{"id":7451,"date":"2022-11-22T13:00:22","date_gmt":"2022-11-22T10:00:22","guid":{"rendered":"https:\/\/urbancare.clinic\/symmetrical-white-matter-lesions-in-a-patient-with-systemic-lupus-erythematosus\/"},"modified":"2022-11-22T13:00:22","modified_gmt":"2022-11-22T10:00:22","slug":"symmetrische-lasionen-der-weisen-substanz-bei-einem-patienten-mit-systemischem-lupus-erythematodes","status":"publish","type":"post","link":"https:\/\/urbancare.clinic\/de\/symmetrical-white-matter-lesions-in-a-patient-with-systemic-lupus-erythematosus\/","title":{"rendered":"Symmetrische L\u00e4sionen der wei\u00dfen Substanz bei einem Patienten mit systemischem Lupus erythematodes"},"content":{"rendered":"<div><img decoding=\"async\" src=\"https:\/\/urbancare.clinic\/wp-content\/uploads\/2023\/01\/symmetrical-white-matter-lesions-in-a-patient-with-systemic-lupus-erythematosus.jpg\" class=\"ff-og-image-inserted\" style=\"display:none\"><\/div>\n<p><span class=\"highwire-journal-article-marker-start\"><\/span><\/p>\n<p id=\"p-2\">Ein 16-j\u00e4hriges M\u00e4dchen stellte sich mit zwei Episoden von Kopfschmerzen, Nackenschmerzen und Erbrechen in den letzten 4 Monaten vor. In der ersten Episode wurde sie f\u00fcnf Tage lang mit Antibiotika behandelt und anschlie\u00dfend mit Steroiden behandelt, da ihre Symptome nicht nachlie\u00dfen. Bei der Ausschleichung der Steroide kam es zu einer Verschlimmerung der Symptome, zus\u00e4tzlich zu einer L\u00e4hmung des rechten lateralen Rektus und einer Schwellung des linken Kniegelenks. Sie litt unter zeitweiliger Belastungsdyspnoe, lichtempfindlichen Ausschl\u00e4gen auf den Wangen, Gewichtsverlust, Bl\u00e4sse und Keulenschlagen. Sie hatte 4\/5 Kraft an den beidseitigen H\u00fcftgelenken. \u2026 <\/p>\n<p><span class=\"highwire-journal-article-marker-end\"><\/span><a href=\"http:\/\/pmj.bmj.com\/cgi\/content\/short\/98\/1166\/e25?rss=1\">Medizinische t\u00e4gliche Quelle<\/a><\/p>\n<p>","protected":false},"excerpt":{"rendered":"<p>Ein 16-j\u00e4hriges M\u00e4dchen litt in den letzten 4 Monaten an zwei Episoden von Kopfschmerzen, Nackenschmerzen und Erbrechen. W\u00e4hrend der ersten Episode wurde sie 5 Tage lang mit Antibiotika behandelt, danach wurden Steroide hinzugef\u00fcgt, da ihre Symptome nicht nachlie\u00dfen. Ihre Symptome verschlimmerten sich, als die Steroide ausgeschlichen wurden, und es kam zus\u00e4tzlich zu einer rechtsseitigen Rektusl\u00e4hmung und einer Schwellung des linken Kniegelenks. Sie litt an zeitweiser Belastungsdyspnoe, lichtempfindlichen Ausschl\u00e4gen auf den Wangen, Gewichtsverlust, Bl\u00e4sse und Trommelschlegelfingern. Ihre Beweglichkeit in den H\u00fcftgelenken war auf beiden Seiten auf 4\/5 beschr\u00e4nkt.<\/p>\n<p>Die Magnetresonanztomographie des Gehirns zeigte konfluente, bilateral symmetrische T2-Hyperintensit\u00e4ten in der periventrikul\u00e4ren, subkortikalen und tiefen wei\u00dfen Substanz, was auf eine Leukodystrophie hindeutet (<cross-ref type=\"fig\" refid=\"F1\">Abbildung 1A<\/cross-ref>). Die Untersuchung der Zerebrospinalfl\u00fcssigkeit (CSF) ergab einen hohen Druck von 37 mmHg bei null Zellen und normalem Glukose- und Proteingehalt. Die maligne Zytologie der CSF war negativ. John Cunningham, Cytomegalovirus und BK-Virus-DNA in der CSF waren nicht nachweisbar. HIV-ELISA war negativ.<\/p>\n<p>Symmetrisches Wei\u00df\u2026<\/p>","protected":false},"author":2,"featured_media":7452,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"Default","format":"standard","meta":{"page_builder":"","fifu_image_url":"https:\/\/urbancare.clinic\/wp-content\/uploads\/2023\/01\/symmetrical-white-matter-lesions-in-a-patient-with-systemic-lupus-erythematosus.jpg","fifu_image_alt":"","footnotes":""},"categories":[185],"tags":[],"class_list":["post-7451","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-research-medical-articles"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Symmetrical white matter lesions in a patient with systemic lupus erythematosus - Urban Care