{"id":7527,"date":"2022-11-22T13:00:22","date_gmt":"2022-11-22T10:00:22","guid":{"rendered":"https:\/\/urbancare.clinic\/complete-resolution-of-calciphylaxis-in-a-renal-transplant-patient-with-calcifediol\/"},"modified":"2022-11-22T13:00:22","modified_gmt":"2022-11-22T10:00:22","slug":"vollstandige-auflosung-der-calciphylaxie-bei-einem-nierentransplantationspatienten-mit-calcifediol","status":"publish","type":"post","link":"https:\/\/urbancare.clinic\/de\/complete-resolution-of-calciphylaxis-in-a-renal-transplant-patient-with-calcifediol\/","title":{"rendered":"Vollst\u00e4ndige Aufl\u00f6sung der Calciphylaxie bei einem Nierentransplantationspatienten mit Calcifediol"},"content":{"rendered":"<div><img decoding=\"async\" src=\"https:\/\/urbancare.clinic\/wp-content\/uploads\/2023\/02\/complete-resolution-of-calciphylaxis-in-a-renal-transplant-patient-with-calcifediol.jpg\" class=\"ff-og-image-inserted\" style=\"display:none\"><\/div>\n<p><span class=\"highwire-journal-article-marker-start\"><\/span><\/p>\n<p id=\"p-1\">Pr\u00e4sentation:<\/p>\n<p id=\"p-2\">Eine 62-j\u00e4hrige Frau mit einer Lebendspende-Nierentransplantation im Jahr 2008, die an einer chronischen Nierenerkrankung III, Lupusnephritis und Hypothyreose (jedoch ohne Diabetes in der Vorgeschichte) litt, stellte sich mit schmerzhaften, bilateralen, medialen isch\u00e4mischen Ulzerationen an der Wade vor (Abbildung 1), die auf Die Stanzbiopsie ergab eine Calciphylaxie (Abbildung 2). Ihr Gewicht betrug 66,3 kg, sie war 1,6 m gro\u00df und hatte einen Body-Mass-Index von 25,9 kg\/m<sup>2<\/sup>. Sie nahm Hydroxychloroquin, Mycophenolat und Prednison gegen Lupus\/Transplantation und 125 \u00b5g Levothyroxin t\u00e4glich gegen Hypothyreose. Ihr Ausgangswert ist intaktes Nebenschilddr\u00fcsenhormon (iPTH), Kalzium, Phosphor \u2026 <\/p>\n<p><span class=\"highwire-journal-article-marker-end\"><\/span><a href=\"http:\/\/pmj.bmj.com\/cgi\/content\/short\/98\/1166\/e35?rss=1\">Medizinische t\u00e4gliche Quelle<\/a><\/p>\n<p>","protected":false},"excerpt":{"rendered":"<p>Pr\u00e4sentation:<\/p>\n<p>Eine 62-j\u00e4hrige Frau, die 2008 eine Nierentransplantation von einem Lebendspender erhalten hatte und an chronischer Nierenerkrankung III, Lupusnephritis und Hypothyreose litt (aber keine Diabetes-Vorgeschichte), stellte sich mit schmerzhaften, beidseitigen isch\u00e4mischen Ulzerationen an der medialen Wade vor (<cross-ref type=\"fig\" refid=\"F1\">Abbildung 1<\/cross-ref>), die bei der Stanzbiopsie eine Kalziphylaxie ergab (<cross-ref type=\"fig\" refid=\"F2\">Figur 2<\/cross-ref>). Ihr Gewicht betrug 66,3 kg, ihre Gr\u00f6\u00dfe 1,6 m und ihr Body-Mass-Index 25,9 kg\/m<sup>2<\/sup>. Sie nahm Hydroxychloroquin, Mycophenolat und Prednison gegen Lupus\/Transplantation und t\u00e4glich 125 mcg Levothyroxin gegen Hypothyreose ein. Ihre Ausgangswerte f\u00fcr intaktes Parathormon (iPTH), Kalzium, Phosphor und 25-Hydroxyvitamin D lagen bei 372 pg\/ml, 9,4 mg\/dl, 3,8 mg\/dl bzw. 17,4 ng\/ml (<cross-ref type=\"tbl\" refid=\"T1\">Tabelle 1<\/cross-ref>Darstellung von Laborwerten und Medikamenten\u00e4nderungen im Laufe der Zeit). Sie nahm Calcitriol (0,75 mcg\/Tag), Ergocalciferol (50.000 Einheiten w\u00f6chentlich) und Cinacalcet 30 