{"id":7318,"date":"2023-01-20T12:55:34","date_gmt":"2023-01-20T09:55:34","guid":{"rendered":"https:\/\/urbancare.clinic\/hiv-vaccine-in-late-stage-trial-fails-extending-wait-for-effective-jab\/"},"modified":"2023-01-20T12:55:34","modified_gmt":"2023-01-20T09:55:34","slug":"le-vaccin-anti-vih-echoue-a-un-stade-avance-de-son-essai-ce-qui-prolonge-lattente-dun-vaccin-efficace","status":"publish","type":"post","link":"https:\/\/urbancare.clinic\/fr\/hiv-vaccine-in-late-stage-trial-fails-extending-wait-for-effective-jab\/","title":{"rendered":"L\u2019essai d\u2019un vaccin contre le VIH \u00e0 un stade avanc\u00e9 \u00e9choue, prolongeant l\u2019attente pour un vaccin efficace"},"content":{"rendered":"<div><img decoding=\"async\" src=\"https:\/\/urbancare.clinic\/wp-content\/uploads\/2023\/01\/hiv-vaccine-in-late-stage-trial-fails-extending-wait-for-effective-jab.jpg\" class=\"ff-og-image-inserted\" style=\"display:none\"><\/div>\n<p>Le seul vaccin contre le VIH test\u00e9 \u00e0 un stade avanc\u00e9 a \u00e9chou\u00e9. Ces sombres nouvelles constituent un frein aux efforts concert\u00e9s de lutte contre le VIH.&nbsp;<\/p>\n<p>L&#039;annonce a \u00e9t\u00e9 faite par les chercheurs impliqu\u00e9s mercredi, <a href=\"https:\/\/www.nbcnews.com\/nbc-out\/out-health-and-wellness\/another-major-hiv-vaccine-trial-fails-rcna66324\" rel=\"nofollow noopener\" target=\"_blank\">NBCActualit\u00e9s<\/a> signal\u00e9. L\u2019essai vaccinal du produit nomm\u00e9 Mosaico \u00e9tait un partenariat public-priv\u00e9 entre le gouvernement am\u00e9ricain et le g\u00e9ant pharmaceutique Janssen.<\/p>\n<p>L&#039;essai, lanc\u00e9 en 2019, a \u00e9t\u00e9 men\u00e9 dans huit pays d&#039;Europe et d&#039;Am\u00e9rique, dont les \u00c9tats-Unis. Pr\u00e8s de 3 900 hommes ayant des rapports sexuels avec des hommes et personnes transgenres ont \u00e9t\u00e9 recrut\u00e9s pour l&#039;\u00e9tude et ont tous \u00e9t\u00e9 consid\u00e9r\u00e9s comme pr\u00e9sentant un risque accru de VIH.<\/p>\n<p>Un comit\u00e9 ind\u00e9pendant de surveillance des donn\u00e9es et de la s\u00e9curit\u00e9 a examin\u00e9 les r\u00e9sultats de l&#039;essai et n&#039;a trouv\u00e9 aucun lien entre le vaccin et le taux d&#039;acquisition du VIH. Les chercheurs ont donc pris la d\u00e9cision d\u2019arr\u00eater leurs travaux.<\/p>\n<div id=\"dfp-ad-oop2\" class=\"dfp-tag-wrapper\"> <\/div>\n<p>&quot;C&#039;est \u00e9videmment d\u00e9cevant&quot;, a d\u00e9clar\u00e9 le Dr Anthony Fauci, ancien directeur de l&#039;Institut national des allergies et des maladies infectieuses (NIAID) et partenaire \u00e0 part enti\u00e8re de l&#039;essai, selon le m\u00e9dia. Il a ajout\u00e9 qu&#039;\u00ab il existe de nombreuses autres approches \u00bb dans le domaine de la recherche sur les vaccins anti-VIH \u00e0 l&#039;\u00e9tude et qu&#039;il consid\u00e8re comme prometteuses.<\/p>\n<p>&quot;Je ne pense pas que les gens devraient abandonner le domaine du vaccin contre le VIH&quot;, a d\u00e9clar\u00e9 Fauci.<\/p>\n<p>Cet \u00e9chec n\u2019est pas surprenant, selon les experts. Un vaccin similaire dans un essai clinique distinct appel\u00e9 Imbokodo a \u00e9galement \u00e9chou\u00e9.&nbsp;<a href=\"https:\/\/www.nih.gov\/news-events\/news-releases\/hiv-vaccine-candidate-does-not-sufficiently-protect-women-against-hiv-infection\" rel=\"nofollow noopener\" target=\"_blank\">en ao\u00fbt 2021<\/a>. Le vaccin a \u00e9t\u00e9 test\u00e9 aupr\u00e8s de femmes en Afrique. Le NIAID a d\u00e9pens\u00e9 au total $56 millions pour les deux essais, selon un porte-parole de l&#039;agence.