{"id":8631,"date":"2023-09-08T10:17:04","date_gmt":"2023-09-08T07:17:04","guid":{"rendered":"https:\/\/urbancare.clinic\/breast-cancer-and-pregnancy-study-explains-why-older-first-time-moms-are-at-higher-risk\/"},"modified":"2023-09-08T10:17:04","modified_gmt":"2023-09-08T07:17:04","slug":"eine-studie-zu-brustkrebs-und-schwangerschaft-erklart-warum-altere-erstgebarende-einem-hoheren-risiko-ausgesetzt-sind","status":"publish","type":"post","link":"https:\/\/urbancare.clinic\/de\/eine-studie-zu-brustkrebs-und-schwangerschaft-erklart-warum-altere-erstgebarende-einem-hoheren-risiko-ausgesetzt-sind\/","title":{"rendered":"Brustkrebs und Schwangerschaft: Studie erkl\u00e4rt, warum \u00e4ltere Erstgeb\u00e4rende einem h\u00f6heren Risiko ausgesetzt sind"},"content":{"rendered":"
<\/div>\n

Es besteht ein komplizierter Zusammenhang zwischen Brustkrebs und Schwangerschaft. In einer Studie erkl\u00e4ren Forscher, warum Frauen, die sp\u00e4ter im Leben zum ersten Mal Mutter werden, langfristig ein h\u00f6heres Brustkrebsrisiko haben als Frauen, die fr\u00fch Mutter werden.<\/p>\n

Studien zeigen, dass junge Erstgeb\u00e4rende, also solche, die w\u00e4hrend ihrer ersten Schwangerschaft unter 24 Jahre alt waren, langfristig ein wesentlich geringeres Risiko haben Brustkrebs<\/a> (ungef\u00e4hr 20-35%) im Vergleich zu Frauen, die keine Kinder hatten.<\/p>\n

Mit zunehmendem Alter der Erstgeb\u00e4renden nimmt jedoch auch das Brustkrebsrisiko zunehmend zu, wobei alle f\u00fcnf Jahre ein 5%-Risikoanstieg zu verzeichnen ist.<\/p>\n

\u201eIn den letzten Jahrzehnten haben Frauen aufgrund gesellschaftlicher Ver\u00e4nderungen und pers\u00f6nlicher Vorlieben begonnen, sp\u00e4ter Kinder zu bekommen. Fr\u00fchere Untersuchungen haben ergeben, dass dies mit einem erh\u00f6hten Brustkrebsrisiko verbunden ist\u201c, sagte Dr. Biancastella Cereser, eine Hauptautorin der Studie, in der Pressemitteilung.<\/p>\n

\u201eUnsere eigene Forschung befasst sich mit den genetischen Geheimnissen, die dieses Risiko bestimmen. Wir fanden heraus, dass die menschliche Brust wie andere Organe mit zunehmendem Alter Mutationen anh\u00e4uft, aber auch, dass eine Schwangerschaft einen zus\u00e4tzlichen Effekt hat, was bedeutet, dass \u00e4ltere Erstgeb\u00e4rende im Vergleich zu anderen Frauen m\u00f6glicherweise ein h\u00f6heres Risiko haben, sch\u00e4dliche Ver\u00e4nderungen in ihren Brustzellen zu entwickeln. \u201c, sagte Cereser.<\/p>\n

In der neuesten Studie, ver\u00f6ffentlicht in der Tagebuch<\/a> Forscher von Nature Communications analysierten die zellul\u00e4ren und genetischen Ver\u00e4nderungen, die bei gesunden Brustzellen auftreten, wenn sie sich drehen krebsartig<\/a>. Nach der Sequenzierung von 29 gefrorenen gesunden Brustgeweben von Spendern stellte das Team fest, dass diese gesunden Brustgewebe mit zunehmendem Alter Mutationen anh\u00e4ufen, und zwar in einer Gr\u00f6\u00dfenordnung von etwa 15 Mutationen pro Jahr. Obwohl die meisten dieser Mutationen keinen Einfluss auf die Gene haben und nicht krebserregend sind, besteht mit zunehmender Zeit eine gr\u00f6\u00dfere Wahrscheinlichkeit, dass Treibermutationen auftreten, die mit Krebs in Zusammenhang stehen.<\/p>\n