Clinic<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/urbancare.clinic\/de\/symmetrische-lasionen-der-weisen-substanz-bei-einem-patienten-mit-systemischem-lupus-erythematodes\/\" \/>\n<meta property=\"og:locale\" content=\"de_DE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Symmetrical white matter lesions in a patient with systemic lupus erythematosus - Urban Care Clinic\" \/>\n<meta property=\"og:description\" content=\"A 16-year-old girl presented with two episodes of headache, neck pain and vomiting in the last 4 months. In the first episode, she was treated with antibiotics for 5 days following which steroids were added, as her symptoms did not resolve. She had aggravation of symptoms when steroids were tapered with additional right lateral rectus palsy and left knee joint swelling. She had intermittent exertional dyspnoea, photosensitive rashes on cheeks, weight loss, pallor and clubbing. She had 4\/5 power at bilateral hip joints. MRI brain showed confluent bilaterally symmetrical T2 hyperintensities in periventricular, subcortical and deep white matter which was reported to be suggestive of leukodystrophy (figure 1A). Cerebrospinal fluid (CSF) examination showed high pressure of 37 mm Hg with nil cells and normal glucose and protein. CSF malignant cytology was negative. John Cunningham, Cytomegalovirus and BK virus DNA in CSF was not detectable. HIV ELISA was negative. Symmetrical white...\" \/>\n<meta property=\"og:url\" content=\"https:\/\/urbancare.clinic\/de\/symmetrische-lasionen-der-weisen-substanz-bei-einem-patienten-mit-systemischem-lupus-erythematodes\/\" \/>\n<meta property=\"og:site_name\" content=\"Urban Care Clinic\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/urbancarezanzibar\" \/>\n<meta property=\"article:published_time\" content=\"2022-11-22T10:00:22+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/urbancare.clinic\/wp-content\/uploads\/2023\/01\/symmetrical-white-matter-lesions-in-a-patient-with-systemic-lupus-erythematosus.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1024\" \/>\n\t<meta property=\"og:image:height\" content=\"1024\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Urban Care Clinic\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Verfasst von\" \/>\n\t<meta name=\"twitter:data1\" content=\"Urban Care Clinic\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/urbancare.clinic\\\/symmetrical-white-matter-lesions-in-a-patient-with-systemic-lupus-erythematosus\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/urbancare.clinic\\\/symmetrical-white-matter-lesions-in-a-patient-with-systemic-lupus-erythematosus\\\/\"},\"author\":{\"name\":\"Urban Care Clinic\",\"@id\":\"https:\\\/\\\/urbancare.clinic\\\/#\\\/schema\\\/person\\\/a304a61bcf298680ee41e2e9ae193930\"},\"headline\":\"Symmetrical white matter lesions in a patient with systemic lupus erythematosus\",\"datePublished\":\"2022-11-22T10:00:22+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/urbancare.clinic\\\/symmetrical-white-matter-lesions-in-a-patient-with-systemic-lupus-erythematosus\\\/\"},\"wordCount\":94,\"publisher\":{\"@id\":\"https:\\\/\\\/urbancare.clinic\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/urbancare.clinic\\\/symmetrical-white-matter-lesions-in-a-patient-with-systemic-lupus-erythematosus\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/urbancare.clinic\\\/wp-content\\\/uploads\\\/2023\\\/01\\\/symmetrical-white-matter-lesions-in-a-patient-with-systemic-lupus-erythematosus.jpg\",\"articleSection\":[\"Research Articles\"],\"inLanguage\":\"de\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/urbancare.clinic\\\/symmetrical-white-matter-lesions-in-a-patient-with-systemic-lupus-erythematosus\\\/\",\"url\":\"https:\\\/\\\/urbancare.clinic\\\/symmetrical-white-matter-lesions-in-a-patient-with-systemic-lupus-erythematosus\\\/\",\"name\":\"Symmetrical white matter lesions in a patient with systemic lupus erythematosus - 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