{"id":8202,"date":"2023-05-19T03:24:07","date_gmt":"2023-05-19T00:24:07","guid":{"rendered":"https:\/\/urbancare.clinic\/who-wants-vaccine-manufacturers-to-ditch-original-strain-in-updated-formulations\/"},"modified":"2023-05-23T17:29:53","modified_gmt":"2023-05-23T14:29:53","slug":"wer-mochte-dass-impfstoffhersteller-den-ursprunglichen-stamm-in-aktualisierten-formulierungen-weglassen","status":"publish","type":"post","link":"https:\/\/urbancare.clinic\/de\/who-wants-vaccine-manufacturers-to-ditch-original-strain-in-updated-formulations\/","title":{"rendered":"Die WHO m\u00f6chte, dass Impfstoffhersteller in aktualisierten Formulierungen auf Originalst\u00e4mme verzichten"},"content":{"rendered":"<div><img decoding=\"async\" src=\"https:\/\/urbancare.clinic\/wp-content\/uploads\/2023\/05\/who-wants-vaccine-manufacturers-to-ditch-original-strain-in-updated-formulations.jpg\" class=\"ff-og-image-inserted\"  style=\"display:none\"><\/div>\n<p>Die Weltgesundheitsorganisation (WHO) hat eine Stellungnahme zur Antigenzusammensetzung der COVID-19-Impfstoffe abgegeben.<\/p>\n<p>Die Sonderorganisation der Vereinten Nationen sagte am Donnerstag, dass Impfstoffhersteller Aktualisierungen entwickeln sollten, die nicht mehr auf den urspr\u00fcnglichen Stamm von SARS-CoV-2 abzielen.<\/p>\n<p>\u201eW\u00e4hrend derzeit zugelassene COVID-19-Impfstoffe, einschlie\u00dflich derjenigen, die auf dem Indexvirus basieren, weiterhin Schutz vor schweren Erkrankungen bieten, empfiehlt die TAG-CO-VAC, von der Einbeziehung des Indexvirus in k\u00fcnftige Formulierungen von COVID-19-Impfstoffen Abstand zu nehmen. &quot; Die <a rel=\"noopener nofollow\" href=\"https:\/\/www.who.int\/news\/item\/18-05-2023-statement-on-the-antigen-composition-of-covid-19-vaccines\" target=\"_blank\">Das erkl\u00e4rte die WHO auf ihrer Website<\/a>.<\/p>\n<p>TAG-CO-VAC ist die technische Beratergruppe der WHO zur Zusammensetzung von COVID-19-Impfstoffen. Die Beratergruppe hat die Aufgabe, regelm\u00e4\u00dfig zusammenzukommen, um die Auswirkungen neuer Mutationen auf die Antigenzusammensetzung k\u00fcnftiger Impfstoffe zu bewerten.<\/p>\n<p>F\u00fcr dieses Jahr wird erwartet, dass sich TAG-CO-VAC mindestens zweimal trifft. Der erste Termin war f\u00fcr Mai geplant, ein Folgetermin soll etwa sechs Monate sp\u00e4ter erfolgen. Die Gruppe traf sich offiziell vom 11. bis 12. Mai, um die neuesten Daten zu zirkulierenden SARS-CoV-2-Varianten und der Impfstoffzusammensetzung zu diskutieren.<\/p>\n<p>Letztes Jahr, <a rel=\"noopener nofollow\" href=\"https:\/\/www.who.int\/news\/item\/17-06-2022-interim-statement-on--the-composition-of-current-COVID-19-vaccines\" target=\"_blank\">TAG-CO-VAC angegeben<\/a> dass das Ziel der Aktualisierung der Antigenzusammensetzung des COVID-19-Impfstoffs darin bestand, die impfstoffinduzierten Immunreaktionen auf derzeit zirkulierende Coronavirus-Varianten zu verst\u00e4rken. Sollte die Gruppe die Notwendigkeit erkennen, die Formulierungen zu \u00e4ndern, w\u00fcrde sie der WHO raten, alle Impfstoffhersteller zu informieren.<\/p>\n<p>Die j\u00fcngste Empfehlung der Gruppe, in k\u00fcnftigen Formulierungen auf den urspr\u00fcnglichen Stamm zu verzichten, hat mehrere Gr\u00fcnde. Einer davon hat damit zu tun, dass das Indexvirus und andere fr\u00fchere St\u00e4mme nicht mehr beim Menschen zirkulieren. Ein weiterer Grund liegt darin, dass der urspr\u00fcngliche Stamm nicht nachweisbare oder nur sehr geringe Mengen an neutralisierenden Antik\u00f6rpern gegen die neueren Varianten hervorruft.<\/p>\n<p>Der dritte von der Gruppe genannte Grund hat etwas mit der Konzentration der Komposition zu tun. Durch die Einbeziehung des Indexvirus in die bivalenten oder multivalenten Impfstoffe und Auffrischungsimpfungen kann die Konzentration der neuen Zielantigene geringer sein. Dies verringert das Ausma\u00df der humoralen Immunantwort gegen die derzeit zirkulierenden Varianten.