{"id":7021,"date":"2022-12-22T13:03:40","date_gmt":"2022-12-22T10:03:40","guid":{"rendered":"https:\/\/www.medicaldaily.com\/6-neurogenerative-diseases-have-common-and-unique-cellular-signposts-study-467615"},"modified":"2022-12-22T14:43:03","modified_gmt":"2022-12-22T11:43:03","slug":"6-maladies-neurogeneratives-ont-des-signes-cellulaires-communs-et-uniques-selon-une-etude","status":"publish","type":"post","link":"https:\/\/urbancare.clinic\/fr\/6-neurogenerative-diseases-have-common-and-unique-cellular-signposts-study-finds\/","title":{"rendered":"6 maladies neurog\u00e9n\u00e9ratives ont des signes cellulaires communs et uniques, selon une \u00e9tude"},"content":{"rendered":"<div><img decoding=\"async\" src=\"https:\/\/urbancare.clinic\/wp-content\/uploads\/2022\/12\/6-neurogenerative-diseases-have-common-and-unique-cellular-signposts-study-finds.jpg\" class=\"ff-og-image-inserted\"  style=\"display:none\"><\/div>\n<p>Une \u00e9tude a r\u00e9v\u00e9l\u00e9 que plusieurs maladies neurod\u00e9g\u00e9n\u00e9ratives ont des processus cellulaires dysfonctionnels communs et uniques.<\/p>\n<p>Les six maladies neurod\u00e9g\u00e9n\u00e9ratives qui ont montr\u00e9 ce point commun comprennent la scl\u00e9rose lat\u00e9rale amyotrophique ou maladie de Lou Gehrig, la maladie d&#039;Alzheimer, l&#039;ataxie de Friedreich, la d\u00e9mence frontotemporale, la maladie de Huntington et la maladie de Parkinson.<\/p>\n<p>Pour l&#039;\u00e9tude publi\u00e9e dans&nbsp;<a href=\"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/epdf\/10.1002\/alz.12880\" rel=\"nofollow noopener\" target=\"_blank\">Alzheimer et d\u00e9mence\u00a0: le journal de l&#039;Association Alzheimer<\/a><em><a href=\"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/epdf\/10.1002\/alz.12880\" rel=\"nofollow noopener\" target=\"_blank\">,<\/a>&nbsp;<\/em>les chercheurs ont d\u00e9ploy\u00e9 une analyse d&#039;apprentissage automatique de l&#039;ARN \u00e0 partir d&#039;\u00e9chantillons de sang. Les \u00e9chantillons de sang ont \u00e9t\u00e9 pr\u00e9lev\u00e9s dans une base de donn\u00e9es accessible au public appel\u00e9e Gene Expression Omnibus. L&#039;\u00e9quipe de recherche a ensuite compar\u00e9 plusieurs maladies pour identifier les marqueurs d&#039;ARN qui surviennent dans plusieurs maladies neurod\u00e9g\u00e9n\u00e9ratives et ceux qui sont propres \u00e0 chaque trouble.<\/p>\n<p>L&#039;\u00e9tude a trouv\u00e9 huit points communs \u00e0 travers six maladies neurod\u00e9g\u00e9n\u00e9ratives. Il s&#039;agit de la r\u00e9gulation de la transcription, de la d\u00e9granulation (associ\u00e9e au processus inflammatoire), de la r\u00e9ponse immunitaire, de la synth\u00e8se prot\u00e9ique, de la mort cellulaire ou de l&#039;apoptose, des composants du cytosquelette, de l&#039;ubiquitylation\/prot\u00e9asome (partie de la d\u00e9gradation des prot\u00e9ines) et des complexes mitochondriaux (superviser la d\u00e9pense \u00e9nerg\u00e9tique dans les cellules), selon <a href=\"https:\/\/www.news-medical.net\/news\/20221221\/Study-explores-cellular-alterations-in-six-distinct-neurodegenerative-diseases.aspx?showform=cookiesettings\" rel=\"nofollow noopener\" target=\"_blank\">Actualit\u00e9sM\u00e9dical<\/a>.<\/p>\n<div id=\"dfp-ad-oop2\" class=\"dfp-tag-wrapper\"> <\/div>\n<p>Ces huit dysfonctionnements cellulaires sont li\u00e9s \u00e0 des pathologies identifiables dans le cerveau pour chaque maladie. Outre ces huit, l&#039;\u00e9tude a \u00e9galement trouv\u00e9 des marqueurs uniques pour chaque maladie.