{"id":7517,"date":"2023-02-01T12:52:21","date_gmt":"2023-02-01T09:52:21","guid":{"rendered":"https:\/\/urbancare.clinic\/novel-ultrasound-technique-releases-hidden-neurodegenerative-markers-in-blood\/"},"modified":"2023-02-01T12:52:21","modified_gmt":"2023-02-01T09:52:21","slug":"une-nouvelle-technique-dechographie-libere-des-marqueurs-neurodegeneratifs-caches-dans-le-sang","status":"publish","type":"post","link":"https:\/\/urbancare.clinic\/fr\/une-nouvelle-technique-dechographie-libere-des-marqueurs-neurodegeneratifs-caches-dans-le-sang\/","title":{"rendered":"Une nouvelle technique d'\u00e9chographie lib\u00e8re des marqueurs neurod\u00e9g\u00e9n\u00e9ratifs cach\u00e9s dans le sang"},"content":{"rendered":"
<\/div>\n

Les chercheurs ont d\u00e9couvert qu\u2019une technique d\u2019\u00e9chographie cibl\u00e9e, connue sous le nom de sonobiopsie, peut lib\u00e9rer davantage de biomarqueurs de troubles neurod\u00e9g\u00e9n\u00e9ratifs dans le sang pour faciliter le diagnostic des maladies.<\/p>\n

L'\u00e9tude, publi\u00e9e mardi dans la revue Radiologie<\/a>, ont d\u00e9couvert une m\u00e9thode non invasive pour d\u00e9tecter des biomarqueurs dans le sang qui \u00e9taient auparavant restreints par la barri\u00e8re h\u00e9mato-enc\u00e9phalique.<\/p>\n

Selon l'\u00e9tude, la biopsie liquide m\u00e9di\u00e9e par ultrasons focalis\u00e9s sur un mod\u00e8le murin a lib\u00e9r\u00e9 plus de prot\u00e9ines tau et un autre biomarqueur dans le sang que sans elle. De nombreuses maladies neurod\u00e9g\u00e9n\u00e9ratives, dont la maladie d'Alzheimer, sont caract\u00e9ris\u00e9es par la pr\u00e9sence de prot\u00e9ines tau dans le cerveau.<\/p>\n

En sonobiopsie, des ultrasons focalis\u00e9s sont utilis\u00e9s pour cibler un emplacement pr\u00e9cis dans le cerveau.<\/p>\n

<\/div>\n

\u00ab Une fois localis\u00e9s, les chercheurs injectent des microbulles dans le sang qui se d\u00e9placent vers les tissus cibl\u00e9s par les ultrasons et palpitent, ce qui ouvre en toute s\u00e9curit\u00e9 la barri\u00e8re h\u00e9mato-enc\u00e9phalique. Les ouvertures temporaires permettent \u00e0 des biomarqueurs, tels que les prot\u00e9ines tau et la prot\u00e9ine de cha\u00eene l\u00e9g\u00e8re des neurofilaments (NfL), toutes deux indicatives de troubles neurod\u00e9g\u00e9n\u00e9ratifs, de traverser la barri\u00e8re h\u00e9mato-enc\u00e9phalique et de se lib\u00e9rer dans le sang \u00bb, ont \u00e9crit les chercheurs dans un communiqu\u00e9. communiqu\u00e9 de presse.<\/a><\/p>\n

La m\u00e9thode est pr\u00e9sent\u00e9e comme le premier diagnostic et suivi non invasif et cibl\u00e9 des troubles neurod\u00e9g\u00e9n\u00e9ratifs utilisant la technique des ultrasons.<\/p>\n

Dans l\u2019\u00e9tude, des \u00e9chantillons de sang ont \u00e9t\u00e9 pr\u00e9lev\u00e9s sur de jeunes souris pr\u00e9sentant des prot\u00e9ines tau anormales dans le cerveau, ou tauopathie, qui recevaient une sonobiopsie ou faisaient partie du groupe t\u00e9moin.<\/p>\n