<\/p>\n<p>TAG-CO-VAC erkannte die Einschr\u00e4nkungen der verf\u00fcgbaren Daten zum Zeitpunkt, zu spezifischen Mutationen, antigenen Eigenschaften und potenziellen Risiken f\u00fcr die \u00f6ffentliche Gesundheit zuk\u00fcnftiger Varianten an. Informationen zur Kreuzreaktivit\u00e4t von Immunantworten, die durch neuere St\u00e4mme hervorgerufen werden, sind ebenfalls begrenzt. Unterdessen sind Daten zu Impfstoffkandidaten gegen die XBB.1-Abstammungslinie immer noch auf Tiermodelle beschr\u00e4nkt.<\/p>\n<p>Trotz der Einschr\u00e4nkungen sagte die Beratergruppe, dass sie weiterhin die zuk\u00fcnftige Entwicklung von COVID-19-Impfstoffen f\u00f6rdert, die die Schleimhautimmunit\u00e4t st\u00e4rken, um den Schutz vor Virusinfektionen zu verbessern und die \u00dcbertragung von SARS-CoV-2 zu reduzieren, insbesondere in den USA <a rel=\"nofollow\" href=\"https:\/\/www.medicaldaily.com\/how-stay-safe-post-pandemic-era-469772\">\u00c4ra nach der Pandemie<\/a>.<\/p>\n<p>Ver\u00f6ffentlicht von Medicaldaily.com<\/p>\n<p><a href=\"https:\/\/www.medicaldaily.com\/who-wants-vaccine-manufacturers-ditch-original-strain-updated-formulations-469822\">Medizinische t\u00e4gliche Quelle<\/a><\/p>\n<p>","protected":false},"excerpt":{"rendered":"<div><img decoding=\"async\" src=\"https:\/\/urbancare.clinic\/wp-content\/uploads\/2023\/05\/who-wants-vaccine-manufacturers-to-ditch-original-strain-in-updated-formulations.jpg\" class=\"ff-og-image-inserted\"><\/div>\n<p>Die Weltgesundheitsorganisation (WHO) hat eine Stellungnahme zur Antigenzusammensetzung der COVID-19-Impfstoffe abgegeben.<\/p>\n<p>Die Sonderorganisation der Vereinten Nationen sagte am Donnerstag, dass Impfstoffhersteller Aktualisierungen entwickeln sollten, die nicht mehr auf den urspr\u00fcnglichen Stamm von SARS-CoV-2 abzielen.<\/p>\n<p>\u201eW\u00e4hrend derzeit zugelassene COVID-19-Impfstoffe, einschlie\u00dflich derjenigen, die auf dem Indexvirus basieren, weiterhin Schutz vor schweren Erkrankungen bieten, empfiehlt die TAG-CO-VAC, von der Einbeziehung des Indexvirus in k\u00fcnftige Formulierungen von COVID-19-Impfstoffen Abstand zu nehmen. &quot; Die <a rel=\"noopener nofollow\" href=\"https:\/\/www.who.int\/news\/item\/18-05-2023-statement-on-the-antigen-composition-of-covid-19-vaccines\" target=\"_blank\">Das erkl\u00e4rte die WHO auf ihrer Website<\/a>.<\/p>\n<p>TAG-CO-VAC ist die technische Beratergruppe der WHO zur Zusammensetzung von COVID-19-Impfstoffen. Die Beratergruppe hat die Aufgabe, regelm\u00e4\u00dfig zusammenzukommen, um die Auswirkungen neuer Mutationen auf die Antigenzusammensetzung k\u00fcnftiger Impfstoffe zu bewerten.<\/p>\n<p>F\u00fcr dieses Jahr wird erwartet, dass sich TAG-CO-VAC mindestens zweimal trifft. Der erste Termin war f\u00fcr Mai geplant, ein Folgetermin soll etwa sechs Monate sp\u00e4ter erfolgen. Die Gruppe traf sich offiziell vom 11. bis 12. Mai, um die neuesten Daten zu zirkulierenden SARS-CoV-2-Varianten und der Impfstoffzusammensetzung zu diskutieren.<\/p>\n<p>Letztes Jahr, <a rel=\"noopener nofollow\" href=\"https:\/\/www.who.int\/news\/item\/17-06-2022-interim-statement-on--the-composition-of-current-COVID-19-vaccines\" target=\"_blank\">TAG-CO-VAC angegeben<\/a> dass das Ziel der Aktualisierung der Antigenzusammensetzung des COVID-19-Impfstoffs darin bestand, die impfstoffinduzierten Immunreaktionen auf derzeit zirkulierende Coronavirus-Varianten zu verst\u00e4rken. Sollte die Gruppe die Notwendigkeit erkennen, die Formulierungen zu \u00e4ndern, w\u00fcrde sie der WHO raten, alle Impfstoffhersteller zu informieren.<\/p>\n<p>Die j\u00fcngste Empfehlung der Gruppe, in k\u00fcnftigen Formulierungen auf den urspr\u00fcnglichen Stamm zu verzichten, hat mehrere Gr\u00fcnde. Einer davon hat damit zu tun, dass das Indexvirus und andere fr\u00fchere St\u00e4mme nicht mehr beim Menschen zirkulieren. Ein weiterer Grund liegt darin, dass der urspr\u00fcngliche Stamm nicht nachweisbare oder nur sehr geringe Mengen an neutralisierenden Antik\u00f6rpern gegen die neueren Varianten hervorruft.