{"id":8319,"date":"2023-06-13T10:02:48","date_gmt":"2023-06-13T07:02:48","guid":{"rendered":"https:\/\/urbancare.clinic\/why-is-weight-loss-hard-for-obese-people-study-explains-reason\/"},"modified":"2023-06-13T10:02:48","modified_gmt":"2023-06-13T07:02:48","slug":"warum-fallt-es-ubergewichtigen-menschen-schwer-gewicht-zu-verlieren-studie-erklart-den-grund","status":"publish","type":"post","link":"https:\/\/urbancare.clinic\/de\/warum-fallt-es-ubergewichtigen-menschen-schwer-gewicht-zu-verlieren-studie-erklart-den-grund\/","title":{"rendered":"Warum ist Gewichtsverlust f\u00fcr \u00fcbergewichtige Menschen schwierig? Studie erkl\u00e4rt Vernunft"},"content":{"rendered":"<p>F\u00fcr Menschen mit Adipositas ist es immer schwierig, Gewicht zu verlieren und das Gewicht aufrechtzuerhalten. Eine aktuelle Studie erkl\u00e4rte, wie die Gehirnreaktionen \u00fcbergewichtiger Menschen auf Zucker und Fett unterschiedlich funktionieren, was das Abnehmen zu einem schwierigen Weg macht.<\/p>\n<p>Die Erkenntnisse der <a rel=\"noopener nofollow\" href=\"https:\/\/www.nature.com\/articles\/s42255-023-00816-9.epdf?sharing_token=liw89VwU9-jQHHBr5eY9tdRgN0jAjWel9jnR3ZoTv0M1SadTImevZtbaTQ0zrz0bHR-l_kFBGfPLzIqJZudrjrKDKf6W2s8_vtlPvT25PJ1GUdNaWTyzHUYEj_xeSrWlRPRB5lJs5_PoIBcO9HB7Wy1q3RBBF2ybRmkW-e-FGzVOPpT1iagk6opfit7llTVf0e7hc2oitOk5Se2ZWbaK072zNf6O_KJuk9jHw4Ix_Fg%3D&amp;tracking_referrer=www.usnews.com\" target=\"_blank\">lernen<\/a>, ver\u00f6ffentlicht in der Zeitschrift Nature Metabolism, erkl\u00e4rte, wie Fettleibigkeit dazu f\u00fchrte, dass das Gehirn die Ausrichtung auf das Geschehen im Darm verlor.<\/p>\n<p>\u201eUnsere Interpretation ist, dass bei Menschen mit Fettleibigkeit die N\u00e4hrstoffwahrnehmung allgemein eingeschr\u00e4nkt ist. Es k\u00f6nnte helfen zu erkl\u00e4ren, warum Gewichtsverlust und Gewichtserhaltung so schwierig sind\u201c, sagt die leitende Forscherin Dr. Mireille Serlie <a rel=\"noopener nofollow\" href=\"https:\/\/www.usnews.com\/news\/health-news\/articles\/2023-06-12\/obesity-might-permanently-blunt-brains-responses-to-sugary-fatty-foods\" target=\"_blank\">genannt<\/a>.<\/p>\n<p>In der Studie wurden 30 Erwachsene mit gesundem K\u00f6rpergewicht und 30 Erwachsene mit Fettleibigkeit untersucht. Die Gehirnreaktionen der Teilnehmer auf Zucker und Fett wurden erfasst, nachdem die N\u00e4hrstoffe direkt in den Darm gelangt waren.<\/p>\n<p>Die schlanken Teilnehmer zeigten bei der Zufuhr der N\u00e4hrstoffe spezifische Muster der Gehirnaktivit\u00e4t, w\u00e4hrend diese bei adip\u00f6sen Menschen \u201estark beeintr\u00e4chtigt\u201c waren. Bei den \u00fcbergewichtigen Teilnehmern kam es au\u00dferdem zu einer geringeren Aussch\u00fcttung von Dopamin aus dem Striatum des Gehirns, das f\u00fcr die Regulierung der Essgewohnheiten verantwortlich ist.<\/p>\n<p>Selbst nachdem sie drei Monate lang mit einer kalorienreduzierten Di\u00e4t 10% ihres Gewichts verloren hatten, kehrten sich die Gehirnreaktionen der adip\u00f6sen Teilnehmer nicht um.<\/p>\n<p>Forscher glauben, dass eine beeintr\u00e4chtigte N\u00e4hrstoffsignalisierung nicht dauerhaft ist und mit mehr Zeit und anhaltendem Gewichtsverlust wiederhergestellt werden kann.<\/p>\n<p>Fr\u00fchere Experimente an Labortieren deuteten darauf hin <a rel=\"nofollow\" href=\"https:\/\/www.medicaldaily.com\/why-does-stress-make-us-crave-comfort-food-tips-prevent-emotional-eating-470084\">Gehirn<\/a> reagierte auf das Vorhandensein von N\u00e4hrstoffen im Darm, auch ohne die sensorische Erfahrung des Essens.