan\u00e9e de r\u00e9utiliser le contenu de diff\u00e9rentes mani\u00e8res.<\/p>\n<p><a href=\"http:\/\/pmj.bmj.com\/cgi\/content\/short\/98\/1166\/919?rss=1\">Source quotidienne m\u00e9dicale<\/a><\/p>\n<p>","protected":false},"excerpt":{"rendered":"<p><sec><st>Introduction<\/st><\/p>\n<p>Le cancer pulmonaire est une sorte de tumeur profond\u00e9ment invasive, difficile \u00e0 traiter et dont le taux de mortalit\u00e9 est \u00e9lev\u00e9. Des recherches ant\u00e9rieures ont montr\u00e9 que l&#039;activation du compl\u00e9ment pourrait contribuer \u00e0 la progression du cancer du poumon non \u00e0 petites cellules (CPPC). Cependant, peu de recherches ont \u00e9t\u00e9 men\u00e9es sur le SCLC.<\/p>\n<p><\/sec><br \/>\n<sec><st>M\u00e9thodes<\/st><\/p>\n<p>Le facteur du compl\u00e9ment H (CFH), les compl\u00e9ments C3 ainsi que C4 ont \u00e9t\u00e9 mesur\u00e9s chez les patients, et l&#039;impact pronostique de diff\u00e9rents param\u00e8tres a \u00e9t\u00e9 \u00e9valu\u00e9 par une analyse de la fonction log-rank et des mod\u00e8les multifactoriels de Cox. En outre, nous avons construit un mod\u00e8le pr\u00e9dictif bas\u00e9 sur des fractions compl\u00e9mentaires et valid\u00e9 la pr\u00e9cision du mod\u00e8le.<\/p>\n<p><\/sec><br \/>\n<sec><st>R\u00e9sultats<\/st><\/p>\n<p>Parmi ces 242 patients, 200 (82,6%) sont d\u00e9c\u00e9d\u00e9s. La dur\u00e9e m\u00e9diane de survie \u00e9tait de 18,3 mois. Nous avons constat\u00e9 par analyse multifactorielle que des niveaux \u00e9lev\u00e9s de CFH diminuaient le risque de d\u00e9c\u00e8s (HR 0,23, 95% IC 0,10 \u00e0 0,57, p &lt;0,001), tandis qu&#039;un compl\u00e9ment C4 \u00e9lev\u00e9 affichait un mauvais pronostic (HR 2,28, 95% IC 1,66 \u00e0 3,13, p &lt;0,001). ). Nous avons examin\u00e9 les variables \u00e0 l&#039;aide de mod\u00e8les de Cox et construit des mod\u00e8les de pr\u00e9diction bas\u00e9s sur CFH pour tracer un nomogramme par validation interne. Le nomogramme a montr\u00e9 une excellente pr\u00e9cision dans l&#039;\u00e9valuation de la probabilit\u00e9 de d\u00e9c\u00e8s, donnant une statistique C ajust\u00e9e de 0,905.<\/p>\n<p><\/sec><br \/>\n<sec><st>Conclusions<\/st><\/p>\n<p>Le CFH peut \u00eatre reconnu comme un biomarqueur pour pr\u00e9dire le risque de d\u00e9c\u00e8s dans le CPPC. Le mod\u00e8le de pr\u00e9diction \u00e9tabli sur la base des niveaux de CFH, C3 et C4 pr\u00e9sente une bonne pr\u00e9cision dans l&#039;\u00e9valuation pronostique des patients.<\/p>\n<p><\/sec><\/p>","protected":false},"author":2,"featured_media":7609,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"page_builder":"","fifu_image_url":"https:\/\/urbancare.clinic\/wp-content\/uploads\/2023\/02\/low-level-of-complement-factor-h-increases-the-risk-of-cancer-related-death-in-patients-with-small-cell-lung-cancer.jpg","fifu_image_alt":"","footnotes":""},"categories":[185],"tags":[150],"class_list":["post-7608","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-research-medical-articles","tag-cancer"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Low level of complement factor H increases the risk of cancer-related death in patients with small-cell lung cancer - Urban Care Clinic<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/urbancare.clinic\/fr\/un-faible-niveau-de-facteur-h-du-complement-augmente-le-risque-de-deces-lie-au-cancer-chez-les-patients-atteints-dun-cancer-du-poumon-a-petites-cellules\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Low level of complement factor H increases the risk of cancer-related death in patients with small-cell lung cancer - Urban Care Clinic\" \/>\n<meta property=\"og:description\" content=\"Introduction Pulmonary cancer is a kind of deeply invasive tumour which is difficult to treat, and its mortality rate is high. Previous research has shown that activation of complement could contribute to the progression of non-small-cell lung cancer (SCLC). However, little research has been done on SCLC. Methods Complement factor H (CFH), complements C3 as well as C4 were measured in patients, and the prognostic impact of different parameters was assessed by log-rank function analysis and Cox multifactor models. Besides, we constructed a predictive model based on complement fractions and validated the accuracy of the model. Results Among these 242 patients, 200 (82.6%) died. The median survival time was 18.3 months. We found by multifactorial analysis that high levels of CFH decreased the risk of death (HR 0.23, 95% CI 0.10 to 0.57, p&lt;0.001), while elevated complement C4 displayed poor prognosis (HR 2.28, 95% CI 1.66 to 3.13, p&lt;0.001). We screened variables by Cox models and constructed CFH-based prediction models to plot a nomogram by internal validation. The nomogram showed excellent accuracy in assessing the probability of death, yielding an adjusted C-statistics of 0.905. Conclusions CFH can be recognised as a biomarker to predict the risk of death in SCLC. The prediction model established based on CFH, C3 and C4 levels has good accuracy in patients&#039; prognostic assessment.