{"id":7557,"date":"2023-02-09T12:57:32","date_gmt":"2023-02-09T09:57:32","guid":{"rendered":"https:\/\/urbancare.clinic\/ashkenazi-jews-susceptible-to-rare-genetic-disease-that-protects-them-from-tb-study\/"},"modified":"2023-02-09T12:57:32","modified_gmt":"2023-02-09T09:57:32","slug":"aschkenasische-juden-sind-anfallig-fur-eine-seltene-genetische-erkrankung-die-sie-vor-einer-tuberkulose-studie-schutzt","status":"publish","type":"post","link":"https:\/\/urbancare.clinic\/de\/ashkenazi-jews-susceptible-to-rare-genetic-disease-that-protects-them-from-tb-study\/","title":{"rendered":"Aschkenasische Juden sind anf\u00e4llig f\u00fcr seltene genetische Krankheiten, die sie vor Tuberkulose sch\u00fctzen: Studie"},"content":{"rendered":"<div><img decoding=\"async\" src=\"https:\/\/urbancare.clinic\/wp-content\/uploads\/2023\/02\/ashkenazi-jews-susceptible-to-rare-genetic-disease-that-protects-them-from-tb-study.jpg\" class=\"ff-og-image-inserted\" style=\"display:none\"><\/div>\n<p>Durch einen Zufall haben Wissenschaftler herausgefunden, dass eine seltene genetische Krankheit, von der aschkenasische Juden h\u00e4ufiger betroffen sind, sie auch vor Tuberkulose sch\u00fctzt.<\/p>\n<p>In der Studie, ver\u00f6ffentlicht in der Zeitschrift <a href=\"https:\/\/www.pnas.org\/doi\/full\/10.1073\/pnas.2217673120\" rel=\"nofollow noopener\" target=\"_blank\">PNAS<\/a>Forscher fanden heraus, dass die Gaucher-Krankheit (ausgesprochen go-SHAY), eine lysosomale Erkrankung, unbeabsichtigten Schutz vor Tuberkulose bietet.<\/p>\n<p>Einer Sch\u00e4tzung zufolge rund&nbsp;<a href=\"https:\/\/www.who.int\/teams\/global-tuberculosis-programme\/tb-reports\/global-tuberculosis-report-2022\/tb-disease-burden\/2-1-tb-incidence\" rel=\"nofollow noopener\" target=\"_blank\">10,6 Millionen Menschen<\/a>&nbsp;Weltweit erkrankten Menschen an Tuberkulose (TB) und im Jahr 2021 starben 1,6 Millionen Menschen an der Krankheit.<\/p>\n<p>Allerdings erkranken 95% der Menschen, die mit den Tuberkulosebakterien infiziert sind, nicht. Dem Immunsystem dieser Personen gelingt es, den Erreger erfolgreich abzut\u00f6ten.<\/p>\n<div id=\"dfp-ad-oop2\" class=\"dfp-tag-wrapper\"> <\/div>\n<p>\u201eMeine Kollegen und ich interessieren uns daf\u00fcr, was manche Menschen anf\u00e4llig f\u00fcr Tuberkulose macht, w\u00e4hrend andere scheinbar gesch\u00fctzt sind. \u201eWir verwenden Zebrafische, um die Krankheit zu untersuchen, da ihr Immunsystem viele \u00c4hnlichkeiten mit dem des Menschen aufweist und es m\u00f6glich ist, ihre Gene im Labor zu manipulieren\u201c, so Lalita Ramakrishnan, Professorin f\u00fcr Mikrobiologie an der Universit\u00e4t Cambridge, und Laura Whitworth, Gruppenlabor Der Manager der medizinischen Abteilung der Universit\u00e4t Cambridge sagte zusammen: <a href=\"https:\/\/www.sciencealert.com\/rare-genetic-disease-appears-to-defend-ashkenazi-jews-against-tb\" rel=\"nofollow noopener\" target=\"_blank\">ScienceAlert<\/a> gemeldet.<\/p>\n<p>Die Gaucher-Krankheit ist eine seltene genetische Erkrankung, von der aschkenasische Juden \u00fcberproportional betroffen sind&nbsp;<a href=\"https:\/\/gaucher-institute.com\/burden-of-disease\/epidemiology-of-gaucher-disease\/gaucher-disease-in-the-ashkenazi-jewish-population\" rel=\"nofollow noopener\" target=\"_blank\">eine von 800 Geburten<\/a>. Aber die Krankheit kann jeden treffen. Die Krankheit hat relativ milde Symptome, darunter eine Vergr\u00f6\u00dferung von Milz und Leber sowie An\u00e4mie.