<\/p>\n<p>\u201eDer Fortschritt dieser Studie besteht darin, dass sie zeigen, dass dies auch beim Menschen geschieht, aber die Reaktion ist bei Menschen mit Fettleibigkeit v\u00f6llig abgeschw\u00e4cht\u201c, sagte Alexandra DiFeliceantonio, eine Co-Autorin der Studie.<\/p>\n<p>Die N\u00e4hrstoffsignalisierung zwischen Darm und Gehirn hilft den Menschen bei der Auswahl ihrer Essgewohnheiten, aber die Signal\u00fcbertragung sei aufgrund von Fettleibigkeit \u201eirgendwie unterbrochen\u201c, f\u00fcgte DiFeliceantonio hinzu.<\/p>\n<p>Unterdessen konnten die Forscher nicht genau bestimmen, wann genau die Signal\u00fcbertragung beeintr\u00e4chtigt wird und wie.<\/p>\n<p>Der Studie zufolge liegt das Geheimnis einer dauerhaften Gewichtsabnahme nicht immer in der \u201eWillenskraft\u201c, die Di\u00e4t fortzusetzen, da \u00fcbergewichtige Menschen nicht nur st\u00e4ndig gegen die Verlockungen von billigem, leicht verf\u00fcgbarem Junkfood ank\u00e4mpfen, sondern auch gegen ein \u201ehungriges Gehirn\u201c. erschwert Ern\u00e4hrungsumstellungen und Gewichtsabnahme.<\/p>\n<p>\u201eIch glaube schon, dass den Leuten die Schuld gegeben wird. Hier geht es nicht um Willenskraft. Es ist ein echter Kampf. Und wir beginnen zu verstehen, warum Menschen Schwierigkeiten haben\u201c, sagte Serlie.<\/p>\n<p>Durch Ern\u00e4hrung, \u00c4nderungen des Lebensstils und Medikamente hoffen die Forscher jedoch, in Zukunft einen Weg zu finden, die N\u00e4hrstoffsignalisierung zu korrigieren.<\/p>\n<figure class=\"imageBox\">\n<div class=\"innerBox\"><picture class=\"mapping-embed\" width=\"736\" height=\"552\"><source type=\"image\/webp\" media=\"(min-width: 1100px)\" sizes=\"736px\" srcset=\"https:\/\/d.medicaldaily.com\/en\/full\/445610\/burger.webp?w=736&amp;f=990f4970890e24283f85ffb6eb2bfb48 736w\"><source type=\"image\/jpeg\" media=\"(min-width: 1100px)\" sizes=\"736px\" srcset=\"https:\/\/urbancare.clinic\/wp-content\/uploads\/2023\/06\/why-is-weight-loss-hard-for-obese-people-study-explains-reason.jpg 736w\"><source type=\"image\/webp\" media=\"(min-width: 768px)\" sizes=\"1000px\" srcset=\"https:\/\/d.medicaldaily.com\/en\/full\/445610\/burger.webp?w=1100&amp;f=d0344a1848f73f5887983c12133460d2 1100w\"><source type=\"image\/jpeg\" media=\"(min-width: 768px)\" sizes=\"1000px\" srcset=\"https:\/\/d.medicaldaily.com\/en\/full\/445610\/burger.jpg?w=1100&amp;f=d0344a1848f73f5887983c12133460d2 1100w\"><source type=\"image\/webp\" media=\"(min-width: 480px)\" sizes=\"736px\" srcset=\"https:\/\/d.medicaldaily.com\/en\/full\/445610\/burger.webp?w=736&amp;f=990f4970890e24283f85ffb6eb2bfb48 736w\"><source type=\"image\/jpeg\" media=\"(min-width: 480px)\" sizes=\"736px\" srcset=\"https:\/\/urbancare.clinic\/wp-content\/uploads\/2023\/06\/why-is-weight-loss-hard-for-obese-people-study-explains-reason.jpg 736w\"><source type=\"image\/webp\" media=\"(min-width: 0px)\" sizes=\"480px\" srcset=\"https:\/\/d.medicaldaily.com\/en\/full\/445610\/burger.webp?w=480&amp;f=2fdd49a08c05dcdaae5a4b7e8e4e04d3 480w\"><source type=\"image\/jpeg\" media=\"(min-width: 0px)\" sizes=\"480px\" srcset=\"https:\/\/d.medicaldaily.com\/en\/full\/445610\/burger.jpg?w=480&amp;f=2fdd49a08c05dcdaae5a4b7e8e4e04d3 480w\"><source type=\"image\/webp\" srcset=\"https:\/\/d.medicaldaily.com\/en\/full\/445610\/burger.webp?w=736&amp;f=990f4970890e24283f85ffb6eb2bfb48\"><img loading=\"lazy\" decoding=\"async\" class=\"mapping-embed imgPhoto\" id=\"i445610\" src=\"https:\/\/urbancare.clinic\/wp-content\/uploads\/2023\/06\/why-is-weight-loss-hard-for-obese-people-study-explains-reason.jpg\" alt=\"burger\" width=\"736\" height=\"552\" style=\"display:none\"><\/picture><\/div><figcaption class=\"caption\">\n<span class=\"cap\">Eine aktuelle Studie erkl\u00e4rt, wie die Gehirnreaktionen bei \u00fcbergewichtigen Menschen unterschiedlich auf Zucker und Fett reagieren, was das Abnehmen zu einem schwierigen Weg macht.