{"id":7051,"date":"2022-12-23T12:51:18","date_gmt":"2022-12-23T09:51:18","guid":{"rendered":"https:\/\/www.medicaldaily.com\/common-acne-treatment-adolescents-can-have-long-term-effects-skeletal-system-467625"},"modified":"2022-12-23T12:51:18","modified_gmt":"2022-12-23T09:51:18","slug":"le-traitement-courant-de-lacne-chez-les-adolescents-peut-avoir-des-effets-a-long-terme-sur-letude-du-systeme-squelettique","status":"publish","type":"post","link":"https:\/\/urbancare.clinic\/fr\/common-acne-treatment-in-adolescents-can-have-long-term-effects-on-skeletal-system-study\/","title":{"rendered":"Le traitement courant de l'acn\u00e9 chez les adolescents peut avoir des effets \u00e0 long terme sur le syst\u00e8me squelettique : \u00e9tude"},"content":{"rendered":"
<\/div>\n

Les adolescents souffrant d\u2019acn\u00e9 devront peut-\u00eatre r\u00e9fl\u00e9chir \u00e0 deux fois avant de commencer un traitement antibiotique courant destin\u00e9 \u00e0 r\u00e9soudre les probl\u00e8mes de peau. Une nouvelle \u00e9tude a r\u00e9v\u00e9l\u00e9 que le traitement antibiotique peut alt\u00e9rer le syst\u00e8me squelettique avec des effets \u00e0 long terme.<\/p>\n

L'\u00e9tude, publi\u00e9e dans le Journal d'investigation clinique (JCI) Insight<\/a>, ont montr\u00e9 que l'utilisation topique \u00e0 long terme d'un antibiotique syst\u00e9mique, la minocycline, pouvait avoir des effets inattendus sur le d\u00e9veloppement osseux de l'adolescent.<\/p>\n

Le traitement \u00e0 la minocycline peut durer jusqu'\u00e0 deux ans. Cet antibiotique modifie le microbiome intestinal, c'est-\u00e0-dire la population de micro-organismes qui vivent dans l'intestin.<\/p>\n

Des chercheurs de l\u2019Universit\u00e9 m\u00e9dicale de Caroline du Sud (MUSC) ont d\u00e9couvert une forte corr\u00e9lation entre la composition du microbiome intestinal et une maturation saine du squelette.<\/p>\n

<\/div>\n

Pour l\u2019\u00e9tude, l\u2019\u00e9quipe de recherche a administr\u00e9 une dose appropri\u00e9e de minocycline \u00e0 des souris pendant la phase de croissance pubertaire\/postpub\u00e8re, qui est l\u2019\u00e2ge \u00e9quivalent de l\u2019adolescence chez l\u2019homme.<\/p>\n

Il a \u00e9t\u00e9 constat\u00e9 dans l\u2019\u00e9tude que, m\u00eame si le traitement par la minocycline n\u2019entra\u00eenait aucun effet cytotoxique ni n\u2019induisait de r\u00e9ponse pro-inflammatoire, il modifiait la composition du microbiome intestinal, ce qui entra\u00eenait une diminution de l\u2019accumulation de masse osseuse et une maturation squelettique inefficace.<\/p>\n

"Il y a des changements soutenus dans le microbiome intestinal apr\u00e8s un traitement syst\u00e9mique \u00e0 long terme par la minocycline, ce qui entra\u00eene une r\u00e9duction de la maturation osseuse", a d\u00e9clar\u00e9 le premier auteur, Matthew Carson, du laboratoire Novince. SciTechQuotidien<\/a>.<\/p>\n

"D'un point de vue clinique, non seulement le traitement \u00e0 la minocycline provoque des modifications du squelette en cours de maturation, mais le microbiome et le squelette ne sont pas capables de se r\u00e9tablir compl\u00e8tement apr\u00e8s une antibioth\u00e9rapie", Chad Novince, chercheur principal et professeur agr\u00e9g\u00e9 au D\u00e9partement des sciences de la sant\u00e9 bucco-dentaire. au Coll\u00e8ge de m\u00e9decine dentaire ajout\u00e9.<\/p>\n