<\/p>\n<p>Par exemple, des transcriptions li\u00e9es \u00e0 un processus connu sous le nom de r\u00e9gulation des splic\u00e9osomes ont \u00e9t\u00e9 d\u00e9tect\u00e9es uniquement dans le cas de <a href=\"https:\/\/www.medicaldaily.com\/study-finds-multiple-rare-damaging-genetic-variants-increase-alzheimers-risk-467528\">La maladie d&#039;Alzheimer.<\/a><\/p>\n<p>\u00ab Il semble que plusieurs maladies neurod\u00e9g\u00e9n\u00e9ratives abritent des processus cellulaires dysfonctionnels fondamentaux similaires. Les diff\u00e9rences entre les maladies peuvent \u00eatre essentielles pour d\u00e9couvrir les vuln\u00e9rabilit\u00e9s r\u00e9gionales des types de cellules et les cibles th\u00e9rapeutiques pour chaque maladie \u00bb, a d\u00e9clar\u00e9 le premier auteur de l&#039;\u00e9tude, Carol Huseby, chercheuse au centre de recherche sur les maladies neurod\u00e9g\u00e9n\u00e9ratives ASU-Banner, selon le point de vente.<\/p>\n<p>Selon les Nations Unies, le bilan mondial des d\u00e9c\u00e8s dus \u00e0 toutes les maladies neurod\u00e9g\u00e9n\u00e9ratives combin\u00e9es pourrait \u00eatre de 1 milliard de personnes, selon le point de vente.<\/p>\n<p>Dans ce contexte, le besoin de nouvelles m\u00e9thodes de diagnostic pr\u00e9coce, de meilleurs traitements et m\u00eame de m\u00e9thodes de pr\u00e9vention est supr\u00eame.<\/p>\n<p>Les transcrits d&#039;ARN extraits du sang sont transmis \u00e0 l&#039;algorithme d&#039;apprentissage automatique, connu sous le nom de Random Forest, qui analyse ensuite les donn\u00e9es et compare les r\u00e9sultats avec des mod\u00e8les connus associ\u00e9s aux voies biologiques li\u00e9es \u00e0 la maladie.<\/p>\n<p>Les autres formes habituelles de tests sont souvent moins d\u00e9taill\u00e9es, co\u00fbteuses, invasives et \u00e0 forte intensit\u00e9 de main-d&#039;\u0153uvre. En revanche, le diagnostic par sang total est une alternative peu co\u00fbteuse. Il peut \u00eatre facilement collect\u00e9 chez des patients \u00e0 tous les stades de la vie.<\/p>\n<p>De plus, les changements dans le r\u00e9sultat sanguin peuvent \u00eatre suivis, ce qui peut aider \u00e0 suivre la progression de la maladie.<\/p>\n<p>L&#039;\u00e9tude ouvre la possibilit\u00e9 que des modifications de l&#039;ARN courantes dans plusieurs maladies puissent se d\u00e9velopper ult\u00e9rieurement en maladies neurod\u00e9g\u00e9n\u00e9ratives individuelles. Cependant, le m\u00e9canisme derri\u00e8re ce ph\u00e9nom\u00e8ne reste un myst\u00e8re.<\/p>\n<p><a href=\"https:\/\/www.medicaldaily.com\/6-neurogenerative-diseases-have-common-and-unique-cellular-signposts-study-467615?utm_source=Public&#038;utm_medium=Feed&#038;utm_campaign=Distribution\">Source quotidienne m\u00e9dicale<\/a><\/p>\n<p>","protected":false},"excerpt":{"rendered":"<p>Selon les Nations Unies, le bilan mondial des d\u00e9c\u00e8s dus \u00e0 toutes les maladies neurod\u00e9g\u00e9n\u00e9ratives combin\u00e9es pourrait \u00eatre d&#039;un milliard de personnes.<\/p>","protected":false},"author":2,"featured_media":7022,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"page_builder":"","fifu_image_url":"https:\/\/urbancare.clinic\/wp-content\/uploads\/2022\/12\/6-neurogenerative-diseases-have-common-and-unique-cellular-signposts-study-finds.jpg","fifu_image_alt":"","footnotes":""},"categories":[121],"tags":[],"class_list":["post-7021","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-health-articles"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>6 Neurogenerative Diseases Have Common And Unique Cellular Signposts, Study Finds - Urban Care Clinic<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" 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