<\/span><br \/>\n<span class=\"credit\">Pixabay<\/span><br \/>\n<\/figcaption><\/figure>\n<p>Ver\u00f6ffentlicht von Medicaldaily.com<\/p>\n<p><a href=\"https:\/\/www.medicaldaily.com\/why-weight-loss-hard-obese-people-study-explains-reason-470091\">Medizinische t\u00e4gliche Quelle<\/a><\/p>\n<p>","protected":false},"excerpt":{"rendered":"<p>F\u00fcr Menschen mit Adipositas ist es immer schwierig, Gewicht zu verlieren und das Gewicht aufrechtzuerhalten. Eine aktuelle Studie erkl\u00e4rte, wie die Gehirnreaktionen \u00fcbergewichtiger Menschen auf Zucker und Fett unterschiedlich funktionieren, was das Abnehmen zu einem schwierigen Weg macht.<\/p>\n<p>Die Erkenntnisse der <a rel=\"noopener nofollow\" href=\"https:\/\/www.nature.com\/articles\/s42255-023-00816-9.epdf?sharing_token=liw89VwU9-jQHHBr5eY9tdRgN0jAjWel9jnR3ZoTv0M1SadTImevZtbaTQ0zrz0bHR-l_kFBGfPLzIqJZudrjrKDKf6W2s8_vtlPvT25PJ1GUdNaWTyzHUYEj_xeSrWlRPRB5lJs5_PoIBcO9HB7Wy1q3RBBF2ybRmkW-e-FGzVOPpT1iagk6opfit7llTVf0e7hc2oitOk5Se2ZWbaK072zNf6O_KJuk9jHw4Ix_Fg%3D&amp;tracking_referrer=www.usnews.com\" target=\"_blank\">lernen<\/a>, ver\u00f6ffentlicht in der Zeitschrift Nature Metabolism, erkl\u00e4rte, wie Fettleibigkeit dazu f\u00fchrte, dass das Gehirn die Ausrichtung auf das Geschehen im Darm verlor.<\/p>\n<p>\u201eUnsere Interpretation ist, dass bei Menschen mit Fettleibigkeit die N\u00e4hrstoffwahrnehmung allgemein eingeschr\u00e4nkt ist. Es k\u00f6nnte helfen zu erkl\u00e4ren, warum Gewichtsverlust und Gewichtserhaltung so schwierig sind\u201c, sagt die leitende Forscherin Dr. Mireille Serlie <a rel=\"noopener nofollow\" href=\"https:\/\/www.usnews.com\/news\/health-news\/articles\/2023-06-12\/obesity-might-permanently-blunt-brains-responses-to-sugary-fatty-foods\" target=\"_blank\">genannt<\/a>.<\/p>\n<p>In der Studie wurden 30 Erwachsene mit gesundem K\u00f6rpergewicht und 30 Erwachsene mit Fettleibigkeit untersucht. Die Gehirnreaktionen der Teilnehmer auf Zucker und Fett wurden erfasst, nachdem die N\u00e4hrstoffe direkt in den Darm gelangt waren.<\/p>\n<p>Die schlanken Teilnehmer zeigten bei der Zufuhr der N\u00e4hrstoffe spezifische Muster der Gehirnaktivit\u00e4t, w\u00e4hrend diese bei adip\u00f6sen Menschen \u201estark beeintr\u00e4chtigt\u201c waren. Bei den \u00fcbergewichtigen Teilnehmern kam es au\u00dferdem zu einer geringeren Aussch\u00fcttung von Dopamin aus dem Striatum des Gehirns, das f\u00fcr die Regulierung der Essgewohnheiten verantwortlich ist.<\/p>\n<p>Selbst nachdem sie drei Monate lang mit einer kalorienreduzierten Di\u00e4t 10% ihres Gewichts verloren hatten, kehrten sich die Gehirnreaktionen der adip\u00f6sen Teilnehmer nicht um.<\/p>\n<p>Forscher glauben, dass eine beeintr\u00e4chtigte N\u00e4hrstoffsignalisierung nicht dauerhaft ist und mit mehr Zeit und anhaltendem Gewichtsverlust wiederhergestellt werden kann.<\/p>\n<p>Fr\u00fchere Experimente an Labortieren deuteten darauf hin <a rel=\"nofollow\" href=\"https:\/\/www.medicaldaily.com\/why-does-stress-make-us-crave-comfort-food-tips-prevent-emotional-eating-470084\">Gehirn<\/a> reagierte auf das Vorhandensein von N\u00e4hrstoffen im Darm, auch ohne die sensorische Erfahrung des Essens.<\/p>\n<p>\u201eDer Fortschritt dieser Studie besteht darin, dass sie zeigen, dass dies auch beim Menschen geschieht, aber die Reaktion ist bei Menschen mit Fettleibigkeit v\u00f6llig abgeschw\u00e4cht\u201c, sagte Alexandra DiFeliceantonio, eine Co-Autorin der Studie.