{"id":9220,"date":"2023-12-29T08:10:06","date_gmt":"2023-12-29T05:10:06","guid":{"rendered":"https:\/\/urbancare.clinic\/an-alternative-approach-to-treat-obesity-scientists-develop-vibrating-ingestible-capsule-that-makes-you-feel-full\/"},"modified":"2023-12-29T08:10:06","modified_gmt":"2023-12-29T05:10:06","slug":"ein-alternativer-ansatz-zur-behandlung-von-fettleibigkeit-wissenschaftler-entwickeln-vibrierende-einnehmbare-kapseln-die-ein-sattigungsgefuhl-hervorrufen","status":"publish","type":"post","link":"https:\/\/urbancare.clinic\/de\/an-alternative-approach-to-treat-obesity-scientists-develop-vibrating-ingestible-capsule-that-makes-you-feel-full\/","title":{"rendered":"Ein alternativer Ansatz zur Behandlung von Fettleibigkeit? Wissenschaftler entwickeln vibrierende, einnehmbare Kapseln, die f\u00fcr ein S\u00e4ttigungsgef\u00fchl sorgen"},"content":{"rendered":"
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Forscher haben eine einnehmbare Kapsel entwickelt, die bei Einnahme vor einer Mahlzeit im Magen vibriert und Signale an das Gehirn sendet, um ein illusorisches S\u00e4ttigungsgef\u00fchl zu erzeugen und es dazu zu bringen, mit dem Essen aufzuh\u00f6ren. Die neue Kapsel k\u00f6nnte sich als minimalinvasive und kosteng\u00fcnstige M\u00f6glichkeit zur Behandlung von Fettleibigkeit erweisen.<\/p>\n

Forscher vom Massachusetts Institute of Technology gepr\u00fcft<\/a> die neue Kapsel an Tieren und stellte fest, dass sie, wenn sie 20 Minuten vor dem Essen verabreicht wurde, die Freisetzung von Hormonen stimulierte, die ein S\u00e4ttigungsgef\u00fchl signalisieren, und die Nahrungsaufnahme des Tieres um etwa 40% reduzierte. Die Ergebnisse wurden in der Fachzeitschrift Science Advances ver\u00f6ffentlicht.<\/p>\n

\u201eJemand, der abnehmen oder seinen Appetit kontrollieren m\u00f6chte, kann es vor jeder Mahlzeit einnehmen. \u201eDas k\u00f6nnte insofern wirklich interessant sein, als es eine Option w\u00e4re, die die Nebenwirkungen, die wir bei anderen pharmakologischen Behandlungen sehen, minimieren k\u00f6nnte\u201c, sagte Hauptautorin Shriya Srinivasan von der Harvard University in einem Pressemitteilung<\/a>.<\/p>\n

Wenn Sie vor einer Mahlzeit ein Glas Wasser trinken, versp\u00fcren Sie weniger Hunger. Denn wenn der Magen mit Fl\u00fcssigkeit gef\u00fcllt ist, senden die Mechanorezeptoren der Magenschleimhaut Signale an das Gehirn, die f\u00fcr ein S\u00e4ttigungsgef\u00fchl sorgen. Forscher arbeiteten an dieser Idee und testeten, ob eine einnehmbare Kapsel, die im Magen vibriert, die Mechanorezeptoren k\u00fcnstlich dehnen und das gleiche S\u00e4ttigungsgef\u00fchl erzeugen k\u00f6nnte.<\/p>\n

\u201eWenn sich der Magen ausdehnt, sp\u00fcren spezialisierte Zellen, sogenannte Mechanorezeptoren, diese Dehnung und senden \u00fcber den Vagusnerv Signale an das Gehirn. Dadurch stimuliert das Gehirn die Produktion von Insulin sowie von Hormonen wie C-Peptid, Pyy und GLP-1. Alle diese Hormone wirken zusammen, um den Menschen dabei zu helfen, ihre Nahrung zu verdauen, sich satt zu f\u00fchlen und mit dem Essen aufzuh\u00f6ren. Gleichzeitig sinkt der Spiegel von Ghrelin, einem Hormon, das den Hunger f\u00f6rdert\u201c, erkl\u00e4rten die Forscher.<\/p>\n