<\/p>\n<p>Der dritte von der Gruppe genannte Grund hat etwas mit der Konzentration der Komposition zu tun. Durch die Einbeziehung des Indexvirus in die bivalenten oder multivalenten Impfstoffe und Auffrischungsimpfungen kann die Konzentration der neuen Zielantigene geringer sein. Dies verringert das Ausma\u00df der humoralen Immunantwort gegen die derzeit zirkulierenden Varianten.<\/p>\n<p>TAG-CO-VAC erkannte die Einschr\u00e4nkungen der verf\u00fcgbaren Daten zum Zeitpunkt, zu spezifischen Mutationen, antigenen Eigenschaften und potenziellen Risiken f\u00fcr die \u00f6ffentliche Gesundheit zuk\u00fcnftiger Varianten an. Informationen zur Kreuzreaktivit\u00e4t von Immunantworten, die durch neuere St\u00e4mme hervorgerufen werden, sind ebenfalls begrenzt. Unterdessen sind Daten zu Impfstoffkandidaten gegen die XBB.1-Abstammungslinie immer noch auf Tiermodelle beschr\u00e4nkt.<\/p>\n<p>Trotz der Einschr\u00e4nkungen sagte die Beratergruppe, dass sie weiterhin die zuk\u00fcnftige Entwicklung von COVID-19-Impfstoffen f\u00f6rdert, die die Schleimhautimmunit\u00e4t st\u00e4rken, um den Schutz vor Virusinfektionen zu verbessern und die \u00dcbertragung von SARS-CoV-2 zu reduzieren, insbesondere in den USA <a rel=\"nofollow\" href=\"https:\/\/www.medicaldaily.com\/how-stay-safe-post-pandemic-era-469772\">\u00c4ra nach der Pandemie<\/a>.<\/p>\n<p>Ver\u00f6ffentlicht von Medicaldaily.com<\/p>","protected":false},"author":2,"featured_media":8203,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"page_builder":"","fifu_image_url":"https:\/\/urbancare.clinic\/wp-content\/uploads\/2023\/05\/who-wants-vaccine-manufacturers-to-ditch-original-strain-in-updated-formulations.jpg","fifu_image_alt":"","footnotes":""},"categories":[27],"tags":[193],"class_list":["post-8202","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blog","tag-vaccination"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>WHO Wants Vaccine Manufacturers To Ditch Original Strain In Updated Formulations - Urban Care Clinic<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/urbancare.clinic\/de\/wer-mochte-dass-impfstoffhersteller-den-ursprunglichen-stamm-in-aktualisierten-formulierungen-weglassen\/\" \/>\n<meta property=\"og:locale\" content=\"de_DE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"WHO Wants Vaccine Manufacturers To Ditch Original Strain In Updated Formulations - Urban Care Clinic\" \/>\n<meta property=\"og:description\" content=\"The World Health Organization (WHO) has issued a statement on the antigen composition of the COVID-19 vaccines.The specialized agency of the United Nations said Thursday that vaccine manufacturers should design updates that no longer target the original strain of SARS-CoV-2.&quot;While currently approved COVID-19 vaccines, including those based on the index virus, continue to provide protection against severe disease, the TAG-CO-VAC advises moving away from the inclusion of the index virus in future formulations of COVID-19 vaccines,&quot; the WHO stated on its website.TAG-CO-VAC is the WHO&#039;s Technical Advisory Group on COVID-19 Vaccine Composition. The advisory group is tasked to convene regularly to assess the implications of newer mutations for the antigen composition of future vaccines.For this year, TAG-CO-VAC is expected to meet at least twice. The first one was scheduled in May, and a follow-up should be done about six months later. The group officially convened on May 11-12 to discuss the latest data on circulating SARS-CoV-2 variants and vaccine composition.Last year, TAG-CO-VAC stated that the objective of updating the COVID-19 vaccine antigen composition was to enhance vaccine-induced immune responses to currently circulating coronavirus variants. Should the group find