<\/p>\n<p>Die N\u00e4hrstoffsignalisierung zwischen Darm und Gehirn hilft den Menschen bei der Auswahl ihrer Essgewohnheiten, aber die Signal\u00fcbertragung sei aufgrund von Fettleibigkeit \u201eirgendwie unterbrochen\u201c, f\u00fcgte DiFeliceantonio hinzu.<\/p>\n<p>Unterdessen konnten die Forscher nicht genau bestimmen, wann genau die Signal\u00fcbertragung beeintr\u00e4chtigt wird und wie.<\/p>\n<p>Der Studie zufolge liegt das Geheimnis einer dauerhaften Gewichtsabnahme nicht immer in der \u201eWillenskraft\u201c, die Di\u00e4t fortzusetzen, da \u00fcbergewichtige Menschen nicht nur st\u00e4ndig gegen die Verlockungen von billigem, leicht verf\u00fcgbarem Junkfood ank\u00e4mpfen, sondern auch gegen ein \u201ehungriges Gehirn\u201c. erschwert Ern\u00e4hrungsumstellungen und Gewichtsabnahme.<\/p>\n<p>\u201eIch glaube schon, dass den Leuten die Schuld gegeben wird. Hier geht es nicht um Willenskraft. Es ist ein echter Kampf. Und wir beginnen zu verstehen, warum Menschen Schwierigkeiten haben\u201c, sagte Serlie.<\/p>\n<p>Durch Ern\u00e4hrung, \u00c4nderungen des Lebensstils und Medikamente hoffen die Forscher jedoch, in Zukunft einen Weg zu finden, die N\u00e4hrstoffsignalisierung zu korrigieren.<\/p>\n<figure class=\"imageBox\">\n<div class=\"innerBox\"><img loading=\"lazy\" decoding=\"async\" class=\"mapping-embed imgPhoto\" id=\"i445610\" src=\"https:\/\/urbancare.clinic\/wp-content\/uploads\/2023\/06\/why-is-weight-loss-hard-for-obese-people-study-explains-reason.jpg\" alt=\"burger\" width=\"736\" height=\"552\"><\/div><figcaption class=\"caption\">\n<span class=\"cap\">Eine aktuelle Studie erkl\u00e4rt, wie die Gehirnreaktionen bei \u00fcbergewichtigen Menschen unterschiedlich auf Zucker und Fett reagieren, was das Abnehmen zu einem schwierigen Weg macht.<\/span><br \/>\n<span class=\"credit\">Pixabay<\/span><br \/>\n<\/figcaption><\/figure>\n<p>Ver\u00f6ffentlicht von Medicaldaily.com<\/p>","protected":false},"author":2,"featured_media":8320,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"Default","format":"standard","meta":{"fifu_image_url":"https:\/\/urbancare.clinic\/wp-content\/uploads\/2023\/06\/why-is-weight-loss-hard-for-obese-people-study-explains-reason.jpg","fifu_image_alt":"","footnotes":""},"categories":[27],"tags":[],"class_list":["post-8319","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blog"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.6 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Why Is Weight Loss Hard For Obese People? Study Explains Reason - Urban Care Clinic<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/urbancare.clinic\/de\/warum-fallt-es-ubergewichtigen-menschen-schwer-gewicht-zu-verlieren-studie-erklart-den-grund\/\" \/>\n<meta property=\"og:locale\" content=\"de_DE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Why Is Weight Loss Hard For Obese People? Study Explains Reason - Urban Care Clinic\" \/>\n<meta property=\"og:description\" content=\"Losing weight and maintaining weight loss is always difficult for people with obesity. A recent study explained how the brain responses in overweight people function differently in response to sugar and fat, making weight loss a tough journey.The findings of the study, published in the journal Nature Metabolism, explained how obesity caused the brain to lose alignment with what was happening in the gut.