mcg jeden zweiten Tag ein. Wir begannen mit 30 mg Calcifediol, die Dosis wurde sp\u00e4ter auf 60 mg t\u00e4glich erh\u00f6ht. Ihre Calcitriol- und Ergocalciferol-Dosen wurden langsam reduziert, w\u00e4hrend die Cinacalcet-Dosis gleich blieb. Dies\u2026<\/p>","protected":false},"author":2,"featured_media":7528,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"Default","format":"standard","meta":{"page_builder":"","fifu_image_url":"https:\/\/urbancare.clinic\/wp-content\/uploads\/2023\/02\/complete-resolution-of-calciphylaxis-in-a-renal-transplant-patient-with-calcifediol.jpg","fifu_image_alt":"","footnotes":""},"categories":[185],"tags":[],"class_list":["post-7527","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-research-medical-articles"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Complete resolution of calciphylaxis in a renal transplant patient with Calcifediol - Urban Care Clinic<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/urbancare.clinic\/de\/vollstandige-auflosung-der-calciphylaxie-bei-einem-nierentransplantationspatienten-mit-calcifediol\/\" \/>\n<meta property=\"og:locale\" content=\"de_DE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Complete resolution of calciphylaxis in a renal transplant patient with Calcifediol - Urban Care Clinic\" \/>\n<meta property=\"og:description\" content=\"Presentation: A 62-year-old woman with a Living Donor Kidney transplant in 2008 complicated with chronic kidney disease III, lupus nephritis, hypothyroidism (but no history of diabetes) presented with painful, bilateral, medial calf ischaemic ulcerations (figure 1), which on punch biopsy revealed calciphylaxis (figure 2). Her weight was 66.3 kg, height 1.6 m and body mass index of 25.9 kg\/m2. She was on hydroxychloroquine, mycophenolate and prednisone for lupus\/transplant and levothyroxine 125 mcg daily for hypothyroidism. Her baseline intact parathyroid harmone (iPTH), calcium, phosphorus and 25-hydroxy-vitamin D was 372 pg\/mL, 9.4 mg\/dL, 3.8 mg\/dL and 17.4 ng\/mL, respectively (table 1depicting laboratories and medication changes over time). She was on calcitriol (0.75 mcg\/daily), ergocalciferol (50 000 units weekly) and cinacalcet 30 mcg every other day. We started her on calcifediol 30 mg, which was later increased to 60 mg daily. Her calcitriol and ergocalciferol doses were reduced slowly, while cinacalcet remained the same. 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Her weight was 66.3 kg, height 1.6 m and body mass index of 25.9 kg\/m2. She was on hydroxychloroquine, mycophenolate and prednisone for lupus\/transplant and levothyroxine 125 mcg daily for hypothyroidism. Her baseline intact parathyroid harmone (iPTH), calcium, phosphorus and 25-hydroxy-vitamin D was 372 pg\/mL, 9.4 mg\/dL, 3.8 mg\/dL and 17.4 ng\/mL, respectively (table 1depicting laboratories and medication changes over time). She was on calcitriol (0.75 mcg\/daily), ergocalciferol (50 000 units weekly) and cinacalcet 30 mcg every other day. We started her on calcifediol 30 mg, which was later increased to 60 mg daily. Her calcitriol and ergocalciferol doses were reduced slowly, while cinacalcet remained the same. 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