{"id":7543,"date":"2022-11-22T13:00:22","date_gmt":"2022-11-22T10:00:22","guid":{"rendered":"https:\/\/urbancare.clinic\/warfarin-induced-skin-necrosis\/"},"modified":"2023-05-23T17:37:36","modified_gmt":"2023-05-23T14:37:36","slug":"warfarin-verursachte-hautnekrose","status":"publish","type":"post","link":"https:\/\/urbancare.clinic\/de\/warfarin-induced-skin-necrosis\/","title":{"rendered":"Warfarin verursachte Hautnekrose"},"content":{"rendered":"
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","protected":false},"excerpt":{"rendered":"

Warfarin, ein Doppelschwert, hilft nicht nur bei der Antikoagulation durch Hemmung von Vitamin-K-abh\u00e4ngigen Gerinnungsfaktoren, sondern verhindert auch die Aufl\u00f6sung von Blutgerinnseln durch Hemmung von Protein C und Protein S. Die Halbwertszeit von Protein C und S ist k\u00fcrzer als die von Vitamin-K-abh\u00e4ngigen Gerinnungsfaktoren, daher sinkt ihre Plasmakonzentration schneller. Wenn der Patient allein mit Warfarin behandelt wird, besteht das Risiko einer durch Warfarin verursachten Hautnekrose, einer potenziell verheerenden, wenn auch seltenen Komplikation (0,01%\u20130,1%), die normalerweise 2\u20135 Tage nach Beginn der Warfarin-Therapie auftritt.<\/p>\n

Bei einem 63-j\u00e4hrigen Mann wurde k\u00fcrzlich eine rheumatische Herzerkrankung mit schwerer Mitralstenose diagnostiziert. Seit 2 Tagen zeigt er eine verminderte Urinausscheidung. Vor 2 Wochen wurde ihm einmal t\u00e4glich eine Tablette Warfarin 5 mg und zweimal t\u00e4glich eine Tablette Furosemid 20 mg verschrieben. Die k\u00f6rperliche Untersuchung ergab eine Pulsfrequenz von 98 Schl\u00e4gen pro Minute, einen Blutdruck von 140\/88 mmHg und eine Atemfrequenz von 26 Atemz\u00fcgen pro Minute. Die Herzauskultation ergab einen unregelm\u00e4\u00dfigen Rhythmus\u2026.<\/p>","protected":false},"author":2,"featured_media":7544,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"page_builder":"","fifu_image_url":"https:\/\/urbancare.clinic\/wp-content\/uploads\/2023\/02\/warfarin-induced-skin-necrosis.jpg","fifu_image_alt":"","footnotes":""},"categories":[185],"tags":[198],"class_list":["post-7543","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-research-medical-articles","tag-blood-pressure"],"yoast_head":"\nWarfarin induced skin necrosis - Urban Care Clinic<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/urbancare.clinic\/de\/warfarin-verursachte-hautnekrose\/\" \/>\n<meta property=\"og:locale\" content=\"de_DE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Warfarin induced skin necrosis - Urban Care Clinic\" \/>\n<meta property=\"og:description\" content=\"Warfarin, a double sword not only helps in anticoagulation by inhibition of vitamin K dependent clotting factors but also prevents clot lysis by inhibiting protein C and protein S. 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