Das Forschungsteam entwarf eine Kapsel in der Gr\u00f6\u00dfe eines Multivitaminpr\u00e4parats, die von einer kleinen Silberoxidbatterie angetrieben wird. Nachdem die Kapsel eingenommen wurde, l\u00f6sen die Magenfl\u00fcssigkeiten die sie bedeckende Membran auf, schlie\u00dfen den elektronischen Schaltkreis und aktivieren den Vibrationsmotor.<\/p>\n

Bei Tierversuchen stellten die Forscher fest, dass der Hormonspiegel bei Vibration des Ger\u00e4ts den Mustern nach einer normalen Mahlzeit sehr \u00e4hnlich war. Es gab keine Anzeichen einer Verstopfung, Perforation oder anderer negativer Auswirkungen bei den Tieren, w\u00e4hrend sich die Pille im Verdauungstrakt befand. Die Pillen passierten den Verdauungstrakt innerhalb von vier bis f\u00fcnf Tagen.<\/p>\n

Die aktuelle Version der Pille kann etwa 30 Minuten lang vibrieren, nachdem sie den Magen erreicht hat. Forscher planen, es \u00fcber l\u00e4ngere Zeitr\u00e4ume zu verl\u00e4ngern und die M\u00f6glichkeit zu testen, es drahtlos zu aktivieren und zu deaktivieren.<\/p>\n

Forscher hoffen, dass die neue Pille eine sicherere Alternative zu den aktuellen Methoden zur Behandlung von Fettleibigkeit sein k\u00f6nnte, wenn Di\u00e4t und Bewegung versagen. Viele bestehende medizinische Eingriffe wie Magenbypass-Operationen und Magenballons gelten oft als invasiv und werden aus Sicherheitsgr\u00fcnden nicht allgemein empfohlen. W\u00e4hrend Medikamente wie GLP-1-Agonisten bei der Gewichtsabnahme helfen k\u00f6nnen, erfordern viele von ihnen eine Injektion, was sie f\u00fcr viele weniger praktisch und unerschwinglich macht.<\/p>\n

\u201eF\u00fcr viele Bev\u00f6lkerungsgruppen sind einige der wirksameren Therapien gegen Fettleibigkeit sehr kostspielig. Im gro\u00dfen Ma\u00dfstab k\u00f6nnte unser Ger\u00e4t zu einem recht kosteng\u00fcnstigen Preis hergestellt werden. Ich w\u00fcrde gerne sehen, wie sich dadurch die Pflege und Therapie f\u00fcr Menschen in globalen Gesundheitseinrichtungen ver\u00e4ndern w\u00fcrde, die m\u00f6glicherweise keinen Zugang zu einigen der anspruchsvolleren oder teureren Optionen haben, die heute verf\u00fcgbar sind\u201c, sagte Srinivasan.<\/p>\n

Medizinische t\u00e4gliche Quelle<\/a><\/p>\n

","protected":false},"excerpt":{"rendered":"

<\/div>\n

Forscher haben eine einnehmbare Kapsel entwickelt, die bei Einnahme vor einer Mahlzeit im Magen vibriert und Signale an das Gehirn sendet, um ein illusorisches S\u00e4ttigungsgef\u00fchl zu erzeugen und es dazu zu bringen, mit dem Essen aufzuh\u00f6ren. Die neue Kapsel k\u00f6nnte sich als minimalinvasive und kosteng\u00fcnstige M\u00f6glichkeit zur Behandlung von Fettleibigkeit erweisen.<\/p>\n