Apr\u00e8s analyse, il a \u00e9t\u00e9 constat\u00e9 que la sonobiopsie entra\u00eenait une augmentation de 1,7 fois des niveaux normalis\u00e9s de prot\u00e9ine tau phosphoryl\u00e9e pTau-181 et une augmentation de 1,4 fois de la pTau-231 normalis\u00e9e par rapport au groupe de souris t\u00e9moin.<\/p>\n

Ensuite, les chercheurs ont de nouveau proc\u00e9d\u00e9 \u00e0 une sonobiopsie, cette fois en ciblant soit l'hippocampe, soit le cortex c\u00e9r\u00e9bral aux premiers stades neurod\u00e9g\u00e9n\u00e9ratifs du mod\u00e8le de tauopathie. Des \u00e9chantillons de sang avant et apr\u00e8s la sonobiopsie ont \u00e9t\u00e9 pr\u00e9lev\u00e9s et analys\u00e9s. La sonobiopsie cibl\u00e9e a montr\u00e9 une augmentation de 2,3 fois de la prot\u00e9ine NfL \u2013 un biomarqueur secondaire des maladies neurod\u00e9g\u00e9n\u00e9ratives \u2013 dans le groupe sonobiopsie.<\/p>\n

"Dans notre \u00e9tude de validation de principe, nous avons cherch\u00e9 \u00e0 d\u00e9terminer si la sonobiopsie \u00e9tait capable de lib\u00e9rer des esp\u00e8ces tau phosphoryl\u00e9es et du NfL dans la circulation sanguine en ouvrant la barri\u00e8re h\u00e9mato-enc\u00e9phalique", Hong Chen, professeur agr\u00e9g\u00e9 de g\u00e9nie biom\u00e9dical \u00e0 la McKelvey School of Ing\u00e9nierie et de radio-oncologie \u00e0 l'\u00c9cole de m\u00e9decine, a d\u00e9clar\u00e9 dans le communiqu\u00e9 de presse. "Cette d\u00e9monstration a montr\u00e9 que la sonobiopsie am\u00e9liorait de mani\u00e8re significative la lib\u00e9ration de prot\u00e9ines pTau et d'un marqueur secondaire de la neurod\u00e9g\u00e9n\u00e9rescence dans la circulation sanguine pour un diagnostic non invasif des maladies neurod\u00e9g\u00e9n\u00e9ratives."<\/p>\n

Dans une autre d\u00e9monstration d'ing\u00e9niosit\u00e9, un autre groupe de scientifiques a cr\u00e9\u00e9 un syst\u00e8me innovant \u00ab\u00a0patch intelligent\u00a0\u00bb<\/a> en utilisant la technologie des micro-aiguilles, qui peut d\u00e9tecter les signes avant-coureurs de la maladie d'Alzheimer en seulement six minutes, avant m\u00eame que les sympt\u00f4mes n'apparaissent. Le dispositif cr\u00e9\u00e9 par des scientifiques de l\u2019Universit\u00e9 de Swansea recherche des biomarqueurs inflammatoires des maladies neurologiques et peut les rep\u00e9rer avec une grande pr\u00e9cision.<\/p>\n

Source quotidienne m\u00e9dicale<\/a><\/p>\n

","protected":false},"excerpt":{"rendered":"

La m\u00e9thode est pr\u00e9sent\u00e9e comme le premier diagnostic et suivi non invasif et cibl\u00e9 des troubles neurod\u00e9g\u00e9n\u00e9ratifs utilisant la technique des ultrasons.<\/p>","protected":false},"author":2,"featured_media":7518,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"Default","format":"standard","meta":{"fifu_image_url":"https:\/\/urbancare.clinic\/wp-content\/uploads\/2023\/02\/novel-ultrasound-technique-releases-hidden-neurodegenerative-markers-in-blood.jpg","fifu_image_alt":"","footnotes":""},"categories":[27],"tags":[],"class_list":["post-7517","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blog"],"yoast_head":"\nNovel Ultrasound Technique Releases Hidden Neurodegenerative Markers In Blood - Urban Care Clinic<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/urbancare.clinic\/fr\/une-nouvelle-technique-dechographie-libere-des-marqueurs-neurodegeneratifs-caches-dans-le-sang\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Novel Ultrasound Technique Releases Hidden Neurodegenerative Markers In Blood - 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