&quot;Our interpretation is, there&#039;s a generally reduced nutrient-sensing in people with obesity. It could help explain why weight loss and weight-loss maintenance are so hard,&quot; senior researcher Dr. Mireille Serlie said.The study evaluated 30 adults with a healthy body weight and 30 with obesity. The brain responses of the participants to sugar and fat were captured after the nutrients were delivered directly to the gut.The lean participants showed specific patterns of brain activity when the nutrients were delivered, while these were &quot;severely impaired&quot; in obese people. The participants who were overweight also had a lesser release of dopamine from the striatum of the brain responsible for regulating eating habits.Even after shedding 10% of their weight on a reduced-calorie diet for three months, the brain responses of the obese participants did not reverse.Researchers believe that impaired nutrient signaling is not permanent and can be regained with more time and sustained weight loss.Earlier experiments on lab animals indicated the brain responded to the presence of nutrients in the gut even without the sensory experience of eating.&quot;The leap forward in this study is that they&#039;re showing this is happening in humans, too, but the response is completely blunted in people with obesity,&quot; Alexandra DiFeliceantonio, a co-author of the study, said.The nutrient signaling between the gut and the brain helps people choose what they eat, but the signaling is &quot;broken in some way&quot; due to obesity, DiFeliceantonio added.Meanwhile, the researchers could not determine when exactly the signaling becomes impaired or how.According to the study, the secret to lasting weight loss is not always about the &quot;willpower&quot; to continue the diet, as obese people are constantly fighting not only the temptations of cheap, readily available junk food, but also a &quot;hungry brain&quot; that makes diet changes and weight loss difficult.&quot;I do think people get blamed. This is not about willpower. It&#039;s a real struggle. And we&#039;re starting to understand why people struggle,&quot; Serlie said.However, through diet, lifestyle changes, and medications the researchers hope to find a way to correct the nutrient signaling in the future. A recent study explains how the brain responses in overweight people function differently in response to sugar and fat, making weight loss a tough journey. Pixabay Published by Medicaldaily.com\" \/>\n<meta property=\"og:url\" content=\"https:\/\/urbancare.clinic\/de\/warum-fallt-es-ubergewichtigen-menschen-schwer-gewicht-zu-verlieren-studie-erklart-den-grund\/\" \/>\n<meta property=\"og:site_name\" content=\"Urban Care Clinic\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/urbancarezanzibar\" \/>\n<meta property=\"article:published_time\" content=\"2023-06-13T07:02:48+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/urbancare.clinic\/wp-content\/uploads\/2023\/06\/why-is-weight-loss-hard-for-obese-people-study-explains-reason.jpg\" \/>\n<meta name=\"author\" content=\"Urban Care Clinic\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:image\" content=\"https:\/\/urbancare.clinic\/wp-content\/uploads\/2023\/06\/why-is-weight-loss-hard-for-obese-people-study-explains-reason.jpg\" \/>\n<meta name=\"twitter:label1\" content=\"Verfasst von\" \/>\n\t<meta name=\"twitter:data1\" content=\"Urban Care Clinic\" \/>\n\t<meta name=\"twitter:label2\" content=\"Gesch\u00e4tzte Lesezeit\" \/>\n\t<meta name=\"twitter:data2\" content=\"2\u00a0Minuten\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/urbancare.clinic\/why-is-weight-loss-hard-for-obese-people-study-explains-reason\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/urbancare.clinic\/why-is-weight-loss-hard-for-obese-people-study-explains-reason\/\"},\"author\":{\"name\":\"Urban Care Clinic\",\"@id\":\"https:\/\/urbancare.clinic\/#\/schema\/person\/f286c4d84be896d302aceda3ed7e789c\"},\"headline\":\"Why Is Weight Loss Hard For Obese People? 