{"id":8643,"date":"2023-09-15T13:20:23","date_gmt":"2023-09-15T10:20:23","guid":{"rendered":"https:\/\/urbancare.clinic\/us-surgeons-report-longest-successful-pig-to-human-kidney-transplant\/"},"modified":"2023-09-15T13:20:23","modified_gmt":"2023-09-15T10:20:23","slug":"us-chirurgen-berichten-uber-die-langste-erfolgreiche-nierentransplantation-vom-schwein-zum-menschen","status":"publish","type":"post","link":"https:\/\/urbancare.clinic\/de\/us-chirurgen-berichten-uber-die-langste-erfolgreiche-nierentransplantation-vom-schwein-zum-menschen\/","title":{"rendered":"US-Chirurgen berichten \u00fcber l\u00e4ngste erfolgreiche Nierentransplantation vom Schwein zum Menschen"},"content":{"rendered":"<div><img decoding=\"async\" src=\"https:\/\/urbancare.clinic\/wp-content\/uploads\/2023\/09\/us-surgeons-report-longest-successful-pig-to-human-kidney-transplant.jpg\" class=\"ff-og-image-inserted\" style=\"display:none\"><\/div>\n<p>US-Chirurgen, die einem hirntoten Patienten eine gentechnisch ver\u00e4nderte Schweineniere transplantiert hatten, gaben am Donnerstag bekannt, dass sie ihr Experiment nach rekordverd\u00e4chtigen 61 Tagen beendet hatten.<\/p>\n<p>Das neueste experimentelle Verfahren ist Teil eines wachsenden Forschungsfelds, das darauf abzielt, art\u00fcbergreifende Transplantationen voranzutreiben, wobei die Technik haupts\u00e4chlich an K\u00f6rpern getestet wird, die f\u00fcr die Wissenschaft gespendet wurden.<\/p>\n<p>In den Vereinigten Staaten warten mehr als 103.000 Menschen auf eine Organtransplantation, 88.000 davon ben\u00f6tigen Nieren.<\/p>\n<p>\u201eWir haben in den letzten zwei Monaten der genauen Beobachtung und Analyse viel gelernt, und es gibt guten Grund, hoffnungsvoll f\u00fcr die Zukunft zu sein\u201c, sagte Robert Montgomery, Direktor des Langone Transplant Institute der New York University, der die Operation leitete Juli.<\/p>\n<p>Es war die f\u00fcnfte sogenannte Xenotransplantation von Montgomery, der im September 2021 auch die weltweit erste gentechnisch ver\u00e4nderte Schweinenierentransplantation durchf\u00fchrte.<\/p>\n<p>W\u00e4hrend der Studie gesammeltes Gewebe deutete darauf hin, dass ein leichter Absto\u00dfungsprozess begonnen hatte, der eine Intensivierung der immunsupprimierenden Medikamente erforderte.<\/p>\n<p>Durch das \u201eAusschalten\u201c des Gens, das f\u00fcr ein Biomolek\u00fcl namens Alpha-Gal verantwortlich ist \u2013 ein Hauptziel f\u00fcr umherziehende menschliche Antik\u00f6rper \u2013 konnte das Langone-Team der NYU die sofortige Absto\u00dfung stoppen.<\/p>\n<p>Das Spenderschwein in diesem Experiment stammte aus einer Herde des in Virginia ans\u00e4ssigen Biotech-Unternehmens Revivicor.<\/p>\n<p>Die Herde wurde auch von der Food and Drug Administration als Fleischquelle f\u00fcr Menschen mit \u00dcberempfindlichkeit gegen das Alpha-Gal-Molek\u00fcl, einer Allergie, die durch einige Zeckenstiche verursacht wird, zugelassen.<\/p>\n<p>Diese Schweine werden gez\u00fcchtet und nicht geklont, was bedeutet, dass der Prozess einfacher skaliert werden kann.<\/p>\n<p>Die fr\u00fche Xenotransplantationsforschung konzentrierte sich auf die Organentnahme von Primaten \u2013 beispielsweise wurde 1984 einem Neugeborenen namens \u201eBaby Fae\u201c ein Pavianherz transplantiert, das jedoch nur 20 Tage \u00fcberlebte.<\/p>\n<p>Aktuelle Bem\u00fchungen konzentrieren sich auf Schweine, die aufgrund ihrer Organgr\u00f6\u00dfe, ihres schnellen Wachstums und ihrer gro\u00dfen W\u00fcrfe sowie der Tatsache, dass sie bereits als Nahrungsquelle gehalten werden, als ideale Spender f\u00fcr den Menschen gelten.<\/p>\n<p>Im Januar 2022 f\u00fchrten Chirurgen der University of Maryland Medical School die weltweit erste Schweine-zu-Mensch-Transplantation an einem lebenden Patienten durch \u2013 dieses Mal mit Beteiligung eines Herzens.<\/p>\n<p>Er starb zwei Monate nach dem Meilenstein, was sp\u00e4ter auf das Vorhandensein des Schweine-Cytomegalievirus in dem Organ zur\u00fcckgef\u00fchrt wurde.<\/p>\n<p>Letzte Woche ver\u00f6ffentlichten chinesische Wissenschaftler eine Arbeit, die zeigt, dass es ihnen gelungen ist, Schweine-Mensch-Hybridnieren in Schweinembryonen herzustellen, ein alternativer Ansatz, der auch das Potenzial hat, eines Tages dazu beizutragen, den Mangel an Organspenden zu beheben.