Forscher vom Massachusetts Institute of Technology gepr\u00fcft<\/a> die neue Kapsel an Tieren und stellte fest, dass sie, wenn sie 20 Minuten vor dem Essen verabreicht wurde, die Freisetzung von Hormonen stimulierte, die ein S\u00e4ttigungsgef\u00fchl signalisieren, und die Nahrungsaufnahme des Tieres um etwa 40% reduzierte. Die Ergebnisse wurden in der Fachzeitschrift Science Advances ver\u00f6ffentlicht.<\/p>\n

\u201eJemand, der abnehmen oder seinen Appetit kontrollieren m\u00f6chte, kann es vor jeder Mahlzeit einnehmen. \u201eDas k\u00f6nnte insofern wirklich interessant sein, als es eine Option w\u00e4re, die die Nebenwirkungen, die wir bei anderen pharmakologischen Behandlungen sehen, minimieren k\u00f6nnte\u201c, sagte Hauptautorin Shriya Srinivasan von der Harvard University in einem Pressemitteilung<\/a>.<\/p>\n

Wenn Sie vor einer Mahlzeit ein Glas Wasser trinken, versp\u00fcren Sie weniger Hunger. Denn wenn der Magen mit Fl\u00fcssigkeit gef\u00fcllt ist, senden die Mechanorezeptoren der Magenschleimhaut Signale an das Gehirn, die f\u00fcr ein S\u00e4ttigungsgef\u00fchl sorgen. Forscher arbeiteten an dieser Idee und testeten, ob eine einnehmbare Kapsel, die im Magen vibriert, die Mechanorezeptoren k\u00fcnstlich dehnen und das gleiche S\u00e4ttigungsgef\u00fchl erzeugen k\u00f6nnte.<\/p>\n

\u201eWenn sich der Magen ausdehnt, sp\u00fcren spezialisierte Zellen, sogenannte Mechanorezeptoren, diese Dehnung und senden \u00fcber den Vagusnerv Signale an das Gehirn. Dadurch stimuliert das Gehirn die Produktion von Insulin sowie von Hormonen wie C-Peptid, Pyy und GLP-1. Alle diese Hormone wirken zusammen, um den Menschen dabei zu helfen, ihre Nahrung zu verdauen, sich satt zu f\u00fchlen und mit dem Essen aufzuh\u00f6ren. Gleichzeitig sinkt der Spiegel von Ghrelin, einem Hormon, das den Hunger f\u00f6rdert\u201c, erkl\u00e4rten die Forscher.<\/p>\n

Das Forschungsteam entwarf eine Kapsel in der Gr\u00f6\u00dfe eines Multivitaminpr\u00e4parats, die von einer kleinen Silberoxidbatterie angetrieben wird. Nachdem die Kapsel eingenommen wurde, l\u00f6sen die Magenfl\u00fcssigkeiten die sie bedeckende Membran auf, schlie\u00dfen den elektronischen Schaltkreis und aktivieren den Vibrationsmotor.<\/p>\n

Bei Tierversuchen stellten die Forscher fest, dass der Hormonspiegel bei Vibration des Ger\u00e4ts den Mustern nach einer normalen Mahlzeit sehr \u00e4hnlich war. Es gab keine Anzeichen einer Verstopfung, Perforation oder anderer negativer Auswirkungen bei den Tieren, w\u00e4hrend sich die Pille im Verdauungstrakt befand. Die Pillen passierten den Verdauungstrakt innerhalb von vier bis f\u00fcnf Tagen.<\/p>\n

Die aktuelle Version der Pille kann etwa 30 Minuten lang vibrieren, nachdem sie den Magen erreicht hat. Forscher planen, es \u00fcber l\u00e4ngere Zeitr\u00e4ume zu verl\u00e4ngern und die M\u00f6glichkeit zu testen, es drahtlos zu aktivieren und zu deaktivieren.<\/p>\n