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Studie erkl\u00e4rt den Grund \u2013 Urban Care Clinic","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/urbancare.clinic\/de\/warum-fallt-es-ubergewichtigen-menschen-schwer-gewicht-zu-verlieren-studie-erklart-den-grund\/","og_locale":"de_DE","og_type":"article","og_title":"Why Is Weight Loss Hard For Obese People? Study Explains Reason - Urban Care Clinic","og_description":"Losing weight and maintaining weight loss is always difficult for people with obesity. A recent study explained how the brain responses in overweight people function differently in response to sugar and fat, making weight loss a tough journey.The findings of the study, published in the journal Nature Metabolism, explained how obesity caused the brain to lose alignment with what was happening in the gut.\"Our interpretation is, there's a generally reduced nutrient-sensing in people with obesity. It could help explain why weight loss and weight-loss maintenance are so hard,\" senior researcher Dr. Mireille Serlie said.The study evaluated 30 adults with a healthy body weight and 30 with obesity. The brain responses of the participants to sugar and fat were captured after the nutrients were delivered directly to the gut.The lean participants showed specific patterns of brain activity when the nutrients were delivered, while these were \"severely impaired\" in obese people. The participants who were overweight also had a lesser release of dopamine from the striatum of the brain responsible for regulating eating habits.Even after shedding 10% of their weight on a reduced-calorie diet for three months, the brain responses of the obese participants did not reverse.Researchers believe that impaired nutrient signaling is not permanent and can be regained with more time and sustained weight loss.Earlier experiments on lab animals indicated the brain responded to the presence of nutrients in the gut even without the sensory experience of eating.\"The leap forward in this study is that they're showing this is happening in humans, too, but the response is completely blunted in people with obesity,\" Alexandra DiFeliceantonio, a co-author of the study, said.The nutrient signaling between the gut and the brain helps people choose what they eat, but the signaling is \"broken in some way\" due to obesity, DiFeliceantonio added.Meanwhile, the researchers could not determine when exactly the signaling becomes impaired or how.According to the study, the secret to lasting weight loss is not always about the \"willpower\" to continue the diet, as obese people are constantly fighting not only the temptations of cheap, readily available junk food, but also a \"hungry brain\" that makes diet changes and weight loss difficult.\"I do think people get blamed. This is not about willpower. It's a real struggle. And we're starting to understand why people struggle,\" Serlie said.However, through diet, lifestyle changes, and medications the researchers hope to find a way to correct the nutrient signaling in the future. A recent study explains how the brain responses in overweight people function differently in response to sugar and fat, making weight loss a tough journey. 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