La minocycline appartient \u00e0 la classe des antibiotiques t\u00e9tracyclines. Ce groupe comprend \u00e9galement des antibiotiques tels que la t\u00e9tracycline, la doxycycline et la sar\u00e9cycline. Ces antibiotiques agissent en emp\u00eachant la croissance et la propagation des bact\u00e9ries. Dans le cas d acn\u00e9<\/a>, ils tuent les bact\u00e9ries qui infectent les pores et r\u00e9duisent certaines substances grasses naturelles responsables de l'acn\u00e9.<\/p>\n

"Ce qui est vraiment int\u00e9ressant, c'est que si vous provoquez des changements dans le microbiome pendant cette phase adolescente, alors que votre microbiote progresse encore vers un \u00e9tat adulte stable, vous allez avoir des effets profonds sur le squelette en pleine maturation", a d\u00e9clar\u00e9 Carson, selon le m\u00e9dia.<\/p>\n

Fait int\u00e9ressant, l\u2019\u00e9quipe a d\u00e9couvert que les modifications du microbiome intestinal dues \u00e0 la minocycline affectaient \u00e9galement la communication entre le foie et l\u2019intestin gr\u00eale, qui s\u2019effectue par l\u2019interm\u00e9diaire de mol\u00e9cules appel\u00e9es acides biliaires.<\/p>\n

"Les acides biliaires n'\u00e9taient pas auparavant consid\u00e9r\u00e9s comme des mol\u00e9cules de communication importantes entre l'intestin et le squelette", a d\u00e9clar\u00e9 Novince, selon le m\u00e9dia. "En modifiant le microbiome intestinal, la composition des acides biliaires est modifi\u00e9e, ce qui influence la physiologie de l'h\u00f4te, y compris la maturation du squelette."<\/p>\n

L\u2019alt\u00e9ration du microbiome intestinal a cr\u00e9\u00e9 un pool diff\u00e9rent d\u2019acides biliaires. Ces diff\u00e9rents types d\u2019acides biliaires ne pouvaient pas activer les cellules formant les os appel\u00e9es ost\u00e9oblastes, ce qui, \u00e0 leur tour, diminuait la formation osseuse et la min\u00e9ralisation de plus de 30%.<\/p>\n

"Il s'agissait d'une v\u00e9ritable science collaborative, et c'est l\u00e0 que je pense que nous en sommes aujourd'hui", a d\u00e9clar\u00e9 Novince. \u00ab Pour mener une science \u00e0 fort impact, vous devez faire appel \u00e0 des experts de diff\u00e9rentes professions et disciplines. Nous avons eu la chance d\u2019avoir une \u00e9quipe vraiment solide. C\u2019\u00e9tait amusant \u2013 tout cela \u00e9tait excitant\u00a0!\u00a0\u00bb<\/p>\n

Source quotidienne m\u00e9dicale<\/a><\/p>\n

","protected":false},"excerpt":{"rendered":"

L\u2019\u00e9tude a r\u00e9v\u00e9l\u00e9 que le traitement par la minocycline modifiait la composition du microbiome intestinal, ce qui entra\u00eenait une diminution de l\u2019accumulation de masse osseuse et une maturation squelettique inefficace.<\/p>","protected":false},"author":2,"featured_media":7052,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"Default","format":"standard","meta":{"page_builder":"","fifu_image_url":"https:\/\/urbancare.clinic\/wp-content\/uploads\/2022\/12\/common-acne-treatment-in-adolescents-can-have-long-term-effects-on-skeletal-system-study.jpg","fifu_image_alt":"","footnotes":""},"categories":[27],"tags":[],"class_list":["post-7051","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blog"],"yoast_head":"\nCommon Acne Treatment In Adolescents Can Have Long-Term Effects On Skeletal System: Study - Urban Care Clinic<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, 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