{"id":7527,"date":"2022-11-22T13:00:22","date_gmt":"2022-11-22T10:00:22","guid":{"rendered":"https:\/\/urbancare.clinic\/complete-resolution-of-calciphylaxis-in-a-renal-transplant-patient-with-calcifediol\/"},"modified":"2022-11-22T13:00:22","modified_gmt":"2022-11-22T10:00:22","slug":"resolution-complete-de-la-calciphylaxie-chez-un-patient-transplante-renal-avec-du-calcifediol","status":"publish","type":"post","link":"https:\/\/urbancare.clinic\/fr\/complete-resolution-of-calciphylaxis-in-a-renal-transplant-patient-with-calcifediol\/","title":{"rendered":"R\u00e9solution compl\u00e8te de la calciphylaxie chez un patient transplant\u00e9 r\u00e9nal avec Calcifediol"},"content":{"rendered":"<div><img decoding=\"async\" src=\"https:\/\/urbancare.clinic\/wp-content\/uploads\/2023\/02\/complete-resolution-of-calciphylaxis-in-a-renal-transplant-patient-with-calcifediol.jpg\" class=\"ff-og-image-inserted\" style=\"display:none\"><\/div>\n<p><span class=\"highwire-journal-article-marker-start\"><\/span><\/p>\n<p id=\"p-1\">Pr\u00e9sentation:<\/p>\n<p id=\"p-2\">Une femme de 62 ans ayant re\u00e7u une greffe de rein d&#039;un donneur vivant en 2008 compliqu\u00e9e d&#039;une maladie r\u00e9nale chronique III, d&#039;une n\u00e9phrite lupique, d&#039;une hypothyro\u00efdie (mais sans ant\u00e9c\u00e9dent de diab\u00e8te) a pr\u00e9sent\u00e9 des ulc\u00e9rations isch\u00e9miques douloureuses, bilat\u00e9rales et m\u00e9diales du mollet (figure 1), qui sur la biopsie \u00e0 l&#039;emporte-pi\u00e8ce a r\u00e9v\u00e9l\u00e9 une calciphylaxie (figure 2). Son poids \u00e9tait de 66,3 kg, sa taille de 1,6 m et son indice de masse corporelle de 25,9 kg\/m.<sup>2<\/sup>. Elle prenait de l&#039;hydroxychloroquine, du mycoph\u00e9nolate et de la prednisone pour le lupus\/greffe et de la l\u00e9vothyroxine 125 mcg par jour pour l&#039;hypothyro\u00efdie. Son harmonie parathyro\u00efdienne intacte de base (iPTH), son calcium, son phosphore\u2026 <\/p>\n<p><span class=\"highwire-journal-article-marker-end\"><\/span><a href=\"http:\/\/pmj.bmj.com\/cgi\/content\/short\/98\/1166\/e35?rss=1\">Source quotidienne m\u00e9dicale<\/a><\/p>\n<p>","protected":false},"excerpt":{"rendered":"<p>Pr\u00e9sentation:<\/p>\n<p>Une femme de 62 ans ayant re\u00e7u une greffe de rein provenant d&#039;un donneur vivant en 2008 avec complications li\u00e9es \u00e0 une maladie r\u00e9nale chronique de type III, une n\u00e9phrite lupique, une hypothyro\u00efdie (mais sans ant\u00e9c\u00e9dents de diab\u00e8te) pr\u00e9sentait des ulc\u00e9rations isch\u00e9miques bilat\u00e9rales douloureuses au niveau du mollet m\u00e9dial (<cross-ref type=\"fig\" refid=\"F1\">Figure 1<\/cross-ref>), qui, lors d&#039;une biopsie au poin\u00e7on, a r\u00e9v\u00e9l\u00e9 une calciphylaxie (<cross-ref type=\"fig\" refid=\"F2\">Figure 2<\/cross-ref>). Son poids \u00e9tait de 66,3 kg, sa taille de 1,6 m et son indice de masse corporelle de 25,9 kg\/m<sup>2<\/sup>Elle prenait de l&#039;hydroxychloroquine, du mycoph\u00e9nolate et de la prednisone pour le lupus\/la transplantation et de la l\u00e9vothyroxine 125 mcg par jour pour l&#039;hypothyro\u00efdie. Ses valeurs initiales d&#039;harmonine parathyro\u00efdienne intacte (iPTH), de calcium, de phosphore et de 25-hydroxy-vitamine D \u00e9taient respectivement de 372 pg\/mL, 9,4 mg\/dL, 3,8 mg\/dL et 17,4 ng\/mL (<cross-ref type=\"tbl\" refid=\"T1\">Tableau 1<\/cross-ref>(illustrant les