{"id":7081,"date":"2022-12-29T13:12:32","date_gmt":"2022-12-29T10:12:32","guid":{"rendered":"https:\/\/www.medicaldaily.com\/scientists-develop-blood-test-alzheimers-diagnosis-467657"},"modified":"2022-12-29T13:12:32","modified_gmt":"2022-12-29T10:12:32","slug":"des-scientifiques-developpent-un-test-sanguin-pour-le-diagnostic-dalzheimer","status":"publish","type":"post","link":"https:\/\/urbancare.clinic\/fr\/scientists-develop-blood-test-for-alzheimers-diagnosis\/","title":{"rendered":"Des scientifiques d\u00e9veloppent un test sanguin pour le diagnostic de la maladie d&#039;Alzheimer"},"content":{"rendered":"<div><img decoding=\"async\" src=\"https:\/\/urbancare.clinic\/wp-content\/uploads\/2022\/12\/scientists-develop-blood-test-for-alzheimers-diagnosis.jpg\" class=\"ff-og-image-inserted\" style=\"display:none\"><\/div>\n<p>Les scientifiques ont cr\u00e9\u00e9 un test sanguin radical pour d\u00e9tecter la maladie d&#039;Alzheimer. Ce test sanguin aurait un avantage sur les autres tests sanguins dans le domaine.<\/p>\n<p>La maladie d&#039;Alzheimer est une maladie neurod\u00e9g\u00e9n\u00e9rative et constitue la forme de d\u00e9mence la plus courante, mais son diagnostic constitue un d\u00e9fi, en particulier au d\u00e9but de la maladie.<\/p>\n<p>Pour un diagnostic r\u00e9ussi, la d\u00e9tection de trois marqueurs distincts est recommand\u00e9e. Ceux-ci incluent une accumulation excessive de prot\u00e9ines amylo\u00efdes et tau, ainsi qu\u2019une perte lente et progressive de cellules neuronales dans des r\u00e9gions sp\u00e9cifiques du cerveau.<\/p>\n<p>Actuellement, le diagnostic de la maladie d&#039;Alzheimer n\u00e9cessite une imagerie c\u00e9r\u00e9brale co\u00fbteuse et une ponction lombaire douloureuse, selon <a href=\"https:\/\/www.theguardian.com\/society\/2022\/dec\/28\/scientists-develop-blood-test-for-alzheimers-disease\" rel=\"nofollow noopener\" target=\"_blank\">Le gardien<\/a>. Par cons\u00e9quent, la n\u00e9cessit\u00e9 d\u2019un diagnostic plus simple par test sanguin est \u00e9vidente.<\/p>\n<div id=\"dfp-ad-oop2\" class=\"dfp-tag-wrapper\"> <\/div>\n<p>L\u2019imagerie c\u00e9r\u00e9brale est non seulement co\u00fbteuse, mais n\u00e9cessite \u00e9galement un long temps d\u2019attente pour \u00eatre programm\u00e9e.<\/p>\n<p>\u00ab De nombreux patients, m\u00eame aux \u00c9tats-Unis, n&#039;ont pas acc\u00e8s aux scanners IRM et TEP. L&#039;accessibilit\u00e9 est un probl\u00e8me majeur \u00bb, professeur Thomas Karikari de l&#039;Universit\u00e9 de Pittsburgh, en Pennsylvanie, aux \u00c9tats-Unis, co-auteur de l&#039;\u00e9tude publi\u00e9e dans la revue <a href=\"https:\/\/academic.oup.com\/brain\/advance-article\/doi\/10.1093\/brain\/awac407\/6960988?login=false\" rel=\"nofollow noopener\" target=\"_blank\">Cerveau<\/a>, dit.<\/p>\n<p>La ponction lombaire est une proc\u00e9dure tr\u00e8s douloureuse utilis\u00e9e pour extraire le liquide c\u00e9phalorachidien (LCR) de la moelle \u00e9pini\u00e8re. On peut m\u00eame pr\u00e9senter des maux de t\u00eate ou des maux de dos apr\u00e8s la proc\u00e9dure.<\/p>\n<p>En plus d\u2019\u00eatre indolores et facilement disponibles, les analyses de sang contribueront \u00e9galement \u00e0 la d\u00e9tection pr\u00e9coce de la maladie, ce qui conduira \u00e0 l\u2019instauration pr\u00e9coce d\u2019un traitement.<\/p>\n<p>&quot;Un test sanguin est moins cher, plus s\u00fbr et plus facile \u00e0 administrer, et il peut am\u00e9liorer la confiance clinique dans le diagnostic de la maladie d&#039;Alzheimer et la s\u00e9lection des participants aux essais cliniques et au suivi de la maladie&quot;, a d\u00e9clar\u00e9 Karikari, a rapport\u00e9 le m\u00e9dia.