the need to change formulations, it would advise the WHO to inform all vaccine manufacturers.The latest recommendation of the group to ditch the original strain in future formulations is due to several reasons. One of which has to do with the index virus and other earlier strains no longer circulating in humans. Another reason is how the original strain elicits undetectable or very low levels of neutralizing antibodies against the newer variants.The third reason cited by the group has something to do with the concentration of the composition. By including the index virus in the bivalent or multivalent vaccines and boosters, the concentration of the new target antigens may be lower. This decreases the magnitude of the humoral immune response against the currently circulating variants.TAG-CO-VAC acknowledged the limitations of the available data on the timing, specific mutations, antigenic characteristics and potential public health risks of future variants. Information on the cross-reactivity of immune responses elicited by newer strains is also limited. Meanwhile, data on candidate vaccines against XBB.1 descendent lineage are still limited to animal models.Despite the limitations, the advisory group said it continues to encourage the future development of COVID-19 vaccines that enhance mucosal immunity for improved protection against viral infection and reduce the transmission of SARS-CoV-2, especially in the post-pandemic era.Published by Medicaldaily.com\" \/>\n<meta property=\"og:url\" content=\"https:\/\/urbancare.clinic\/de\/wer-mochte-dass-impfstoffhersteller-den-ursprunglichen-stamm-in-aktualisierten-formulierungen-weglassen\/\" \/>\n<meta property=\"og:site_name\" content=\"Urban Care Clinic\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/urbancarezanzibar\" \/>\n<meta property=\"article:published_time\" content=\"2023-05-19T00:24:07+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-05-23T14:29:53+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/urbancare.clinic\/wp-content\/uploads\/2023\/05\/who-wants-vaccine-manufacturers-to-ditch-original-strain-in-updated-formulations.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1024\" \/>\n\t<meta property=\"og:image:height\" content=\"1024\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Urban Care Clinic\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Verfasst von\" \/>\n\t<meta name=\"twitter:data1\" content=\"Urban Care Clinic\" \/>\n\t<meta name=\"twitter:label2\" content=\"Gesch\u00e4tzte Lesezeit\" \/>\n\t<meta name=\"twitter:data2\" content=\"2\u00a0Minuten\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/urbancare.clinic\\\/who-wants-vaccine-manufacturers-to-ditch-original-strain-in-updated-formulations\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/urbancare.clinic\\\/who-wants-vaccine-manufacturers-to-ditch-original-strain-in-updated-formulations\\\/\"},\"author\":{\"name\":\"Urban Care Clinic\",\"@id\":\"https:\\\/\\\/urbancare.clinic\\\/#\\\/schema\\\/person\\\/a304a61bcf298680ee41e2e9ae193930\"},\"headline\":\"WHO Wants Vaccine Manufacturers To Ditch Original Strain In Updated Formulations\",\"datePublished\":\"2023-05-19T00:24:07+00:00\",\"dateModified\":\"2023-05-23T14:29:53+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/urbancare.clinic\\\/who-wants-vaccine-manufacturers-to-ditch-original-strain-in-updated-formulations\\\/\"},\"wordCount\":429,\"publisher\":{\"@id\":\"https:\\\/\\\/urbancare.clinic\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/urbancare.clinic\\\/who-wants-vaccine-manufacturers-to-ditch-original-strain-in-updated-formulations\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/urbancare.clinic\\\/wp-content\\\/uploads\\\/2023\\\/05\\\/who-wants-vaccine-manufacturers-to-ditch-original-strain-in-updated-formulations.jpg\",\"keywords\":[\"Vaccination\"],\"articleSection\":[\"Medical