<\/p>\n<p>Les vaccins des deux essais utilisaient un virus du rhume pour d\u00e9livrer des immunog\u00e8nes mosa\u00efques. L&#039;hypoth\u00e8se \u00e9tait que l&#039;immunog\u00e8ne d\u00e9clencherait une r\u00e9ponse immunitaire robuste car il inclurait du mat\u00e9riel g\u00e9n\u00e9tique provenant d&#039;un m\u00e9lange de souches de VIH r\u00e9pandues dans le monde,&nbsp;<a href=\"https:\/\/www.nih.gov\/news-events\/news-releases\/nih-partners-launch-hiv-vaccine-efficacy-study\" rel=\"nofollow noopener\" target=\"_blank\">selon les National Institutes of Health<\/a>. Mosaico avait une longueur d&#039;avance dans la mesure o\u00f9 il incluait un \u00e9l\u00e9ment suppl\u00e9mentaire pour \u00e9largir la r\u00e9ponse immunitaire.&nbsp;<\/p>\n<p>Dans l\u2019essai Mosaico, les participants \u00e2g\u00e9s de 18 \u00e0 60 ans ont re\u00e7u quatre injections sur un an. Apr\u00e8s analyse, le comit\u00e9 de surveillance <a href=\"https:\/\/newatlas.com\/medical\/large-phase-3-hiv-vaccine-trial-fails-nih\/\" rel=\"nofollow noopener\" target=\"_blank\">je n&#039;ai trouv\u00e9 aucune diff\u00e9rence<\/a> du taux d&#039;acquisition du VIH entre les deux groupes - vaccin et placebo.<\/p>\n<p>Le fait que le vaccin Mosaico ait produit ce que l\u2019on appelle des anticorps non neutralisants contre le VIH et des anticorps non neutralisants est devenu sa limite, a not\u00e9 Fauci.<\/p>\n<p>\u00ab Il devient clair, a-t-il d\u00e9clar\u00e9, que les vaccins qui n\u2019induisent pas d\u2019anticorps neutralisants ne sont pas efficaces contre le VIH. \u00bb<\/p>\n<p>L&#039;\u00e9chec du proc\u00e8s est un \u00ab rappel brutal de l&#039;insaisissabilit\u00e9 d&#039;un <a href=\"https:\/\/www.medicaldaily.com\/common-anti-viral-drugs-can-stop-hiv-transmission-mother-child-467581\">VIH<\/a> &quot;Le vaccin l&#039;est vraiment et pourquoi ce type de recherche continue d&#039;\u00eatre important&quot;, a d\u00e9clar\u00e9 Jennifer Kates, directrice de la sant\u00e9 mondiale et de la politique relative au VIH \u00e0 la Kaiser Family Foundation.<\/p>\n<p>&quot;Heureusement, il existe d\u00e9j\u00e0 un certain nombre d&#039;interventions de pr\u00e9vention du VIH tr\u00e8s efficaces&quot;, a ajout\u00e9 Kates. \u00ab Le d\u00e9fi est de les \u00e9tendre pour atteindre toutes les personnes \u00e0 risque. \u00bb&nbsp;<\/p>\n<p><a href=\"https:\/\/www.medicaldaily.com\/hiv-vaccine-late-stage-trial-fails-extending-wait-effective-jab-467815?utm_source=Public&#038;utm_medium=Feed&#038;utm_campaign=Distribution\">Source quotidienne m\u00e9dicale<\/a><\/p>\n<p>","protected":false},"excerpt":{"rendered":"<p>L&#039;\u00e9chec de l&#039;essai est un &quot;rappel brutal \u00e0 quel point un vaccin contre le VIH est insaisissable et pourquoi ce type de recherche continue d&#039;\u00eatre important&quot;, a d\u00e9clar\u00e9 Jennifer Kates, directrice de la sant\u00e9 mondiale et de la politique VIH \u00e0 la Kaiser Family Foundation.<\/p>","protected":false},"author":2,"featured_media":7319,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"Default","format":"standard","meta":{"page_builder":"","fifu_image_url":"https:\/\/urbancare.clinic\/wp-content\/uploads\/2023\/01\/hiv-vaccine-in-late-stage-trial-fails-extending-wait-for-effective-jab.jpg","fifu_image_alt":"","footnotes":""},"categories":[27],"tags":[],"class_list":["post-7318","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blog"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.4 - 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