<\/p>\n<p>Bien que les tests sanguins actuels puissent d\u00e9tecter des niveaux anormaux de prot\u00e9ines amylo\u00efdes et tau, il s\u2019av\u00e8re difficile de rep\u00e9rer les marqueurs de l\u00e9sions des cellules nerveuses sp\u00e9cifiques au cerveau. C\u2019est l\u00e0 que diff\u00e8re le test sanguin d\u00e9velopp\u00e9 par Karikari et son \u00e9quipe. L\u2019\u00e9quipe de recherche a d\u00e9velopp\u00e9 un test sanguin bas\u00e9 sur les anticorps qui d\u00e9tecte une forme particuli\u00e8re de prot\u00e9ine tau appel\u00e9e tau d\u00e9riv\u00e9e du cerveau. Cette prot\u00e9ine est sp\u00e9cifique de la maladie d&#039;Alzheimer.<\/p>\n<p>Pour cette \u00e9tude, les chercheurs ont test\u00e9 600 patients souffrant de diff\u00e9rents stades de la maladie d&#039;Alzheimer. Ils ont constat\u00e9 que les niveaux de tau d\u2019origine c\u00e9r\u00e9brale \u00e9taient proportionnels aux niveaux de tau dans le LCR. En outre, l&#039;analyse sanguine pourrait distinguer la maladie d&#039;Alzheimer des autres maladies neurod\u00e9g\u00e9n\u00e9ratives.<\/p>\n<p>Les niveaux de prot\u00e9ines ont \u00e9galement montr\u00e9 une forte association avec la gravit\u00e9 des plaques amylo\u00efdes et des enchev\u00eatrements de tau dans les tissus c\u00e9r\u00e9braux pr\u00e9lev\u00e9s sur des personnes d\u00e9c\u00e9d\u00e9es \u00e0 cause de la maladie d&#039;Alzheimer, selon l&#039;\u00e9tude.<\/p>\n<p>La surveillance des niveaux de tau d&#039;origine c\u00e9r\u00e9brale dans le sang pourrait aider \u00e0 cr\u00e9er des essais cliniques efficaces pour les traitements contre la maladie d&#039;Alzheimer, esp\u00e9rait Karikari.<\/p>\n<p>Une \u00e9tude distincte a r\u00e9v\u00e9l\u00e9 <a href=\"https:\/\/www.medicaldaily.com\/study-finds-multiple-rare-damaging-genetic-variants-increase-alzheimers-risk-467528\">variantes g\u00e9n\u00e9tiques rares et dommageables<\/a> qui augmentent le risque de maladie d&#039;Alzheimer.<\/p>\n<p>&quot;Nos r\u00e9sultats fournissent des preuves suppl\u00e9mentaires du r\u00f4le majeur du traitement des prot\u00e9ines pr\u00e9curseurs de l&#039;amylo\u00efde-\u03b2, de l&#039;agr\u00e9gation de l&#039;amylo\u00efde-\u03b2, du m\u00e9tabolisme des lipides et de la fonction microgliale dans la MA&quot;, ont \u00e9crit les auteurs dans leur article.<\/p>\n<p>En utilisant l&#039;analyse de la charge g\u00e9n\u00e9tique \u00e0 la place des \u00e9tudes d&#039;association pang\u00e9nomiques (GWAS) plus courantes, les chercheurs ont d\u00e9couvert un lien \u00e9troit entre des variantes rares et dommageables de l&#039;ATP8B4 et de l&#039;ABCA1 avec un risque de MA et un signal dans l&#039;ADAM10, ainsi que de rares -charge de variantes dans les g\u00e8nes RIN3, CLU, ZCWPW1 et ACE, selon GenEngNews.<\/p>\n<p><a href=\"https:\/\/www.medicaldaily.com\/scientists-develop-blood-test-alzheimers-diagnosis-467657?utm_source=Public&#038;utm_medium=Feed&#038;utm_campaign=Distribution\">Source quotidienne m\u00e9dicale<\/a><\/p>\n<p>","protected":false},"excerpt":{"rendered":"<p>&quot;Un test sanguin est moins cher, plus s\u00fbr et plus facile \u00e0 administrer, et il peut am\u00e9liorer la confiance clinique dans le diagnostic de la maladie d&#039;Alzheimer et la s\u00e9lection des participants aux essais cliniques et au suivi de la maladie&quot;, a d\u00e9clar\u00e9 le professeur Thomas Karikari.<\/p>","protected":false},"author":2,"featured_media":7082,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"Default","format":"standard","meta":{"page_builder":"","fifu_image_url":"https:\/\/urbancare.clinic\/wp-content\/uploads\/2022\/12\/scientists-develop-blood-test-for-alzheimers-diagnosis.jpg","fifu_image_alt":"","footnotes":""},"categories":[27],"tags":[],"class_list":["post-7081","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blog"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.4 - 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