<\/p>\n<p>Die Entwicklung wirft jedoch ethische Fragen auf \u2013 insbesondere, da einige menschliche Zellen auch im Gehirn der Schweine gefunden wurden, sagten Experten.<\/p>\n<p>Ver\u00f6ffentlicht von Medicaldaily.com<\/p>\n<p><a href=\"https:\/\/www.medicaldaily.com\/us-surgeons-report-longest-successful-pig-human-kidney-transplant-470809\">Medizinische t\u00e4gliche Quelle<\/a><\/p>\n<p>","protected":false},"excerpt":{"rendered":"<div><img decoding=\"async\" src=\"https:\/\/urbancare.clinic\/wp-content\/uploads\/2023\/09\/us-surgeons-report-longest-successful-pig-to-human-kidney-transplant.jpg\" class=\"ff-og-image-inserted\"><\/div>\n<p>US-Chirurgen, die einem hirntoten Patienten eine gentechnisch ver\u00e4nderte Schweineniere transplantiert hatten, gaben am Donnerstag bekannt, dass sie ihr Experiment nach rekordverd\u00e4chtigen 61 Tagen beendet hatten.<\/p>\n<p>Das neueste experimentelle Verfahren ist Teil eines wachsenden Forschungsfelds, das darauf abzielt, art\u00fcbergreifende Transplantationen voranzutreiben, wobei die Technik haupts\u00e4chlich an K\u00f6rpern getestet wird, die f\u00fcr die Wissenschaft gespendet wurden.<\/p>\n<p>In den Vereinigten Staaten warten mehr als 103.000 Menschen auf eine Organtransplantation, 88.000 davon ben\u00f6tigen Nieren.<\/p>\n<p>\u201eWir haben in den letzten zwei Monaten der genauen Beobachtung und Analyse viel gelernt, und es gibt guten Grund, hoffnungsvoll f\u00fcr die Zukunft zu sein\u201c, sagte Robert Montgomery, Direktor des Langone Transplant Institute der New York University, der die Operation leitete Juli.<\/p>\n<p>Es war die f\u00fcnfte sogenannte Xenotransplantation von Montgomery, der im September 2021 auch die weltweit erste gentechnisch ver\u00e4nderte Schweinenierentransplantation durchf\u00fchrte.<\/p>\n<p>W\u00e4hrend der Studie gesammeltes Gewebe deutete darauf hin, dass ein leichter Absto\u00dfungsprozess begonnen hatte, der eine Intensivierung der immunsupprimierenden Medikamente erforderte.<\/p>\n<p>Durch das \u201eAusschalten\u201c des Gens, das f\u00fcr ein Biomolek\u00fcl namens Alpha-Gal verantwortlich ist \u2013 ein Hauptziel f\u00fcr umherziehende menschliche Antik\u00f6rper \u2013 konnte das Langone-Team der NYU die sofortige Absto\u00dfung stoppen.<\/p>\n<p>Das Spenderschwein in diesem Experiment stammte aus einer Herde des in Virginia ans\u00e4ssigen Biotech-Unternehmens Revivicor.<\/p>\n<p>Die Herde wurde auch von der Food and Drug Administration als Fleischquelle f\u00fcr Menschen mit \u00dcberempfindlichkeit gegen das Alpha-Gal-Molek\u00fcl, einer Allergie, die durch einige Zeckenstiche verursacht wird, zugelassen.<\/p>\n<p>Diese Schweine werden gez\u00fcchtet und nicht geklont, was bedeutet, dass der Prozess einfacher skaliert werden kann.<\/p>\n<p>Die fr\u00fche Xenotransplantationsforschung konzentrierte sich auf die Organentnahme von Primaten \u2013 beispielsweise wurde 1984 einem Neugeborenen namens \u201eBaby Fae\u201c ein Pavianherz transplantiert, das jedoch nur 20 Tage \u00fcberlebte.<\/p>\n<p>Aktuelle Bem\u00fchungen konzentrieren sich auf Schweine, die aufgrund ihrer Organgr\u00f6\u00dfe, ihres schnellen Wachstums und ihrer gro\u00dfen W\u00fcrfe sowie der Tatsache, dass sie bereits als Nahrungsquelle gehalten werden, als ideale Spender f\u00fcr den Menschen gelten.<\/p>\n<p>Im Januar 2022 f\u00fchrten Chirurgen der University of Maryland Medical School die weltweit erste Schweine-zu-Mensch-Transplantation an einem lebenden Patienten durch \u2013 dieses Mal mit Beteiligung eines Herzens.<\/p>\n<p>Er starb zwei Monate nach dem Meilenstein, was sp\u00e4ter auf das Vorhandensein des Schweine-Cytomegalievirus in dem Organ zur\u00fcckgef\u00fchrt wurde.<\/p>\n<p>Letzte Woche ver\u00f6ffentlichten chinesische Wissenschaftler eine Arbeit, die zeigt, dass es ihnen gelungen ist, Schweine-Mensch-Hybridnieren in Schweinembryonen herzustellen, ein alternativer Ansatz, der auch das Potenzial hat, eines Tages dazu beizutragen, den Mangel an Organspenden zu beheben.<\/p>\n<p>Die Entwicklung wirft jedoch ethische Fragen auf \u2013 insbesondere, da einige menschliche Zellen auch im Gehirn der Schweine gefunden wurden, sagten Experten.