\u201eDies allein reicht m\u00f6glicherweise nicht aus, um Krebs zu verursachen. Eine Schwangerschaft k\u00f6nnte jedoch zu einem \u201edoppelten Schlag\u201c f\u00fchren, da sie als Vorbereitung auf das Stillen eine schnelle Vergr\u00f6\u00dferung der Brustzellen induziert. Wenn Zellen, die Treibermutationen beherbergen, sich replizieren und ausdehnen, k\u00f6nnten sie einen Wettbewerbsvorteil gegen\u00fcber benachbarten, nicht mutierten Zellen haben, was m\u00f6glicherweise zu einem au\u00dfer Kontrolle geratenen Effekt und letztendlich zur Entstehung eines Krebstumors f\u00fchren k\u00f6nnte\u201c, erkl\u00e4rte Cereser.<\/p>\n

Ver\u00f6ffentlicht von Medicaldaily.com<\/p>\n

Medizinische t\u00e4gliche Quelle<\/a><\/p>\n

","protected":false},"excerpt":{"rendered":"

<\/div>\n

Es besteht ein komplizierter Zusammenhang zwischen Brustkrebs und Schwangerschaft. In einer Studie erkl\u00e4ren Forscher, warum Frauen, die sp\u00e4ter im Leben zum ersten Mal Mutter werden, langfristig ein h\u00f6heres Brustkrebsrisiko haben als Frauen, die fr\u00fch Mutter werden.<\/p>\n

Studien zeigen, dass junge Erstgeb\u00e4rende, also solche, die w\u00e4hrend ihrer ersten Schwangerschaft unter 24 Jahre alt waren, langfristig ein wesentlich geringeres Risiko haben Brustkrebs<\/a> (ungef\u00e4hr 20-35%) im Vergleich zu Frauen, die keine Kinder hatten.<\/p>\n

Mit zunehmendem Alter der Erstgeb\u00e4renden nimmt jedoch auch das Brustkrebsrisiko zunehmend zu, wobei alle f\u00fcnf Jahre ein 5%-Risikoanstieg zu verzeichnen ist.<\/p>\n

\u201eIn den letzten Jahrzehnten haben Frauen aufgrund gesellschaftlicher Ver\u00e4nderungen und pers\u00f6nlicher Vorlieben begonnen, sp\u00e4ter Kinder zu bekommen. Fr\u00fchere Untersuchungen haben ergeben, dass dies mit einem erh\u00f6hten Brustkrebsrisiko verbunden ist\u201c, sagte Dr. Biancastella Cereser, eine Hauptautorin der Studie, in der Pressemitteilung.<\/p>\n

\u201eUnsere eigene Forschung befasst sich mit den genetischen Geheimnissen, die dieses Risiko bestimmen. Wir fanden heraus, dass die menschliche Brust wie andere Organe mit zunehmendem Alter Mutationen anh\u00e4uft, aber auch, dass eine Schwangerschaft einen zus\u00e4tzlichen Effekt hat, was bedeutet, dass \u00e4ltere Erstgeb\u00e4rende im Vergleich zu anderen Frauen m\u00f6glicherweise ein h\u00f6heres Risiko haben, sch\u00e4dliche Ver\u00e4nderungen in ihren Brustzellen zu entwickeln. \u201c, sagte Cereser.<\/p>\n