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/urbancare.clinic\/fr\/un-faible-niveau-de-facteur-h-du-complement-augmente-le-risque-de-deces-lie-au-cancer-chez-les-patients-atteints-dun-cancer-du-poumon-a-petites-cellules\/\" \/>\n<meta property=\"og:site_name\" content=\"Urban Care Clinic\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/urbancarezanzibar\" \/>\n<meta property=\"article:published_time\" content=\"2022-11-22T10:00:22+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-05-23T14:38:32+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/urbancare.clinic\/wp-content\/uploads\/2023\/02\/low-level-of-complement-factor-h-increases-the-risk-of-cancer-related-death-in-patients-with-small-cell-lung-cancer.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1024\" \/>\n\t<meta property=\"og:image:height\" content=\"1024\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Urban Care Clinic\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"\u00c9crit par\" \/>\n\t<meta name=\"twitter:data1\" content=\"Urban Care Clinic\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/urbancare.clinic\\\/low-level-of-complement-factor-h-increases-the-risk-of-cancer-related-death-in-patients-with-small-cell-lung-cancer\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/urbancare.clinic\\\/low-level-of-complement-factor-h-increases-the-risk-of-cancer-related-death-in-patients-with-small-cell-lung-cancer\\\/\"},\"author\":{\"name\":\"Urban Care Clinic\",\"@id\":\"https:\\\/\\\/urbancare.clinic\\\/#\\\/schema\\\/person\\\/a304a61bcf298680ee41e2e9ae193930\"},\"headline\":\"Low level of complement factor H increases the risk of cancer-related death in patients with small-cell lung cancer\",\"datePublished\":\"2022-11-22T10:00:22+00:00\",\"dateModified\":\"2023-05-23T14:38:32+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/urbancare.clinic\\\/low-level-of-complement-factor-h-increases-the-risk-of-cancer-related-death-in-patients-with-small-cell-lung-cancer\\\/\"},\"wordCount\":69,\"publisher\":{\"@id\":\"https:\\\/\\\/urbancare.clinic\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/urbancare.clinic\\\/low-level-of-complement-factor-h-increases-the-risk-of-cancer-related-death-in-patients-with-small-cell-lung-cancer\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/urbancare.clinic\\\/wp-content\\\/uploads\\\/2023\\\/02\\\/low-level-of-complement-factor-h-increases-the-risk-of-cancer-related-death-in-patients-with-small-cell-lung-cancer.jpg\",\"keywords\":[\"cancer\"],\"articleSection\":[\"Research Articles\"],\"inLanguage\":\"fr-FR\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/urbancare.clinic\\\/low-level-of-complement-factor-h-increases-the-risk-of-cancer-related-death-in-patients-with-small-cell-lung-cancer\\\/\",\"url\":\"https:\\\/\\\/urbancare.clinic\\\/low-level-of-complement-factor-h-increases-the-risk-of-cancer-related-death-in-patients-with-small-cell-lung-cancer\\\/\",\"name\":\"Low level of complement factor H increases the risk of cancer-related death in patients with small-cell lung cancer - 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Urban Care Clinic","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/urbancare.clinic\/fr\/un-faible-niveau-de-facteur-h-du-complement-augmente-le-risque-de-deces-lie-au-cancer-chez-les-patients-atteints-dun-cancer-du-poumon-a-petites-cellules\/","og_locale":"fr_FR","og_type":"article","og_title":"Low level of complement factor H increases the risk of cancer-related death in patients with small-cell lung cancer - Urban Care Clinic","og_description":"Introduction Pulmonary cancer is a kind of deeply invasive tumour which is difficult to treat, and its mortality rate is high. Previous research has shown that activation of complement could contribute to the progression of non-small-cell lung cancer (SCLC). However, little research has been done on SCLC. Methods Complement factor H (CFH), complements C3 as well as C4 were measured in patients, and the prognostic impact of different parameters was assessed by log-rank function analysis and Cox multifactor models. Besides, we constructed a predictive model based on complement fractions and validated the accuracy of the model. Results Among these 242 patients, 200 (82.6%) died. The median survival time was 18.3 months. We found by multifactorial analysis that high levels of CFH decreased the risk of death (HR 0.23, 95% CI 0.10 to 0.57, p&lt;0.001), while elevated complement C4 displayed poor prognosis (HR 2.28, 95% CI 1.66 to 3.13, p&lt;0.001). We screened variables by Cox models and constructed CFH-based prediction models to plot a nomogram by internal validation. The nomogram showed excellent accuracy in assessing the probability of death, yielding an adjusted C-statistics of 0.905. Conclusions CFH can be recognised as a biomarker to predict the risk of death in SCLC. 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