<\/p>\n<p>Ver\u00f6ffentlicht von Medicaldaily.com<\/p>","protected":false},"author":2,"featured_media":8644,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"Default","format":"standard","meta":{"fifu_image_url":"https:\/\/urbancare.clinic\/wp-content\/uploads\/2023\/09\/us-surgeons-report-longest-successful-pig-to-human-kidney-transplant.jpg","fifu_image_alt":"","footnotes":""},"categories":[27],"tags":[],"class_list":["post-8643","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blog"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.6 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>US Surgeons Report Longest Successful Pig-To-Human Kidney Transplant - Urban Care Clinic<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/urbancare.clinic\/de\/us-chirurgen-berichten-uber-die-langste-erfolgreiche-nierentransplantation-vom-schwein-zum-menschen\/\" \/>\n<meta property=\"og:locale\" content=\"de_DE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"US Surgeons Report Longest Successful Pig-To-Human Kidney Transplant - Urban Care Clinic\" \/>\n<meta property=\"og:description\" content=\"U.S. surgeons who transplanted a genetically modified pig kidney into a brain-dead patient announced Thursday they had ended their experiment after a record-breaking 61 days.The latest experimental procedure is part of a growing field of research aimed at advancing cross-species transplants, mainly testing the technique on bodies that have been donated for science.There are more than 103,000 people waiting for organ transplants in the United States, 88,000 of whom need kidneys.&quot;We have learned a great deal throughout these past two months of close observation and analysis, and there is great reason to be hopeful for the future,&quot; said Robert Montgomery, director of the New York University Langone Transplant Institute, who led the surgery in July.It was the fifth so-called xenotransplant performed by Montgomery, who also carried out the world&#039;s first genetically modified pig kidney transplant in September 2021.Tissue collected during the study indicated a mild rejection process had begun, requiring intensification of immunosuppression medication.By &quot;knocking out&quot; the gene responsible for a biomolecule called alpha-gal -- a prime target for roving human antibodies -- the NYU Langone team were able to stop immediate rejection.The donor pig in this experiment came from a herd cultivated by Virginia-based biotech company Revivicor.The herd has also been approved by the Food and Drug Administration as a source of meat for people with hypersensitivity to the alpha-gal molecule, an allergy caused by some tick bites.These pigs are bred, not cloned, meaning the process can be more easily scaled.Early xenotransplantation research focused on harvesting organs from primates -- for example, a baboon heart was transplanted into a newborn known as &quot;Baby Fae&quot; in 1984, but she survived only 20 days.Current efforts focus on pigs, which are thought to be ideal donors for humans because of their organ size, their rapid growth and large litters, and the fact they are already raised as a food source.In January 2022, surgeons at the University of Maryland Medical School carried out the world&#039;s first pig-to-human transplant on a living patient -- this time involving a heart.He died two months after the milestone, with the presence of porcine cytomegalovirus in the organ later blamed.Last week, Chinese scientists published a paper showing they had succeeded in hybrid pig-human kidneys in pig embryos, an alternative approach that also has the potential to one day help address organ donation shortages.But the development raised ethical issues -- especially since some human cells were also found in the pigs&#039; brains, experts said.Published by Medicaldaily.com\" \/>\n<meta property=\"og:url\" content=\"https:\/\/urbancare.clinic\/de\/us-chirurgen-berichten-uber-die-langste-erfolgreiche-nierentransplantation-vom-schwein-zum-menschen\/\" \/>\n<meta property=\"og:site_name\" content=\"Urban Care Clinic\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/urbancarezanzibar\" \/>\n<meta