In der neuesten Studie, ver\u00f6ffentlicht in der Tagebuch<\/a> Forscher von Nature Communications analysierten die zellul\u00e4ren und genetischen Ver\u00e4nderungen, die bei gesunden Brustzellen auftreten, wenn sie sich drehen krebsartig<\/a>. Nach der Sequenzierung von 29 gefrorenen gesunden Brustgeweben von Spendern stellte das Team fest, dass diese gesunden Brustgewebe mit zunehmendem Alter Mutationen anh\u00e4ufen, und zwar in einer Gr\u00f6\u00dfenordnung von etwa 15 Mutationen pro Jahr. Obwohl die meisten dieser Mutationen keinen Einfluss auf die Gene haben und nicht krebserregend sind, besteht mit zunehmender Zeit eine gr\u00f6\u00dfere Wahrscheinlichkeit, dass Treibermutationen auftreten, die mit Krebs in Zusammenhang stehen.<\/p>\n

\u201eDies allein reicht m\u00f6glicherweise nicht aus, um Krebs zu verursachen. Eine Schwangerschaft k\u00f6nnte jedoch zu einem \u201edoppelten Schlag\u201c f\u00fchren, da sie als Vorbereitung auf das Stillen eine schnelle Vergr\u00f6\u00dferung der Brustzellen induziert. Wenn Zellen, die Treibermutationen beherbergen, sich replizieren und ausdehnen, k\u00f6nnten sie einen Wettbewerbsvorteil gegen\u00fcber benachbarten, nicht mutierten Zellen haben, was m\u00f6glicherweise zu einem au\u00dfer Kontrolle geratenen Effekt und letztendlich zur Entstehung eines Krebstumors f\u00fchren k\u00f6nnte\u201c, erkl\u00e4rte Cereser.<\/p>\n

