{"id":7678,"date":"2023-03-15T12:43:51","date_gmt":"2023-03-15T09:43:51","guid":{"rendered":"https:\/\/urbancare.clinic\/cholesterol-lowering-medication-can-protect-heart-health-of-people-with-sleep-apnea-study\/"},"modified":"2023-05-23T17:37:47","modified_gmt":"2023-05-23T14:37:47","slug":"studie-cholesterinsenkende-medikamente-konnen-die-herzgesundheit-von-menschen-mit-schlafapnoe-schutzen","status":"publish","type":"post","link":"https:\/\/urbancare.clinic\/de\/cholesterol-lowering-medication-can-protect-heart-health-of-people-with-sleep-apnea-study\/","title":{"rendered":"Cholesterinsenkende Medikamente k\u00f6nnen die Herzgesundheit von Menschen mit Schlafapnoe sch\u00fctzen: Studie"},"content":{"rendered":"
<\/div>\n

Eine neue von Forschern der Columbia University durchgef\u00fchrte Studie hat herausgefunden, dass cholesterinsenkende Medikamente, sogenannte Statine, m\u00f6glicherweise das Risiko schwerer Herzerkrankungen bei Menschen mit Schlafapnoe verringern k\u00f6nnen.<\/p>\n

Schlafapnoe ist eine h\u00e4ufige Erkrankung bei \u00e4lteren Erwachsenen. In der Folge kommt es zu Einschlafschwierigkeiten, was wiederum zu Bluthochdruck und schlie\u00dflich zu einer Reihe von Herzerkrankungen wie Herzrhythmusst\u00f6rungen (unregelm\u00e4\u00dfiger Herzschlag), Herzinfarkten und Schlaganf\u00e4llen f\u00fchrt.<\/p>\n

Die Studie, ver\u00f6ffentlicht<\/a> legt in der Zeitschrift Annals of the American Thoracic Society nahe, dass das Medikament sogar f\u00fcr diejenigen von Vorteil sein kann, die CPAP-Ger\u00e4te (Continuous Positive Airway Pressure) verwenden, um eine normale Schlafordnung zu erm\u00f6glichen Medizinischer Express.<\/a><\/p>\n

CPAP bietet Menschen mit obstruktiver Schlafapnoe einen erholsamen Schlaf, indem es die Tagesm\u00fcdigkeit reduziert. J\u00fcngste klinische Studien haben jedoch gezeigt, dass es nicht das Potenzial hat, die Herzgesundheit zu verbessern, wie \u00c4rzte f\u00e4lschlicherweise vermutet haben.<\/p>\n

<\/div>\n

Daher versp\u00fcrten \u00c4rzte die dringende Notwendigkeit, nach einer besseren Alternative zu suchen, da die Erkrankung das Risiko einer Herzerkrankung, eines Schlaganfalls oder anderer kardiovaskul\u00e4rer Auswirkungen verdreifacht. Die von Sanja Jelic, au\u00dferordentliche Professorin f\u00fcr Medizin am Vagelos College of Physicians and Surgeons der Columbia University, geleitete Studie ergab, dass Statine eine solche Methode sind.<\/p>\n

An der Studie nahmen 87 Personen mit k\u00fcrzlich festgestellter Schlafapnoe teil, die CPAP verwenden. Den Patienten wurden nach dem Zufallsprinzip entweder Statine oder ein Placebo verabreicht. Die Forscher stellten fest, dass Statine und nicht CPAP die Blutgef\u00e4\u00dfe vor den gef\u00e4hrlichen entz\u00fcndlichen Ver\u00e4nderungen sch\u00fctzten, die bei Menschen mit Schlafapnoe auftreten.<\/p>\n

Im Rahmen der Studie stellten die Forscher fest, dass ein niedrigerer Cholesterinspiegel den Spiegel des CD59-Proteins stabilisieren kann \u2013 einer Komponente, die Entz\u00fcndungen in Blutgef\u00e4\u00dfen unter Kontrolle h\u00e4lt, indem sie Zellen vor Komplementaktivit\u00e4t (einer Gruppe von Proteinen, die Entz\u00fcndungen f\u00f6rdern) sch\u00fctzt. Die \u00c4rzte stellten fest, dass die Studienteilnehmer nach vierw\u00f6chiger Therapie mit cholesterinsenkenden Statinen einen stabileren CD59-Spiegel im Blut aufwiesen, was mit CPAP allein nicht m\u00f6glich war.<\/p>\n

\u201eDie Wirkung, die wir bei Statinen festgestellt haben, ist wichtig\u201c, sagt Jelic Schlafbericht.<\/a> \u201eEntz\u00fcndungen in den Blutgef\u00e4\u00dfen sind ein wichtiger Schritt im Fortschreiten von Herz-Kreislauf-Erkrankungen. Daher ist alles, was wir tun k\u00f6nnen, um CD59 bei diesen Patienten zu stabilisieren, wahrscheinlich von Vorteil f\u00fcr die Herzgesundheit.\u201c<\/p>\n

Die \u00c4rzte fanden au\u00dferdem heraus, dass CPAP mehr schadet als n\u00fctzt, da es den Angiopoietin-2-Spiegel im Blut erh\u00f6ht. Angiopoietin-2 ist ein Protein, das mit verst\u00e4rkten Entz\u00fcndungen und anderen Herzerkrankungen in Verbindung gebracht wird. W\u00e4hrend der Studie senkten Statine den Angiopoietin-2-Spiegel bei Patienten mit Schlafapnoe.<\/p>\n

\u201eWir glauben nach wie vor, dass CPAP sehr n\u00fctzlich ist, da es den Schlaf verbessert und die Tagesm\u00fcdigkeit verringert\u201c, sagt Jelic. \u201eCPAP scheint aber auch negative Auswirkungen auf das Herz-Kreislauf-System zu haben. Wir m\u00fcssen untersuchen, ob wir zur Behandlung von Patienten mit obstruktiver Schlafapnoe konservativere Atemwegsdr\u00fccke oder andere, weniger genutzte Behandlungen wie orale Apparaturen anwenden sollten.\u201c<\/p>\n

Weitere klinische Studien zur Statintherapie seien erforderlich, um ein endg\u00fcltiges Urteil \u00fcber ihre Wirksamkeit bei der Heilung von Herzerkrankungen zu f\u00e4llen, sagte Jelic. Derzeit werden Statine nur 8-13% der Gesamtzahl der Patienten mit Schlafapnoe verschrieben.<\/p>\n

Medizinische t\u00e4gliche Quelle<\/a><\/p>\n

","protected":false},"excerpt":{"rendered":"

Die Forscher stellten fest, dass Statine die Blutgef\u00e4\u00dfe vor den gef\u00e4hrlichen entz\u00fcndlichen Ver\u00e4nderungen sch\u00fctzten, die bei Menschen mit Schlafapnoe auftreten.<\/p>","protected":false},"author":2,"featured_media":7679,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"page_builder":"","fifu_image_url":"https:\/\/urbancare.clinic\/wp-content\/uploads\/2023\/03\/cholesterol-lowering-medication-can-protect-heart-health-of-people-with-sleep-apnea-study.jpg","fifu_image_alt":"","footnotes":""},"categories":[27],"tags":[198],"class_list":["post-7678","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blog","tag-blood-pressure"],"yoast_head":"\nCholesterol-Lowering Medication Can Protect Heart Health Of People With Sleep Apnea: Study - Urban Care Clinic<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, 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