property=\"article:published_time\" content=\"2023-09-15T10:20:23+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/urbancare.clinic\/wp-content\/uploads\/2023\/09\/us-surgeons-report-longest-successful-pig-to-human-kidney-transplant.jpg\" \/>\n<meta name=\"author\" content=\"Urban Care Clinic\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:image\" 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Care Clinic","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/urbancare.clinic\/de\/us-chirurgen-berichten-uber-die-langste-erfolgreiche-nierentransplantation-vom-schwein-zum-menschen\/","og_locale":"de_DE","og_type":"article","og_title":"US Surgeons Report Longest Successful Pig-To-Human Kidney Transplant - Urban Care Clinic","og_description":"U.S. surgeons who transplanted a genetically modified pig kidney into a brain-dead patient announced Thursday they had ended their experiment after a record-breaking 61 days.The latest experimental procedure is part of a growing field of research aimed at advancing cross-species transplants, mainly testing the technique on bodies that have been donated for science.There are more than 103,000 people waiting for organ transplants in the United States, 88,000 of whom need kidneys.\"We have learned a great deal throughout these past two months of close observation and analysis, and there is great reason to be hopeful for the future,\" said Robert Montgomery, director of the New York University Langone Transplant Institute, who led the surgery in July.It was the fifth so-called xenotransplant performed by Montgomery, who also carried out the world's first genetically modified pig kidney transplant in September 2021.Tissue collected during the study indicated a mild rejection process had begun, requiring intensification of immunosuppression medication.By \"knocking out\" the gene responsible for a biomolecule called alpha-gal -- a prime target for roving human antibodies -- the NYU Langone team were able to stop immediate rejection.The donor pig in this experiment came from a herd cultivated by Virginia-based biotech company Revivicor.The herd has also been approved by the Food and Drug Administration as a source of meat for people with hypersensitivity to the alpha-gal molecule, an allergy caused by some tick bites.These pigs are bred, not cloned, meaning the process can be more easily scaled.Early xenotransplantation research focused on harvesting organs from primates -- for example, a baboon heart was transplanted into a newborn known as \"Baby Fae\" in 1984, but she survived only 20 days.Current efforts focus on pigs, which are thought to be ideal donors for humans because of their organ size, their rapid growth and large litters, and the fact they are already raised as a food source.In January 2022, surgeons at the University of Maryland Medical School carried out the world's first pig-to-human transplant on a living patient -- this time involving a heart.He died two months after the milestone, with the presence of porcine cytomegalovirus in the organ later blamed.Last week, Chinese scientists published a paper showing they had succeeded in hybrid pig-human kidneys in pig embryos, an alternative approach that also has the potential to one day help address organ donation shortages.But the development raised ethical issues -- especially since some human cells were also found in the pigs' brains, experts said.Published by Medicaldaily.com","og_url":"https:\/\/urbancare.clinic\/de\/us-chirurgen-berichten-uber-die-langste-erfolgreiche-nierentransplantation-vom-schwein-zum-menschen\/","og_site_name":"Urban Care Clinic","article_publisher":"https:\/\/www.facebook.com\/urbancarezanzibar","article_published_time":"2023-09-15T10:20:23+00:00","og_image":[{"url":"https:\/\/urbancare.clinic\/wp-content\/uploads\/2023\/09\/us-surgeons-report-longest-successful-pig-to-human-kidney-transplant.jpg","type":"","width":"","height":""}],"author":"Urban Care Clinic","twitter_card":"summary_large_image","twitter_image":"https:\/\/urbancare.clinic\/wp-content\/uploads\/2023\/09\/us-surgeons-report-longest-successful-pig-to-human-kidney-transplant.jpg","twitter_misc":{"Verfasst von":"Urban Care Clinic","Gesch\u00e4tzte 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