Ver\u00f6ffentlicht von Medicaldaily.com<\/p>","protected":false},"author":2,"featured_media":8632,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"Default","format":"standard","meta":{"fifu_image_url":"https:\/\/urbancare.clinic\/wp-content\/uploads\/2023\/09\/breast-cancer-and-pregnancy-study-explains-why-older-first-time-moms-are-at-higher-risk.jpg","fifu_image_alt":"","footnotes":""},"categories":[27],"tags":[],"class_list":["post-8631","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blog"],"yoast_head":"\nBreast Cancer And Pregnancy: Study Explains Why Older First-Time Moms Are At Higher Risk - Urban Care Clinic<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/urbancare.clinic\/de\/eine-studie-zu-brustkrebs-und-schwangerschaft-erklart-warum-altere-erstgebarende-einem-hoheren-risiko-ausgesetzt-sind\/\" \/>\n<meta property=\"og:locale\" content=\"de_DE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Breast Cancer And Pregnancy: Study Explains Why Older First-Time Moms Are At Higher Risk - Urban Care Clinic\" \/>\n<meta property=\"og:description\" content=\"There is an intricate connection between breast cancer and pregnancy. In a study, researchers explain why women who become first-time mothers later in life have a higher long-term risk of breast cancer than those who become moms early.Studies show that young first-time mothers, those who are below the age of 24 during their initial pregnancy, experience a substantially lower long-term risk of breast cancer (approximately 20-35%) compared to women who have not had kids.However, as the age of first-time mothers goes up, the breast cancer risk also progressively increases, with a 5% spike in risk every five years."In recent decades, women have begun having children later because of societal changes and personal preferences. Previous research has found that this is associated with a heightened breast cancer risk," Dr. Biancastella Cereser, a lead author of the study, said in the news release."Our own research delves into the genetic mysteries that govern this risk. We found that the human breast, like other organs, accumulates mutations with age, but also that pregnancy has an additional effect, meaning that older first-time mothers might have a higher chance of developing harmful changes in their breast cells compared to other women," Cereser said.In the latest study, published in the journal Nature Communications, researchers analyzed the cellular and genetic changes that happen to healthy breast cells as they turn cancerous. After sequencing 29 frozen healthy breast tissues from donors, the team found that with age, these healthy breast tissues accumulate mutations, at the rate of around 15 mutations every year. Although the majority of these mutations do not affect the genes and are not cancer-causing, with more time, there is a greater chance of having driver mutations associated with cancer."This might not be enough to cause cancer by itself. But, pregnancy could provide a 'double whammy', because it induces a rapid expansion of breast cells, in preparation for breastfeeding. If cells harboring driver mutations replicate and expand, they could have a competitive advantage over neighboring non-mutated cells, potentially leading to a runaway effect, and ultimately creating a cancerous tumor," Cereser explained.Published by Medicaldaily.com\" \/>\n<meta property=\"og:url\" content=\"https:\/\/urbancare.clinic\/de\/eine-studie-zu-brustkrebs-und-schwangerschaft-erklart-warum-altere-erstgebarende-einem-hoheren-risiko-ausgesetzt-sind\/\" \/>\n<meta property=\"og:site_name\" content=\"Urban Care Clinic\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/urbancarezanzibar\" \/>\n<meta property=\"article:published_time\" content=\"2023-09-08T07:17:04+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/urbancare.clinic\/wp-content\/uploads\/2023\/09\/breast-cancer-and-pregnancy-study-explains-why-older-first-time-moms-are-at-higher-risk.jpg\" \/>\n<meta name=\"author\" content=\"Urban Care Clinic\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:image\" content=\"https:\/\/urbancare.clinic\/wp-content\/uploads\/2023\/09\/breast-cancer-and-pregnancy-study-explains-why-older-first-time-moms-are-at-higher-risk.jpg\" \/>\n<meta name=\"twitter:label1\" content=\"Verfasst von\" \/>\n\t<meta name=\"twitter:data1\" content=\"Urban Care Clinic\" \/>\n\t<meta name=\"twitter:label2\" content=\"Gesch\u00e4tzte Lesezeit\" \/>\n\t<meta name=\"twitter:data2\" content=\"2\u00a0Minuten\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/urbancare.clinic\/breast-cancer-and-pregnancy-study-explains-why-older-first-time-moms-are-at-higher-risk\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/urbancare.clinic\/breast-cancer-and-pregnancy-study-explains-why-older-first-time-moms-are-at-higher-risk\/\"},\"author\":{\"name\":\"Urban Care Clinic\",\"@id\":\"https:\/\/urbancare.clinic\/#\/schema\/person\/f286c4d84be896d302aceda3ed7e789c\"},\"headline\":\"Breast Cancer And Pregnancy: Study Explains Why Older First-Time Moms Are At Higher Risk\",\"datePublished\":\"2023-09-08T07:17:04+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/urbancare.clinic\/breast-cancer-and-pregnancy-study-explains-why-older-first-time-moms-are-at-higher-risk\/\"},\"wordCount\":367,\"publisher\":{\"@id\":\"https:\/\/urbancare.clinic\/#organization\"},\"image\":{\"@id\":\"https:\/\/urbancare.clinic\/breast-cancer-and-pregnancy-study-explains-why-older-first-time-moms-are-at-higher-risk\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/urbancare.clinic\/wp-content\/uploads\/2023\/09\/breast-cancer-and-pregnancy-study-explains-why-older-first-time-moms-are-at-higher-risk.jpg\",\"articleSection\":[\"Medical Daily\"],\"inLanguage\":\"de\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/urbancare.clinic\/breast-cancer-and-pregnancy-study-explains-why-older-first-time-moms-are-at-higher-risk\/\",\"url\":\"https:\/\/urbancare.clinic\/breast-cancer-and-pregnancy-study-explains-why-older-first-time-moms-are-at-higher-risk\/\",\"name\":\"Breast Cancer And Pregnancy: Study Explains Why Older First-Time Moms Are At Higher Risk - 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We found that the human breast, like other organs, accumulates mutations with age, but also that pregnancy has an additional effect, meaning that older first-time mothers might have a higher chance of developing harmful changes in their breast cells compared to other women,\" Cereser said.In the latest study, published in the journal Nature Communications, researchers analyzed the cellular and genetic changes that happen to healthy breast cells as they turn cancerous. After sequencing 29 frozen healthy breast tissues from donors, the team found that with age, these healthy breast tissues accumulate mutations, at the rate of around 15 mutations every year. Although the majority of these mutations do not affect the genes and are not cancer-causing, with more time, there is a greater chance of having driver mutations associated with cancer.\"This might not be enough to cause cancer by itself. 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