{"id":7543,"date":"2022-11-22T13:00:22","date_gmt":"2022-11-22T10:00:22","guid":{"rendered":"https:\/\/urbancare.clinic\/warfarin-induced-skin-necrosis\/"},"modified":"2023-05-23T17:37:36","modified_gmt":"2023-05-23T14:37:36","slug":"necrose-cutanee-induite-par-la-warfarine","status":"publish","type":"post","link":"https:\/\/urbancare.clinic\/fr\/warfarin-induced-skin-necrosis\/","title":{"rendered":"N\u00e9crose cutan\u00e9e induite par la warfarine"},"content":{"rendered":"
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La warfarine, une double arme, aide non seulement \u00e0 l'anticoagulation en inhibant les facteurs de coagulation d\u00e9pendants de la vitamine K, mais pr\u00e9vient \u00e9galement la lyse des caillots en inhibant la prot\u00e9ine C et la prot\u00e9ine S. La demi-vie des prot\u00e9ines C et S est plus courte que celle des facteurs de coagulation d\u00e9pendants de la vitamine K, d'o\u00f9 son la concentration plasmatique diminue plus rapidement. S'il est commenc\u00e9 seul, le patient risque de d\u00e9velopper une n\u00e9crose cutan\u00e9e induite par la warfarine, une complication potentiellement d\u00e9sastreuse bien que rare (0,01% \u2013 0,1%) survenant g\u00e9n\u00e9ralement 2 \u00e0 5 jours apr\u00e8s le d\u00e9but du traitement par la warfarine.<\/p>\n

Un homme de 63 ans a r\u00e9cemment diagnostiqu\u00e9 une cardiopathie rhumatismale accompagn\u00e9e d'une st\u00e9nose mitrale s\u00e9v\u00e8re et pr\u00e9sentait depuis 2 jours une diminution du d\u00e9bit urinaire. Il a commenc\u00e9 \u00e0 prendre un comprim\u00e9 de warfarine \u00e0 5 mg une fois par jour et un comprim\u00e9 de furos\u00e9mide \u00e0 20 mg deux fois par jour il y a 2 semaines. L'examen physique a montr\u00e9 un pouls de 98 bpm, une tension art\u00e9rielle de 140\/88 mm Hg et une fr\u00e9quence respiratoire de 26 respirations\/min. L'auscultation cardiaque a montr\u00e9 un rythme irr\u00e9gulier\u2026.<\/p>","protected":false},"author":2,"featured_media":7544,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"page_builder":"","fifu_image_url":"https:\/\/urbancare.clinic\/wp-content\/uploads\/2023\/02\/warfarin-induced-skin-necrosis.jpg","fifu_image_alt":"","footnotes":""},"categories":[185],"tags":[198],"class_list":["post-7543","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-research-medical-articles","tag-blood-pressure"],"yoast_head":"\nWarfarin induced skin necrosis - Urban Care Clinic<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/urbancare.clinic\/fr\/necrose-cutanee-induite-par-la-warfarine\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Warfarin induced skin necrosis - Urban Care Clinic\" \/>\n<meta property=\"og:description\" content=\"Warfarin, a double sword not only helps in anticoagulation by inhibition of vitamin K dependent clotting factors but also prevents clot lysis by inhibiting protein C and protein S. 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