<\/p>\n<p>Die in den Lysosomen der Zellen vorhandenen Enzyme bauen unerw\u00fcnschte Stoffe wie Proteine und Fette ab. Eine Verringerung dieser Enzyme kann zur Ansammlung toxischer Stoffe f\u00fchren.<\/p>\n<p>Diese Ansammlung ist sehr sch\u00e4dlich f\u00fcr die normale Funktion von Zellen, die Makrophagen genannt werden.<\/p>\n<p>\u201eEin Zelltyp, der f\u00fcr diese Ansammlung anf\u00e4llig ist, sind die Makrophagen, eine Zelle, die toxisches Material, einschlie\u00dflich Bakterien und Abfallprodukte, \u201efrisst\u201c. Bei lysosomalen Erkrankungen bewegen sich die Makrophagen langsam und vergr\u00f6\u00dfern sich, weil sie unverdautes Material in ihren Lysosomen ansammeln, wodurch sie weniger in der Lage sind, Infektionen zu bek\u00e4mpfen\u201c, so die Autoren.<\/p>\n<p>Als die Forscher Zebrafische nach dem Vorbild der Gaucher-Krankheit gentechnisch ver\u00e4nderten, stellten sie fest, dass die Fische \u201eeher TB-resistent als anf\u00e4llig\u201c wurden.<\/p>\n<p>\u201eDer Grund f\u00fcr diese Infektionsresistenz liegt in der Fettchemikalie, die sich bei der Gaucher-Krankheit in den Makrophagen ansammelt. Es wurde festgestellt, dass diese fetthaltige Chemikalie als L\u00f6sungsmittel wirkt, das Tuberkulosebakterien innerhalb von Minuten abt\u00f6ten kann, indem es ihre Zellw\u00e4nde zerst\u00f6rt\u201c, erkl\u00e4rten die Forscher.<\/p>\n<p>Die aschkenasischen Juden erlebten jahrhundertelange Verfolgung, lebten in Ghettos und zogen von Land zu Land. Seit <a href=\"https:\/\/www.medicaldaily.com\/woman-tuberculosis-faces-jail-time-ditching-isolation-467998\">TB<\/a> Da sich die Erkrankung in \u00e4rmeren Lebensbedingungen und dicht besiedelten Gebieten schneller ausbreitet, m\u00fcssen die Juden in hohem Ma\u00dfe der Tuberkulose ausgesetzt gewesen sein.<\/p>\n<p>\u201eDiese Fische haben uns unwissentlich in eine Debatte gebracht, die in der Humangenetik im Gange ist&nbsp;<a href=\"https:\/\/www.pnas.org\/doi\/full\/10.1073\/pnas.2217673120\" rel=\"nofollow noopener\" target=\"_blank\">f\u00fcr Jahrzehnte<\/a>: Sind aschkenasische Juden \u2013 von denen wir wissen, dass sie einem viel gr\u00f6\u00dferen Risiko f\u00fcr die Gaucher-Krankheit ausgesetzt sind \u2013 irgendwie weniger wahrscheinlich, dass sie eine Tuberkulose-Infektion bekommen? Die Antwort scheint ja zu sein\u201c, schlussfolgerten die Forscher.<\/p>\n<p><a href=\"https:\/\/www.medicaldaily.com\/ashkenazi-jews-susceptible-rare-genetic-disease-protects-them-tb-study-468037?utm_source=Public&#038;utm_medium=Feed&#038;utm_campaign=Distribution\">Medizinische t\u00e4gliche Quelle<\/a><\/p>\n<p>","protected":false},"excerpt":{"rendered":"<p>Einer Sch\u00e4tzung zufolge erkrankten im Jahr 2021 weltweit rund 10,6 Millionen Menschen an Tuberkulose (TB), 1,6 Millionen Menschen starben an der Krankheit.<\/p>","protected":false},"author":2,"featured_media":7558,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"Default","format":"standard","meta":{"page_builder":"","fifu_image_url":"https:\/\/urbancare.clinic\/wp-content\/uploads\/2023\/02\/ashkenazi-jews-susceptible-to-rare-genetic-disease-that-protects-them-from-tb-study.jpg","fifu_image_alt":"","footnotes":""},"categories":[27],"tags":[],"class_list":["post-7557","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blog"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Ashkenazi Jews Susceptible To Rare Genetic Disease That Protects Them From TB: Study - Urban Care Clinic<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" 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