Daily\"],\"inLanguage\":\"de\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/urbancare.clinic\\\/who-wants-vaccine-manufacturers-to-ditch-original-strain-in-updated-formulations\\\/\",\"url\":\"https:\\\/\\\/urbancare.clinic\\\/who-wants-vaccine-manufacturers-to-ditch-original-strain-in-updated-formulations\\\/\",\"name\":\"WHO Wants Vaccine Manufacturers To Ditch Original Strain In Updated Formulations - 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Urban Care Clinic","og_description":"The World Health Organization (WHO) has issued a statement on the antigen composition of the COVID-19 vaccines.The specialized agency of the United Nations said Thursday that vaccine manufacturers should design updates that no longer target the original strain of SARS-CoV-2.\"While currently approved COVID-19 vaccines, including those based on the index virus, continue to provide protection against severe disease, the TAG-CO-VAC advises moving away from the inclusion of the index virus in future formulations of COVID-19 vaccines,\" the WHO stated on its website.TAG-CO-VAC is the WHO's Technical Advisory Group on COVID-19 Vaccine Composition. The advisory group is tasked to convene regularly to assess the implications of newer mutations for the antigen composition of future vaccines.For this year, TAG-CO-VAC is expected to meet at least twice. The first one was scheduled in May, and a follow-up should be done about six months later. The group officially convened on May 11-12 to discuss the latest data on circulating SARS-CoV-2 variants and vaccine composition.Last year, TAG-CO-VAC stated that the objective of updating the COVID-19 vaccine antigen composition was to enhance vaccine-induced immune responses to currently circulating coronavirus variants. Should the group find the need to change formulations, it would advise the WHO to inform all vaccine manufacturers.The latest recommendation of the group to ditch the original strain in future formulations is due to several reasons. One of which has to do with the index virus and other earlier strains no longer circulating in humans. Another reason is how the original strain elicits undetectable or very low levels of neutralizing antibodies against the newer variants.The third reason cited by the group has something to do with the concentration of the composition. By including the index virus in the bivalent or multivalent vaccines and boosters, the concentration of the new target antigens may be lower. This decreases the magnitude of the humoral immune response against the currently circulating variants.TAG-CO-VAC acknowledged the limitations of the available data on the timing, specific mutations, antigenic characteristics and potential public health risks of future variants. Information on the cross-reactivity of immune responses elicited by newer strains is also limited. Meanwhile, data on candidate vaccines against XBB.1 descendent lineage are still limited to animal models.Despite the limitations, the advisory group said it continues to encourage the future development of COVID-19 vaccines that enhance mucosal immunity for improved protection against viral infection and reduce the transmission of SARS-CoV-2, especially in the post-pandemic era.Published by Medicaldaily.com","og_url":"https:\/\/urbancare.clinic\/de\/wer-mochte-dass-impfstoffhersteller-den-ursprunglichen-stamm-in-aktualisierten-formulierungen-weglassen\/","og_site_name":"Urban Care Clinic","article_publisher":"https:\/\/www.facebook.com\/urbancarezanzibar","article_published_time":"2023-05-19T00:24:07+00:00","article_modified_time":"2023-05-23T14:29:53+00:00","og_image":[{"url":"https:\/\/urbancare.clinic\/wp-content\/uploads\/2023\/05\/who-wants-vaccine-manufacturers-to-ditch-original-strain-in-updated-formulations.jpg","width":1024,"height":1024,"type":"image\/jpeg"}],"author":"Urban 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