Forscher hoffen, dass die neue Pille eine sicherere Alternative zu den aktuellen Methoden zur Behandlung von Fettleibigkeit sein k\u00f6nnte, wenn Di\u00e4t und Bewegung versagen. Viele bestehende medizinische Eingriffe wie Magenbypass-Operationen und Magenballons gelten oft als invasiv und werden aus Sicherheitsgr\u00fcnden nicht allgemein empfohlen. W\u00e4hrend Medikamente wie GLP-1-Agonisten bei der Gewichtsabnahme helfen k\u00f6nnen, erfordern viele von ihnen eine Injektion, was sie f\u00fcr viele weniger praktisch und unerschwinglich macht.<\/p>\n

\u201eF\u00fcr viele Bev\u00f6lkerungsgruppen sind einige der wirksameren Therapien gegen Fettleibigkeit sehr kostspielig. Im gro\u00dfen Ma\u00dfstab k\u00f6nnte unser Ger\u00e4t zu einem recht kosteng\u00fcnstigen Preis hergestellt werden. Ich w\u00fcrde gerne sehen, wie sich dadurch die Pflege und Therapie f\u00fcr Menschen in globalen Gesundheitseinrichtungen ver\u00e4ndern w\u00fcrde, die m\u00f6glicherweise keinen Zugang zu einigen der anspruchsvolleren oder teureren Optionen haben, die heute verf\u00fcgbar sind\u201c, sagte Srinivasan.<\/p>","protected":false},"author":2,"featured_media":9221,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"Default","format":"standard","meta":{"page_builder":"","fifu_image_url":"https:\/\/urbancare.clinic\/wp-content\/uploads\/2024\/01\/an-alternative-approach-to-treat-obesity-scientists-develop-vibrating-ingestible-capsule-that-makes-you-feel-full.jpg","fifu_image_alt":"","footnotes":""},"categories":[27],"tags":[],"class_list":["post-9220","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blog"],"yoast_head":"\nAn Alternative Approach To Treat Obesity? Scientists Develop Vibrating, Ingestible Capsule That Makes You Feel Full - Urban Care Clinic<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/urbancare.clinic\/de\/ein-alternativer-ansatz-zur-behandlung-von-fettleibigkeit-wissenschaftler-entwickeln-vibrierende-einnehmbare-kapseln-die-ein-sattigungsgefuhl-hervorrufen\/\" \/>\n<meta property=\"og:locale\" content=\"de_DE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"An Alternative Approach To Treat Obesity? Scientists Develop Vibrating, Ingestible Capsule That Makes You Feel Full - Urban Care Clinic\" \/>\n<meta property=\"og:description\" content=\"Researchers have developed an ingestible capsule, which when ingested before a meal, vibrates in the stomach, sending signals to the brain to create an illusory sense of fullness and trick it to stop eating. The new capsule could emerge as a minimally invasive and cost-effective way to treat obesity.Researchers from the Massachusetts Institute of Technology tested the new capsule on animals and found that when given 20 minutes before eating, it stimulated the release of hormones that signal satiety and reduced the animal's food intake by about 40%. The results were published in the journal Science Advances."For somebody who wants to lose weight or control their appetite, it could be taken before each meal. This could be really interesting in that it would provide an option that could minimize the side effects that we see with the other pharmacological treatments out there," lead author Shriya Srinivasan, from Harvard University, said in a news release.Drinking a glass of water before a meal makes you feel less hungry. This is because when the stomach is full of liquid, the mechanoreceptors of the stomach lining send signals to the brain, making you feel satiated. Researchers worked on this idea and tested if an ingestible capsule that vibrates within the stomach could artificially stretch the mechanoreceptors and create the same sense of fullness."When the stomach becomes distended, specialized cells called mechanoreceptors sense that stretching and send signals to the brain via the vagus nerve. As a result, the brain stimulates the production of insulin, as well as hormones such as C-peptide, Pyy and GLP-1. All of these hormones work together to help people digest their food, feel full, and stop eating. At the same time, levels of ghrelin, a hunger-promoting hormone, go down," researchers explained.The research team designed a capsule about the size of a multivitamin, powered by a small silver oxide battery. After the capsule gets ingested, the gastric fluids dissolve the membrane that covers it, complete