changements de laboratoire et de m\u00e9dicaments au fil du temps). Elle prenait du calcitriol (0,75 mcg\/jour), de l&#039;ergocalcif\u00e9rol (50 000 unit\u00e9s par semaine) et du cinacalcet 30 mcg tous les deux jours. Nous avons commenc\u00e9 par lui donner du calcifediol 30 mg, qui a ensuite \u00e9t\u00e9 augment\u00e9 \u00e0 60 mg par jour. Ses doses de calcitriol et d&#039;ergocalcif\u00e9rol ont \u00e9t\u00e9 r\u00e9duites lentement, tandis que le cinacalcet est rest\u00e9 le m\u00eame. Ceci\u2026<\/p>","protected":false},"author":2,"featured_media":7528,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"Default","format":"standard","meta":{"page_builder":"","fifu_image_url":"https:\/\/urbancare.clinic\/wp-content\/uploads\/2023\/02\/complete-resolution-of-calciphylaxis-in-a-renal-transplant-patient-with-calcifediol.jpg","fifu_image_alt":"","footnotes":""},"categories":[185],"tags":[],"class_list":["post-7527","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-research-medical-articles"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Complete resolution of calciphylaxis in a renal transplant patient with Calcifediol - Urban Care Clinic<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/urbancare.clinic\/fr\/resolution-complete-de-la-calciphylaxie-chez-un-patient-transplante-renal-avec-du-calcifediol\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Complete resolution of calciphylaxis in a renal transplant patient with Calcifediol - Urban Care Clinic\" \/>\n<meta property=\"og:description\" content=\"Presentation: A 62-year-old woman with a Living Donor Kidney transplant in 2008 complicated with chronic kidney disease III, lupus nephritis, hypothyroidism (but no history of diabetes) presented with painful, bilateral, medial calf ischaemic ulcerations (figure 1), which on punch biopsy revealed calciphylaxis (figure 2). Her weight was 66.3 kg, height 1.6 m and body mass index of 25.9 kg\/m2. She was on hydroxychloroquine, mycophenolate and prednisone for lupus\/transplant and levothyroxine 125 mcg daily for hypothyroidism. Her baseline intact parathyroid harmone (iPTH), calcium, phosphorus and 25-hydroxy-vitamin D was 372 pg\/mL, 9.4 mg\/dL, 3.8 mg\/dL and 17.4 ng\/mL, respectively (table 1depicting laboratories and medication changes over time). She was on calcitriol (0.75 mcg\/daily), ergocalciferol (50 000 units weekly) and cinacalcet 30 mcg every other day. We started her on calcifediol 30 mg, which was later increased to 60 mg daily. Her calcitriol and ergocalciferol doses were reduced slowly, while cinacalcet remained the same. 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Her weight was 66.3 kg, height 1.6 m and body mass index of 25.9 kg\/m2. She was on hydroxychloroquine, mycophenolate and prednisone for lupus\/transplant and levothyroxine 125 mcg daily for hypothyroidism. Her baseline intact parathyroid harmone (iPTH), calcium, phosphorus and 25-hydroxy-vitamin D was 372 pg\/mL, 9.4 mg\/dL, 3.8 mg\/dL and 17.4 ng\/mL, respectively (table 1depicting laboratories and medication changes over time). She was on calcitriol (0.75 mcg\/daily), ergocalciferol (50 000 units weekly) and cinacalcet 30 mcg every other day. We started her on calcifediol 30 mg, which was later increased to 60 mg daily. Her calcitriol and ergocalciferol doses were reduced slowly, while cinacalcet remained the same. 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