{"id":7937,"date":"2023-04-19T12:38:20","date_gmt":"2023-04-19T09:38:20","guid":{"rendered":"https:\/\/urbancare.clinic\/irregular-sleeping-habits-can-lead-to-potentially-fatal-lung-disease-study\/"},"modified":"2023-05-23T17:33:58","modified_gmt":"2023-05-23T14:33:58","slug":"unregelmasige-schlafgewohnheiten-konnen-zu-potenziell-todlichen-lungenerkrankungen-fuhren","status":"publish","type":"post","link":"https:\/\/urbancare.clinic\/de\/irregular-sleeping-habits-can-lead-to-potentially-fatal-lung-disease-study\/","title":{"rendered":"Unregelm\u00e4\u00dfige Schlafgewohnheiten k\u00f6nnen zu einer potenziell t\u00f6dlichen Lungenerkrankung f\u00fchren: Studie"},"content":{"rendered":"

Eine neue Studie ergab, dass die Nichteinhaltung eines regelm\u00e4\u00dfigen Schlafplans zu t\u00f6dlichen Lungenerkrankungen f\u00fchren kann.<\/p>\n

Die Studie, ver\u00f6ffentlicht in der Zeitschrift Naturkommunikation<\/a>, stellte fest, dass unregelm\u00e4\u00dfige Schlafmuster die nat\u00fcrliche biologische Uhr des K\u00f6rpers (auch als zirkadiane Uhr bekannt) beeintr\u00e4chtigen k\u00f6nnen, was zu Lungennarben oder Lungenfibrose f\u00fchren kann, einer potenziell t\u00f6dlichen Krankheit, bei der sich Bindegewebe in der Lunge ansammelt, diese verh\u00e4rtet und verh\u00e4rtet Atembeschwerden verursachen.<\/p>\n

Es handelt sich um ein Protein namens REV-ERB\u03b1, das mit der zirkadianen Uhr verbunden ist, ein zirkadianes Rhythmusprotein, das die Kollagenproduktion im K\u00f6rper reguliert. Ein Mangel an REV-ERB\u03b1 kann dazu beitragen, die Kollagenproduktion anzukurbeln, was wiederum zur Verh\u00e4rtung des Lungengewebes und schlie\u00dflich zur Fibrose f\u00fchren kann.<\/p>\n

Das Team hinter der Studie unter der Leitung von Irfan Rahman, Ph.D., Dekanatsprofessor f\u00fcr Umweltmedizin am University of Rochester Medical Center, fand niedrige REV-ERB\u03b1-Werte und erh\u00f6hte Kollagen- und Lysyloxidasewerte in Lungenproben von Lungenfibrose Patienten, nach Hindustan Times<\/a>.<\/p>\n

In einer Mausmodellstudie fanden Forscher heraus, dass REV-ERB\u03b1 im Laufe des Tages schwankt, mittags seinen H\u00f6hepunkt erreicht und in der Nacht abf\u00e4llt. Bei einer Verletzung in der Nacht zeigten M\u00e4usemodelle im Vergleich zu M\u00e4usen, die tags\u00fcber verletzt wurden, einen gr\u00f6\u00dferen Anstieg der Lysyloxidase und der Kollagenproteine, gr\u00f6\u00dfere Lungensch\u00e4den und niedrigere \u00dcberlebensraten.<\/p>\n

Rahman sagte, Nachtschichtmitarbeiter seien einem h\u00f6heren Risiko f\u00fcr die Erkrankung ausgesetzt. \u201eNachtschichtarbeit findet normalerweise um Mitternacht statt, wenn die Expression von REV-ERB\u03b1 am niedrigsten ist\u201c, erkl\u00e4rte er. \u201eUnsere Ergebnisse legen nahe, dass die Aktivierung von REV-ERB\u03b1 in der Nacht weniger Schutz vor Lungenfibrose bietet.\u201c<\/p>\n

Qixin Wang, Ph.D., ein Postdoktorand, der in Rahmans Labor arbeitet, sagte in der Studie, dass es dem Markt an genug mangele Fibrose<\/a> Medikamente, und mit der neuen Studie wollen Wissenschaftler neue Medikamente entwickeln, um die Lungenerkrankung besser zu behandeln.<\/p>\n

\u201eDerzeit gibt es nur zwei von der FDA zugelassene Medikamente zur Behandlung von Fibrose, und sie verz\u00f6gern nur den Prozess, sie heilen die Krankheit nicht\u201c, sagte Wang. \u201eREV-ERB\u03b1-aktivierende Medikamente k\u00f6nnten als potenzielle Therapeutika dienen, um Fibrose vorzubeugen und den Krankheitsprozess zu stoppen.\u201c<\/p>\n

\n
\"Lunge\"<\/picture><\/div>
\nDie Hauptmerkmale einer autoimmunen Lungenerkrankung sind Entz\u00fcndungen und Narbenbildung. <\/span>
\nPixabay<\/span>
\n<\/figcaption><\/figure>\n

Medizinische t\u00e4gliche Quelle<\/a><\/p>\n

","protected":false},"excerpt":{"rendered":"

Schlafmangel f\u00fchrt zu einer St\u00f6rung der Produktion eines biologischen Uhrproteins namens REV-ERB\u03b1, was Lungenfibrose verursachen kann.<\/p>","protected":false},"author":2,"featured_media":7938,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"page_builder":"","fifu_image_url":"https:\/\/urbancare.clinic\/wp-content\/uploads\/2023\/04\/irregular-sleeping-habits-can-lead-to-potentially-fatal-lung-disease-study.jpg","fifu_image_alt":"","footnotes":""},"categories":[27],"tags":[203],"class_list":["post-7937","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blog","tag-sleep"],"yoast_head":"\nIrregular Sleeping Habits Can Lead To Potentially Fatal Lung Disease: Study - Urban Care Clinic<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" 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