the electronic circuit and activate the vibrating motor.During animal trials, researchers noticed that when the device was vibrating, hormone levels closely mimicked the patterns seen after a regular meal. There were no signs of obstruction, perforation or other negative impacts in animals while the pill was in their digestive tract. The pills passed through the digestive tract within four or five days.The current version of the pill can vibrate for about 30 minutes after reaching the stomach. Researchers plan to extend it for longer periods and test the possibility of activating and deactivating it wirelessly.Researchers hope the new pill could work as a safer alternative to the current methods of treating obesity when diet and exercise fail. Many existing medical interventions such as gastric bypass surgery and gastric balloons are often considered invasive and are not widely recommended due to safety concerns. While drugs like GLP-1 agonists can help in weight loss, many of them require injection, making them less convenient and unaffordable for many."For a lot of populations, some of the more effective therapies for obesity are very costly. At scale, our device could be manufactured at a pretty cost-effective price point. I'd love to see how this would transform care and therapy for people in global health settings who may not have access to some of the more sophisticated or expensive options that are available today," Srinivasan said.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/urbancare.clinic\/de\/ein-alternativer-ansatz-zur-behandlung-von-fettleibigkeit-wissenschaftler-entwickeln-vibrierende-einnehmbare-kapseln-die-ein-sattigungsgefuhl-hervorrufen\/\" \/>\n<meta property=\"og:site_name\" content=\"Urban Care Clinic\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/urbancarezanzibar\" \/>\n<meta property=\"article:published_time\" content=\"2023-12-29T05:10:06+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/urbancare.clinic\/wp-content\/uploads\/2024\/01\/an-alternative-approach-to-treat-obesity-scientists-develop-vibrating-ingestible-capsule-that-makes-you-feel-full.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1024\" \/>\n\t<meta property=\"og:image:height\" content=\"1024\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Urban Care Clinic\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Verfasst von\" \/>\n\t<meta name=\"twitter:data1\" content=\"Urban Care Clinic\" \/>\n\t<meta name=\"twitter:label2\" content=\"Gesch\u00e4tzte Lesezeit\" \/>\n\t<meta name=\"twitter:data2\" content=\"3\u00a0Minuten\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/urbancare.clinic\\\/an-alternative-approach-to-treat-obesity-scientists-develop-vibrating-ingestible-capsule-that-makes-you-feel-full\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/urbancare.clinic\\\/an-alternative-approach-to-treat-obesity-scientists-develop-vibrating-ingestible-capsule-that-makes-you-feel-full\\\/\"},\"author\":{\"name\":\"Urban Care Clinic\",\"@id\":\"https:\\\/\\\/urbancare.clinic\\\/#\\\/schema\\\/person\\\/a304a61bcf298680ee41e2e9ae193930\"},\"headline\":\"An Alternative Approach To Treat Obesity? 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Wissenschaftler entwickeln vibrierende, einnehmbare Kapsel, die f\u00fcr ein S\u00e4ttigungsgef\u00fchl sorgt \u2013 Urban Care Clinic","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/urbancare.clinic\/de\/ein-alternativer-ansatz-zur-behandlung-von-fettleibigkeit-wissenschaftler-entwickeln-vibrierende-einnehmbare-kapseln-die-ein-sattigungsgefuhl-hervorrufen\/","og_locale":"de_DE","og_type":"article","og_title":"An Alternative Approach To Treat Obesity? Scientists Develop Vibrating, Ingestible Capsule That Makes You Feel Full - Urban Care Clinic","og_description":"Researchers have developed an ingestible capsule, which when ingested before a meal, vibrates in the stomach, sending signals to the brain to create an illusory sense of fullness and trick it to stop eating. The new capsule could emerge as a minimally invasive and cost-effective way to treat obesity.Researchers from the Massachusetts Institute of Technology tested the new capsule on animals and found that when given 20 minutes before eating, it stimulated the release of hormones that signal satiety and reduced the animal's food intake by about 40%. The results were published in the journal Science Advances.\"For somebody who wants to lose weight or control their appetite, it could be taken before each meal. This could be really interesting in that it would provide an option that could minimize the side effects that we see with the other pharmacological treatments out there,\" lead author Shriya Srinivasan, from Harvard University, said in a news release.Drinking a glass of water before a meal makes you feel less hungry. This is because when the stomach is full of liquid, the mechanoreceptors of the stomach lining send signals to the brain, making you feel satiated. Researchers worked on this idea and tested if an ingestible capsule that vibrates within the stomach could artificially stretch the mechanoreceptors and create the same sense of fullness.\"When the stomach becomes distended, specialized cells called mechanoreceptors sense that stretching and send signals to the brain via the vagus nerve. As a result, the brain stimulates the production of insulin, as well as hormones such as C-peptide, Pyy and GLP-1. All of these hormones work together to help people digest their food, feel full, and stop eating. At the same time, levels of ghrelin, a hunger-promoting hormone, go down,\" researchers explained.The research team designed a capsule about the size of a multivitamin, powered by a small silver oxide battery. After the capsule gets ingested, the gastric fluids dissolve the membrane that covers it, complete the electronic circuit and activate the vibrating motor.During animal trials, researchers noticed that when the device was vibrating, hormone levels closely mimicked the patterns seen after a regular meal. There were no signs of obstruction, perforation or other negative impacts in animals while the pill was in their digestive tract. The pills passed through the digestive tract within four or five days.The current version of the pill can vibrate for about 30 minutes after reaching the stomach. Researchers plan to extend it for longer periods and test the possibility of activating and deactivating it wirelessly.Researchers hope the new pill could work as a safer alternative to the current methods of treating obesity when diet and exercise fail. Many existing medical interventions such as gastric bypass surgery and gastric balloons are often considered invasive and are not widely recommended due to safety concerns. While drugs like GLP-1 agonists can help in weight loss, many of them require injection, making them less convenient and unaffordable for many.\"For a lot of populations, some of the more effective therapies for obesity are very costly. At scale, our device could be manufactured at a pretty cost-effective price point. I'd love to see how this would transform care and therapy for people in global health settings who may not have access to some of the more sophisticated or expensive options that are available today,\" Srinivasan said.","og_url":"https:\/\/urbancare.clinic\/de\/ein-alternativer-ansatz-zur-behandlung-von-fettleibigkeit-wissenschaftler-entwickeln-vibrierende-einnehmbare-kapseln-die-ein-sattigungsgefuhl-hervorrufen\/","og_site_name":"Urban Care Clinic","article_publisher":"https:\/\/www.facebook.com\/urbancarezanzibar","article_published_time":"2023-12-29T05:10:06+00:00","og_image":[{"url":"https:\/\/urbancare.clinic\/wp-content\/uploads\/2024\/01\/an-alternative-approach-to-treat-obesity-scientists-develop-vibrating-ingestible-capsule-that-makes-you-feel-full.jpg","width":1024,"height":1024,"type":"image\/jpeg"}],"author":"Urban Care Clinic","twitter_card":"summary_large_image","twitter_misc":{"Verfasst von":"Urban Care Clinic","Gesch\u00e4tzte Lesezeit":"3\u00a0Minuten"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/urbancare.clinic\/an-alternative-approach-to-treat-obesity-scientists-develop-vibrating-ingestible-capsule-that-makes-you-feel-full\/#article","isPartOf":{"@id":"https:\/\/urbancare.clinic\/an-alternative-approach-to-treat-obesity-scientists-develop-vibrating-ingestible-capsule-that-makes-you-feel-full\/"},"author":{"name":"Urban Care Clinic","@id":"https:\/\/urbancare.clinic\/#\/schema\/person\/a304a61bcf298680ee41e2e9ae193930"},"headline":"An Alternative Approach To Treat Obesity? 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